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US20140113876 BIOMARKERS FOR ASSESSING TREATMENT OF SIALIC ACID DEFICIENCY DISEASES AND CONDITIONS  
The present invention relates to methods of monitoring and assessing sialic acid deficiency treatment as well as to methods of predicting/determining responsiveness to treatment for a sialic acid...
US20120225925 Micro-RNA Biomarkers and Methods of Using Same  
A procedure and an apparatus are described for identifying individuals at risk of pulmonary tumour and/or for diagnosing a pulmonary tumour using the study of levels of expression of miRNA in the...
US20130035240 Markers for Obesity and Methods of Use Thereof  
Markers for obesity, particularly childhood obesity, are provided along with methods of use thereof.
US20150030615 BIOMARKERS FOR CANCER STEM CELLS AND RELATED METHODS OF USE  
Novel methods of classifying subjects as candidates for treatment with a cancer associated mesenchymal cell, tumor initiating cancer cell, or cancer stem cell inhibitor treatment and subsequent...
US20100304987 METHODS AND KITS FOR DIAGNOSIS AND/OR PROGNOSIS OF THE TOLERANT STATE IN LIVER TRANSPLANTATION  
The long-term survival of transplanted grafts critically depends on the life-long administration of immunosuppressive drugs to prevent graft rejection. These drugs are very effective at preventing...
US20140221252 DETECTING NEOPLASM  
This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal...
US20110098186 PHYSIOGENOMIC METHOD FOR PREDICTING DRUG METABOLISM RESERVE FOR ANTIDEPRESSANTS AND STIMULANTS  
Disclosed herein are compositions and methods relevant to a novel Drug Metabolism Reserve Physiotype to determine the metabolic capacity of a human individual. The Drug Metabolism Reserve...
US20150225797 MOLECULAR ASSAY REAGENTS AND METHODS  
Methods, kits, and compositions for evaluating the quality of nucleic acids within a biological sample for analysis in a molecular assay are provided. A kit is provided for evaluating a biological...
US20120122718 BRM Expression and Related Diagnostics  
The present invention relates to isolated polynucleotides comprising a polymorphism in a promoter region of a BRM gene, and methods and compounds for causing BRM re-expression in cells, such as...
US20130261018 INTERFERON GENE SIGNATURE AND METHODS OF USE THEREOF  
The present invention is a method and kit for determining responsiveness of a subject to treatment with a Type I interferon based upon the expression of gene signatures shown to be stimulated by...
US20110117134 Gene library of Brucella suis surface antigens  
The invention relates to a bacterial antigen library of Brucella suis surface antigens, its preparation and use. The library comprises 205 surface protein genes of Brucella suis constructed in an...
US20150218620 METHODS TO CAPTURE AND/OR REMOVE HIGHLY ABUNDANT RNAS FROM A HETEROGENOUS RNA SAMPLE  
The invention is directed to a method of using DNA oligonucleotides as baits to capture and selectively remove highly abundant RNAs from a heterogeneous RNA sample for improved enrichment of other...
US20150259727 ALLELIC DISCRIMINATION ASSAYS FOR MRSA STRAINS  
The present invention provides assays, methods and kits that may be used to detect and differentiate MRSA isolates, e.g., USA100, USA300 and USA600 strains.
US20110130302 BIOLOGICAL PATHWAYS ASSOCIATED WITH CHEMOTHERAPY OUTCOME FOR BREAST CANCER  
The present invention provides methods for preparing drug response and/or resistance profiles for breast tumor specimens, or cells derived therefrom. The drug response and/or resistance profiles...
US20140378330 Multi-primer Assay for Mycoplasma Detection  
Disclosed is a multi-primer amplification assay, method and kits for detecting Mycoplasma species and closely related species utilizing a plurality of oligonucleotide primers in contact with a...
US20150133329 METHODS OF DETECTING INFLUENZA VIRUS  
Disclosed herein are methods of detecting influenza virus in a sample from a subject. In some embodiments, the disclosed methods include contacting a sample with at least one primer 10-40...
US20100298168 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions  
Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for...
US20130267426 MICROSATELLITE INSTABILITY MARKERS IN DETECTION OF CANCER  
The present application relates to the field of cancer, particularly to mismatch repair (MMR−) deficient tumors. New markers are presented herein that have a high sensitivity to detect whether a...
