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US20140378315 ENZYMATIC LIGATION OF NUCLEIC ACIDS  
Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein. The short polynucleotides are optionally no more than 7 nucleotides in length, and can be as...
US20090156412 SURFACE-CAPTURE OF TARGET NUCLEIC ACIDS  
The disclosure provides methods of capturing target nucleic acids (e.g., gene or gene fragments) onto a solid support for further analysis. The disclosed methods utilize a capture probe that...
US20090131275 Method For Preparing Genome Library, And Genome Library Prepared By The Method  
There is provided a first method of preparing a genome library in which PCR is carried out with the use of genomic DNA of target biological species per se or fragment thereof as a direct template...
US20100285985 Methods and Systems for the Generation of Plurality of Security Markers and the Detection Therof  
This invention pertains to methods for generating large quantities of DNA security markers by combinatorial variation techniques using polymorphic fragment length DNA for unique identification...
US20130261026 LINKERS AND CO-COUPLING AGENTS FOR OPTIMIZATION OF OLIGONUCLEOTIDE SYNTHESIS AND PURIFICATION ON SOLID SUPPORTS  
A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and...
US20090022736 Monoclonal Antibodies That Specifically Bind To And Neutralize Bacillus Anthracis Toxin, Compositions, And Methods Of Use  
The invention features compositions relating to antibodies that specifically bind to the protective antigen of Bacillus anthracis, fragments thereof, and nucleic acids encoding same. The invention...
US20070048793 Compositions and methods for biocatalytic engineering  
Provided herein are compositions and methods for metabolic pathway engineering. The methods involve combining two or more cells expressing potential pathway proteins extracellularly in the...
US20130338008 METHOD OF MAKING AN ARRAY OF NUCLEIC ACID COLONIES  
A method of making an array of nucleic acid colonies, including the steps of (a) providing a substrate having a patterned surface of features, wherein the features are spatially organized in a...
US20150232929 METHODS AND COMPOSITIONS FOR DNA PROFILING  
Embodiments disclosed herein provide methods for constructing a DNA profile comprising: providing a nucleic acid sample, amplifying the nucleic acid sample with a plurality of primers that...
US20140148359 MULTI-NUCLEIC-ACID AMPLIFICATION REACTION TOOL  
According to one embodiment, a multi-nucleic-acid amplification reaction tool includes a support and a plurality of types of primer sets. The support is configured to be able to support a reaction...
US20140024542 METHODS AND COMPOSITIONS FOR ENRICHMENT OF TARGET POLYNUCLEOTIDES  
The invention provides methods, apparatuses, and compositions for high-throughput amplification sequencing of specific target sequences in one or more samples. In some aspects, barcode-tagged...
US20120316086 PATTERNED FLOW-CELLS USEFUL FOR NUCLEIC ACID ANALYSIS  
Provided is a surface having metal regions and an interstitial region having a composition that differs from the metal regions, wherein a continuous gel layer coats the surface across the metal...
US20090275485 Reversible Natural Product Glycosyltransferase-Catalyzed Reactions, Compounds and Related Methods  
The present invention relates to methods of use of glycosyltransferases and related novel compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars,...
US20140038842 CELL SURFACE DISPLAY USING PDZ DOMAINS  
Novel materials and methods useful for displaying polypeptides on the surface of a cell are provided, including cell surface proteins fused to a PDZ domain peptide and antibodies fused to...
US20090163379 Eukaryotic cell display systems  
The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic...
US20110319299 METHODS AND COMPOSITIONS FOR POLYNUCLEOTIDE LIBRARY PRODUCTION, IMMORTALIZATION AND REGION OF INTEREST EXTRACTION  
Aspects of the present invention are drawn to methods and compositions for the genetic analysis of regions of interest (ROI) from one or more starting polynucleotide sample(s). In certain aspects,...
US20110039732 cDNA Synthesis Using Non-Random Primers  
The present invention provides methods for selectively amplifying a target population of nucleic acid molecules in a population of RNA template molecules (e.g., all mRNA molecules expressed in a...
