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US20130274114 MULTIPOTENT STEM CELL-BASED CULTURE SYSTEMS AND MODELS  
This invention generally relates to multipotent stem cell-based research tools. More particularly, the present invention relates to culture systems and 3-dimensional tissue models that may be used...
US20130040824 DETECTION OF GENETIC OR MOLECULAR ABERRATIONS ASSOCIATED WITH CANCER  
Biological samples including cell-free DNA fragments are analyzed to identify imbalances in chromosomal regions, e.g., due to deletions and/or amplifications in a tumor. Multiple loci are used for...
US20140377861 Precise Control of Recombinant Protein Levels by Engineering Translation  
Compositions and methods are provided for user-specified fine-tuned protein expression levels, by controlling the initiation of protein translation; and a model for analysis of expression. This...
US20130303383 METHODS AND APPARATUS FOR PREDICTING PROTEIN STRUCTURE  
The present invention relates to a method for predicting three-dimensional structure of a protein from its sequence. Three-dimensional structure may be determined by: (a) generating a multiple...
US20140371256 PERSONALIZED PAIN MANAGEMENT AND ANESTHESIA: PREEMPTIVE RISK IDENTIFICATION AND THERAPEUTIC DECISION SUPPORT  
Methods and compositions disclosed herein generally relate to methods of improving clinical and economic outcomes to address adverse effects related to anesthesia, analgesics, opioids, and...
US20150110718 METHODS AND KITS FOR DETERMINING A PLACEBO PROFILE IN SUBJECTS FOR CLINICAL TRIALS AND FOR TREATMENT OF PATIENTS  
The present invention is directed to methods and assays for identifying subjects participating in clinical trials that may exhibit a placebo response and identifying treatments for subjects with...
US20150167075 IDENTIFYING MODIFIED BASES USING HEMI-NATURAL NUCLEIC ACIDS  
Methods, compositions, and systems are provided for characterization of modified nucleic acids. Methods are provided for sequencing hemi-natural nucleic acids such as hemi-genomic DNA, having two...
US20150072866 MARKER PANEL FOR DETECTING CANCER  
Provided herein is technology relating to detecting cancer and particularly, but not exclusively, to methods for detecting colorectal cancer by evaluating multiple markers in paired plasma and...
US20150218577 SUCROSE TRANSPORTER GENES FOR INCREASING PLANT SEED LIPIDS  
This invention relates to polynucleotide sequences encoding SUT2 or SUT4 sucrose transporter genes. Methods for increasing seed oil content and evaluating increased oil content in a plant seed are...
US20140235458 METHODS AND TOOLS FOR THE DIAGNOSIS AND PROGNOSIS OF UROGENITAL CANCERS  
The present invention provides a microarray useful as a tool in the diagnosis and/or prognosis of certain types of cancers, particularly urogenital cancers. The microarray can include a plurality...
US20110312506 METHODS AND KITS FOR SCREENING PROTEIN SOLUBILITY  
Methods and kits useful for identifying conditions which solubilize proteins and/or reduce or eliminate protein aggregation are provided. The disclosed methods and kits find utility in any number...
US20140051587 CANCER MARKERS  
Hence, the invention relates to a method for diagnosis and/or prognosis of cancer, comprising the steps of analyzing in a sample of a subject the DNA methylation status of a genomic region of at...
US20150197815 METHODS AND SYSTEMS FOR IDENTIFYING DISEASE-INDUCED MUTATIONS  
The invention includes methods and systems for identifying diseased-induced mutations by producing multi-dimensional reference sequence constructs that account for variations between individuals,...
US20120214677 LUCIFERASE BIOSENSOR  
A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided.
US20130316919 BIOMARKERS FOR THE DIAGNOSIS OF MULTIPLE SCLEROSIS  
The invention relates to biological markers for use in the diagnosis of multiple sclerosis and the use of said markers for distinguishing between patients with multiple sclerosis and patients with...
US20150099754 TREATMENT OF CANCER CHARACTERIZED BY GENE MUTATIONS  
Provided herein are methods for treating and/or preventing a cancer in a patient, comprising administering an effective amount of a TOR kinase inhibitor to a patient having cancer characterized by...
