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US20090143245 MICROARRAYS FOR GENOTYPING AND METHODS OF USE  
The present invention provides a microarray for detecting a genotype at a polymorphic site in a plurality of nucleic acid samples, comprising a first set of nucleic acid fragments derived from the...
US20080009420 Isothermal methods for creating clonal single molecule arrays  
The present invention is directed to a method for isothermal amplification of a plurality of different target nucleic acids, wherein the different target nucleic acids are amplified using...
US20110152108 Devices and Methods for Thermally-Mediated Chemical Reactions  
One aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a...
US20090253591 METHODS FOR IDENTIFYING NEURIPOTENT CELLS  
The invention is a method for using an avian embryo to identify the neuripotency of a cell population. The invention may be used for applications such as screening for candidate neuripotent cell...
US20080241892 Modified surfaces for immobilization of active molecules  
Modified surfaces, substrates, and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide either non-reactive surfaces or low density...
US20090280478 GENE METHYLATION AND EXPRESSION  
The invention provides a method of analyzing the methylation status of all or part of an entire genome. Moreover, the invention features methods of and reagents for characterizing biological cells...
US20120045394 HUMAN AND MOUSE TARGETING PEPTIDES IDENTIFIED BY PHAGE DISPLAY  
The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed....
US20140283150 Animal Models and Therapeutic Molecules  
The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof...
US20140378350 COMPOSITIONS AND METHODS FOR SAMPLE PROCESSING  
This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries...
US20140378349 COMPOSITIONS AND METHODS FOR SAMPLE PROCESSING  
This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries...
US20140378345 COMPOSITIONS AND METHODS FOR SAMPLE PROCESSING  
This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries...
US20110237779 CDR-REPAIRED ANTIBODIES  
The present application concerns restoring antigen binding during humanization of antibodies through the selection of repaired hypervariable regions rather than through framework changes.
US20120231974 Self-Assembling High Density Ordered Patterned Biomolecule Array and Method for Making and Using the Same  
A method for fabricating a universal substrate for attaching biomolecules, including sequencing features and the resulting substrate. A method of direct detection of analytes utilizes a...
US20110293573 METHOD AND APPARATUS FOR CULTURING TISSUE  
A method for culturing microtissue is provided. The method includes steps of: (a) forming a pattern microarray on a hydrophobic film; (b) adhering the hydrophobic film to a carrier; (c) disposing...
US20110237447 METHOD OF DETERMINING CHROMATIN STRUCTURE  
A method of determining chromatin structure is described. The method comprises the steps of (i) fragmenting a nucleotide sequence at multiple HSs; and (ii) analysing fragments formed in step (i)...
US20100273680 METHOD AND SYSTEM FOR THE ANALYSIS OF HIGH DENSITY CELLS SAMPLES  
Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are...
US20050059082 Method for producing protein libraries and for selecting proteins from said libraries  
The invention relates to a method for the production of a protein library, in particular an antibody library, which is highly diverse and for the selection of proteins, in particular antibodies,...
US20090280489 Ig genes specific oligonucleotides and uses thereof  
The present invention provides oligonucleotides for detection of rearrangement of immunoglobulin genes for identifying clonality of cells, cancer cells, hypermutation in immunoglobulin gene,...
US20120053064 DETERMINING THE IDENTITY OF TERMINAL NUCLEOTIDES  
This document provides methods and materials for determining the identity of the terminal nucleotide (e.g., the 3′ terminal nucleotide) of a nucleic acid molecule. For example, methods and...
US20100069264 Libraries of recombinant chimeric proteins  
The provides methods for generating divergent libraries of recombinant chimeric proteins, comprising identifying a plurality of conserved amino acid sequences, selecting a plurality of consensus...
US20140113830 Azoline Compound and Azole Compound Library and Method for Producing Same  
An object of the present invention is to provide a method of efficiently constructing a library abundant in diversity and also usable for screening of a compound that binds to a target substance...
US20090038023 Lyase Enzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them  
This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the...
US20130296197 Device for Nucleic Acid Analysis and Nucleic Acid Analyzer  
Sample nucleic acids are prevented from removing from a sample-immobilizing layer during a sequencing reaction. A reaction device for nucleic acid analysis is provided that enables high throughput...
US20090062129 REAGENTS, METHODS, AND LIBRARIES FOR GEL-FREE BEAD-BASED SEQUENCING  
The present disclosure provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles typically comprise...
US20140206554 Methods and Systems for Processing Polynucleotides  
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including...
US20050048578 Methods of screening for monoclonal antibodies with desirable activity  
The invention provides methods for screening for a monoclonal antibody with a desirable activity. The methods involve altering a nucleic acid encoding a selected parental humanized monoclonal...
US20100075861 4C  
The present invention relates in one aspect to a method for analyzing the frequency of interaction of a target nucleotide sequence with one or more nucleotide sequences of interest (e.g., one or...
