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US20130274118 COMBINATORIAL PROBE LIBRARIES  
Provided herein is a set of reagents comprising: a plurality of at least three probe libraries, wherein each library of the plurality comprises one or more probe sets that are each specific for a...
US20150126395 Methods and Kits for Detecting a Prostate Carcinoma and Predicting Disease Outcomes for Prostate Cancers  
The present invention provides methods for diagnosing whether a human subject has a prostate carcinoma, methods for differentiating a high grade prostate cancer from a low grade prostate cancer in...
US20150126392 METHOD, SYSTEM, AND KIT FOR CHARACTERIZING A CANCER  
A method for characterizing a cancer in a subject, comprising: (a) providing a biological sample from the subject;(b) determining expression levels of genes in the biological sample to obtain a...
US20130012398 Methods for small RNA sequencing  
Next generation sequencing technologies are becoming a preferred method for sequencing nucleic acids and profiling miRNAs. Experimental results disclosed herein show that the most common platform...
US20150252417 SIGNATURES OF RADIATION RESPONSE  
The present invention relates, in general, to gene expression profiles, and in particular, to a gene expression profile of an environmental exposure, ionizing radiation. The invention further...
US20110294687 SYSTEM AND METHOD FOR PROPAGATING INFORMATION USING MODIFIED NUCLEIC ACIDS  
A method for improving a nucleic acid-based molecular computing system includes (A) identifying a computing system comprised of (i) a nucleic acid structure that includes an incompletely...
US20110059859 Molecule Detecting System  
The invention disclosed here has several key elements: direct probe-on-sensor detection, mesh probe, and mesh reporter. Furthermore, the mesh probe and reporter shall have some physical...
US20150011401 Cancer Diagnostics Using Non-Coding Transcripts  
Disclosed herein, in certain instances, are methods for the diagnosis, prognosis and determination of cancer progression of a cancer in a subject. Further disclosed herein, in certain instances,...
US20130117877 METHODS FOR DETERMINING FITNESS IN PLANTS  
Means and methods are provided to produce abiotic stress tolerant plants with improved yield based on the specific identification of a DNA methylation signature in said plants out of a population...
US20110263459 DIRECT SELECTION OF STRUCTURALLY DEFINED APTAMERS  
The present invention provides aptamer libraries with pre-defined secondary structures that can be used for oversampled screening for affinity binding. In one embodiment, a multiplex approach is...
US20140315844 MULTI-GENE SIGNATURES FOR PREDICTING RESPONSE TO CHEMOTHERAPY OR RISK OF METASTASIS FOR BREAST CANCER  
Exemplary embodiments of the invention provide methods and compositions relating to a multi-gene signature, and subsets thereof, for predicting whether an individual with breast cancer will...
US20140274728 Systems and Methods For Probe Design to Detect the Presence of Simple and Complex Indels  
Methods and systems for the determination of a collection of relevant single nucleotide polymorphisms (SNP) probe compatible insertion/deletion probes across a genome to determine probes that can...
US20140100120 METHODS OF X-APTAMER GENERATION AND COMPOSITIONS THEREOF  
Provided herein are methods for a novel bead-based next-generation “X-aptamer” selection scheme that extends aptamer technology to include X-modified bases, thus resulting in X-aptamers, at any...
US20110086776 PROCESS AND METHOD FOR DIAGNOSING ALZHEIMER'S DISEASE  
The present invention concerns methods and compositions usable for diagnosing Alzheimer's disease in mammals, in particular humans. It particularly describes serum markers for Alzheimer's disease...
US20130004980 TWO-WAY, PORTABLE RIBOSWITCH MEDIATED GENE EXPRESSION CONTROL DEVICE  
A regulatable gene expression construct comprising a nucleic acid molecule comprising a two-way riboswitch operably linked to a target sequence. Also provided is a library screening strategy for...
US20130150255 DNA METHYLATION BIOMARKERS OF LUNG FUNCTION  
Biomarkers of lung disease are provided. The biomarkers comprise target genomic DNA sequences having one or more CpG dinucleotides that are differentially methylated in genomic DNA of subjects...
