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US20120264627 Oligonucleotide Array For Tissue Typing  
Oligonucleotide-based microarrays for tissue typing (e.g., HLA tissue typing) are provided. More particularly, the microarrays are high resolution arrays useful for diagnostic evaluations and...
US20140274777 LIPID DROPLET PROTEIN MARKERS FOR ALGAL OIL ACCUMULATION  
The application relates to apparatuses, methods and kits for detecting and quantifying oil content in algal samples.
US20150079116 DIAGNOSTIC TOOLS FOR RESPONSE TO 6-THIOPURINE THERAPY  
NK cell licensing predisposes patients to chronic inflammatory disease. Methods and kits to diagnose and treat chronic inflammatory disease based on genetic haplotype and cytokine profile are...
US20110034347 Signatures Associated with Rejection or Recurrence of Cancer  
Methods and tools for assessing the prognosis for patients following treatment of primary tumors are provided. The methods involve identifying immune-related genetic markers whose differential...
US20120094292 FORENSIC IDENTIFICATION  
The invention provides allelic ladder mixtures and individual alleles suitable for use in such mixtures. The allelic ladder mixtures give improved identification and distinguishing capabilities,...
US20120015832 METHODS, PANELS OF IDENTIFICATION MARKERS, AND KITS FOR IDENTIFYING FORENSIC SAMPLES  
Methods for identifying forensic samples using panels of markers and gene expression profiling, including without limitation, mRNA profiling, miRNA profiling, or both, are disclosed. Panels of...
US20150110897 Sperm Protein as a Detection Biomarker of Early Stage Ovarian Cancer  
This disclosure provides a method for determining if a patient is likely to, or not likely to, experience ovarian cancer utilizing SP17 as a biomarker. It also provides methods and therapies to...
US20120264720 IDENTIFICATION AND TREATMENT OF CANCER SUBSETS  
Methods of predicting whether or not a tumor will be responsive to IP6 treatment, methods of treating patients with cancer using IP6, methods of predicting the progression of a disease, and kits...
US20120225791 ARRAY-BASED METHOD FOR DETECTION OF COPY NUMBER VARIATIONS IN THE HLA LOCUS FOR THE GENETIC DETERMINATION OF SUSCEPTIBILITY OF DEVELOPMENT OF VENOUS MALFORMATIONS IN THE EXTRACRANIAL SEGMENTS OF THE CEREBROSPINAL VEINS AND KIT THEREOF  
Method for in vitro diagnosis of susceptiblility of developing venous malformations i the extracranial segment of the cerebrospinal veins in a patient comprising the detection of copy number...
US20150259739 DETERMINING AGE RANGES OF SKIN SAMPLES  
The present invention provides methods for characterizing a skin sample of a subject as belonging to an age range by analyzing nucleic acid or protein molecules obtained from the subject. The...
US20110301054 Method of Stratifying Breast Cancer Patients Based on Gene Expression  
The present invention assists in prospectively predicting the metastatic likelihood, and thereby, the likely clinical outcome of breast cancer patients, based on the genotype of the patient, in...
US20120065084 METHODS AND TOOLS FOR PREDICTING THE EFFICIENCY OF ANTHRACYCLINES IN CANCER  
A gene set, kit and method predict the efficiency of anthracyclines-based treatment of breast cancer.
US20110177957 Polymorphisms Associated With Age-Related Macular Degeneration And Methods For Evaluating Patient Risk  
The present invention provides for certain polynucleotide sequences that have been correlated to AMD. These polynucleotides are useful as diagnostics, and are preferably used to fabricate an...
US20130058863 4-Protein Biomarker Panel for the Diagnosis of Lymphoma from Biospecimen  
A panel of lymphoma related biomarkers are provided. The panel allows the identification of a subject at risk for a lymphoma. Further provided are methods of optimizing therapeutic efficacy...
US20150045237 METHOD FOR IDENTIFICATION OF THE SEQUENCE OF POLY(A)+RNA THAT PHYSICALLY INTERACTS WITH PROTEIN  
The invention relates to an in vitro method for identifying the sequence of one or more poly(A)+RNA molecules that physically interacts with protein. The present invention provides a method to...
US20120185174 Prognostic Signature for Colorectal Cancer Recurrance  
An assay system is useful for predicting recurrence and/or non-recurrence of colorectal cancer in a patient. The assay system is adapted to analyze a patient sample for quantitative expression of...
US20140377861 Precise Control of Recombinant Protein Levels by Engineering Translation  
Compositions and methods are provided for user-specified fine-tuned protein expression levels, by controlling the initiation of protein translation; and a model for analysis of expression. This...
