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US20100298160 METHOD AND TOOLS FOR PROGNOSIS OF CANCER IN ER-PATIENTS  
A gene or protein set includes at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41,...
US20110312521 Genomic Transcriptional Analysis as a Tool for Identification of Pathogenic Diseases  
The discovery and validation of a candidate biomarker signature for the diagnosis of sepsis, and more particularly septicemic meliodiosis, based on genomic transcriptional profiling using...
US20130230884 Methods to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation  
The present invention provides reagents and methods for identifying translation enhancing elements, as well as isolated translation enhancing elements and their use in protein expression reagents...
US20120065084 METHODS AND TOOLS FOR PREDICTING THE EFFICIENCY OF ANTHRACYCLINES IN CANCER  
A gene set, kit and method predict the efficiency of anthracyclines-based treatment of breast cancer.
US20110257042 Debulking Catheters And Methods  
A debulking catheter comprising a tissue debulking assembly for removing a continuous strand of material from a body lumen. Catheters of the present invention generally include a catheter body...
US20110039723 MALIGNANCY-RISK SIGNATURE FROM HISTOLOGICALLY NORMAL BREAST TISSUE  
The invention provides for malignancy-risk gene signatures that predict the risk of developing breast cancer, the recurrence of breast cancer, and/or the metastasis of breast cancer. These...
US20130178442 GENE EXPRESSION PROFILES AND PRODUCTS FOR THE DIAGNOSIS AND PROGNOSIS OF POSTINJURY SYNOVITIS AND OSTEOARTHRITIS  
Associations between inflammation and pain/function scores were tested by univariate and multivariate analyses. Gene expression was analyzed by microarray and real-time PCR comparing patients with...
US20110190157 Biomarkers for Diagnosis and Treatment of Chronic Lymphocytic Leukemia  
A molecular classification procedure based on activity levels of modules in protein networks, wherein the proteins are biomarkers for chronic lymphocytic leukemia (CLL), and method for use of the...
US20110306507 METHOD AND TOOLS FOR PROGNOSIS OF CANCER IN HER2+PARTIENTS  
A gene or protein set includes at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, and possibly 40, 45, 50,...
US20140221621 SINGLE-CHAIN MULTIVALENT BINDING PROTEIN COMPOSITIONS AND METHODS  
Provided are protein, nucleic acid, and cellular libraries of single chain multivalent binding proteins (e.g., scDVD and scDVDFab molecules) and methods of using these of these libraries for the...
US20110183863 PROTEIN SCREENING METHODS  
The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.
US20130324438 METAGENE EXPRESSION SIGNATURE FOR PROGNOSIS OF BREAST CANCER PATIENTS  
Described are gene expression signatures able to distinguish individuals having or suspected to have breast cancer with good clinical prognosis from individuals with poor clinical prognosis, based...
US20110046002 Seven Gene Breast Cancer Predictor  
The invention provides a molecular marker set that can be used for prognosis of breast cancer in a patient using histologically normal tissue. The invention also provides methods for evaluating...
US20110086772 MULTIPLEX (+/-) STRANDED ARRAYS AND ASSAYS FOR DETECTING CHROMOSOMAL ABNORMALITIES ASSOCIATED WITH CANCER AND OTHER DISEASES  
Multiplex (+/−) stranded analyses, such as array comparative genomic hybridization (aCGH), are provided for detecting chromosomal rearrangements associated with cancer and other diseases. For...
US20110143956 Diagnostic Kits and Methods for SCD or SCA Therapy Selection  
Variations in certain genomic sequences useful as genetic markers of Sudden Cardiac Death (“SCD”) or Sudden Cardiac Arrest (“SCA”) risk are described. Novel diagnostic kits, DNA microarrays, and...
US20130203609 LIBRARY-BASED METHODS AND COMPOSITIONS FOR INTRODUCING MOLECULAR SWITCH FUNCTIONALITY INTO PROTEIN AFFINITY REAGENTS  
Methods and compositions are disclosed for introducing molecular switch functionality into a protein affinity reagent to render its binding to a target molecule sensitive to an environmental...
