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US20160362725 Oscillating Amplification Reaction for Nucleic Acids  
One embodiment of the present invention provides for a method for amplifying a template of nucleic acid target sequence contained in a sample. The method includes contacting the sample with an...
US20160362682 Recombinant Fusion Proteins and Libraries from Immune Cell Repertoires  
Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
US20160362681 Recombinant Fusion Proteins and Libraries from Immune Cell Repertoires  
Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
US20160362680 COMPOSITIONS AND METHODS FOR NEGATIVE SELECTION OF NON-DESIRED NUCLEIC ACID SEQUENCES  
The present invention provides methods, compositions and kits for the generation of next generation sequencing (NGS) libraries in which non-desired polynucleotides have been depleted or...
US20160362470 Recombinant Fusion Proteins and Libraries from Immune Cell Repertoires  
Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
US20160356681 MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES  
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described....
US20160355879 AMPLIFICATION AND ANALYSIS OF WHOLE GENOME AND WHOLE TRANSCRIPTOME LIBRARIES GENERATED BY A DNA POLYMERIZATION PROCESS  
The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is...
US20160355878 Method for Generating of Oligonucleotide Arrays Using In Situ Block Synthesis Approach  
The idea of this invention is to prepare ordered oligonucleotides arrays from two or more pre-synthesized shorter parts—block-synthesis approach. The parts are linked together enzymatically to...
US20160340632 CULTURING STATION FOR MICROFLUIDIC DEVICE  
A station for culturing biological cells in a microfluidic device is provided. The station includes one or more thermally conductive mounting interfaces, each mounting interface configured for...
US20160339409 DE NOVO SYNTHESIZED GENE LIBRARIES  
De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are...
US20160326517 COMPOSITIONS AND METHODS FOR THE CONSTRUCTION OF A RANDOM ALLELIC SERIES  
The present disclosure provides a method of making a systematic single point mutation in a target nucleic acid and a method of generating a mutational library comprising target nucleic acids with...
US20160318978 Methods of Transcription Activator Like Effector Assembly  
The disclosure describes methods that include providing a first nucleic acid having a sequence encoding a first set comprising one or more transcription activator-like effector (TALE) repeat...
US20160312276 METHODS AND COMPOSITIONS FOR WHOLE TRANSCRIPTOME AMPLIFICATION  
The disclosure provides for methods, compositions, systems, devices, and kits for whole transcriptome amplification using stochastic barcodes.
US20160310948 Fluidic Test Cassette  
A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct...
US20160304947 RNA AMPLIFICATION AND OLIGONUCLEOTIDE LIBRARY PREPARATION  
This disclosure describes, in one aspect, a method of amplifying an RNA template. Generally, the method includes synthesizing an oligonucleotide from the RNA template, isolating at least a portion...
US20160304860 POLYNUCLEOTIDE BARCODE GENERATION  
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including...
US20160303534 FABRICATION OF PATTERNED ARRAYS  
Provided herein are methods and compositions for the fabrication of patterned arrays, such as nucleotide arrays. The methods and compositions are suited for the transfer and reorientation of array...
US20160289755 DNA-ADAPTER-MOLECULES FOR THE PREPARATION OF DNA-LIBRARIES AND METHOD FOR PRODUCING THEM AND USE  
The invention relates to DNA-adapter-molecules for the preparation of DNA-libraries and methods for producing them and their use. The invention is useful for the application in molecular biology,...
US20160289670 COMPOSITIONS AND METHODS FOR MOLECULAR LABELING  
The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a...
US20160289669 DEVICES AND SYSTEMS FOR MOLECULAR BARCODING OF NUCLEIC ACID TARGETS IN SINGLE CELLS  
Disclosed herein are devices and systems comprising a) a substrate comprising at least 100 microwells and a plurality of beads, wherein a plurality of the at least 100 microwells each contain a...
US20160288124 DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT AND REACTION  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
US20160282376 THERMAL MANAGEMENT IN THE CONTEXT OF AUTOMATED HISTOLOGICAL PROCESSING OF BIOLOGICAL SPECIMENS AND ASSOCIATED TECHNOLOGY  
Methods and system capable of processing specimens carried by slides within an automated histological staining system. A slide carrier is moved toward and into a temperature-controlled internal...
US20160282375 AUTOMATED PROCESSING SYSTEMS AND METHODS OF THERMALLY PROCESSING MICROSCOPE SLIDES  
Methods and apparatus that enable drying and curing a plurality of specimens carried by a plurality of microscope slides. Slide carriers are positioned at a first position while the slide carrier...
US20160282374 STAINING REAGENTS AND OTHER LIQUIDS FOR HISTOLOGICAL PROCESSING OF BIOLOGICAL SPECIMENS AND ASSOCIATED TECHNOLOGY  
Processing specimens in an automated histological staining system comprising robotically moving a slide carrier into a stainer of the system, the slide carrier carrying slides which respectively...
US20160272954 NUCLEIC ACID AMPLIFICATION  
In some embodiments, the present teachings provide methods for nucleic acid amplification, comprising forming a reaction mixture, and subjecting the reaction mixture to conditions suitable for...
US20160271604 Systems and Methods for Loading Liquid Samples  
A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first...
US20160266019 METHOD FOR SEPARATING MULTIPLE BIOLOGICAL MATERIALS  
The present invention relates to a method for separating multiple biological materials using characteristics of magnetic nanoparticles. The method of the present invention is able to separate...