US20150018323 3B-HYDROXYSTEROID DEHYDROGENASE IN STEROID-DEPENDENT DISEASE  
Methods and kits for characterizing a subject having a steroid-dependent disease such as prostate cancer are described. A method of treating a steroid-dependent disease in a subject by obtaining a...
US20140031258 SERUM-BASED MIRNA MICROARRAY AND ITS USE IN DIAGNOSIS AND TREATMENT OF BARRETT'S ESOPHAGUS (BE) AND ESOPHAGEAL ADENOCARCINOMA (EAC)  
Robust and reliable molecular diagnostic screening tools for early detection of esophageal and gastrointestinal tract cancers and pre-cancerous lesions, such as Barrett's Esophagus, and esophageal...
US20120316080 DIFFERENTIATION BETWEEN BRCA2-ASSOCIATED TUMOURS AND SPORADIC TUMOURS VIA ARRAY COMPARATIVE GENOMIC HYBRIDIZATION  
Array comparative genomic hybridization classifiers, arrays comprising the classifiers and methods of using the same for differentiating between BRCA2-associated tumors and sporadic tumors by...
US20120178640 Nanotube Array for Optical Detection of Protein-Protein Interactions  
A composition can include a nanostructure, and a linker associated with the nanostructure, wherein the linker is configured to interact with a capture protein. The nanostructure can include a...
US20110143962 METHOD OF EVALUATING ORAL CANCER RISK IN HUMAN  
A method of providing a risk evaluation and diagnosis of human oral cancer, by examining at the presence in human saliva sample of a combination of particulate nucleic acids from bacteria, virus,...
US20140274773 SYSTEMS AND METHODS FOR EMPLOYING PODOCALYXIN AND TRA HUMAN STEM CELL MARKERS AS PROGNOSTIC MARKERS FOR AGGRESSIVE AND METASTATIC CANCER  
The invention relates to systems and methods to detect podocalyxin-expressing and TRA-expressing cancer stem cells or cancer cells with stem cell-like properties in a tissue cell sample obtained...
US20130090256 BIOMARKERS FOR EARLY DETECTION OF OVARIAN CANCER  
Biomarker proteins that can be used in the diagnosis of early-stage ovarian cancer (OC) are described. The biomarker panels not only permit the distinction of patients with ovarian neoplasia...
US20130096022 Methods and Materials Related to Ovarian Cancer  
Described herein are methods for diagnosing ovarian cancer. In particular, certain microRNAs are useful to the response to chemotherapy of ovarian cancer patients.
US20140235458 METHODS AND TOOLS FOR THE DIAGNOSIS AND PROGNOSIS OF UROGENITAL CANCERS  
The present invention provides a microarray useful as a tool in the diagnosis and/or prognosis of certain types of cancers, particularly urogenital cancers. The microarray can include a plurality...
US20140017227 GENE SIGNATURES FOR USE WITH HEPATOCELLULAR CARCINOMA  
The present invention provides a method for predicting prognosis of hepatocellular carcinoma patients based on measurement of the relative level of expression of a combination of 15 immune genes...
US20150197816 METHODS FOR THE DETECTION, VISUALIZATION AND HIGH RESOLUTION PHYSICAL MAPPING OF GENOMIC REARRANGEMENTS IN BREAST AND OVARIAN CANCER GENES AND LOCI BRCA1 AND BRCA2 USING GENOMIC MORSE CODE IN CONJUNCTION WITH MOLECULAR COMBING  
Methods for detecting genomic rearrangements in BRCA1 and BRCA2 genes at high resolution using Molecular Combing and for determining a predisposition to a disease or disorder associated with these...
US20130324438 METAGENE EXPRESSION SIGNATURE FOR PROGNOSIS OF BREAST CANCER PATIENTS  
Described are gene expression signatures able to distinguish individuals having or suspected to have breast cancer with good clinical prognosis from individuals with poor clinical prognosis, based...
US20140378334 METHOD FOR QUANTIFYING RENAL MARKERS BY ASSAYING URINE  
The invention pertains to a method of in vitro diagnosis of pathologies in a patient. According to the invention, the method comprises the following steps: a) obtaining a urine sample from said...
US20140221242 GENOME-WIDE METHYLATION ANALYSIS AND USE TO IDENTIFY GENES SPECIFIC TO BREAST CANCER HORMONE RECEPTOR STATUS AND RISK OF RECURRANCE  
To better understand the biology of hormone receptor-positive and negative breast cancer and to identify methylated gene markers of disease progression, a genome-wide methylation array analysis...
