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US20130324587 Factors Controlling Skin and Hair Color  
Use of autophagic activity in regulation of the amount of melanin in a keratinocyte, the control of skin or hair color, or selection of an agent for regulating the amount of melanin in a...
US20130178388 Methods and Kits for the Diagnosis of Rheumatoid Arthritis  
The present invention relates to the identification and use of proteins with clinical relevance to rheumatoid arthritis (RA). In particular, the invention provides the identity of marker proteins...
US20120077210 Measuring G Protein Coupled Receptor Activation  
The present invention relates to methods and polypeptides for detecting a compound in a sample. In particular, the present invention relates to the use of a cell-free composition comprising at...
US20110189700 CYR61 AS A BIOMARKER FOR DIAGNOSIS AND PROGNOSIS OF CANCERS OF EPITHELIAL ORIGIN  
Urinary Cyr61 protein levels are up regulated in patients that have cancers of epithelial origin, i.e. breast cancer and ovarian cancer. Accordingly, the present invention is directed to methods...
US20140073604 Ladder-Frame Polyether Conjugates  
Disclosed are compounds that are conjugates of ladder frame polyether compounds and biologically active compounds or research compounds, pharmaceutical formulations comprising the conjugates, and...
US20120003209 METHODS AND KITS USED IN IDENTIFYING GLIOBLASTOMA  
The invention encompasses methods and kits used in the identification of invasive glioblastoma based upon the expression of Akt1, Akt2, and Akt3. The methods and kits also allow prediction of...
US20130165345 METHOD FOR ASSAYING PERITONITIS IN HUMANS  
The present invention relates to a reliable method of prediction of infectious peritonitis in humans, wherein the level of pancreatic stone protein/regenerating protein (PSP/reg) is determined in...
US20120088681 METHODS AND KITS USED IN CLASSIFYING ADRENOCORTICAL CARCINOMA  
The invention encompasses methods and kits used to detect biomarkers that may be used to predict disease outcome in adrenocortical carcinoma patients.
US20120201747 System and Method for Diagnosis and Treatment  
This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy...
US20120035069 PROGNOSIS OF BREAST CANCER PATIENTS BY MONITORING THE EXPRESSION OF TWO GENES  
The present invention relates to the expression of two genes, CyclinG2 and Sharp1, which correlates with prognosis in individuals having breast cancer. Specifically, this invention provides a...
US20120190046 DEK as a urine based biomarker for bladder cancer  
The present invention is directed to a method of detecting DEK protein in a urine sample. Methods and compositions are provided herein for detecting and diagnosing bladder cancer by...
US20130217036 NEW DIAGNOSTIC TOOLS FOR CHARCOT-MARIE-TOOTH DISEASE  
The present invention relates in particular to methods of detecting predisposition to or diagnosis and/or prognosis of Charcot-Marie-Tooth (CMT) and related disorders. More specifically, the...
US20130018001 METHODS OF DIAGNOSING CANCER  
Provided are methods of predicting or assessing the level of severity of cancer or cancer progression in a patient comprising measuring levels of SET expression in a biological sample from a...
US20150104809 DETECTION AND TREATMENT OF CANCER  
The present invention relates to a method for diagnosing, evaluating the prognosis of a cancer patient and evaluating the aggressiveness of a cancer. The methods comprise detecting the...
US20130157880 METHODS AND USES RELATING TO THE IDENTIFICATION OF COMPOUND INVOLVED IN PAIN AS WELL AS METHODS OF DIAGNOSING ALGESIA  
The present invention relates to a method of identifying a compound involved in pain, the use of Car3 nucleic acid or Car3 protein for identifying a compound involved in pain as well as methods of...
US20150056634 Methods for Preparing Dry Formulations of Glucose Binding Protein  
Methods and compositions for preparing dry formulations of Glucose Binding Proteins (GBPs) are disclosed. The GBPs may be stored as a dry formulation without significant loss of activity. After...
US20120164663 Methylated Arginine Metabolites as Risk Predictors of Cardiovascular Disease  
Methods for using methylated arginine metabolites and the arginine methylation index as markers for cardiovascular disease are described: The methods typically include determining the levels of...
