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US20120231969 PROTEIN ARRAYS AND USES THEREOF  
Illustrative embodiments herein disclosed relate to protein arrays, methods for making the arrays and methods for using them, among others. In some embodiments known proteins representing at least...
US20150018251 PROTEIN CHIPS, PREPARATION AND USE THEREOF  
The present invention relates to the field of medicine, in particular of research and diagnosis. It relates more particularly to a novel tool for detecting antibodies in a biological sample...
US20110130324 METHODS FOR SYSTEMATIC CONTROL OF PROTEIN STABILITY  
Methods and compositions to control the stability of proteins with special emphasis on antibodies and proteins with antibody-like structures, e.g., having an “immunoglobulin-like” fold, are...
US20140221621 SINGLE-CHAIN MULTIVALENT BINDING PROTEIN COMPOSITIONS AND METHODS  
Provided are protein, nucleic acid, and cellular libraries of single chain multivalent binding proteins (e.g., scDVD and scDVDFab molecules) and methods of using these of these libraries for the...
US20110183863 PROTEIN SCREENING METHODS  
The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.
US20110034350 Protein Arrays and Methods of Use Thereof  
The present invention provides human protein arrays that include at least 1000 human proteins. In another embodiment, the present invention provides a method for identifying a substrate of an...
US20150204890 MICROARRAYS OF G PROTEIN COUPLED RECEPTORS  
Microarrays encompassing GPCRs, methods of making such microarrays, and methods of using such microarrays are described.
US20150051096 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS  
Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided...
US20120302464 METHODS FOR PRODUCING RECOMBINANT PROTEINS  
Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.
US20110118131 METHODS AND MATERIALS FOR TARGETED MUTAGENESIS  
The present disclosure relates to methods and materials for mutagenesis, including for the generation of novel or improved proteins and libraries or arrays of mutant proteins or nucleic acids...
US20150232953 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via...
US20150225702 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via...
US20140364338 Adeno-Associated Virus Virions with Variant Capsid and Methods of Use Thereof  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via...
US20120225085 DISPLAY OF DISULFIDE LINKED DIMERIC PROTEINS IN FILAMENTOUS PHAGE  
Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion...
US20120066783 AAV CAPSID LIBRARY AND AAV CAPSID PROTEINS  
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.
US20150057189 IN VIVO TRANSDUCTION WITH A CHIMERIC AAV CAPSID PROTEIN  
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.
US20150119292 METHOD FOR RETAINING EVEN COVERAGE OF SHORT INSERT LIBRARIES  
The invention relates to a method of preparing a library of template polynucleotides with uniform sequence representation and to use of a library of templates prepared using this method for...
US20120129717 Collection and Methods For Its Use  
The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties...
US20140051585 METHODS AND COMPOSITIONS FOR REDUCING GENETIC LIBRARY CONTAMINATION  
Embodiments include methods, compositions, and kits for creating genetic libraries useful for massively parallel genetic sequencing. Some embodiments are directed to methods of preventing the...
US20130274129 TAL-EFFECTOR ASSEMBLY PLATFORM, CUSTOMIZED SERVICES, KITS AND ASSAYS  
The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional...
US20130079243 Fibronectin Type III Repeat Based Protein Scaffolds with Alternative Binding Surfaces  
Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors,...
US20110275535 Yeast Display Systems  
The present invention relates to the field of protein display libraries and library screening. In preferred embodiments, the present invention provides a three component system for display...
US20130190210 ENGINEERED TISSUES FOR IN VITRO RESEARCH USES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME  
Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.
US20110201514 Methods Using 06-Alkylguanine-DNA Alkytransferase  
A method of using O6-alkylguanine-DNA alkyltransferase (AGT) is disclosed for transferring a label from a substrate to a fusion protein comprising the AGT. This allows the detection and/or...
US20150119294 SYNTHETIC POLYPEPTIDE LIBRARIES AND METHODS FOR GENERATING NATURALLY DIVERSIFIED POLYPEPTIDE VARIANTS  
The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide...
US20150005201 SYNTHETIC POLYPEPTIDE LIBRARIES AND METHODS FOR GENERATING NATURALLY DIVERSIFIED POLYPEPTIDE VARIANTS  
The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide...
US20110118149 Synthetic Polypeptide Libraries and Methods for Generating Naturally Diversified Polypeptide Variants  
The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide...
US20110065610 Synthetic Polypeptide Libraries and Methods for Generating Naturally Diversified Polypeptide Variants  
The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide...
US20140066335 Method of preparing libraries of template polynucleotides  
The present invention relates to a method for preparing a library of template polynucleotides and use thereof in methods of solid-phase nucleic acid amplification. More specifically, the invention...
