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US20120309639 Compositions and Methods for Diagnosing Genome Related Diseases and Disorders  
Compositions, methods, and kits for diagnosing genetic disorders such as type I diabetes are disclosed.
US20140378335 METHOD FOR THE DIAGNOSIS AND/OR PROGNOSIS OF ACUTE RENAL DAMAGE  
The invention relates to miRNAs: miR-26b, miR-29a, miR-454, miR-146a, miR-27a, mi-R93 and miR-10a, as markers of acute renal damage, and to a method and kit for the diagnosis and/or prognosis of...
US20150166997 SINGLE MOLECULE NUCLEIC ACID NANOPARTICLES  
The present technology relates to a nanoparticle platform based on the unique and varied properties of DNA. Circular DNA can be replicated using a strand displacing polymerase to generate long...
US20120263783 SINGLE MOLECULE NUCLEIC ACID NANOPARTICLES  
The present technology relates to a nanoparticle platform based on the unique and varied properties of DNA. Circular DNA can be replicated using a strand displacing polymerase to generate long...
US20130310279 NOVEL METHOD FOR SIMULTANEOUS DETECTION AND DISCRIMINATION OF BACTERIAL, FUNGAL, PARASITIC AND VIRAL INFECTIONS OF EYE AND CENTRAL NERVOUS SYSTEM  
The present invention relates to the diagnostic methods for identification of the single causative agent or more than one causative agent of ocular and nervous system infections among many...
US20150233927 IDENTIFYING TAXANE SENSITIVITY IN PROSTATE CANCER PATIENTS  
The invention relates to detection and/or treatment of a subset of prostate cancer patients who may benefit from taxane treatment. The method comprises testing whether an androgen receptor (AR)...
US20110251088 LARIAT APTAMER: APTAMER CANDIDATE EXCLUSION BY NUCLEASE DIGESTION  
A method for identifying aptamers that bind to target molecules may include contacting an oligonucleotide library with target molecule and digesting unbound oligonucleotides with one or more...
US20110172124 COMPOSITIONS AND PROCESSES FOR IMPROVED MASS SPECTROMETRY ANALYSIS  
The invention provides a novel additive for improved analysis by mass spectrometry. More specifically, ascorbic acid has been found to reduce or eliminate the presence of adducts commonly present...
US20150064138 TUNING MICROBIAL POPULATIONS WITH PROGRAMMABLE NUCLEASES  
Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as,...
US20150119265 METHOD FOR THE DIAGNOSIS OR PROGNOSIS, IN VITRO, OF LUNG CANCER  
The subject matter of the present invention is a method for the diagnosis or prognosis, in vitro, of lung cancer, which includes a step of detecting at least one expression product of at least one...
US20120108462 MIRNA FINGERPRINT IN THE DIAGNOSIS OF LUNG CANCER  
The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in disease states compared to healthy controls.
US20150133335 DETECTION OF DIGESTIVE ORGAN CANCER, GASTRIC CANCER, COLORECTAL CANCER, PANCREATIC CANCER, AND BILIARY TRACT CANCER BY GENE EXPRESSION PROFILING  
The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing...
US20150133334 DETECTION OF DIGESTIVE ORGAN CANCER, GASTRIC CANCER, COLORECTAL CANCER, PANCREATIC CANCER, AND BILIARY TRACT CANCER BY GENE EXPRESSION PROFILING  
The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing...
US20150126397 DETECTION OF DIGESTIVE ORGAN CANCER, GASTRIC CANCER, COLORECTAL CANCER, PANCREATIC CANCER, AND BILIARY TRACT CANCER BY GENE EXPRESSION PROFILING  
The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing...
US20120157341 DETECTION OF DIGESTIVE ORGAN CANCER, GASTRIC CANCER, COLORECTAL CANCER, PANCREATIC CANCER, AND BILIARY TRACT CANCER BY GENE EXPRESSION PROFILING  
The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing...