US20090298708 2'-DEOXY-2'-FLUORO-BETA-D-ARABINONUCLEOSIDE 5'-TRIPHOSPHATES AND THEIR USE IN ENZYMATIC NUCLEIC ACID SYNTHESIS  
The invention relates to arabinose modified nucleoside 5′ triphosphates and to the biosynthesis and amplification of oligonucleotides containing and/or from templates containing arabinose modified...
US20150141295 SOLID-PHASE CLONAL AMPLIFICATION AND RELATED METHODS  
The present invention provides methods and compositions for analyzing nucleic acid sequences. In some aspects, the methods utilize clonal objects, such as DNA balls, that have been captured on...
US20130040863 SOLID-PHASE CLONAL AMPLIFICATION AND RELATED METHODS  
The present invention provides methods and compositions for analyzing nucleic acid sequences. In some aspects, the methods utilize clonal objects, such as DNA balls, that have been captured on...
US20090099040 DEGENERATE OLIGONUCLEOTIDES AND THEIR USES  
The present invention provides a plurality of oligonucleotides comprising a semi-random sequence, wherein the semi-random sequence comprises degenerate nucleotides that are substantially...
US20090208577 Inkjet Printing of Tissues and Cells  
Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable...
US20120308575 FULL HUMAN ANTI-TNF-ALPHA MONOCLONAL ANTIBODY, PREPARATION METHOD AND USE THEREOF  
The present invention provides a full human anti-TNF-α monoclonal antibody, the preparation method and use thereof. The antibody in the present invention has an amino acid sequence of heavy chain...
US20100041561 Preparation of Nucleic Acid Templates for Solid Phase Amplification  
The invention relates to a method of preparing template constructs for solid-phase nucleic acid amplification and to use of the templates in methods of solid-phase nucleic acid amplification. The...
US20090005268 Compositions and Methods for Cancer Diagnostics Comprising Pan-Cancer Markers  
The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, so-called “pan cancer markers”. In particular, the present invention provides...
US20150057192 Methods for Dynamic Vector Assembly of DNA Cloning Vector Plasmids  
A method for using cloning vector plasmids to produce DNA molecules, such as transgenes, in a single cloning step. The transgenes can be used for the purpose of gene expression or analysis of gene...
US20090312196 METHOD OF SYNTHESIZING POLYNUCLEOTIDE VARIANTS  
The present disclosure relates to methods for generating libraries of polynucleotide variants comprising defined nucleotide differences relative to a reference polynucleotide.
US20130244907 METHOD FOR PREPARING B CELL WHICH PRODUCES HUMAN-TYPE ANTIBODY  
Provided is a method for preparing B cells which produce a human-type antibody, comprising substituting an antibody gene of B cells with a human antibody gene, wherein the B cells are non-human...
US20090082226 Gene expression analysis using array with immobilized tags of more than 25 bp (SuperSAGE-Array)  
This invention provides a method of gene expression analysis that enables extensive gene expression analysis and simultaneous analysis of multiple samples of organisms for which genomic analysis...
US20110039722 LIBRARIES, ARRAYS AND THEIR USES FOR TARGETED AFFINITY ENHANCEMENT  
The present disclosure relates to methods and materials for enhancing the binding affinity of an antibody by means of generating a library or an array of targeted amino acid changes (e.g.,...
US20140274808 DIGITAL TO BIOLOGICAL CONVERTER  
The present invention provides a system for receiving biological sequence information and activating the synthesis of a biological entity. The system has a receiving unit for receiving a signal...
US20090105094 Error-free amplification of DNA for clonal sequencing  
Methods of preparing nucleic acid templates and providing the nucleic acid templates to low copy number reaction volumes are provided. Related compositions of nucleic acid templates are also provided.
US20110245108 Universal Antibody Libraries  
Universal antibody libraries are described which are synthetic and derived from expressed human antibody sequences selected accordingly to certain criteria, for example, that the sequences are...
US20140179547 Methods For The Generation Of Multispecific And Multivalent Antibodies  
The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific...