US20130281321 MOLECULE DETECTION SYSTEM ON A SOLID SUPPORT  
Disclosed herein are compositions and methods used for detecting different types of molecules associated with a site on a solid support.
US20150094377 HEREDITARY CANCER GENES  
The invention generally relates to a molecular classification of disease predisposition and particularly to molecular markers for cancer predisposition and methods of use thereof.
US20120122713 RNA LABELING METHOD  
A method of sample analysis is provided. In certain embodiments, the method involves: a) obtaining a fragmented RNA sample comprising fragments of long RNA molecules and short RNA molecules; b)...
US20120122702 RNA LABELING METHOD  
A method of sample analysis is provided. In certain embodiments, the method involves: a) obtaining a fragmented RNA sample comprising fragments of long RNA molecules and short RNA molecules; b)...
US20110039731 Enhanced Sequencing by Hybridization Using Pools of Probes  
The invention provides methods for sequencing by hybridization (SBH) using pools of probes that allow greater efficiency in conducting SBH by reducing the number of separate measurements of...
US20150065389 MULTI-WELL MICROPATTERNING BY ABLATION  
The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen...
US20120040849 GENE EXPRESSION PROFILE AS AN ENDOMETRIAL RECEPTIVITY MARKER  
The present invention relates to determining the receptivity of human endometrium from a gene expression profile. More specifically, the invention consists of developing a specific expression...
US20140039036 Methods for Identifying Subjects with a Genetic Risk for Developing IgA Nephropathy  
Seven protective alleles for IgA nephropathy have been discovered that can be identified by analyzing a DNA sample for seven respective SNPs. A method is provided for identifying and treating...
US20140371081 Compositions for and Methods of Detecting, Diagnosing, and Prognosing Thymic Cancer  
Biomarkers are provided for detecting, diagnosing and prognosing thymic cancer in individuals having or suspected of having thymic cancer. In addition, kits are provided for measuring expression...
US20150118243 Methods and Compositions for Identifying, Diagnosing, and Treating Neuroblastoma  
Methods and compositions for identifying, diagnosing, and treating neuroblastoma are disclosed.
US20110020365 Methods and Compositions for Identifying, Diagnosing, and Treating Neuroblastoma  
Methods and compositions for identifying, diagnosing, and treating neuroblastoma are disclosed.
US20150133324 MULTIPLEX REAL-TIME PCR DETECTION OF INFLUENZA VIRUSES 2009 H1N1, INFLUENZA A AND INFLUENZA B  
The present invention relates to assays, diagnostic kits and methods for the simultaneous real-time PCR detection of influenza viruses selected from influenza A subtypes H1 and/or H3 and/or...
US20120071356 Variants in Complement Regulatory Genes Predict Age-Related Macular Degeneration  
Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk...
US20110151430 VIRUS-SPECIFIC miRNA SIGNATURES FOR DIAGNOSIS AND THERAPEUTIC TREATMENT OF VIRAL INFECTION  
The present invention related to miRNA signatures and diagnostic and therapeutic applications of miRNA signatures. The miRNA signatures are defined by a test sample miRNA profile relative to an...
US20120065087 BIOMARKERS FOR DIAGNOSIS OF STROKE AND ITS CAUSES  
The present invention provides compositions and methods for the diagnosis of the occurrence and cause of stroke.
US20110158979 GENETIC COMPONENT OF COMPLICATIONS IN TYPE 2 DIABETES  
The invention provides with means to predict, in subjects affected by type 2 diabetes (T2D), the probability of developing complications related to the disease. The invention involves 1) use of...
US20130237457 METHOD OF DETECTING PATHOGENIC LEGIONELLA STRAINS  
The invention relates to a kit for detecting pathogenic Legionella pneumophila strains by hybridizing genomic DNA of a sample suspected to contain Legionella to two or five specific sequence...
US20140179552 METHODS AND COMPOSITIONS FOR DIAGNOSING OSTEOARTHRITIS IN A FELINE  
Methods, compositions and kits for diagnosing osteoarthritis in a feline are disclosed. The methods of the invention comprise detecting differential expression of at least one biomarker in a body...
US20150259746 BIOMARKER SIGNATURE METHOD, AND APPARATUS AND KITS THEREFOR  
The present invention discloses methods, kits, and apparatus as well as reagents and compositions associated therewith for deriving an indicator for use in diagnosing the presence, absence or...