US20140206565 Esophageal Cancer Markers  
The present invention is directed to methods for diagnosing cancer in a subject. Morphologically normal epithelial cells of the esophagus are assayed for marker expression. Characteristic...
US20110110926 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PROSTATE CANCER AND FOR DETECTING ANDROGEN RECEPTOR VARIANTS  
The invention features diagnostic and therapeutic methods and compositions featuring androgen receptor variant proteins and nucleic acid molecules whose expression is increased in androgen related...
US20140274747 SUPER RESOLUTION IMAGING  
A detection apparatus that includes (a) an array of responsive pads on a substrate surface; (b) an array of pixels, wherein each pixel in the array has a detection zone on the surface that...
US20140274746 SUPER RESOLUTION IMAGING  
A detection apparatus that includes (a) an array of responsive pads on a substrate surface; (b) an array of pixels, wherein each pixel in the array has a detection zone on the surface that...
US20110076288 Compositions for and Methods of Identifying Antigens  
Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a...
US20140323321 DETECTION OF HEAD AND NECK CANCER USING HYPERMETHYLATED GENE DETECTION  
Methods and kits for detection of a cell proliferative disorder, such as head and neck cancer are provided utilizing analysis of the methylation state of targeted genes or regulatory regions of...
US20150247205 DIAGNOSIS OF MULTIPLE MYELOMA AND LYMPHOMA  
The present application relates to methods for diagnosing and treating multiple myeloma (MM) and non-Hodgkin lymphoma (NHL), e.g., based on the detection of clonal IgK or IgL-expressing cells.
US20110172120 Compositions and Systems for the Regulation of Genes  
The present invention provides compositions and methods of modulating or regulating eukaryotic gene expression through the controlled or regulated expression of polynucleotide constructs that...
US20130040858 RECURRENT GENE FUSIONS IN PROSTATE CANCER  
Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and...
US20140161721 Methods And Compositions For Screening And Treating Developmental Disorders  
This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess...
US20130316911 METHODS AND COMPOSITIONS FOR SCREENING AND TREATING DEVELOPMENTAL DISORDERS  
This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess...
US20130085079 Cardiovascular Risk Event Prediction and Uses Thereof  
The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the evaluation of risk of a caradiovascular (CV) Event within 5 years. In one aspect, the disclosure...
US20110275531 METHOD FOR THE URINARY DETECTION OF BLADDER CANCER  
The invention relates to the diagnosis of bladder cancer and more specifically to the detection in urine samples of bladder carcinomas of the transitional type. The detection method according to...
US20150018222 METHOD FOR IN VITRO DIAGNOSIS OR PROGNOSIS OF BREAST CANCER  
The present invention relates to a method for the in vitro diagnosis or prognosis of breast cancer, which includes a step of detecting at least one expression product of at least one HERV nucleic...
US20110306521 SEPARATION OF PYROPHOSPHATE RELEASE AND PYROPHOSPHATE DETECTION  
The present technology relates to methods and systems for detection of pyrophosphate. As such, disclosed herein are methods and systems that permit improved pyrophosphate detection. Also disclosed...
US20120135892 siRNA targeting spleen tyrosine kinase  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene...
US20110111983 siRNA targeting spleen tyrosine kinase  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene...
US20120094871 Particle Population and Methods of Making and Using  
The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their...
US20130178382 Identification of Modulators of Autophagy  
Methods for identifying compounds that inhibit or stimulate the autophagy pathway are described. Devices for detecting the expression of autophagy-related genes and kits for assaying the...
US20120190562 METHODS AND COMPOSITIONS FOR DETERMINING SEVERITY OF HEART FAILURE IN A SUBJECT  
The application provides a method of determining a severity of heart failure in a human test subject, by determining a level of RNA encoded by one or more heart failure marker genes in blood of...
US20120040855 TISSUE-SPECIFIC AGING BIOMARKERS  
The invention provides methods of developing tissue-specific biomarkers of aging, sets of robust biomarkers identified by those methods, and uses of the biomarkers to identify nutrients and other...