US20130225420 MOLECULAR SUBTYPING OF ORAL SQUAMOUS CELL CARCINOMA TO DISTINGUISH A SUBTYPE THAT IS UNLIKELY TO METASTASIZE  
The present invention provides methods of analyzing a sample from a subject having oral epithelial dysplasia or oral SCC or suspected of having oral epithelial dysplasia or oral SCC.
US20140274727 CARIES GENETIC PREDISPOSITION ANALYSIS BY MOLECULAR TESTING  
Means and methods of predicting future dental problems are disclosed. Molecular tests use biological matter from a patient to obtain information regarding various genes. The tests and methods...
US20150141391 SYSTEMS AND METHODS FOR DETERMINING A TREATMENT COURSE OF ACTION  
The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their...
US20150167080 METHOD OF DETERMINING CLONOTYPES AND CLONOTYPE PROFILES  
The invention is directed to methods for determining clonotypes and clonotype profiles in assays for analyzing immune repertoires by high throughput nucleic acid sequencing of somatically...
US20150057161 HIGH-RESOLUTION TRANSCRIPTOME OF HUMAN MACROPHAGES  
The invention is based on the finding of specific surface markers for M1-like (classically activated) and M2-like (alternatively activated) macrophages and provides for a method for the...
US20150185224 PREDICTING BLADDER CANCER RESPONSIVENESS TO BCG  
Bacillus Calmette-Guerin (BCG) administration plays a central role in managing carcinoma in situ of the bladder. Unfortunately, recurrence or progression of disease is seen in up to 30% of treated...
US20140342926 Methods for Assessing Risk for Cardiac Dysrythmia in a Human Subject  
The present invention relates to methods for assessing the risk of a patient for developing a potentially fatal cardiac dysrhythmia and for diagnosing Andersen's Syndrome. A tissue sample from a...
US20130045873 METHODS FOR IDENTIFYING AND USING ORGAN-SPECIFIC PROTEINS IN BLOOD  
The present invention relates generally to methods for identifying organ-specific secreted proteins and for identifying organ-specific molecular blood fingerprints therefrom. As such, the present...
US20150211053 BIOMARKERS FOR DIABETES AND USAGES THEREOF  
Biomarkers for diabetes and usages thereof are provided. And the biomarkers are Akkermansia muciniphila, Bacteroides intestinalis, Bacteroides sp. 20_3, Clostridium bolteae, Clostridium hathewayi,...
US20150225800 METHODS AND ASSAYS FOR TREATMENT OF BLADDER CANCER  
The technology described herein relates to methods of prognosing and treating bladder cancer.
US20130252826 LARGE DELETIONS IN HUMAN PMS2 GENE AND USE THEREOF  
Large deletions have been identified in the PMS2 gene in patients. The large deletions predispose the patients to Lynch syndrome associated cancers. Thus, methods for detecting the genetic...
US20150259749 METHODS FOR PRODUCING HIGH-FIDELITY AUTOLOGOUS IDIOTYPE VACCINES  
The present invention concerns methods for selecting and producing idiotype vaccines, and in particular methods for selecting and producing an idiotype vaccine for treatment of a B-cell derived...
US20140256564 METHODS OF USING HUR-ASSOCIATED BIOMARKERS TO FACILITATE THE DIAGNOSIS OF, MONITORING THE DISEASE STATUS OF, AND THE PROGRESSION OF TREATMENT OF BREAST CANCERS  
The present invention relates to methods of identifying gene targets, including methods of using ribonucleoprotein (RNP) immunoprecipitation-microarrays to identify cancer gene targets, such as...
US20150247208 GENE SIGNATURES FOR CANCER PROGNOSIS  
Biomarkers and methods using the biomarkers for classifying cancer in a patient (e.g., predicting the risk of cancer-specific death or cancer recurrence) are provided.
US20100298151 EXOSOME-ASSOCIATED MICRORNA AS A DIAGNOSTIC MARKER  
The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more microRNAs present in cancer-derived...