US20150218640 BIOMARKER SIGNATURE METHOD, AND APPARATUS AND KITS THEREFOR  
The present invention discloses methods, kits, and apparatus as well as reagents and compositions associated therewith for deriving an indicator for use in diagnosing the presence, absence or...
US20140113839 Methods of Making Oligonucleotide Probes  
The present invention relates to methods of making linear nucleic acid probes using rolling circle amplification methods.
US20130065789 COMPOSITIONS AND METHODS FOR CLASSIFYING LUNG CANCER AND PROGNOSING LUNG CANCER SURVIVAL  
The application provides methods of prognosmg, diagnosing, screening and classifying lung cancer patients into poor survival groups or good survival groups. A number of altered genomic regions...
US20110224313 COMPOSITIONS AND METHODS FOR CLASSIFYING LUNG CANCER AND PROGNOSING LUNG CANCER SURVIVAL  
The application provides methods of prognosing, diagnosing, screening and classifying lung cancer patients into poor survival groups or good survival groups. A number of altered genomic regions...
US20150232943 METHODS OF DIAGNOSING LIVER CANCER IN A SUBJECT AND A KIT FOR DIAGNOSING LIVER CANCER  
Disclosed are methods of diagnosing liver cancer in a subject as well as methods of assessing the risk of a subject having chronic hepatitis and liver cirrhosis of developing liver cancer. Also...
US20120258125 METHOD TO IDENTIFY A NOVEL CLASS OF IMMUNOLOGIC ADJUVANTS  
Methods of identifying an adjuvant capable of activating dendritic cells including measuring expression level genes in skin of an animal prior to exposure to a test compound, wherein the genes are...
US20110130304 METHOD FOR CREATING A VIRAL GENOMIC LIBRARY, A VIRAL GENOMIC LIBRARY AND A KIT FOR CREATING THE SAME  
A method for creating an alphavirus-based genomic library, comprising a) ligation of foreign sequence (s) from an expression library or a random library into plasmids containing cloned alphaviral...
US20150126447 METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF WOUNDS  
The present invention relates to a method and kit for the classification and prognosis of wounds of mammalian, in particular in human. The method defines a molecular signature that enables one to...
US20120190575 INFLUENZA DETECTION METHOD AND KIT THEREFOR  
The invention provides oligonucleotide(s) for simple, specific and/or sensitive test(s) for the presence of Influenza A and/or B virus. Kit(s) comprising the oligonucleotide(s) for use as probe(s)...
US20110105346 Universal fingerprinting chips and uses thereof  
The present invention discloses a designing strategy for constructing a set of probes useful for analyzing all or most prokaryotic and eukaryotic genomes. A set of capture probes with optimal...
US20150119264 DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE  
The invention relates to novel variants that associate with Alzheimer's disease AD and their use in kits as a means for diagnosing AD; and also their use in nucleic acid molecules or cells/cell...
US20150141491 Therapeutic Targets for Alzheimer's Disease  
The present invention relates to novel methods for the prevention, treatment and diagnosis of Alzheimer's disease. In addition, the invention relates to methods for assessing an individual's...
US20140256573 RAPID QUANTIFICATION OF BIOMOLECULES IN A SELECTIVELY FUNCTIONALIZED NANOFLUIDIC BIOSENSOR AND METHOD THEREOF  
A method and device for the rapid quantification of biomolecules (320) present in a nanochannel (210) is claimed. In particular, the present invention relates to a novel concept of liquid...
US20120107308 GENE EXPRESSION LEVELS OF EGFR, VEGFR2, AND ERCC1 ASSOCIATED WITH CLINICAL OUTCOMES OF CHEMOTHERAPY  
The invention provides compositions and methods for identifying a cancer patient suitable for anti-VEGF therapy. After determining if a patient is likely to be successfully treated, the invention...
US20120295800 OLIGONUCLEOTIDES FOR CANCER DIAGNOSIS  
The present invention provides sets of oligonucleotides corresponding to genes encoding proteins involved in protein synthesis and/or stability or genes encoding proteins involved in the...