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US20160177294 RANDOM RNA LIBRARIES, METHODS OF GENERATING SAME, AND SCREENING METHODS UTILIZING SAME  
This invention provides sets and libraries of short hairpin ribonucleic acid (shRNA) molecules comprising a double-stranded region of random sequence containing random mismatches, methods of...
US20160177293 MODIFIED PEPTIDE DISPLAY  
The invention provides a replicable genetic package displaying a cyclic peptide having at least one intramolecular bond between amino acid side chains. Also provided are a method of preparing such...
US20160176951 SYNTHETIC LIBRARY OF SPECIFIC BINDING MOLECULES  
The present invention provides methods for the production of a library of antigen specific antigen binding molecules having a peptide domain structure represented by the following formula (I): FW...
US20160168642 METHOD FOR DETECTING TELOMERASE VIA WASHING-FREE ANCHORED-EXTENSION AND TELOMERIC-BINDING AMPLIFICATION, AND KIT  
Provided is a new method for telomerase amplification—washing-free anchored-extension and telomeric-binding amplification (WATA). The method comprises: utilizing an anchored telomerase primer to...
US20160168641 AFFINITY MEDIATED AMPLIFICATION METHOD OF TELOMERIC C-SSDNA AND DETECTION KIT  
Provided in the present invention are an affinity mediated amplification method of telomeric C-ssDNA with a template probe and a detection kit using this method for performing alternative...
US20160168578 METHODS AND DEVICES FOR ELECTROMAGNETIC LIGATION OF NUCLEIC ACIDS AND ELECTROMAGNETIC TRANSFORMATION OF CELLS  
Described herein are methods and devices for ligating nucleic acids or nucleic acid fragments as well as methods for transforming or transfecting cells with exogenous DNA. The methods and devices...
US20160168563 EFFICIENT METHOD FOR DISPLAYING PROTEIN MULTIMER  
The invention provides a method of producing a protein multimer-nucleic acid complex comprising a protein multimer and any one target component of the protein multimer. A nucleic acid encoding the...
US20160161496 Cells Having A Spectral Signature And Methods Of Preparation And Use Thereof  
Methods, compositions and articles of manufacture for encoding a cell with semiconductor nanocrystals and/or other fluorophors are provided. The encoded cells can be subjected to functional assays...
US20160160272 Arrays and Methods of Use  
Methods are provided for producing a molecular array comprising a plurality of molecules immobilised to a solid substrate at a density which allows individual immobilised molecules to be...
US20160160265 DEVICES AND METHODS FOR THERMALLY-MEDIATED CHEMICAL REACTIONS  
One aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a...
US20160160210 RNA-Guided Human Genome Engineering  
A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the...
US20160159928 HUMANIZED ANTIBODIES WITH ULTRALONG COMPLEMENTARY DETERMINING REGIONS  
The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
US20160157764 MICRONEEDLE ARRAY DEVICE AND METHOD OF MAKING  
A microneedle array device includes a substrate and an array of microneedles on the substrate. Each microneedle includes a redox enzyme and redox mediator and an electrically conductive layer on...
US20160153039 COMPOSITIONS AND METHODS FOR TARGETED NUCLEIC ACID SEQUENCE ENRICHMENT AND HIGH EFFICIENCY LIBRARY GENERATION  
Provided herein are methods, compositions and kits for targeted nucleic acid sequence enrichment in a nucleic acid sample and for high efficiency nucleic acid library generation for next...
US20160153036 SPECIFIC NUCLEIC ACID AMPLIFICATION WITH COMPOUNDED SELECTIVITY  
The present disclosure provides, in various aspects and embodiments, methods and compositions for selectively amplifying a rare target nucleic acid and/or suppressing amplification of non-target...
US20160153001 METHODS FOR TRANSFORMING YEAST  
This invention is directed to the transformation of yeast, and mutants thereof, by electroporation, which result in stably transformed yeast host cells that express recombinant products. This...
