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US20130237437 NUCLEIC ACID HYBRIDIZATION PROBES  
Compositions of nucleic acid hybridization probes for detecting a nucleic acid target sequence and methods for their production are described. In one preferred embodiment, the nucleic acid...
US20150024959 METHOD FOR AMPLIFYING cDNA DERIVED FROM TRACE AMOUNT OF SAMPLE  
The problem to be solved by the present invention is to provide a method for preparing a sample for comprehensively and accurately analyzing gene expression in a single cell or a few cells, for...
US20120264653 Methods for High Fidelity Production of Long Nucleic Acid Molecules  
In a method for synthesizing a pool of nucleic acid molecules, a first nucleic acid has a first 5′ region and a first 3′ region and a second nucleic acid has a second 5′ region and a second 3′...
US20120094875 PRODUCTION PROCESS OF HIGH AFFINITY AND HIGH SPECIFICITY OLIGONUCLEOTIDES FOR ORGANIC AND INORGANIC MOLECULES  
The object of this patent advances the State of the Art by the following innovations: 1st—It creates a new electrophoretic process to be carried out in fused silica capillary that was previously...
US20110053801 Method for the Random Diversification of a Genetic Sequence While Preserving the Identity of Some Inner Segments of said Genetic Sequence  
The invention relates to a very general method for the random diversification of a nucleotide sequence S by PCR while preserving the identity of some domains of said sequence S; the invention also...
US20120071358 Fluidic devices and methods for multiplex chemical and biochemical reactions  
The present invention describes microfluidic devices that provide novel fluidic structures to facilitate the separation of fluids into isolated, pico-liter sized compartments for performing...
US20110143964 FLUIDIC DEVICES AND METHODS FOR MULTIPLEX CHEMICAL AND BIOCHEMICAL REACTIONS  
The present invention describes microfluidic devices that provide novel fluidic structures to facilitate the separation of fluids into isolated, pico-liter sized compartments for performing...
US20130252823 cDNA SYNTHESIS USING NON-RANDOM PRIMERS  
The present invention provides methods for selectively amplifying a target population of nucleic acid molecules in a population of RNA template molecules (e.g., all mRNA molecules expressed in a...
US20130227741 CELLULOYTIC ENZYMES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM  
The invention is directed to polypeptides having any cellulolytic activity, e.g., a cellulase activity, e.g., endoglucanase, cellobiohydrolase, beta-glucosidase, xylanase, mannanse, β-xylosidase,...
US20120266328 CELLULOYTIC ENZYMES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM  
The invention is directed to polypeptides having any cellulolytic activity, e.g., a cellulase activity, e.g., endoglucanase, cellobiohydrolase, beta-glucosidase, xylanase, mannanse, β-xylosidase,...
US20080220985 Method for Generating Microscopic Patterns of Protein and Other Macromolecules  
Methods and apparatuses for generating microscopic patterns of macromolecules such as proteins on a solid surface are described. Pulsed laser light is used to alter surface portions of a solid...
US20140221248 KITS AND METHODS FOR GENERATING 5' CAPPED RNA  
The present invention relates to kits and methods for efficiently generating 5′ capped RNA having a modified cap nucleotide and for use of such modified-nucleotide-capped RNA molecules. In...
US20150011433 BIS-BIOTINYLATION TAGS  
Multi-biotinylated reactants are provided which can be used in divalent complexes for various applications such as colocalization, labeling, immobilization, and purification. Methods for...
US20090312199 TRACE mRNA AMPLIFICATION METHOD AND USE THEREOF  
In one embodiment of the present invention, a method for amplifying a trace amount of mRNA is disclosed which can amplify a short mRNA and a long mRNA at a same efficiency level, regardless of how...
US20080113872 Classification of Organisms Based on Genome Representing Arrays  
The invention relates to a method of preparing clusters of reference hybridization patterns for a sample nucleic acid, comprising providing an array comprising a plurality of nucleic acid...
