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US20160077104 MEANS AND METHODS FOR PRODUCING ANTI-PROTEOME ANTIBODIES AND IDENTIFYING CONSERVED UNIQUE OR DIFFERENTIALLY EXPRESSING MOLECULES OF ORGANISMS  
Disclosed are methods for identifying one or more amino acid molecules and nucleic acid molecules encoding such amino acid molecules of at least two proteomes that are conserved, unique or express...
US20160076093 MULTIPLEX HOMOLOGY-DIRECTED REPAIR  
Disclosed is a method for introducing a plurality of programmed nucleotide modifications into a single locus of a desired genomic DNA sequence in a single experiment. The method entails...
US20160076025 FLEXIBLE TAPE-BASED CHEMISTRY APPARATUS  
An apparatus and method for applying a chemistry to samples of interest are provided. The apparatus and method include a flexible tape mounted on an arrangement of guide rollers. Samples of...
US20160068897 APPARATUS AND METHOD FOR EXTRACTING MICROBIAL CELLS  
Methods and devices are provided for pretreatment of a sample containing microbial cells. In some embodiments, the pretreatment of the sample is performed via the initial selective lysis, within a...
US20160068889 METHODS FOR SELECTIVELY SUPPRESSING NON-TARGET SEQUENCES  
The invention generally relates to negative selection of nucleic acids. The invention provides methods and systems that remove unwanted segments of nucleic acid in a sample so that a target gene...
US20160068835 FLEXIBLE DISPLAY METHOD  
An improved method used in selecting a useful protein, peptide, peptide analog by an evolution molecule engineering is provided. A transcription-linker association-translation coupling reaction...
US20160067711 SYSTEMS AND METHODS FOR SINGLE CELL ISOLATION AND ANALYSIS  
The present disclosure relates to devices, systems, and methods for single cell isolation and analysis. In particular, the present disclosure relates to systems and methods for isolating single...
US20160060685 COMPOSITIONS AND METHODS FOR DETECTING NUCLEIC ACID FROM MOLLICUTES  
Compositions, reaction mixtures, kits and methods used in amplifying and detecting nucleic acids from various species of the class Mollicutes. Particular regions of the 23S rRNA or its gene have...
US20160059203 METHOD OF FABRICATING CELL ARRAYS AND USES THEREOF  
The present disclosure provides a fabrication process that results in creating large arrays of living cells, such as stem cells, which are subsequently exposed to nanoliter quantities of compounds...
US20160053307 LIGASE-ASSISTED NUCLEIC ACID CIRCULARIZATION AND AMPLIFICATION  
Provided herein are methods for generation and amplification of a single-stranded DNA circle in a single reaction vessel from a linear DNA without any intervening purification steps. The...
US20160053304 Methods Of Depleting Target Sequences Using CRISPR  
Methods of depleting one or more target nucleic acid sequences using the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR associated (Cas) proteins (CRISPR/Cas) system...
US20160053253 NUCLEIC ACID SEQUENCE ANALYSIS FROM SINGLE CELLS  
Presented herein are methods and compositions for multiplexed single cell gene expression analysis. Some methods and compositions include the use of droplets and/or beads bearing unique barcodes...
US20160051959 NUCLEIC ACID SAMPLE PREPARATION METHODS AND COMPOSITIONS  
The present invention provides compositions and methods for preparing a nucleic acid library in a multi-purpose buffer (e.g., employing whole genome amplification), where nucleic acid purification...
US20160051958 HIGH-SPEED ON DEMAND MICROFLUIDIC DROPLET GENERATION AND MANIPULATION  
Methods and devices for the formation and/or merging of droplets in microfluidic systems are provided. In certain embodiments a microfluidic droplet merger component is provided that comprises a...
US20160046998 METHDS AND COMPOSITION TO GENERATE UNIQUE SEQUENCE DNA PROBES, LABELING OF DNA PROBES AND THE USE OF THESE PROBES  
The invention relates generally to the field of the identification of DNA sequences, genes or chromosomes. Methods and composition to obtain Unique Sequence DNA probes are provided. Compositions...
US20160046987 LIBRARY GENERATION FOR NEXT-GENERATION SEQUENCING  
Provided herein is technology relating to next-generation sequencing (NGS) and particularly, but not exclusively, to methods and compositions for preparing NGS libraries, e.g., to prepare NGS...
US20160046930 METHODS OF SEQUENCING NUCLEIC ACIDS IN MIXTURES AND COMPOSITIONS RELATED THERETO  
This disclosure relates to analyzing the end-to-end sequence and the relative distributions in heterogeneous mixtures of polynucleotides and methods and enabling reagents related thereto. In...
US20160046926 NUCLEIC ACID SAMPLE PREPARATION  
The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid...
US20160045884 SINGLE CELL CAPTURE WITH CAPTURE CHIPS  
The present invention provides methods, systems, assemblies, and articles for capturing single cells with a capture chip. In certain embodiments, the capture chip comprises a substrate comprising...
US20160045883 STABILISATION FEATURES  
Devices, systems and methods for making and handling liquid samples are disclosed.
US20160040236 SYSTEMS AND METHODS FOR CHARACTERIZATION OF MULTIPLE SCLEROSIS  
Methods and systems to characterize multiple sclerosis in a subject, e.g., in a subject a progressive form of MS are disclosed.
US20160040229 SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION  
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample...
US20160040158 PROTEIN SCREENING METHODS  
The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.
US20160032396 Identification and Use of Circulating Nucleic Acid Tumor Markers  
Methods for creating a selector of mutated genomic regions and for using the selector set to analyze genetic alterations in a cell-free nucleic acid sample are provided. The methods can be used to...
US20160032377 MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES  
Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3′ sugar hydroxyl, as well as methods and kits using...
