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US20100144548 VECTOR SYSTEMS  
The present invention relates generally to the field of molecular biology and genomics. More specifically, the present invention concerns the cloning of nucleic acid molecules and the production...
US20090074658 COMPOSITIONS AND METHODS FOR GENERATING AND SCREENING ADENOVIRAL LIBRARIES  
The present invention provides DNA libraries, libraries of viral clones and libraries of infectious viral particles and methods of generating and screening these libraries.
US20150031756 LENTIVIRAL VECTORS AND USES THEREOF  
The invention relates to compositions containing polynucleotide vectors capable of expressing a nucleic acid encoding a fusion polypeptide on the surface of a viral particle and/or a eukaryotic cell.
US20100009871 DEVICES AND SYSTEMS FOR CREATION OF DNA CLUSTER ARRAYS  
The present invention comprises systems and devices for isothermal amplification of polynucleotide sequences to produce DNA cluster arrays.
US20140221255 Method for Large-Scale Synthesis of Long-Chain Nucleic Acid Molecule  
Systems and methods for synthesizing long-chain nucleic acids molecules are disclosed. The systems and methods described in this application use a Ligation- Purification-Amplification (“LPA”)...
US20110045990 STRUCTURAL NUCLEIC ACID GUIDED CHEMICAL SYNTHESIS  
Disclosed is a composition comprising a nucleic acid and a chemical compound, said composition forming a star structure defining 3 or more stems extending from a reaction center. The stems are...
US20130053252 NUCLEIC ACID AMPLIFICATION AND SEQUENCING BY SYNTHESIS WITH FLUOROGENIC NUCLEOTIDES  
In general, the invention features methods and systems for sequencing of nucleic acids based on the measurement of the incorporation of fluorogenic nucleotides in microreactors. The invention...
US20150119283 METHOD AND SYSTEM FOR THE ANALYSIS OF HIGH DENSITY CELLS SAMPLES  
Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are...
US20140005060 METHOD AND SYSTEM FOR THE ANALYSIS OF HIGH DENSITY CELLS SAMPLES  
Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are...
US20110212996 METHOD TO PREDICT RESPONSE TO PHARMACOLOGICAL CHAPERONE TREATMENT OF DISEASES  
The present invention provides methods to determine whether a patient with a lysosomal storage disorder will benefit from treatment with a specific pharmacological chaperone. The present invention...
US20110092380 IMPROVED MOLECULAR-BIOLOGICAL PROCESSING EQUIPMENT  
The invention relates to improved molecular-biological processing equipment and an improved method of processing biological samples. The invention combines the provision of biologically functional...
US20100009872 Single molecule loading methods and compositions  
Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided.
US20130096283 Method of Supplementing Culture Media to Prevent Undesirable Amino Acid Substitutions  
The present invention relates to methods of reducing substitution of amino acids during the production of polypeptides of interest in mammalian cells. By varying the concentration of amino acids...
US20090318308 HIGHLY DIVERSIFIED ANTIBODY LIBRARIES  
The present invention provides an in vitro method for obtaining a library of polynucleotides encoding antibodies, derivatives thereof or fragments thereof, comprising the step of performing random...
US20090149348 NUCLEIC ACID LIBRARIES AND PROTEIN STRUCTURES  
A process for constructing an artificial coding sequence is provided. The process comprises providing an enzyme adapted to ligate DNA duplexes containing selected codons into multimers that...
US20090298707 SPARSE MATRIX SYSTEM AND METHOD FOR IDENTIFICATION OF SPECIFIC LIGANDS OR TARGETS  
In certain embodiments, this invention pertains to the creation of “Sparse Matrix” libraries of compounds. The sparse matrix libraries of this invention typically span an n-dimensional parameter...
US20090106853 Methods and materials using signaling probes  
The present invention relates to methods of isolating cells or generating cell lines using signaling probes that produce a signal upon hybridization to a target sequence. Other methods that...
US20110257045 METHOD FOR PREPARING HIGH-THROUGHPUT SEQUENCEABLE DNA FROM INDIVIDUAL PLAQUES OF PHAGES PRESENTING PEPTIDES  
The present invention relates to a process for isolating DNA from individual plaques of peptide-presenting bacteriophages in a high-throughput capacity PCR, wherein the PCR products obtained are...
US20080076671 Applications of Nucleic Acid Fragments  
The present invention relates to a method of isolating fragments of nucleic acid according to the density of CpG dinucleotides and subsequent procedures for producing a library and/or an array or...
US20140045701 SYTEMS AND METHODS FOR AUTOMATED REUSABLE PARALLEL BIOLOGICAL REACTIONS  
A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate,...
US20080108082 Polymerase enzymes and reagents for enhanced nucleic acid sequencing  
Compositions that include DNA polymerases having increased residence times for nucleotide analogues, particularly modified recombinant Φ29-type DNA polymerases with such increased residence times,...
US20100029505 shRNA library  
As noted above, certain aspects of this disclosure relate to a library of nucleic acid vectors, as well as a method for making the same. In certain embodiments, the library of nucleic acid vectors...
US20130217599 NOVEL ARTIFICIAL TRANSLATION/SYNTHESIS SYSTEM  
A new artificial translation-synthesis system of adding tRNAs binding special amino acids to the in vitro translation system and synthesizing peptides with special amino acids incorporated thereto...
US20080076678 Method of creating a library of bacterial clones with varying levels of gene expression  
The present invention relates to a method of creating DNA libraries that include an artificial promoter library and/or a modified ribosome binding site library and transforming bacterial host...