US20140235476 MULTIVALENT BINDING PROTEIN COMPOSITIONS AND METHODS FOR IDENTIFYING VARIANTS OF SAME  
Provided are protein, nucleic acid, and cellular libraries of multivalent binding proteins (e.g., DVD-Fab or DVD-Ig molecules) and the use of these libraries for the screening of multivalent...
US20120184560 MOLECULAR DIAGNOSTIC METHODS FOR PREDICTING BRAIN METASTASIS OF BREAST CANCER  
Disclosed are molecular diagnostic compositions and methods for predicting brain metastasis of breast cancer, as well as methods for drug repositioning to identify existing and new therapeutics...
US20120316321 METHODS FOR IDENTIFYING MARKERS FOR EARLY-STAGE HUMAN CANCER, CANCER PROGRESSION AND RECURRENCE  
A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing...
US20150252409 SYSTEMS GENETICS NETWORK REGULATORS AS DRUG TARGETS  
The present invention provides for methods, processes and platforms to validate systems genetics networks to define their genetic regulators and to optimize translational applicability to humans...
US20110257041 BIO-FIELD PROGRAMMABLE GATE ARRAY AND BIO-PROGRAMMABLE LOGIC ARRAY: RECONFIGURABLE CHASSIS CONSTRUCTION  
Aspects of the invention relate to reconfigurable chassis that allow for rapid construction and optimization of biocircuits.
US20110027184 PROTEIN C PATHWAY ASSOCIATED POLYMORPHISMS AS RESPONSE PREDICTORS TO ACTIVATED PROTEIN C OR PROTEIN C-LIKE COMPOUND ADMINISTRATION  
The invention provides methods, nucleic acids, compositions and kits for predicting a subject's response to treatment with activated protein C or protein C like compound to identify subjects...
US20110207628 OPEN-READING-FRAME (ORF) PHAGE DISPLAY  
A dual display phage system for the identification of protein interaction networks and therapeutic targets.
US20120225789 DNA REPAIR OR BRCA1-LIKE GENE SIGNATURE  
The present invention concerns the identification of individuals that have triple negative breast cancer and/or identification of an appropriate treatment therefor. In certain cases, the...
US20130143747 METHODS OF DETECTING CANCER  
Methods and compositions involving molecular markers for the detection and characterization of cancer in a patient are provided.
US20120021927 Methods for Determining a Prognosis for Survival for a Patient with Breast Cancer  
A method for determining a prognosis for survival for a patient with breast cancer is described. Also described is method for monitoring the effectiveness of a course of treatment for a patient...
US20150203919 METHODS FOR PREDICTING THE SURVIVAL TIME AND TREATMENT RESPONSIVENESS OF A PATIENT SUFFERING FROM A SOLID CANCER WITH A SIGNATURE OF AT LEAST 7 GENES  
The present invention relates to a method for predicting the survival time of a patient suffering from a solid cancer comprising i) determining in a tumor sample obtained from the patient the gene...
US20130130928 METHODS FOR PREDICTING OR MONITORING WHETHER A PATIENT AFFECTED BY A CANCER IS RESPONSIVE TO A TREATMENT WITH A MOLECULE OF THE TAXOID FAMILY  
The present invention concerns in vitro methods for predicting or monitoring whether a patient affected by a cancer is responsive to a treatment with a molecule of the taxoid family based on a...
US20150057189 IN VIVO TRANSDUCTION WITH A CHIMERIC AAV CAPSID PROTEIN  
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.
US20110172123 Arrays  
Protein arrays that allow the analysis of differentially expressed proteins in parallel are disclosed. Methods for making such arrays, and their use for screening and/or evaluating the effect of...
US20130331300 Selection and Enrichment of Proteins Using In Vitro Compartmentalization  
Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a...
US20120172236 Selection and Enrichment of Proteins Using In Vitro Compartmentalization  
Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a...
US20110020317 BREAST TUMOUR GRADING  
We describe a method of assigning a grade to a breast tumour, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of a gene selected from...
US20150247206 Compositions and Methods for Therapy and Diagnosis of Cancer and Cancer Metastasis  
The present invention relates to methods which make possible to assess and/or prognose a cancer disease, the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer....