US20160258002 Synthesis of Pools of Probes by Primer Extension  
Provided herein is a method for making a pool of probes by primer extension. In certain embodiments, the method comprises hybridizing a first population of oligonucleotides comprising a top strand...
US20160257994 SELECTIVE AMPLIFICATION OF OVERLAPPING AMPLICONS  
The present invention relates to a scalable multiplex PCR method that can simultaneously amplify overlapping amplicons without the drawbacks of conventional multiplex PCR. The method selectively...
US20160257984 Processes and Systems for Preparation of Nucleic Acid Sequencing Libraries and Libraries Prepared Using Same  
This disclosure provides methods for preparing a sequencing library including the steps of providing a template nucleic acid sequence, dNTPs, dUTP, a primer, a polymerase, a dUTP excising enzyme,...
US20160251700 NUCLEIC ACID SAMPLE PREPARATION  
This invention relates to the preparation of nucleic acid samples for analysis. The invention may be particularly useful for single stranded samples. Embodiments of the invention involve the...
US20160244742 METHOD FOR CAPTURING AND ENCODING NUCLEIC ACID FROM A PLURALITY OF SINGLE CELLS  
This invention relates to methods for capturing and encoding nucleic acid from a plurality of single cells. A plurality of solid supports is randomly placed into a plurality of compartments, such...
US20160237484 METHOD AND COMPOSITION FOR NUCLEIC ACID AMPLIFICATION  
The present teachings provide methods, compositions, and kits for nucleic acid amplification. In some embodiments of the present teachings, amplification reactions are performed with at least one...
US20160237110 ACOUSTIC MICROREACTOR AND METHODS OF USE THEREOF  
Described herein are microreactors and methods of modifying support particles using acoustic standing waves. A liquid medium containing suspended support particles is flowed along a flow path...
US20160230223 Method Of Amplifying Nucleic Acid Sequences  
The invention is directed to methods of removing amplicons of non target and/or target nucleic acid sequences having one or more modified (e.g., methylated) nucleotides from a sample wherein the...
US20160222380 METHOD OF PREPARING NUCLEIC ACID MOLECULES  
Disclosed is a method of preparing nucleic acid molecules, including: providing a pool of oligonucleotides, each containing restriction enzyme digestion sequences and generic flanking sequences;...
US20160215318 Methods and Devices for Nucleic Acid Synthesis  
Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary embodiments, the device includes a support...
US20160215317 SELF-REPLICATION OF NUCLEIC ACID ORIGAMI TILES  
The present invention provides a method for self-replication of multimers of nucleic acid origami tiles by exponentially amplifying the multimer from initial seeds of monomeric units of nucleic...
US20160208323 Methods for Shearing and Tagging DNA for Chromatin Immunoprecipitation and Sequencing  
Disclosed are methods for shearing and tagging chromatin DNA. The disclosed methods include contacting chromatin DNA with at least one transposome, that includes a transposase enzyme. The...
US20160202241 NANOFIBROUS PHOTOCLICKABLE HYDROGEL MICROARRAYS  
Nanofibrous hydrogel microarray systems that act as facile, high throughput platforms for in vitro drug discovery and investigation and screening of combinatorial effects of physical and...
US20160201126 EFFICIENT BIOMOLECULE RECYCLING METHOD AND SYSTEM  
A technique is disclosed for recapturing and recycling biomolecule reagents. The technique may be applied in a range of settings, including biopolymer synthesis, sequencing, and so forth....
US20160201124 Targeted Sequencing and UID Filtering  
Provided herein are methods, compositions, and kits for targeted sequencing of polynucleotides with high accuracy and low amplification and sequencing errors.
US20160201105 STEP-UP METHOD FOR COLD-PCR ENRICHMENT  
Methods of using polymerase chain reactions to enrich a plurality of target sequences in a sample containing reference sequences and target sequences having high homology and amplifiable by the...
US20160194695 NUCLEIC ACID AMPLIFICATION METHOD USING ALLELE-SPECIFIC REACTIVE PRIMER  
The present invention relates to a method for amplifying nucleic acid using an allele-specific reactive primer (ASRP) designed to solve the problems of conventional allele-specific PCR, and more...
US20160194627 COMBINATORIAL ANTIBODY LIBRARIES AND USES THEREOF  
Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL...
US20160194626 Universal Fibronectin Type III Bottom-Side Binding Domain Libraries  
The invention pertains to a natural-variant combinatorial library of fibronectin Type 3 domain (Fn3) polypeptides useful in screening for the presence of one or more polypeptides having a selected...
US20160193607 TRANSPORTABLE COMPOSITE LIQUID CELLS  
A single-use cartridge, wherein the cartridge defines a plurality of blind bores, each blind bore defining one opening at least one of the plurality of blind bores containing two mutually...
US20160186253 NON-INVASIVE PRENATAL DIAGNOSIS OF FETAL GENETIC CONDITION USING CELLULAR DNA AND CELL FREE DNA  
Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a...
US20160186235 APPARATUS FOR HIGH THROUGHPUT CHEMICAL REACTIONS  
Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be...
US20160177374 Integrated Capture and Amplification of Target Nucleic Acid for Sequencing  
The invention provides efficient methods of preparing a target nucleic acid in a form suitable for sequencing. The methods are particularly amenable for preparing high quality nucleic acids for...