US20140342925 METHOD FOR PREDICTING A MANIFESTATION OF AN OUTCOME MEASURE OF A CANCER PATIENT  
The invention pertains to a method for predicting a manifestation of an outcome measure of a cancer patient based on a tumor DNA containing tissue sample from the cancer patient, comprising,...
US20120289429 BIOCHIP COMPRISING MULTIPLE MICROCHANNELS  
A biochip includes a plurality of microchannels; and a plurality of probes disposed in an inner wall of each of the plurality of microchannels forming a one-dimensional array. The one-dimensional...
US20120184454 GENE SIGNATURE IS ASSOCIATED WITH EARLY STAGE RECTAL CANCER RECURRENCE  
Applicants have identified a 36-gene signature that is associated with recurrence of stage I and II rectal cancers not treated with chemotherapy or radiation. This signature can be used to...
US20130065786 METHOD FOR BREAST CANCER RECURRENCE PREDICTION UNDER ENDOCRINE TREATMENT  
The present invention relates to methods, kits and systems for the prognosis of the disease outcome of breast cancer, said method comprising: (a) determining in a tumor sample from said patient...
US20120021935 SIGNATURE FOR THE DIAGNOSIS OF CANCER AGGRESSIVENESS AND GENETIC INSTABILITY  
The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of said patient, comprising: a) measuring in vitro...
US20110257035 IDENTIFICATION OF SIGNATURE GENES ASSOCIATED WITH HEPATOCELLULAR CARCINOMA  
The present invention relates to, for example, (1) a novel method for identification of clinically useful serum and/or tumor biomarkers and expression signatures that can be used for detection,...
US20130102483 METHODS FOR THE ANALYSIS OF BREAST CANCER DISORDERS  
The present invention relates to methods, arrays and computer programs for assisting in classifying breast cancer diseases. In particular the invention relates to classifying breast cancer...
US20110166107 METHODS AND KITS FOR DETECTING RISK FACTORS FOR DEVELOPMENT OF JAW OSTEONECROSIS AND METHODS OF TREATMENT THEREOF  
Methods of and kits for determining the pharmacogenetic, pharmacokinetic and cellular basis of bisphosphonate-induced osteonecrosis of the jaw (BONJ) involve associating particular proteins and...
US20130267432 IN VITRO DIAGNOSTIC METHOD FOR PATIENTS WITH SPLENIC MARGINAL ZONE LYMPHOMA  
The present invention refers to an in vitro SMZL diagnostic method based on analysis of the expression of a series of genes located in a very specific deleted region of human chromosome 7. The...
US20110152352 SMAD PROTEINS CONTROL DROSHA-MEDIATED MIRNA MATURATION  
The invention, in some aspects, relates to compositions and methods useful for modulating expression of miRNAs that are regulated by the TGF-β/BMP signaling pathway. In some aspects, the invention...
US20110136679 Imprinted Array  
There is described a gene expression array comprising more than one imprinted gene and one or more control genes for the diagnosis of human epigenetic diseases resulting from assisted reproduction...
US20150258170 Diagnosis and Treatment of SMA and SMN Deficiency  
The present invention provides for methods for diagnosing and treating a motor neuron disease. More specifically, the present invention offers new methods for diagnosing and treating SMA or SMN...
US20140274780 METHODS OF IMPROVING SURVIVAL IN CANCER  
Methods of improving cancer therapy outcomes are provided. Diagnostics useful for evaluating patients based on microRNA signatures of cancer tissue are provided.
US20120237488 LSC AND HSC SIGNATURES FOR PREDICTING SURVIVAL OF PATIENTS HAVING HEMATOLOGICAL CANCER  
A method for determining prognosis in a subject having a hematological cancer comprising: a) determining an expression profile by measuring the gene expression levels of a set of genes selected...
US20120041274 CANCER BIOMARKERS  
Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.
US20130065775 Methods for diagnosing skin diseases  
The present invention relates to methods for diagnosing cornification disorders and metabolic diseases. More specifically, the present invention relates to an in vitro method for diagnosing and/or...
US20150094221 Method for Indicating the Presence or Non-Presence of Prostate Cancer  
The present invention relates generally to the detection and identification of various forms of genetic markers, and various forms of proteins, which have the potential utility as diagnostic...
US20150141391 SYSTEMS AND METHODS FOR DETERMINING A TREATMENT COURSE OF ACTION  
The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their...
US20110177096 USE OF GPR151 MODULATORS FOR THE TREATMENT OF PAIN  
The present invention relates to nucleic acid arrays used to detect genes which are up or down regulated following a pain stimulus in a mammal. It further relates to the use of GPR151 in methods...