US20120088690 METHOD FOR DETECTING A POSITION OF PROBE ON MICROARRAY  
A method for detecting hybridization between a probe polynucleotide and a target polynucleotide on a microarray is presented. The method may be used to determine the accuracy of hybridization and...
US20130288924 METHOD FOR DIAGNOSING HEMATOLOGICAL DISORDERS  
Disclosed is a method for the diagnosis, and/or the classification, of a hematological disorder, including the steps of: a). measuring, the expression level of at least the genes of a sub-group of...
US20140031246 CIRCULATING MICRORNAS ARE BIOMARKERS OF VARIOUS DISEASES  
The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to diagnose and monitor various diseases such as cancer.
US20150211048 Microfluidic Devices, Solid Supports for Reagents and Related Methods  
A microfluidic device includes a plurality of reaction wells; and a plurality of solid supports, and each of the solid supports has a reagent attached thereto. The reagent is attached to the solid...
US20130237432 APPLICATION OF A PCR SEQUENCING METHOD, BASED ON DNA BARCODING TECHNIQUE AND DNA INCOMPLETE SHEARING STRATEGY, IN HLA GENOTYPING  
The invention provides a PCR sequencing method, wherein the combination of primer indexes, DNA incomplete shearing strategy and the second generation sequencing technique (Paired-End sequencing...
US20140037549 GENETIC MARKERS FOR PROGNOSIS OF RHEUMATOID ARTHRITIS TREATMENT EFFICACY  
The present invention discloses markers useful in predicting the responsiveness of a subject having, or at risk of developing rheumatoid arthritis (RA) to treatment with anti-TNF agents....
US20150184247 GENE EXPRESSION PROFILES ASSOCIATED WITH METASTATIC BREAST CANCER  
A gain-of-function retroviral cDNA screen reveals that Coco, a secreted antagonist of TGF-β ligands, induces solitary mammary carcinoma cells, which have disseminated to others sites and undergone...
US20140128279 PRIMERS AND PROBES FOR DETECTION AND DISCRIMINATION OF TYPES AND SUBTYPES OF INFLUENZA VIRUSES  
Methods of detecting influenza, including differentiating between type and subtype are disclosed, for example to detect, type, and/or subtype an influenza infection. A sample suspected of...
US20120283135 PRIMERS AND PROBES FOR DETECTION AND DISCRIMINATION OF TYPES AND SUBTYPES OF INFLUENZA VIRUSES  
Methods of detecting influenza, including differentiating between type and subtype are disclosed, for example to detect, type, and/or subtype an influenza infection. A sample suspected of...
US20130203623 METHOD AND KIT FOR CLASSIFYING A PATIENT  
Provided is a Suppressive Subtractive Hybridization-Oligonucleotide Microarray (SSH-OM) method for the prediction of treatment response for personalized medicine applications and for the...
US20140255387 Genetic Alterations and Methods of Use Thereof for the Diagnosis and Treatment of Type 1 Diabetes  
Compositions and methods for the diagnosis and treatment of T1D are disclosed. More specifically, the invention provides gene targets containing single nucleotide polymorphisms associated with...
US20110251083 Multiplexed Amplification of Short Nucleic Acids  
The present teachings provide methods, compositions, and kits for reverse transcribing and amplifying small nucleic acids such as micro RNAs. High levels of multiplexing are provided by the use of...
US20150057169 Biomarkers for Head-and-Neck Cancers and Precancers  
The invention provides markers and methods for detecting head-and-neck precancers, (including OPLs), cancers and related disease conditions in a subject. The invention also provides localization...
US20130333070 SMALL INTERFERING RNAS WITH TARGET-SPECIFIC SEED SEQUENCES  
Disclosed are methods for design and synthesis of siRNA libraries, siRNA libraries produced thereby, siRNA molecules, and uses thereof.
US20130150263 HUMAN T2R NUCLEIC ACID SEQUENCES  
Newly identified mammalian taste-cell-specific G Protein-Coupled Receptors and the genes encoding said receptors are described. Specifically, T2R taste G Protein-Coupled Receptors that are...
