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US20080292632 |
Irta2 Antibodies and Methods of Use
Antibodies that specifically bind the extracellular domain of IRTA2 are disclosed herein. In one embodiment, these antibodies do not specifically bind IRTA1, IRTA3, IRTA4, or IRTA5. In one example,...
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US20080227734 |
Mutant Lrp5/6 Wnt-Signaling Receptors in Cancer Diagnosis, Prognosis, and Treatment
A novel mutant form of lrp5 and lrp6 genes, the mutant LRP5 and LRP6 receptor proteins expressed therefrom, and a cell line which expresses the mutant LRP5 and/or LRP6 receptor proteins. Methods of...
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US20080181885 |
NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 202P5A5 USEFUL IN TREATMENT AND DETECTION OF CANCER
A novel gene 202P5A5 and its encoded protein, and variants thereof, are described wherein 202P5A5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the...
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US20080124331 |
COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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US20080113340 |
Diagnosis and treatment of cervical cancer
In certain aspects, the invention relates to methods of diagnosing cervical cancer by using a combination of certain biomarkers such as hTERT, IGFBP-3, transferrin receptor, beta-catenin, Myc-HPV...
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US20080112940 |
Notch2 signaling as a breast cancer suppressor pathway
The present invention relates to the ability of constitutively active Notch 2 to function as an inhibitor of breast cancer. The invention provides methods and compositions for inhibiting breast...
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US20080108093 |
Novel 27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules,...
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US20080108092 |
Monoclonal antibody for NKX3.1 and method for detecting same
The present invention pertains to a monoclonal antibody, or fragment thereof, having an antigen-binding specific region for NKX3.1 and to a hybridoma cell line for producing the monoclonal...
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US20080108091 |
Proteomic Patterns of Cancer Prognostic and Predictive Signatures
The invention provides method for predicting whether a cancer patient will respond to a therapy. Methods of the invention may involve examining protein from a cell of the cancer patient by...
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US20080102478 |
3D MICRO-SCALE ENGINEERED TISSUE MODEL SYSTEMS
A polymeric chip having at least one three-dimensional porous scaffold, a microfluidic channel inlet to the porous scaffold, and a microfluidic channel outlet from the porous scaffold. In one...
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US20080096235 |
Biomarkers For Cancer Sensitivity And Uses Thereof
Disclosed herein are biomarkers and uses thereof for evaluating anti-cancer efficacy and sensitivity.
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US20080096234 |
Method For Examining Carcinoma And Adenoma
[PROBLEMS] To provide examination methods and reagents able to detect efficiently cancer patients and patients at high risk of cancer. [MEANS FOR SOLVING PROBLEMS] Significant differences in the...
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US20080096215 |
COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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US20080095805 |
Method Of Detecting Cancer Based On Immune Reaction To Boris
The invention provides a method comprising detecting autoantibodies to BORIS in a sample obtained from a mammal, as well as BORIS polypeptides and epitopes, and kits comprising the BORIS...
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US20080095764 |
Use of genetically-and epigenetically-altered protocadherins in methods of diagnosing, prognosing, and treating cancer
The present invention provides methods for determining whether a subject has neoplasia, for assessing the efficacy of therapy to treat neoplasia in a subject who has undergone or is undergoing...
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US20080090258 |
Method and composition for diagnosing endometrial cancer
The present invention is related to methods and reagents for a multifactorial assay for the rapid, early detection of cancer and, more particularly, is related to a multimarker serological...
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US20080090239 |
RARE CELL ANALYSIS USING SAMPLE SPLITTING AND DNA TAGS
Described herein are methods to diagnose or prognose cancer in a subject by enriching, detecting, and analyzing individual rare cells, e.g., epithelial cells, in a sample from the subject. Also...
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US20080089895 |
Use of T-cell immune response cDNA 7 (TIRC7) in angiogenic and anti-angiogenic therapy
A novel use of T-cell immune response cDNA 7 (TIRC7) in angiogenic and anti-vided angiogenic therapy is described. Provided are agents such as anti-TIRC7 antibodies and methods of treatment which...
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US20080089891 |
Cancerous disease modifying antibodies
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer...
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US20080089887 |
Members of the FC Receptor Homolog Gene Family (FcRH1-3,6) Related Reagents and Uses Thereof
The invention relates to members of the Fc receptor homolog (FcRH) subfamily, as well as fragments and variants thereof. Each FcRH is a Type I transmembrane receptor, preferably, comprises an...
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US20080085519 |
Chemo-sensitivity assays using tumor cells exhibiting persistent phenotypic characteristics
The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring the progression of an individual patient malignancy. The assays, methods, tools and...
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US20080085283 |
METHODS FOR THE IDENTIFICATION OF POLYPEPTIDE ANTIGENS ASSOCIATED WITH DISORDERS INVOLVING ABERRANT CELL PROLIFERATION AND COMPOSITIONS USEFUL FOR THE TREATMENT OF SUCH DISORDERS
Methods and compositions for the development of effective cancer therapies using mitotic inhibitors which have limited general toxicity to normal, non-cancerous cells and tissues are provided. The...
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US20080085279 |
Cancer Treatment
The present invention relates to the inhibitors of MDM2 Binding Protein (MTBP) activity that may be used as medicaments. Such medicaments may be used to prevent or treat cancers. A preferred...
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US20080085241 |
Antibody
The present invention provides the amino acid and nucleic acid sequences of heavy and light chain complementarity determining regions of tumor specific binding proteins. In particular, the present...