US20090239232 METHODS OF RNA AMPLIFICATION IN THE PRESENCE OF DNA  
The invention provides methods for amplification of RNA. The methods are particularly suitable for specifically amplifying RNA in the presence of DNA. The methods involve producing a marked first...
US20130109595 METHODS FOR MANUFACTURING MOLECULAR ARRAYS  
The methods of the present invention provide methods for manufacturing a master substrate and methods for manufacturing replica arrays from the master substrate. The methods may be used, for...
US20130096033 METHODS FOR MANUFACTURING MOLECULAR ARRAYS  
The methods of the present invention provide methods for manufacturing a master substrate and methods for manufacturing replica arrays from the master substrate. The methods may be used, for...
US20100041566 ARRAYS AND METHODS FOR GUIDED CELL PATTERNING  
Guided cell patterning arrays for single cell patterning, methods for making the arrays, and methods for using the arrays.
US20090075878 Methods for Generating and Screening Fusion Protein Libraries and Uses Thereof  
The invention provides methods for generating fusion protein libraries, such as immunotoxin libraries. The invention also relates to libraries of recombinant cells encoding nucleic acid sequences...
US20080058215 Chip Production, Hybridization and Data Interpretation for Antibody and Protein Microarrays  
An antibody microarray screen including a substrate, monoclonal and polyclonal antibodies that are purified immunoglobins, wherein the antibodies are spotted on predetermined positions on the...
US20100055125 Peptide Library  
The present invention relates to a vector library comprising a multiplicity of different eukaryotic secretion vectors, wherein each vector comprises under the control of transcriptional and...
US20090099043 Construction of pool of interfering nucleic acids covering entire RNA target sequence and related compositions  
The present invention provides a PCR based high-throughput method for preparing full-sites siRNA polynucleotide pool, comprising: DNase I random digestion; Loop-1 phosphate linker ligation; single...
US20080242560 METHODS FOR GENERATING AMPLIFIED NUCLEIC ACID ARRAYS  
The present invention relates to methods for generating an array of amplified nucleic acid sequences. The methods can utilize amplicons that form nucleic acid balls that can be arrayed on a solid...
US20140127242 NOVEL AND POWERFUL MHC-CLASS II PEPTIDES DERIVED FROM SURVIVIN  
The present invention relates to peptides, nucleic acids, and cells for use in the immunotherapy of cancer. The present invention furthermore relates to survivin-derived tumor-associated cytotoxic...
US20100016178 METHODS FOR RAPID PRODUCTION OF TARGET DOUBLE-STRANDED DNA SEQUENCES  
It has been previously disclosed that DNA segments can be made in massively parallel chemical synthesis operations on a common substrate followed by release of the segments from the substrate and...
US20090098555 METHODS AND APPLICATIONS FOR STITCHED DNA BARCODES  
Methods of identifying the genotypes of a plurality of single cells, wherein each cell includes a plurality of DNA barcodes, each associated with a genetic mutation or marker, are provided. In...
US20150133310 NUCLEIC ACID SEQUENCING SYSTEMS AND METHODS  
The present invention relates to systems and methods for performing isothermal amplification reactions. In particular, the present invention relates to denaturation methods for use in isothermal...
US20140018257 Peptide Library Production Method, Peptide Library, and Screening Method  
Object is to provide a method of constructing a library of peptides having, at a desired position in the random sequence of each peptide, an amino acid having a portion capable of binding to a...
US20100273669 METHOD FOR SELECTING A PEPTIDE OR POLYPEPTIDE WHICH BINDS TO A TARGET  
A method for selecting a peptide or polypeptide which binds to a target is provided. The method is based on protein splicing and phage display.
US20130137604 METHODS OF EVALUATING GENETIC ELEMENTS  
The invention relates to compositions for evaluating a genetic element and methods of use.
US20120270748 PEPTIDE DISPLAY ARRAYS  
The present invention provides arrays, methods of constructing arrays, and methods of use of such arrays. The arrays of the invention comprise a substrate with two or more discrete constructs or...
US20070207502 CYCLIC PEPTIDES  
Methods of producing cyclic peptides and splicing intermediates of peptides in a looped conformation are disclosed. The methods utilize the trans-splicing ability of split inteins to catalyze...
US20070020685 Secretion of antibodies without signal peptides from bacteria  
The present invention is directed generally to compositions and methods for obtaining secretion of antibodies or antigen-binding antibody fragments from prokaryotes without the need for a signal...
US20120322678 NOVEL PHAGE DISPLAY VECTOR  
The invention relates to a minimized phage display vector comprising at least a cloning cassette, a phage display cassette and a bacterial cassette, said cloning cassette comprising a nucleic acid...
US20140066490 SYSTEM AND METHOD FOR MODIFYING DEOXYRIBOZYMES  
A system and method for programming DNAzymes to be utilized as programmable drugs, which are active only in the presence of specific input combinations and/or certain conditions.
US20130210639 MICROFLUIDIC DEVICES  
The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of...
US20090062142 Methods for enhancing bacterial cell display of proteins and peptides  
Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display...