US20140206575 Collection and Methods For Its Use  
The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties...
US20120129717 Collection and Methods For Its Use  
The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties...
US20140351962 GENETIC TEST FOR LIVER COPPER ACCUMULATION IN DOGS  
The present invention provides a method of testing a dog to determine the susceptibility of the dog to liver copper accumulation, comprising detecting in a sample the presence or absence in the...
US20140051585 METHODS AND COMPOSITIONS FOR REDUCING GENETIC LIBRARY CONTAMINATION  
Embodiments include methods, compositions, and kits for creating genetic libraries useful for massively parallel genetic sequencing. Some embodiments are directed to methods of preventing the...
US20150133308 METHOD FOR IMPROVING REPEBODY CONTAINING REPEAT MODULES  
The present invention relates to a method for improving a repebody protein comprising repeat modules and a nucleotide library encoding a repebody protein library for improving the repebody...
US20150212088 COMPOSITIONS AND METHODS FOR DETECTING AND TREATING COLORECTAL CANCER  
The present invention relates to compositions and methods for the detecting, treating, and empirically investigating the interaction between a subject's immune system and cancer stem cells. In...
US20110166868 METHOD FOR PROVIDING GENOMIC CLONES  
Subscription-based systems and methods where a provider provides one or more customers, identified as subscribers or non-subscribers, with research products and services (e.g., for industries...
US20110262025 Cosmetic Compositions and Methods for Maintaining and Improving Barrier Function of the Stratum Corneum and to Reduce the Visible Signs of Aging in Skin  
Gene panels, biomarker panels and microarrays relating to lipid formation in stratum corneum of human skin as a function of extrinsic and/or intrinsic aging conditions, and methods for assessing...
US20130029864 BIOMARKERS FOR ALZHEIMER'S DISEASE  
The invention relates to novel marker sequences for Alzheimer's disease, in particular Alzheimer's dementia, and their diagnostic use including a screening method in order to identify potential...
US20140304845 ALZHEIMER'S DISEASE SIGNATURE MARKERS AND METHODS OF USE  
Methods, biomarkers, and expression signatures are disclosed for assessing the disease progression of Alzheimer's disease (AD). In one embodiment, BioAge (biological age), NdStress...
US20150240312 COPY NUMBER ABERRATION DRIVEN ENDOCRINE RESPONSE GENE SIGNATURE  
Disclosed are methods of predicting the likelihood of long-term survival without recurrence of breast cancer for a subject having estrogen receptor-positive (ER+) breast cancer treated with...
US20150225792 COMPOSITIONS AND METHODS FOR IDENTIFYING DEPRESSIVE DISORDERS  
Provided herein are compositions, kits, and methods for the identification of depressive disorders. In particular, provided herein are compositions, kits, and methods for the detection or...
US20110039708 MOLECULAR CLASSIFIER FOR PROGNOSIS IN MULTIPLE MYELOMA  
The invention relates to a 15-gene molecular classifier consisting of the following genes: CNDP2; STMN1; AFG3L2; STK38; PARP1; CPSF6; LOC151162; C20orf100; FRY; FLJ21438; MGST1; ALDH2; CTSF; ATF4;...
US20130079234 GENE EXPRESSION PROFILING OF PRIMARY BREAST CARCINOMAS USING ARRAYS OF CANDIDATE GENES  
A method for predicting the sensitivity of tumor cells to an anthracycline-based chemotherapy includes determining the differential expression level of a MYBL2 gene in tumors cells. A...
US20150177247 METHOD FOR IDENTIFYING MARKER SEQUENCES FOR GYNAECOLOGICAL MALIGNANT TUMOURS  
The present invention relates to a method for identifying marker sequences for gynaecological malignoma, the marker sequences identified with the aid of this method and diagnostic use thereof,...
US20110136685 METHOD FOR DETERMINING A PREDISPOSITION TO BASAL CELL CARCINOMA AND FOR SCREENING TREATMENTS THEREOF  
The present invention relates to methods for detecting a predisposition to a basal cell carcinoma and methods for screening a treatment of a basal cell carcinoma.