US20160145684 METHODS OF DETECTING SYNTHETIC URINE AND MATCHING A URINE SAMPLE TO A SUBJECT  
Provided herein are methods for determining if a urine sample comprises synthetic urine, methods for matching a urine sample to a subject, and methods for amplifying DNA. Also provided are kits...
US20160145683 MASSIVELY PARALLEL SINGLE CELL ANALYSIS  
The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single...
US20160145605 PEPTIDE-PRESENTING PROTEIN AND PEPTIDE LIBRARY USING SAME  
The object of the present invention is to provide a method for screening peptide(s) highly specific to a target molecule. The object can be solved by a peptide-presenting protein wherein a peptide...
US20160145604 An Integrated System for Library Construction, Affinity Binder Screening and Expression Thereof  
A recombinant polynucleotide suitable for use in a display vector is provided. The recombinant polynucleotide includes from 5′ to 3′: a first nucleic acid sequence (or insert) encoding an amino...
US20160145603 COMPOSITIONS FOR MAKING RANDOM CODON-MUTANT LIBRARIES AND USES THEREOF  
The present disclosure relates to compositions and methods for randomly introducing codon-mutations in a target nucleic acid molecule and, more particularly, using wild-type and triplet-randomized...
US20160144333 Assembly of High Fidelity Polynucleotides  
Methods and apparatus relate to the synthesis of high fidelity polynucleotides and to the reduction of sequence errors generated during synthesis of nucleic acids on a solid support. Specifically,...
US20160144331 METHOD FOR GENERATING AN AFFINITY REAGENT LIBRARY  
The present disclosure provides a method for generating an affinity reagent library against a target protein which interacts with a ligand, which comprises the following steps; i) determining one...
US20160138086 METHODS AND KITS FOR LABELING CELLULAR MOLECULES  
Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality...
US20160138082 Thermo-controllable high-density chips for multiplex analyses  
The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides...
US20160138081 METHOD FOR ISOLATING SPECIFIC GENOMIC REGION USING MOLECULE BINDING SPECIFICALLY TO ENDOGENOUS DNA SEQUENCE  
Provided is a method comprising (A) fragmenting genomic DNA in a state where the interaction of the genomic DNA and molecules interacting therewith is maintained, and(B) bringing genomic DNA into...
US20160138013 SUBSTANTIALLY UNBIASED AMPLIFICATION OF GENOMES  
Methods and manufactures for substantially unbiased amplification of genomes are provided herein. Some embodiments include methods of producing a substantially unbiased amplification library of a...
US20160130643 ACCURATE IN VITRO COPYING OF DNA METHYLATION  
A method of copying a methylated nucleic acid molecule is provided. The method includes copying a nucleic acid molecule into a plurality of nucleic acid molecules; and contacting the plurality of...
US20160130636 QUANTITATING HIGH TITER SAMPLES BY DIGITAL PCR  
The present invention provides systems, devices, methods, kits, and compositions for nucleic acid analysis using digital PCR. In particular, methods are provided to analyze high titer samples that...
US20160130576 COMPOSITIONS AND METHODS FOR DIRECTIONAL NUCLEIC ACID AMPLIFICATION AND SEQUENCING  
The invention provides methods and compositions, including kits, for directional nucleic acid amplification and sequencing. The invention further provides methods and compositions for the...
US20160130326 NOVEL ANTIBODY FRAMEWORKS  
The present invention relates to novel antibody frameworks with advantageous properties.
US20160122811 COMPOSITIONS AND METHODS FOR AMPLIFYING A NUCLEIC ACID SEQUENCE IN A SAMPLE  
The present invention features compositions and methods for amplifying a target oligonucleotide in a sample comprising one or more primer oligonucleotides comprising a 5′ nicking enzyme...
US20160122810 SYSTEMS AND METHODS FOR NUCLEIC ACID CAPTURE  
Provided herein are methods for improving the detection sensitivity of amplification reaction products. In particular, provided herein are methods of improving sensitivity of detection of...
US20160116459 NEURAL NETWORKS FORMED FROM CELLS DERIVED FROM PLURIPOTENT STEM CELLS  
In some aspects, cultures of neurons derived from human induced pluripotent stem cells (iPS cells) that exhibit synchronous firing of neural networks are provided. In some embodiments, neuronal...