US20130065785 PROGNOSIS OF OESOPHAGEAL AND GASTRO-OESOPHAGEAL JUNCTIONAL CANCER  
The present invention relates to a method of aiding in the prognosis of a subject with oesophageal and/or gastro-oesophageal junctional (GOJ) adenocarcinoma, the method comprising the steps of:...
US20150141287 GENETIC MARKERS ASSOCIATED WITH INTELLECTUAL DISABILITY  
Genetic markers associated with intellectual disability as well as compositions, methods and kits for screening for genetic markers of intellectual disability, diagnosing intellectual disability...
US20150065368 METHOD FOR THE IN VITRO DIAGNOSIS OR PROGNOSIS OF OVARIAN CANCER  
The present invention relates to a method for the in vitro diagnosis or prognosis of ovarian cancer, which includes a step of detecting at least one expression product of at least one HERV nucleic...
US20130029873 METHODS AND COMPOSITIONS FOR DIAGNOSING PULMONARY FIBROSIS SUBTYPES AND ASSESSING THE RISK OF PRIMARY GRAFT DYSFUNCTION AFTER LUNG TRANSPLANTATION  
A method for determining pulmonary fibrosis subtype and/or prognosis in a subject having pulmonary fibrosis comprising: a. determining an expression profile by measuring the gene expression levels...
US20120157343 System and Methods to Quantify and Amplify Both Signaling and Probes for cDNA Chips and Gene Expression Microarrays  
The invention provides a series of reagent compositions and methods for making and amplifying novel cDNA based probe sets from RNA samples to improve analysis with gene expression arrays. The...
US20150133318 ENZYMATIC METHOD TO ENRICH FOR CAPPED RNA, KITS FOR PERFORMING SAME, AND COMPOSITIONS DERIVED THEREFROM  
The instant invention is based, at least in part, on the identification of novel methods for the enzymatic enrichment of capped RNAs. The invention provides, e.g., methods for enrichment of capped...
US20120289424 IGF1R POLYMORPHISM PREDICTS TUMOR RECURRENCE IN BREAST CANCER PATIENTS  
The disclosure provides compositions and methods for determining the likely tumor recurrence in breast cancer patients by screening IGFR1 polymorphism in samples isolated from the patient.
US20130116134 METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF WOUNDS  
The invention relates to a method and kit for identifying chronic or acute mammalian wound tissue or for determining the prognosis of mammalian wound tissue based upon the identification of at...
US20120172250 METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF WOUNDS  
The invention relates to a method and kit for identifying chronic or acute mammalian wound tissue or for determining the prognosis of mammalian wound tissue based upon the identification of at...
US20110262570 Transcriptional Profiling and Biomarker-Based Methods for Identifying and Evaluating Agents for Antioxidant Efficacy in Cosmetic Skin Care Formulations  
Gene panels, microarrays and biomarker panels relating to genes and gene products associated with age-related oxidative damage to skin, and transcriptional profiling-based methods for...
US20150132848 HIGH COMPLEXITY siRNA POOLS  
The present invention relates to a method for producing pools of siRNA molecules suitable for RNA interference.
US20130237427 Y-SHAPED PROBE AND VARIANT THEREOF, AND DNA MICROARRAY, KIT AND GENETIC ANALYSIS METHOD USING THE SAME  
The present disclosure relates to a Y-shaped nucleotide probe having two probe parts in one body, which provides improved sensitivity, specificity and accuracy in genotype and genetic analysis and...
US20140221235 BIOMARKER ALGORITHM FOR DETERMINING THE TIME OF STROKE SYMPTOM ONSET AND METHOD  
A method of determining the time of stroke symptom onset is provided including obtaining a biological sample from an individual; contacting the biological sample with a detection composition...
US20140221229 GENOMIC SIGNATURES OF METASTASIS IN PROSTATE CANCER  
A method of determining the risk of metastasis of prostate cancer in a human subject who has or had prostate cancer is disclosed herein. The method is based on detecting in a prostate sample from...