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US20100331192 SURFACE DISPLAY OF RECOMBINANT PROTEINS IN LOWER EUKARYOTES  
Methods for display of recombinant proteins or protein libraries on the surface of lower eukaryotes such as yeast and filamentous fungi are described. The methods are useful for screening...
US20110183855 SOMATIC HYPERMUTATION SYSTEMS  
The present application relates to somatic hypermutation (SHM) systems and synthetic genes. Synthetic genes can be designed using computer-based approaches to increase or decrease susceptibility...
US20100304462 Synthetic Binding Proteins  
Methods and compositions are provided for creating a binding protein that recognizes a rationally chosen recognition sequence in which a first amino acid has been substituted for a second amino...
US20130116125 NOVEL METHODS OF PROTEIN EVOLUTION  
The present invention is relevant to proteins and novel methods of protein evolution. The present invention further relates to methods of identifying and mapping mutant polypeptides formed from,...
US20110306503 TEMPLATE-DEPENDENT NUCLEIC ACID POLYMERIZATION USING OLIGONUCLEOTIDE TRIPHOSPHATES BUILDING BLOCKS  
A novel use of a template-dependent polymerase. The novel use is effected by employing the template-dependent polymerase for incorporating at least one oligonucleotide triphosphate onto a nascent...
US20120172236 Selection and Enrichment of Proteins Using In Vitro Compartmentalization  
Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a...
US20150240231 ISOLATING TRAFFIC-ENHANCING MUTANTS OF DRUG DELIVERY PROTEIN  
The invention relates to methods for isolating traffic-enhancing mutants of drug delivery proteins. In one embodiment, the invention provides a carrier for delivering a therapeutic agent to an...
US20140302999 METHOD FOR DETERMINATION OF PHARMACOLOGICAL PROPERTIES OF RECOMBINANT PROTEINS  
The present invention is directed to a method for obtaining an in vitro pharmacological model of a recombinant protein drug in a given host. A plurality of biomolecules are selected which are...
US20150133308 METHOD FOR IMPROVING REPEBODY CONTAINING REPEAT MODULES  
The present invention relates to a method for improving a repebody protein comprising repeat modules and a nucleotide library encoding a repebody protein library for improving the repebody...
US20110201506 Methods of Primer Extension Using Porous Particle Supports  
The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their...
US20120295793 METHODS OF GENERATING MODIFIED POLYNUCLEOTIDE LIBRARIES AND METHODS OF USING THE SAME FOR DIRECTED PROTEIN EVOLUTION  
The invention provides for methods of generating modified polynucleotide libraries by inserting and/or deleting at least three nucleotide residues in polynucleotide sequences. Theses methods may...
US20140109249 SCREENING METHODS  
The present invention relates to methods for the screening, identification and/or application of microorganisms of use in imparting beneficial properties to plants.
US20120258865 MIRAC PROTEINS  
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly...
US20140243209 METHOD FOR DETECTING PROTEIN THAT INTERACTS WITH TARGET SUBSTANCE  
The present invention provides a method for detecting an interaction, which method can solve not only the problem of false negatives but also the problem of false positives. This method is a...
US20130029850 Competitive Differential Screening  
The invention is drawn to a novel method useful for screening. In particular, the present invention provides methods for competitive differential screening. In some preferred embodiments, the...
US20150203838 Methods for Generating Pools of Variants of a DNA Template  
The invention provides methods for generating pools of variants of DNA templates, and methods of using pools of variants to identify sequences involved in conferring sensitivity or resistance to...
US20120015820 METHODS AND COMPOSITIONS FOR POLYPEPTIDE ENGINEERING  
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods...
US20110053781 METHODS AND COMPOSITIONS FOR POLYPEPTIDE ENGINEERING  
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods...
US20140100120 METHODS OF X-APTAMER GENERATION AND COMPOSITIONS THEREOF  
Provided herein are methods for a novel bead-based next-generation “X-aptamer” selection scheme that extends aptamer technology to include X-modified bases, thus resulting in X-aptamers, at any...
US20150110836 EPITOPE FOCUSING BY VARIABLE EFFECTIVE ANTIGEN SURFACE CONCENTRATION  
The present disclosure provides compositions and methods for the generation of an antibody or immunogenic composition, such as a vaccine, through epitope focusing by variable effective antigen...
US20120028812 METHOD FOR PRODUCING SECOND-GENERATION LIBRARY  
The present invention relates to a method for generating a second-generation library. In a first step, a library of encoded molecules associated with an identifier nucleic acid comprising codons...
US20140200145 METHOD OF METABOLIC EVOLUTION  
The invention relates to a method for metabolic evolution of a variant of a natural small aromatic molecule product of a metabolic pathway, by somatic in vivo assembly and recombination of said...
US20120220010 PHOTOSYNTHETIC HYDROGEN PRODUCTION FROM THE GREEN ALGA CHLAMYDOMONAS REINHARDII  
The present invention relates generally to hydrogen production for use in fuel cells, foodstuffs and chemical production, and more particularly, to biologically and photosynthetically produced...
US20150247843 METHOD OF DETECTING TARGET SUBSTANCE  
Provided are a method of detecting a target substance and the like using a probe with a simple design for target substance detection. The method of detecting a target substance of the present...
US20110098184 Competitve differntial screeing  
The invention is drawn to a novel method useful for screening. In particular, the present invention provides methods for competitive differential screening. In some preferred embodiments, the...