US20130296194 Methods and Devices for Nucleic Acid Synthesis  
Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction...
US20050059074 Cell analysis in multi-through-hole testing plate  
A spatially fixed library of mutated cells and a method for creating such a library. The library is created by creating a set of cells having a genetic diversity, causing the cells to multiply and...
US20120108458 METHOD OF SYNTHESIZING SINGLE-STRANDED CDNA, METHOD OF PREPARING MICROARRAY SAMPLE, AND METHOD OF DETECTING NUCLEIC ACID  
In order to provide a method of amplifying nucleic acid which can produce a nearly constant amount of amplified products despite the amount of RNA to be used as a template, the primer is used at a...
US20080206832 Selection and Enrichment of Proteins Using in vitro Compartmentalization  
Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a...
US20110003699 Thermal Cycler for Microfluidic Array Assays  
A system for thermal cycling a plurality of samples. The system includes a case having a fluid-tight cavity defining an interior volume. A microfluidic array is disposed in the interior volume,...
US20150159152 LONG NUCLEIC ACID SEQUENCES CONTAINING VARIABLE REGIONS  
This invention pertains to improved methods for the synthesis of long, double stranded nucleic acid sequences containing difficult to clone or variable regions.
US20060234296 Method for generating high affinity antibodies  
The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and...
US20100227779 PLASMID RK2-BASED BROAD-HOST-RANGE CLONING VECTOR USEFUL FOR TRANSFER OF METAGENOMIC LIBRARIES TO A VARIETY OF BACTERIAL SPECIES  
The present invention relates to a cloning vector for cloning of DNA in a broad host range of bacteria, the vector being an autonomously replicating artificial chromosome comprising: (i) the RK2...
US20140194324 SAMPLE PREPARATION ON A SOLID SUPPORT  
Presented are methods and compositions for using immobilized transposase and a transposon end for generating an immobilized library of 5′-tagged double-stranded target DNA on a surface. The...
US20100330080 ANTIGEN BINDING POLYPEPTIDES  
The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on the conventional antibody repertoire...
US20090264313 Oligonucleotide library encoding randomised peptides  
The invention relates to a method of producing an oligonucleotide library comprising a plurality of oligonucleotides, each oligonucleotide in the library having at least one predetermined...
US20150259735 POLYMER COATINGS  
The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as...
US20150072869 METHODS AND COMPOSITIONS FOR NUCLEIC ACID SAMPLE PREPARATION  
The present invention provides methods and compositions useful for supplying high throughput nucleic acid sequencing systems with templates. The methods circumvent the need for costly,...
US20100029511 CDNA SYNTHESIS USING NON-RANDOM PRIMERS  
The present invention provides methods for selectively amplifying a target population of nucleic acid molecules in a population of RNA template molecules (e.g., all mRNA molecules expressed in a...
US20090209430 TEMPLATE DIRECTED SPLIT AND MIX SYSTHESIS OF SMALL MOLECULE LIBRARIES  
The present invention provides a method for combining the advantages of encoded molecule fragments made by split and mix synthesis with the advantages of template directed synthesis of molecules....
US20150011407 Bidirectional Promoter  
The invention refers to a library of bidirectional expression cassettes or expression vectors comprising a repertoire of bidirectional promoter sequences, each expression cassette comprising a...
US20140256568 SAMPLE MULTIPLEXING  
The invention generally relates to methods for sample multiplexing. In certain embodiments, methods of the invention obtaining a plurality of different reactant molecules, attaching a unique...
US20130090267 TEMPERATURE CONTROL DEVICE WITH A FLEXIBLE TEMPERATURE CONTROL SURFACE  
A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an...
US20130053272 APPARATUS FOR HIGH THROUGHPUT CHEMICAL REACTIONS  
Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be...
US20090304719 ACTIVATABLE BINDING POLYPEPTIDES AND METHODS OF IDENTIFICATION AND USE THEREOF  
The present disclosure provides activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM). The present disclosure...
US20090143238 Oligonucleotide matrix and methods of use  
The present invention relates broadly to compositions and methods for performing nucleic acid analysis. In particular the invention relates to a universal oligonucleotide probe set and a...
US20080312101 Novel Phage Display Technologies  
The present invention provides novel technologies for producing and screening fusion proteins on the surface of filamentous phage. In particular, a single vector can be used for generating cell...
US20090209436 HYDROGEL LABELED PRIMER EXTENSION METHOD FOR MICROARRAYS  
A method for fabricating hydrogel based microarrays by a nanostamping process is provided. A method of manufacturing a patterned hydrogel array is provided comprising the steps of contacting a...
US20070286846 Novel methods for ester detoxication  
This invention relates to a method for detoxication of inorganic or organic esters including OP nerve agents, cocaine, and respective analogs. More specifically, this invention pertains to the...
US20100069263 SEQUENCE TAG DIRECTED SUBASSEMBLY OF SHORT SEQUENCING READS INTO LONG SEQUENCING READS  
The invention provides compositions and methods for preparing DNA sequencing libraries. In particular, the method relates to preparing DNA sequencing libraries from kilobase scale nucleic acids....
US20140213459 ANTIBODIES WITH IMPROVED FOLDING STABILITY  
The present invention relates to methods for improving the folding stability of antibodies, to antibodies with improved folding stability, nucleic acid and vectors encoding such antibodies, and to...