US20130029882 Nucleic Acids and Libraries  
The invention relates to a nucleic acid comprising the following contiguous elements arranged in the 5 prime to 3 prime direction; a promoter; a selectable marker; a cloning site for receipt of a...
US20110281736 Nucleic Acid Sequencing and Process  
The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting...
US20140357500 SINGLE CELL BAR-CODING FOR ANTIBODY DISCOVERY  
Provided herein are methods and composition for immune repertoire sequencing and single cell barcoding for heavy and IgL pairing if antibodies.
US20110236378 NON-HUMAN MAMMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES  
The invention provides knock-in non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing knock-in cells and mammals. Certain aspects of the invention...
US20130225451 MATERIALS AND METHODS FOR THE SYNTHESIS OF ERROR-MINIMIZED NUCLEIC ACID MOLECULES  
The present invention provides materials and methods useful for error correction of nucleic acid molecules. In one embodiment of the invention, a first plurality of double-stranded nucleic acid...
US20120252702 PROCESSING OF AMPLIFIED DNA FRAGMENTS FOR SEQUENCING  
A processing method to trim ends of DNA fragments, exposing the internal DNA part to give original DNA sequence information enabling application of next generation sequencing for DNA samples to be...
US20120172258 NUCLEIC ACID SAMPLE PREPARATION METHODS AND COMPOSITIONS  
The present invention provides compositions and methods for preparing a nucleic acid library in a multi-purpose buffer (e.g., employing whole genome amplification), where nucleic acid purification...
US20120077716 SYSTEM AND METHOD FOR PRODUCING FUNCTIONALLY DISTINCT NUCLEIC ACID LIBRARY ENDS THROUGH USE OF DEOXYINOSINE  
An embodiment of a nucleic acid adaptor is described that comprises a double stranded nucleic acid element that comprises a plurality of deoxyinosine species positionally located in a spaced...
US20110076752 ANTIBODY LIBRARY DISPLAY BY YEAST CELL PLASMA MEMBRANE  
The present invention relates to antibodies or antibody fragments that may be displayed on the extracellular surface of the plasma membrane when expressed in a host cell. The present invention...
US20110294701 Nucleic acid amplification using non-random primers  
The present invention provides methods for selectively amplifying a target population of nucleic acid molecules (e.g., all mRNA molecules expressed in a cell type except for the most highly...
US20110257044 Structure-based construction of human antibody library  
Methods and systems are provided for constructing recombinant antibody libraries based on three-dimensional structures of antibodies from various species including human. In one aspect, a library...
US20150087557 ENZYME COMPOSITION FOR DNA END REPAIR, ADENYLATION, PHOSPHORYLATION  
Enzyme compositions and their method of use that provide ready-to-use master mixtures. The compositions comprise a modified thermophilic DNA polymerase lacking 5′-3′ and 3′-5′ exonuclease activity...
US20100279305 COMPOSITIONS, METHODS, AND KITS FOR DETECTING RIBONUCLEIC ACID  
Compositions, methods, and kits for detecting one or more species of RNA molecules are disclosed. In one embodiment, a first adaptor and a second adaptor are ligated to the RNA molecule using a...
US20100285993 Systematic Genomic Library and Uses Thereof  
The present invention provides genomic DNA libraries that are systematically arranged on plasmids, methods of making and using the libraries, and plasmids that make up the libraries.
US20100317539 Library of Engineered-Antibody Producing Cells  
A method for producing a library of engineered-antibody producing cells is provided. In certain cases, the method includes isolating nucleic acid sequences encoding IgH variable regions and IgL...
US20150011434 METHOD FOR THE SYNTHESIS OF A BIFUNCTIONAL COMPLEX  
Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a...
US20130040823 METHOD FOR THE SYNTHESIS OF A BIFUNCTIONAL COMPLEX  
Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a...