US20160116453 ARRAYS OF DISCRETE CELL CULTURE MICROENVIRONMENTS, METHOD OF MAKING SUCH ARRAYS AND USES THEREOF  
The invention pertains to a combinatorial method of identifying the hydrogel formulations controlling phenotype and fate of difficult-to-culture cell types.
US20160115544 MOLECULAR BARCODING FOR MULTIPLEX SEQUENCING  
Described herein are methods, compositions and kits for preparing samples for multiplex next generation nucleic acid sequencing. The methods entail the use of in-line barcodes that minimize...
US20160115473 MULTIFUNCTIONAL OLIGONUCLEOTIDES  
Provided herein is technology relating to the manipulation and characterization of nucleic acids and particularly, but not exclusively, to methods and compositions relating to oligonucleotide...
US20160114321 MICROREACTOR WITH VENT CHANNELS FOR REMOVING AIR FROM A REACTION CHAMBER  
A microreactor for performing chemical reactions, includes a body, a first chamber and a second chamber, both formed in the body. Interconnections are provided for fluidly coupling the first...
US20160108468 Isothermal Amplification of Nucleic Acid, and Library Preparation and Clone Generation in Sequencing  
An amplification system that provides methods and reaction components that allow for isothermal amplification for detection of target nucleic acid 24; allow non-enzymatic amplification for...
US20160108461 TARGETED WHOLE GENOME AMPLIFICATION METHOD FOR IDENTIFICATION OF PATHOGENS  
The methods disclosed herein relate to methods and compositions for amplifying nucleic acid sequences, more specifically, from nucleic acid sequences of pathogens by targeted whole genome...
US20160102349 METHODS FOR SEQUENCING POLYNUCLEOTIDES  
The invention relates to methods and systems for sequencing and constructing a high resolution physical map of a polynucleotide. In accordance with the invention, nucleotide sequences are...
US20160098516 METHODS AND SYSTEMS FOR DETECTION OF A GENETIC MUTATION  
Methods and systems for the detection of genetic mutations from a tissue sample (e.g., a preserved tissue sample) are provided. The method includes the steps of a) extracting a nucleic acid from a...
US20160097773 INTERCELLULAR LABELING OF LIGAND-RECEPTOR INTERACTIONS  
An sortase-mediated intercellular labeling method allowing for tracking ligand-receptor interaction both in vitro and in vivo; and uses thereof for tracking molecule interactions both in vitro and...
US20160097050 DEVICES AND METHODS FOR DISPLAY OF ENCODED PEPTIDES, POLYPEPTIDES, AND PROTEINS ON DNA  
A novel method for displaying proteins and peptides is disclosed in which individual proteins or peptides remain associated with the DNA encoding them. Proteins or peptides can be generated by in...
US20160097039 ENGINEERED RENAL TISSUES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME  
Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of...
US20160090591 OLIGONUCLEOTIDE REPLACEMENT FOR DI-TAGGED AND DIRECTIONAL LIBRARIES  
Transposomes and oligonucleotide replacement methods to make DNA libraries that have distinct 5′ and 3′ tags, and to make directional libraries that are enriched for a desired strand.
US20160090400 ANTIBODY LIKE PROTEIN  
A general method and recombinant nucleic acid sequences, by means which the method selects a recombinant protein containing an FHA domain for binding a target molecule from a library proteins with...
US20160083722 COMPOSABILITY AND DESIGN OF PARTS FOR LARGE-SCALE PATHWAY ENGINEERING IN YEAST  
Expression cassettes comprising promoter and terminator combinations are provided and can be used to tune gene expression. Synthetic yeast promoters and methods of making them also are provided.
US20160083720 METHOD FOR THE SYNTHESIS OF A BIFUNCTIONAL COMPLEX  
Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a...
US20160083719 Method for Producing Compound Containing Heterocycle  
An object of the present invention is to provide a method of stably introducing a heterocycle into a substrate peptide by using an azoline backbone introducing enzyme. The present invention...