US20130210661 MARKERS OF VULNERABILITY OF THE ATHEROSCLEROSIS PLAQUE  
The present invention relates to methods for determining the presence of an unstable atherosclerotic plaque in an individual, comprising the steps of measuring the presence and/or level of at...
US20120156694 PROTEINS USED FOR THE DIAGNOSIS OF LYME BORRELIOSIS  
Chimera proteins including: (i) at least one sequence of a VlsE protein of a Borrelia species selected from B. garinii, B. burgdorferi sensu stricto and B. afzelii, and (ii) at least one sequence...
US20120264639 METHODS AND COMPOSITIONS FOR PREDICTING SURVIVAL IN SUBJECTS WITH CANCER  
Methods for generating a prognostic signature for a subject with pancreatic ductal adenocarcinoma (PDAC) are disclosed. In some embodiments, the methods include determining expression levels for...
US20120220469 TOXICITY TYPING USING LIVER STEM CELLS  
This invention provides methods and systems for identifying and typing toxicity of chemical compositions, as well as for screening new compositions for toxicity. The invention involves detecting...
US20120114596 TSLP PROMOTES IMMUNE EVASION AND PERSISTENCE OF VIRUSES  
It relates to the treatment or prevention of a chronic viral infection with a Thymic Stromal Lymphopoietin (TSLP) antagonist thereby avoiding immune evasion and persistence of the virus. It also...
US20130102482 COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF BREAST AND OVARIAN CANCER  
The invention relates to newly discovered nucleic acid molecules and proteins associated with breast or ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing,...
US20110092388 COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER  
The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating...
US20120301897 ACETAMINOPHEN-PROTEIN ADDUCT ASSAY DEVICE AND METHOD  
The present invention describes devices and methods for detecting and measuring the amount of acetaminophen-protein adducts in a sample.
US20110287458 METHOD AND COMPOSITION FOR THE DIAGNOSIS AND MONITORING OF INFLAMMATORY DISEASES  
The present invention provides a canine S100 calcium binding protein useful in diagnosing an inflammatory disease. Also provided are methods of diagnosing an inflammatory disease by assaying a...
US20140106373 METHOD FOR TARGET PROTEIN NORMALIZATION  
The present invention relates to a method for target protein normalization, especially for Western blotting applications. More closely, the invention relates to a method for normalizing target...
US20120094311 GENE AND PROTEIN EXPRESSION PROFILES ASSOCIATED WITH THE THERAPEUTIC EFFICACY OF EGFR-TK INHIBITORS  
The present invention provides protein and gene expression profiles indicative of whether a patient afflicted with non-small cell lung cancer is likely to be responsive to treatment with a...
US20120172247 Method for measuring glycoprotein, method for examining liver disease, reagent for quantitative determination of glycoprotein, and glycan-marker glycoprotein as an index for clinical conditions of liver disease  
An object of the present invention is to provide a method for measuring a glycan-marker glycoprotein, by which liver disease can be detected with higher accuracy than is possible with conventional...
US20150004629 Thermostable Proteins and Methods of Making and Using Thereof  
The present invention relates to functional, modified glucose-galactose binding proteins (GGBPs), that have a greater melting temperature (Tm) than a reference GGBP. The present invention also...
US20120028836 USE OF PROTEIN SATB2 AS A MARKER FOR COLORECTAL CANCER  
The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for...
US20130196866 EXPRESSION OF ETS RELATED GENE (ERG) AND PHOSPHATASE AND TENSIN HOMOLOG (PTEN) CORRELATES WITH PROSTATE CANCER CAPSULAR PENETRATION  
The disclosure provides methods for characterizing a prostate cancer sample by detecting expression of ERG, PTEN or both, changes in which relative to a normal control are shown herein to be...
US20140364452 METHODS TO DETERMINE SUSCEPTIBILITY TO TREATMENT WITH LEUKOTRIENE MODIFIERS  
The present invention provides a method of determining the susceptibility of a subject to treatment with a leukotriene modifier by determining the subject's cysteinyl leukotriene (CysLT) level and...