US20080070804 Synthetic substrates and inhibitors with enhanced specificity  
Novel synthetic enzyme substrates with improved enzymatic specificity are disclosed. These synthetic enzyme substrates consist of a substrate peptide that has had its specificity further improved...
US20110003705 NOVEL METHOD FOR GENERATING AND SCREENING AN ANTIBODY LIBRARY  
The invention relates to a method for generating a DNA sequence coding for the heavy chain or the light chain of at least one antibody from RNA from a cell capable of producing an antibody. More...
US20100022412 USING POPULATIONS OF BEADS FOR THE FABRICATION OF ARRAYS ON SURFACES  
The present invention provides methods for creating an array of features on a surface based on content transferred from a plurality of beads to the surface. Nucleic acid content can be transferred...
US20140274811 Methods for Amplifying a Complete Genome or Transcriptome  
The present invention provides methods for amplifying a complete genome or transcriptome. The genome or transcriptome is prepared as a set of target nucleic acids and mixed with a first primer....
US20130005612 Methods for High Fidelity Production of Long Nucleic Acid Molecules with Error Control  
A method for synthesizing a nucleic acid having a desired sequence and length comprises providing a solid support having an immobilized nucleic acid, performing a nucleic acid addition reaction to...
US20100331208 Cell Display Of Antibody Libraries  
The present invention relates to a viral vector encoding for a library of antibodies or antibody fragments that are displayed on the cell membrane when expressed in a cell. The present invention...
US20150209752 DEVICE AND METHOD FOR REAL-TIME DETECTION OF MOLECULAR ACCUMULATIONS AND/OR MONITORING THE PRODUCTION PROCESS OF A MOLECULAR MICROARRAY  
The invention relates to a method for producing a microarray, wherein the production of this array is detected in real time from the accumulation of the product molecules being produced. The...
US20100273679 METHODS FOR THE PREPARATION OF DNA MICROARRAYS WITH LINEAR HIGH DENSITY PROBES  
A method for the realisation of DNA microarrays with linear high density probes, comprising a phase of replication of template DNA strands of a template microarray and a subsequent phase of...
US20140235492 METHODS FOR PREPARING SINGLE DOMAIN ANTIBODY MICROARRAYS  
The present invention relates to a method for preparing sd Ab microarray comprising the step consisting of: —i) providing a host cell capable of expressing a biotinylation enzyme —ii) transforming...
US20110230374 HIGH AFFINITY RECOMBINANT SEA LAMPREY ANTIBODIES SELECTED BY A YEAST SURFACE DISPLAY PLATFORM  
The present invention relates to a Yeast Surface Display (YSD) vector for expression of VLR proteins by yeast, wherein the vector includes nucleotide sequences encoding segments of yeast...
US20150105299 Method for Differentiation of Polynucleotide Strands  
Objective of the present invention is to provide a method for keeping of directional information in double-stranded DNA. We suggest to convert polynucleotide into a hybrid double-stranded DNA. One...
US20120270755 METHOD FOR PREPARING A SUBSTRATE FOR ARRANGING ANIMAL CELLS IN AN ARRAY AND METHOD FOR PREPARING A SUBSTRATE ON WHICH ANIMAL CELLS ARE ARRANGED IN AN ARRAY  
A new means of separately arranging individual animal cells on a substrate surface is provided. A method for preparing a substrate for arranging animal cells in an array, comprising steps (1) to...
US20130018173 Identifying Affinity-Matured Human Antibodies  
Antigen-specific immunoglobulin V-regions are identified from a library of nucleic acids amplified using polymerase chain reaction using leader sequence-specific forward primers. The use of leader...
US20130053253 Region of Interest Extraction and Normalization Methods  
Aspects of the present invention are drawn to methods and compositions for the genetic analysis of regions of interest from one or more starting polynucleotide sample, e.g., a multiplexed...
US20090143247 Methods for Producing Active scFv Antibodies and Libraries Therefor  
The present disclosure describes scFv antibody libraries, antibodies isolated from the libraries, and methods of producing and using the same.
US20100056383 HIGH DENSITY SELF-CONTAINED BIOLOGICAL ANALYSIS  
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include high density nucleic acid amplification and...