US20090275486 NUCLEIC ACID SEPARATION AND PURIFICATION METHOD BASED ON REVERSIBLE CHARGE INTERACTIONS  
The invention provides a method for purifying nucleic acids using a polycationic reagent and an anionic substrate to form a complex with a nucleic acid to be purified. The complex may be separated...
US20110077164 EXPRESSION PROFILING PLATFORM TECHNOLOGY  
The present invention relates to an efficient mAb panel-based expression profiling technology platform suitable for global and accurate measurement of proteins, peptides and metabolites in complex...
US20130203634 INTEGRATED ANALYSIS SYSTEM  
The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and...
US20120309649 CELL CHIP AND METHOD FOR MANUFACTURING THE SAME  
Disclosed herein are a cell chip and a method for manufacturing the same. The cell chip may include: a substrate; and a first contact member disposed on the substrate, wherein a top end of the...
US20080213387 Cytotrophoblast Stem Cell  
The invention relates to cytotrophoblast stem cells derived from embryonic stem cells; their differentiation into endovascular cytotrophoblast cells; and uses thereof.
US20140228245 METHOD FOR THE SPATIAL ARRANGEMENT OF SAMPLE FRAGMENTS FOR AMPLIFICATION AND IMMOBILIZATION FOR FURTHER DERIVATIZATIONS  
The invention relates to a method for performing a biochemical or chemical reaction for an isolated, spatially separated amplification of sample fragments during a simultaneous immobilization and...
US20050136428 Look-through mutagenesis  
A method of mutagenesis by which a predetermined amino acid is introduced into each and every position of a selected set of positions in a preselected region (or several different regions) of a...
US20140243224 GEL PATTERNED SURFACES  
Provided is an array including a solid support having a surface, the surface having a plurality of wells, the wells containing a gel material, the wells being separated from each other by...
US20110275540 New Molecularly Imprinted Polymer and Method for its Production  
The present invention relates to a molecularly imprinted polymer and a method of producing the same using complementary oligo- and/or polynucleotides.
US20130029881 SELECTIVE TERMINAL TAGGING OF NUCLEIC ACIDS  
Methods are provided for adding a terminal sequence tag to nucleic acid molecules for use in RNA or DNA amplification. The tag introduced may be used as a primer binding site for subsequent...
US20130172216 Arrays and Methods of Use  
Methods are provided for producing a molecular array comprising a plurality of molecules immoblised to a solid substrate at a density which allows individual immobilised molecules to be...
US20140066601 ALPHABODY LIBRARIES AND METHODS FOR PRODUCING THE SAME  
The invention provides single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in...
US20090176662 End Modification to Prevent Over-Representation of Fragments  
The invention relates to a method of preparing a 5′ and 3′ modified library of template polynucleotides and also the use of the 5′ and 3′ modified library of templates in methods of solid-phase...
US20150167072 PURIFIED POLYMERASE / TEMPLATE COMPLEXES  
Methods, Compositions, and Systems are provided for obtaining polymerase-template complex mixtures with improved levels of active polymerase. In some aspects active polymerase-template complex is...
US20090264508 Focused Libraries, Functional Profiling, Laser Selex, and Deselex  
Focused aptamer libraries are constructed in accordance with a proteome (i.e., complex mixture of native biomolecules). The libraries may be screened to identify one or more candidate aptamers...
US20110118147 LIBRARIES OF GENETIC PACKAGES COMPRISING NOVEL HC CDR3 DESIGNS  
Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind...
US20150065393 Methods and Devices for Nucleic Acid Synthesis  
Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary embodiments, the device includes a support...
US20100160176 RAT GENE EXPRESSION PROFILING OF DRUG TRANSPORTERS, CYTOCHROME P450s, TRANSFERASES AND NUCLEAR XENOBIOTIC RECEPTORS FOR PREDICTING DRUG EFFECTS  
The disclosure describes materials and methods for detecting the expression of genes and generating a gene expression profile from drug-treated rat primary cells or established rat cell lines...