US20110262426 METHODS AND KITS USED IN IDENTIFYING GLIOBLASTOMA  
The invention encompasses methods and kits used in the identification of invasive glioblastoma based upon the expression of TROY. The methods and kits also allow prediction of disease outcome as...
US20140134601 USE OF PROTEIN NANOPARTICLE BASED HYDROGEL  
The present invention relates to a use of a protein nanoparticle-based hydrogel, and more particularly, to a use of a protein nanoparticle-based hydrogel capable of highly sensitive and...
US20120225438 SYSTEMS AND METHODS FOR DETECTING ANIMAL PREGNANCY  
Testing systems and methods are disclosed for detecting a pregnancy marker of an animal. A test kit may include a first standard with a first concentration of the marker, a second standard with a...
US20140011811 MYOSIN BINDING PROTEIN-C FOR USE IN METHODS RELATING TO DIASTOLIC HEART FAILURE  
The invention provides methods relating to the diagnosis and treatment of diastolic heart failure, kits for diagnosing diastolic heart failure or diastolic dysfunction, and related systems,...
US20130337476 URINARY sCD14 AS A BIOMARKER FOR CORONARY ARTERY DISEASE  
Disclosed herein is a method for the detection or preliminary screening of coronary artery disease, including: obtaining a urine sample from a human subject suspected of having coronary artery...
US20130115599 INCREASED CIP2A EXPRESSION AND BLADDER CANCER IN HUMANS  
The present invention provides a method of detecting CIP2A protein in a bladder tissue. Methods and compositions are provided herein for detecting and diagnosing bladder cancer by obtaining a...
US20130209490 Diagnostic BioMarkers for Fibrotic Disorders  
The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention...
US20120183543 DIAGNOSTIC BIOMARKERS FOR FIBROTIC DISORDERS  
The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention...
US20150198590 TROPOMYOSIN ISOFORMS RELATED TO ALZHEIMERS DISEASE AND MILD COGNITIVE IMPAIRMENT  
The present invention provides an in vitro method to aid the diagnosis of Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), comprising determining the level of expression of one or more...
US20130288914 Method Of Determining Administration Effect In Cancer Chemotherapy With S-1  
Provided is a method of determining a therapeutic effect of cancer chemotherapy with an anticancer drug obtained by blending three ingredients, i.e., tegafur, gimeracil, and oteracil potassium as...
US20120309024 Electrophoretically Enhanced Detection of Analytes on a Solid Support  
The present embodiments provide systems, kits and methods suitable for performing dry or substantially dry electro-blotting analyses on immobilized protein or nucleic acid samples....
US20110195867 METHOD OF ANALYZING PROTEIN MICROSTRUCTURE AND STRUCTURE FOR THE SAME  
A method of analyzing a protein structure is provided. The method includes immobilizing capture molecules to a substrate, the capture molecules being able to capture target molecules regardless of...
US20120244556 MARKERS FOR IDENTIFYING TUMOR CELLS, METHODS AND KIT THEREOF  
The present disclosure relates to a combination of biological markers for identification of prognosis of cancer. The present disclosure further relates to a method of identifying the said markers,...
US20120214165 Methods and Compositions for the Diagnosis and Treatment of Thyroid Cancer  
Methods for detecting, diagnosing and monitoring thyroid cancer in a subject are described comprising measuring in a sample from the subject markers including Ep-ICD and EpEX. The invention also...
US20140037647 MOLECULAR SUBTYPING, PROGNOSIS AND TREATMENT OF PROSTATE CANCER  
Disclosed herein are new prognostic molecular markers for prostate cancer. More specifically, the invention has identified that overexpression or amplification of at least one of AURKA or MYCN...
US20130171669 POROUS MEMBRANES HAVING A HYDROPHILIC COATING AND METHODS FOR THEIR PREPARATION AND USE  
A modified porous membrane comprising a polymeric hydrophilic coating bonded to a porous membrane is described. The polymeric hydrophilic coatings grafted to the porous membranes comprise, for...
US20130338028 TAZ/WWTR1 FOR DIAGNOSIS AND TREATMENT OF CANCER  
We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to...