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US20080076727 |
UTILITY OF HIGH MOLECULAR WEIGHT MELANOMA ASSOCIATED ANTIGEN IN DIAGNOSIS AND TREATMENT OF CANCER
HMW-MAA antibody cocktails and their uses in detecting cancer and isolating cancer cells are disclosed. Also disclosed are methods of detecting cancer based on the presence of an HMW-MAA genomic...
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US20080075722 |
Compostions, kits, and methods for identification, assessment, prevention, and therapy of cancer
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding...
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US20080075659 |
Proteins with high immunoreactivity and method for their production
The invention relates to (glyco-) proteins, in particular monoclonal antibodies, which have an immunoreactivity of >81%, preferably >90%. The inventive monoclonal antibodies are produced...
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US20080069818 |
Method of Increasing Efficacy of Tumor Cell Killing Using Combinations of Anti-Neoplastic Agents
The present invention provides compositions and methods for increasing the amount of active Syk protein kinase in a cell. The compositions and methods are useful for increasing the efficacy of...
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US20080064049 |
Compositions and methods for treating and diagnosing cancer
The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as...
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US20080064039 |
DOMINANT NEGATIVE LIGAND DRUG DISCOVERY SYSTEM
The present invention relates to novel methods of designing and optimizing polypeptide based ligands which are useful for altering and/or modulating cellular signaling cascades which have become...
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US20080063598 |
Humanized Antibody
Novel humanized and chimeric antibodies, humanized antibody fragments, polypeptides sequences of such antibodies and derivatives thereof that specifically bind AF-20 are provided as well as methods...
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US20080057520 |
IMMUNOASSAYS FOR SPECIFIC DETERMINATION OF SCCA ISOFORMS
The present invention relates to monoclonal antibodies capable of distinguishing squamous cell cancer antigens, SCCA, in either free or complex bound forms, preferably antigens SCCA1 and SCCA2, as...
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US20080057505 |
METHODS AND COMPOSITIONS FOR DETECTING RARE CELLS FROM A BIOLOGICAL SAMPLE
The present invention provides methods and compositions for isolating and detecting rare cells from a biological sample containing other types of cells. In particular, the present invention...
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US20080050758 |
SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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US20080050730 |
Early Detection of Hemangiosarcoma and Angiosarcoma
A variety of methods, compositions and kits are provided for the early detection, diagnosis and treatment of hemangiosarcoma in dogs and angiosarcomas in humans.
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US20080044840 |
ANTIBODIES AGAINST CANCER ANTIGEN TMEFF2 AND USES THEREOF
Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
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US20080044824 |
Expressed profile of thyroid cancer
The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression...
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US20080044418 |
Tumor Antigens and Uses Thereof
The invention features tumor antigens; tumor antigen-encoding nucleic acids; antibodies specific for tumor antigens and methods of using the antibodies; methods of identifying tumor antigens and...
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US20080044416 |
Novel, prostate-specific gene for diagnosis, prognosis and management of prostate cancer
Disclosed are nucleic acid and amino acid sequences encoded by a novel, prostate specific gene (UC41) and diagnostic techniques for the detection of human prostate cancer utilizing such nucleic...
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US20080039416 |
Methods for Treating Disease by Modulating an Osmotic Stress Pathway
The cellular response to osmotic stress ensures that the concentration of water inside the cell is maintained within a range that is compatible with biologic function. Single cell organisms are...
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US20080038754 |
Biomarkers for Early Detection of Ovarian Cancer
Three panels of biomarker proteins that can be used in the diagnosis of early-stage ovarian cancer (OC) are described. The biomarker panels not only permit the distinction of patients with ovarian...
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US20080038729 |
Method For Monitoring The Progress Of Cancer
The present invention relates generally to a method of diagnosing, predicting or monitoring the development or progress of a cancer and, in particular, to a method of diagnosing, predicting or...
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US20080032316 |
TUMOR ASSOCIATED ANTIGENS AND METHODS OF USING THE SAME
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US20080027002 |
COMPOSITIONS AND METHODS FOR TARGETING CANCER-SPECIFIC TRANSCRIPTION COMPLEXES
The invention provides molecules that target cancer-specific transcription complexes (CSTC), compositions and kits comprising CSTC-targeting molecules, and methods of using CSTC-targeting molecules...
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US20080026410 |
Biomarkers for Bladder Cancer
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying bladder cancer status in a patient. In particular, the biomarkers of this invention...
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US20080020409 |
Analytical Platform and Method for Generating Protein Expression Profiles of Cell Populations
The present invention is related to analytical platforms and methods performed therewith for generating qualitative and/or quantitative protein expression profiles, in particular differential...
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US20080014143 |
Methods and compositions for targeting gC1qR/p32
Disclosed are compositions and methods useful for targeting gC1q/p32 receptors. The disclosed targeting is useful for delivering therapeutic and detectable agents to cancerous cells, and to areas...
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US20080008705 |
CANCER PROGNOSTIC DIAGNOSTIC AND TREATMENT METHODS
The invention disclosed herein provides methods comprising detection of EphB2 polypeptide and/or polynucleotide in a biological sample from a subject, wherein the detection of EphB2 is predictive...
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US20080004233 |
Delta-Tocotrienol Treatment and Prevention of Pancreatic Cancer
Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these...
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US20080003624 |
Cancer metastasis determination method
A method of determining metastasis of a cancer to a lymph node, comprising the steps of: quantitating a polypeptide associated with cytokeratin, in a sample for detection prepared using a lymph...
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