US20140228423 BIOMARKERS AND THERAPY FOR CANCER  
In embodiments of the present invention, there are methods and compositions related to diagnosis and treatment of serous ovarian cancer. In specific embodiments, the invention encompasses methods...
US20150139946 DETECTING MUTATIONS IN DISEASE OVER TIME  
Provided is a method for monitoring a gene mutation associated with a cancer in a patient over time. Also provided is a method of selecting and/or applying treatment or therapy for a subject.
US20150072865 Algorithm for Modification of Somatic Cancer Evolution  
Most clinically distinguishable malignant tumors are characterized by specific mutations, specific patterns of chromosomal rearrangements and a predominant mechanism of genetic instability. It has...
US20140283152 METHOD FOR ARTIFICIAL SELECTION  
The present invention provides methods of determining the breeding value of an individual or determining the best pair of individuals to mate based on additive and non-additive factors. The...
US20120184447 Methods and Nucleic Acids for Analysis of Bladder Cell Proliferative Disorders  
The invention provides methods, nucleic acids and kits for detecting bladder carcinoma. The invention discloses genomic sequences the methylation patterns of which have utility for the improved...
US20150232953 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via...
US20130316918 MODEL-BASED RESIDUAL CORRECTION OF INTENSITIES  
A method for improving color calls or base calls utilizes current and prior cycle multi-channel intensity data from a sequencing run to model residual cycle buildup. The model is applied to...
US20110251073 Compositions And Methods Comprising Variant Microbial Proteases  
The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more...
US20140221219 OLIGODENDROGLIOMA DRIVE GENES  
Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19,...
US20140274742 METHODS TO DETERMINE CARCINOGENESIS, IDENTIFY MARKERS FOR EARLY CANCER DIAGNOSIS AND IDENTIFY TARGETS OF THERAPY  
Methods and techniques to identify carcinogenesis pathways and markers for early cancer diagnosis. Cell sampling is performed on a single tumor with multiple samples being taken from the tumor and...
US20120065080 ACID CERAMIDASE POLYMORPHISMS AND METHODS OF PREDICTING TRAITS USING THE ACID CERAMIDASE POLYMORPHISMS  
Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding...
US20150087527 METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF TISSUE OR ORGAN FIBROSIS IN A REPARATIVE OR REACTIVE PROCESS  
The invention relates to methods of diagnosis or prognosis of a tissue or organ fibrosis (e.g., skin fibrosis, hypertrophic scar or a keloid) in a reparative or reactive process comprising the...
US20110136675 IDENTIFICATION AND CHARACTERIZATION OF PROTEINS USING NEW DATABASE SEARCH MODES  
A method of selecting a set of candidate polypeptides for a sample polypeptide that includes a first refining of a collection of candidate polypeptides from differences in mass of fragments of the...
US20140080718 Systems and Methods for Identifying Sequence Variation Associated with Genetic Diseases  
Systems and method for identifying variants associated with a genetic disease can include obtaining calls for a plurality of individuals for a list of variant positions. The calls can be compared...
US20150152507 BIOMARKERS FOR PROSTATE CANCER  
The present application concerns methods and tools for diagnosing prostate cancer and furthermore concerns methods and tools for prognosing disease progression of prostate cancer. The method...
US20150086581 Fast Diagnosis and Personalized Treatment for Acne  
Methods of diagnosing and treating patients afflicted with acne, including diagnosing one as having acne if the individual possesses RT4, RT5, RT7, RT8, RT9, or RT10. Methods for treating acne...
US20140206545 GENE EXPRESSION MARKERS FOR PREDICTION OF PATIENT RESPONSE TO CHEMOTHERAPY  
The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a...
US20120040842 Gene Expression Markers for Prediction of Patient Response to Chemotherapy  
The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a...
US20140179536 Genetic Diagnosis of Hepatic Steatosis  
Disclosed are methods of identifying a genetic variant in a person determined to have or be predisposed having a fatty liver by determining whether the person has PNPLA3-I148M. Also disclosed are...