US20120295793 METHODS OF GENERATING MODIFIED POLYNUCLEOTIDE LIBRARIES AND METHODS OF USING THE SAME FOR DIRECTED PROTEIN EVOLUTION  
The invention provides for methods of generating modified polynucleotide libraries by inserting and/or deleting at least three nucleotide residues in polynucleotide sequences. Theses methods may...
US20130296192 Protein Arrays and Methods of Using and Making the Same  
Methods and devices are provided for preparing a protein array having a plurality of proteins. In one embodiment, the method includes providing a plurality of nucleic acids each having a...
US20140228250 LAYERED MICROFLUIDIC LIVING CELL ARRAY  
A layered, microfluidic living cell array is disclosed. The cell array comprises a first layer comprising at least one cell culture channel; a second layer comprising at least one microfluidic...
US20150152491 COMPOSITIONS OF TOEHOLD PRIMER DUPLEXES AND METHODS OF USE  
Provided herein are primers and primer systems having improved specificity and kinetics over existing primers, and methods of use thereof.
US20150197799 POLYNUCLEOTIDE MODIFICATION ON SOLID SUPPORT  
The present disclosure relates to the field of molecular biology and more specifically to methods for capturing and amplifying target polynucleotides on a solid surface.
US20120252701 METHODS FOR GENERATING POLYNUCLEOTIDES HAVING DESIRED CHARACTERISTICS BY ITERATIVE SELECTION AND RECOMBINATION  
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
US20100331216 CELL CULTURE METHOD  
To provide a cell culture method capable of sustaining in-vivo functions for a long time by suppressing dedifferentiation. A cell culture method in accordance with the present invention is to...
US20140256589 METHODS FOR ACCELERATED SELECTION OF POLYPEPTIDES  
In certain embodiments, the disclosure provides a method for generating an mRNA-protein fusion molecule. In other embodiments, the disclosure provides a method for selecting a desired polypeptide.
US20130210680 SYSTEMS AND METHODS FOR AMPLIFICATION AND PHAGE DISPLAY  
The present invention generally relates to amplification of biological entities, for example, for phage display. In one aspect, members of a library of biological entities are encapsulated in...
US20150119293 SYNTHETIC LIGATION REASSEMBLY IN DIRECTED EVOLUTION  
A directed evolution process for rapid and facilitated production from a progenitor polynucleotide template, of a library of mutagenized progeny polynucleotides wherein each of the 20 naturally...
US20150024972 SELECTIVE NUCLEIC ACID AMPLIFICATION FROM NUCLEIC ACID POOLS  
Provided herein are nucleic acids and methods for selectively amplifying in parallel tens of thousands of high quality oligonucleotides without common sequences. The resultant oligonucleotides can...
US20110092391 PHAGE LAMBDA DISPLAY CONSTRUCTS  
Bacteriophages in general and lambda phage in particular are powerful, flexible reagents who have yet to be exploited to their full potential. As discussed herein, the lambda phage head and/or...
US20140148364 MULTIPLEXED ANCHOR SCANNING PARALLEL END TAG SEQUENCING  
The present invention relates to a novel method and to a kit for preparing nucleic-acid libraries, in particular for high-throughput sequencing. Said method is useful for simultaneously preparing...
US20140066334 METHOD FOR THE PRODUCTION OF READING-FRAME-CORRECT FRAGMENT LIBRARIES  
The present invention relates to reading-frame-correct fragment libraries, methods for their production, and the use of the fragment libraries for selection of functional polypeptide variants with...
US20140235453 GLOBAL TRANSCRIPTION MACHINERY ENGINEERING  
The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes.
US20120077713 Collection and Methods for its Use  
The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having...
US20140087972 METHOD OF IMMOBILISING RNA ONTO A SURFACE  
The invention relates to a method of immobilising at least one RNA molecule onto a surface of a support comprising: i) providing a first support having a surface on which at least one DNA molecule...
US20110027231 METHOD FOR THE RANDOM DIVERSIFICATION OF A GENETIC SEQUENCE WHILE PRESERVING THE IDENTITY OF SOME INNER SEGMENTS OF SAID GENETIC SEQUENCE  
The invention relates to a method for obtaining a variety of recombinant bacteriophages in which the screening proteins have been modified by the insertion in their genetic sequence of randomly...
US20150030681 METHOD OF MAKING A HYDROGEL  
The present invention relates to a novel protocol for making a hydrogel, which shows increased stability compared to hydrogels of the art, and can be reliably reproduced. The hydrogels produced by...
US20140200146 Methods of Amplifying Whole Genome of a Single Cell  
Methods and compositions for amplifying the whole genome of a single cell are provided.
US20120088695 Method and Device for Protein Delivery into Cells  
Methods for performing surface-mediated protein delivery into living cells, and fabricating protein-transfected cell cluster arrays are provided. The method comprises providing a...