US20120258887 CC2D2A GENE MUTATIONS ASSOCIATED WITH JOUBERT SYNDROME AND DIAGNOSTIC METHODS FOR IDENTIFYING THE SAME  
The present invention provides a method of screening a subject for mutations in the CC2D2A gene that are associated with Joubert syndrome, an autosomal recessive form of mental retardation. The...
US20130231266 METHODS AND COMPOSITIONS REDUCING TARGET GENE EXPRESSION USING COCKTAILS OF siRNAS OR CONSTRUCTS EXPRESSING siRNAS  
The present invention concerns methods and compositions involving the production or generation of siRNA mixtures or pools capable of triggering RNA-mediated interference (RNAi) in a cell....
US20150051103 Methods of Detecting Cervical Cancer  
Methods of detecting cervical dysplasia, such as cervical dysplasia likely to progress to carcinoma in a sample of human cervical cells, are provided. Methods of detecting changes in expression of...
US20130310272 METHOD FOR EVALUATING THE PRESENCE OF RHEUMATOID ARTHRITIS AND BIOMARKER SET USED IN THE SAME  
An object is to provide a method for evaluating presence of rheumatoid arthritis by using a new biomarker set. The object is achieved by a method for evaluating presence of rheumatoid arthritis,...
US20110312589 GENETIC TEST MODULE WITH LOW OLIGONUCLEOTIDE PROBE MASS AND REAGENT VOLUMES  
A test module for performing a genetic diagnostic assay, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for a biological sample...
US20130190196 RAPID PHENOTYPIC DIAGNOSIS OF PATHOGENS AND DRUG RESISTANCE USING TRANSCRIPTIONAL EXPRESSION SIGNATURES  
The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate...
US20140038908 Polynucleotides and Polypeptides Associated with Trophoblast Cell Death, Differentiation, Invasion and/or Cell Fusion and Turnover  
The invention relates to polypeptides and polynucleotides associated with trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, and uses of same in the prevention,...
US20120021949 Methylation Ligation-Dependent Macroarray (MLM)  
A method is disclosed for detecting the presence of a methylated site at a specific location on a single stranded target nucleic acid sequence. Further disclosed are nucleic acid probes for use in...
US20140329708 Methods and Compositions for Determining a Graft Tolerant Phenotype in a Subject  
Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression of at least 5 genes in a sample from the subject, e.g., a...
US20150031584 REVERSE TRANSCRIPTION PRIMERS AND METHODS OF DESIGN  
The present invention provides novel algorithms for designing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other...
US20130059759 REVERSE TRANSCRIPTION PRIMERS AND METHODS OF DESIGN  
The present invention provides novel algorithms for designing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other...
US20110257039 REVERSE TRANSCRIPTION PRIMERS AND METHODS OF DESIGN  
The present invention provides novel algorithms for designing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other...
US20110306513 NOVEL BIOMARKER FOR LIVER CANCER AND APPLICATIONS FOR SAME  
The present invention relates to the elucidation of a gene that can act as a novel marker for liver cancer diagnosis and to diagnostic and prognostic measurements of liver cancer using the same....
US20130109584 Hypermethylation Biomarkers for Detection of Cervical Cancer  
Pap smears and HPV infection tests do not distinguish between lesions that will progress to an invasive carcinoma and those that will not. We aimed to identify epigenetic biomarkers for diagnosis...
US20110312594 GENETIC ANALYSIS LOC WITH HYBRIDIZATION PROBES INCLUDING POSITIVE AND NEGATIVE CONTROL PROBES  
A lab-on-a-chip (LOC) device for genetic analysis of nucleic acid sequences extracted from biological material, the LOC device having probes for hybridization with target nucleic acid sequences...
US20140128283 Method of Detecting Cancer through Generalized Loss of Stability of Epigenetic Domains, and Compositions Thereof  
Provided herein is a method of detecting cancer through generalized loss of stability of epigenetic domains as well as compositions useful therein. The present invention is based on the discovery...
US20150218643 DIFFERENTIAL METHYLATION LEVEL OF CPG LOCI THAT ARE DETERMINATIVE OF KIDNEY CANCER  
The present disclosure provides for and relates to the identification of novel biomarkers for diagnosis and prognosis of kidney cancer. The biomarkers of the invention show altered methylation...