US20160032375 NUCLEIC ACID AMPLIFICATION  
In some embodiments, the present teachings provide methods for nucleic acid amplification, comprising forming a reaction mixture, and subjecting the reaction mixture to conditions suitable for...
US20160032359 Methods for Generating Nucleic Acid Molecule Fragments Having a Customized Size Distribution  
The invention provides methods for generating nucleic acid molecule fragments having a customized distribution. In one aspect, a method of generating nucleic acid fragments having a customized...
US20160032283 RANDOM RNAi LIBRARIES, METHODS OF GENERATING SAME, AND SCREENING METHODS UTILIZING SAME  
This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and...
US20160032282 SINGLE CELL BAR-CODING FOR ANTIBODY DISCOVERY  
Provided herein are methods and composition for immune repertoire sequencing and single cell barcoding. The methods and compositions can be used to heavy and light chain antibody sequences...
US20160025709 HIGH THROUGHPUT DNA DAMAGE QUANTIFICATION OF HUMAN TISSUE WITH HOME-BASED COLLECTION DEVICE  
Kits, methods and systems for providing a service to provide a subject with information regarding the state of a subject's DNA damage. Collection, processing and analysis of samples are also...
US20160024556 ENRICHMENT AND NEXT GENERATION SEQUENCING OF TOTAL NUCLEIC ACID COMPRISING BOTH GENOMIC DNA AND cDNA  
The present invention relates to methods of enriching and sequencing a mixture of nucleic acids comprising genomic DNA sequences and cDNA sequences obtained from the test sample.
US20160024490 METHOD FOR SEPARATING DNA BY SIZE  
The present invention provides method for isolating DNA molecules having a size above a certain cut-off value from a DNA containing sample, comprising a) contacting the sample with a binding...
US20160024463 BIOMATRIX SCAFFOLDS FOR INDUSTRIAL SCALE DISPERSAL  
The present invention provides biomatrix scaffolds for industrial scale dispersal.
US20160018304 LIQUID TISSUE PREPARATION FROM HISTOPATHOLOGICALLY PROCESSED BIOLOGICALLY SAMPLES, TISSUES AND CELLS  
The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multiuse biomolecule lysate. This method allows for...
US20160017410 HIGHLY MULTIPLEX SINGLE AMINO ACID MUTAGENESIS FOR MASSIVELY PARALLEL FUNCTIONAL ANALYSIS  
Disclosed is a method for multiplexed mutagenesis of a target nucleotide sequence. The method entails generating, in parallel, a set of mutagenic oligonucleotide primers designed to cover all or...
US20160017408 METHODS AND KITS TO DETERMINE THE SENSITIVITY OF STRAINS OF LACTOCOCCUS LACTIS BACTERIA TO PHAGE INFECTION  
A kit useful for determining the phage susceptibility of one or more strains of Lactococcus lactis is described. The disclosure also describes methods for formulation of mixed defined starter...
US20160017396 POLYNUCLEOTIDE ENRICHMENT USING CRISPR-CAS SYSTEMS  
A method for enriching a target nucleic acid comprising providing an endonuclease system having a crRNA or a derivative thereof, and a Cas protein or a variant thereof. The crRNA or the derivative...
US20160017391 cDNA Synthesis Improvements  
The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods,...
US20160017320 SEMI-RANDOM BARCODES FOR NUCLEIC ACID ANALYSIS  
The present disclosure provides oligonucleotides that comprise semi-random barcode sequences. Such oligonucleotides may be incorporated into reverse transcription primers, PCR primers, or portions...
US20160017283 SYSTEMS AND METHODS FOR CULTURING EPITHELIAL CELLS  
The present invention features assays for co-culturing primary cells while maintaining key biological activities specific to the primary cells. The invention is based, at least in part, on the...
US20160016169 MICROFLUIDIC DEVICES FOR THE RAPID AND AUTOMATED PROCESSING OF SAMPLE POPULATIONS  
Microfluidic devices for the rapid and automated processing of sample populations are provided. Described are multiplexer tiplexer microfluidic devices configured to serially deliver a plurality...
US20160016140 Integrated Analysis System  
The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and...
US20160011176 METHOD AND DEVICE FOR EXAMINING MYOCARDIAL TOXICITY AND EVALUATING CARDIOMYOCYTES  
Regarding cardiomyocytes and fibroblasts, it is meaningful to develop a device or system whereby, upon the transmission of pulsation from an adjacent cardiomyocyte or fibroblast, cell potential...
US20160010082 Methods for Enhancing Bacterial Cell Display of Proteins and Peptides  
Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display...
US20160010078 Two-Dimensional Cell Array Device and Apparatus for Gene Quantification and Sequence Analysis  
In order to conduct gene expression analysis of a number of genes in a number of cells, it has been necessary to separate cells, extract genes therefrom, amplify nucleic acids, and perform...
US20160003806 HIGH THROUGHPUT ASSAYS FOR DETERMINING CONTRACTILE FUNCTION AND DEVICES FOR USE THEREIN  
The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
US20160002720 Enrichment of Target Sequences  
Methods and compositions are provided for enriching for target sequences from a population of nucleic acids, that includes combining in solution, a population of nucleic acids and a target...
US20160002317 Cytoplasmic Expression of Fab Proteins  
The present invention relates generally to antigen binding polypeptides, such as Fab fragments and derivatives thereof, that demonstrate high stability and solubility. The present invention also...
US20160001249 Methods for Loading a Sensor Substrate  
A method of loading beads on a sensor substrate includes applying a suspension including beads to a flow cell defined over a sensor substrate. The sensor substrate includes a plurality of wells....
US20160001248 METHODS AND COMPOSITIONS FOR TAGGING AND ANALYZING SAMPLES  
The invention relates to methods of tagging analytes in a sample.