US20120252681 EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION  
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of...
US20110190140 EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION  
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of...
US20130178368 IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS  
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into...
US20120015819 MIXTURE OF AT LEAST TWO FUSION PROTEINS, THE PRODUCTION THEREOF AND THE USE OF THE SAME  
The present invention concerns a protein mixture comprising at least a first fusion protein comprising a protein or protein fragment, and an interaction domain and a protein translocation...
US20140323315 POLYSPECIFICITY REAGENTS, METHODS FOR THEIR PREPARATION AND USE  
The present invention relates, inter alia, to polyspecificity reagents, methods of making the same, and methods of using the same in, inter alia, the selection, screening, enrichment, and...
US20130090246 METHOD OF GENERATING GENE MOSAICS  
The invention relates to a method for generating a gene mosaic by somatic in vivo recombination, comprising: e) in a single step procedure (vii) transforming a cell with at least one gene A having...
US20150133307 AUTOMATED SCREENING OF ENZYME VARIANTS  
Disclosed are methods for identifying bio-molecules with desired properties (or which are most suitable for a round of directed evolution) from complex bio-molecule libraries or sets of such...
US20150031549 Cellular High Throughput Encapsulation for Screening or Selection  
The invention relates to a method for selecting a sequence set from a library of expressed nucleic acid sequences, wherein cells are provided, each cell comprises an expressed nucleic acid...
US20140357497 DESIGNING PADLOCK PROBES FOR TARGETED GENOMIC SEQUENCING  
Methods, systems, and computer programs for designing probes or primers for nucleic acid sequencing, generating libraries of nucleic acid sequences, and mapping genomic sequences are provided herein,
US20130137582 QUANTITATIVE PCR-BASED METHOD TO PREDICT THE EFFICIENCY OF TARGET ENRICHMENT FOR NEXT-GENERATION SEQUENCING USING REPETITIVE DNA ELEMENTS (LINES/SINES) AS NEGATIVE CONTROLS  
A method for determining an efficiency of target enrichment from a DNA library, includes: adding a negative control sequence and a positive control sequence to the DNA library, or picking a...
US20120178917 RNA APTAMERS AND METHODS FOR IDENTIFYING THE SAME  
RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA...
US20130059732 AAV CAPSID PROTEINS FOR NUCLEIC ACID TRANSFER  
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are...
US20130116417 Methods for the Development of Vaccines Based on Oligosaccharide-Oligonucleotide Conjugates  
Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying...
US20140094373 HIGHLY MULTIPLEX PCR METHODS AND COMPOSITIONS  
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such...
US20120046175 METHODS AND SYSTEMS FOR SOLUTION BASED SEQUENCE ENRICHMENT  
The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention...
US20100204450 Preparation Method for a Protein With New Function Through Simultaneous Incorporation of Functional Elements  
Disclosed is a method for preparing a protein having a new function. The method comprises (A) a functional element-designing step of designing functional elements required for a new function...
US20150119254 NUCLEIC ACID FRAGMENT BINDING TO TARGET PROTEIN  
An object of the present invention is to develop and provide a method for efficiently producing a nucleic acid aptamer, particularly, a DNA aptamer, having higher specificity and binding activity...
US20140256557 METHOD OF GENERATING AN OPTIMIZED, DIVERSE POPULATION OF VARIANTS  
The disclosure relates to a method of generating a diverse set of variants to screen improved and novel properties within the variant population, a system for creating the diverse set of variants,...
US20140056959 NUCLEIC ACID APTAMERS  
The present invention relates to optimized aptamers and methods of using these aptamers.
US20150104433 TAILORED RECOMBINASE FOR RECOMBINING ASYMMETRIC TARGET SITES IN A PLURALITY OF RETROVIRUS STRAINS  
The present invention relates to a method for preparing an expression vector encoding a tailored recombinase, which tailored recombinase is capable of recombining asymmetric target sequences...
US20130164271 TAILORED RECOMBINASE FOR RECOMBINING ASYMMETRIC TARGET SITES IN A PLURALITY OF RETROVIRUS STRAINS  
The present invention relates to a method for preparing an expression vector encoding a tailored recombinase, which tailored recombinase is capable of recombining asymmetric target sequences...
US20120264616 LENTIVIRAL-BASED VECTOR AND ITS USE IN DIRECTED EVOLUTION OF GENOMIC REGIONS, GENES AND POLYNUCLEOTIDES  
The present invention concerns a method of directing evolution of a target polynucleotide of interest for obtaining variants of this target polynucleotide, as well as a method to generate genetic...
US20140121115 CUSTOM-MADE MEGANUCLEASE AND USE THEREOF  
New rare-cutting endonucleases, also called custom-made meganucleases, which recognize and cleave a specific nucleotide sequence, derived polynucleotide sequences, recombinant vector cell, animal,...
US20130045871 ENGINEERING CORRECTLY FOLDED ANTIBODIES USING INNER MEMBRANE DISPLAY OF TWIN-ARGININE TRANSLOCATION INTERMEDIATES  
The present invention provides systems, vectors and methods for isolation of enhanced ligand-binding proteins from combinatorial libraries displayed on the inner membrane of a host cell.
US20140213460 RNA-YY1 Interactions  
Methods relating to obtaining libraries of YY1-binding long non-coding RNAs, libraries obtained thereby, and methods of use thereof.

Matches 1 - 50 out of 197 1 2 3 4 >