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US20120184713 Compositions and Methods for Modulation of Bone Density and Biomineralization  
Compositions and methods for modulating FAM20C kinase action and identifying therapeutic agents for the same are disclosed.
US20110274703 DETECTION AND TREATMENT OF NON-DERMAL FIBROSIS  
The invention relates to methods for the diagnosis, prognosis, and treatment of non-dermal fibrosis, including lung (or pulmonary) fibrosis.
US20130065887 Treatment of Cancer with Dopamine Receptor Antagonists  
Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine...
US20110229885 Methods and Compositions for Determining Predisposition to Inflammation-Mediated Cardiovascular Disease  
The present invention provides methods and compositions for detecting a predisposition to an inflammation-mediated cardiovascular disease in a human subject by detecting a level of leukotriene C4...
US20120003158 Biomarkers for Inflammatory Bowel Disease and Methods Using the Same  
The present invention provides various biomarkers of inflammatory bowel disease, including biomarkers for Crohn's disease and biomarkers for Ulcerative colitis. The present invention also provides...
US20120245095 BIGLYCAN AND RELATED THERAPEUTICS AND METHODS OF USE  
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with...
US20130011850 STEROIDOGENESIS MODIFIED CELLS AND METHODS FOR SCREENING FOR ENDOCRINE DISRUPTING CHEMICALS  
An isolated steroidogenesis modified cell comprising one or more steroid biosynthesis knock down nucleic acid operatively linked to a promoter, wherein the steroid biosynthesis knock down nucleic...
US20110065114 STEROIDOGENESIS MODIFIED CELLS AND METHODS FOR SCREENING FOR ENDOCRINE DISRUPTING CHEMICALS  
An isolated steroidogenesis modified cell comprising one or more steroid biosynthesis knock down nucleic acid operatively linked to a promoter, wherein the steroid biosynthesis knock down nucleic...
US20110262450 MODULATORS OF MONOGLYCERIDE LIPASE IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA  
An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea,...
US20130196927 Smac Mimetic Therapy  
A Smac mimetic therapy wherein the Smac mimetic is selected and developed based at least in part on its cIAP degradation properties.
US20110129833 Gene Expression Markers for Predicting Response to Chemotherapy  
The present invention provides sets of genes the expression of which is important in the prognosis of cancer. In particular, the invention provides gene expression information useful for predicting...
US20130065240 CULTURE MEDIUM, METHOD FOR CULTURING SALMONELLA AND E. COLI AND METHOD FOR DETECTING SALMONELLA AND E. COLI  
In embodiments there are disclosed culture media, compositions for supplementing culture media, and methods for culturing biological samples. In embodiments the methods are methods for detecting...
US20120258462 COMBINATIONS OF TUMOR-ASSOCIATED ANTIGENS IN DIAGNOSTICS FOR VARIOUS TYPES OF CANCERS  
Disclosed herein are methods for matching a cancer condition with an appropriate immunotherapeutic agent and/or regimen. Also disclosed are methods for confirming diagnosis of a particular type of...
US20130239239 LMCD1 CANCER MARKERS AND METHODS FOR THEIR USE  
The present invention provides LMCD1 cancer markers, and methods, compositions, and kits for their use. The invention also provides expression vectors, host cells, and transgenic animals comprising...
US20140088170 DIFFERENTIALLY EXPRESSED MICRORNA MOLECULES FOR THE TREATMENT AND DIAGNOSIS OF CANCER  
A significant challenge in cancer research field is to define molecular features that distinguish cancer stem cells from normal stem cells. In this study, microRNA (miRNA) expression profiles in...
US20140004047 Methods, compositions and kits for modulating trans-differentiation of muscle satellite cells  
Compositions, methods and kits are provided for modulating the trans-differentiation of cells for example muscle satellite cells. The compositions, methods and kits include a modulator of...
US20110313018 CANCER RELATED GENE, LGN/GPSM2  
The present invention provides methods for detecting and diagnosing cancer, which method involves the determination of the expression level of the LGN/GPSM2 gene. Furthermore, the present invention...
US20120276122 METHODS FOR DIAGNOSIS AND TREATMENT OF CELLULAR PROLIFERATIVE DISORDERS  
Methods for the diagnosis or prognosis of cellular proliferative disorders by detecting expression of PKC in cancer cells or tumor cells are provided herein. Also provided are methods for treating...
US20120245051 OBJECTIVE, QUANTITATIVE METHOD TO PREDICT HISTOLOGICAL SUBTYPE IN NON-SMALL CELL LUNG CANCER  
The invention provides a method for determining the histotype of a non-small cell lung cancer tumor which comprises: (a) determining the levels of expression of each of thyroid transcription...
US20130209493 BIOMAKERS FOR CIRCULATING TUMOR CELLS  
Provided are methods for detecting circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker....
US20120165384 INHIBITION OF HISTONE ACETYLTRANSFERASES BY CTK7A AND METHODS THEREOF  
The present disclosure relates to a method for inhibiting histone acetyltransferases by derivative of curcumin, particularly CTK7A. The present disclosure also relates to identification of...
US20120021414 DIAGNOSTIC MARKERS OF IMMUNOSENESCENCE AND METHODS OF USE THEREOF  
Embodiments of the present invention provide diagnostic markers of immunosenescence and methods of identifying individuals with impaired immune function based on a combination of such markers...
US20130058925 EPITHELIAL BIOMARKERS FOR CANCER PROGNOSIS  
Methods, systems and compositions for the prognosis and classification of cancer, especially bladder cancer, are provided. For example, in certain aspects methods for cancer prognosis using...
US20120115151 METHOD FOR TESTING A SUBJECT THOUGHT TO BE PREDISPOSED TO HAVING METASTATIC CANCER USING DELTA133P53BETA  
The present invention concerns a method of testing a subject thought to be predisposed to having a metastatic cancer which comprises: analyzing a biological sample from said subject for detecting...
US20130217594 METHODS FOR SCREENING COMPOUNDS FOR CAPABILITY TO INHIBIT PREMALIGNANT SQUAMOUS EPITHELIAL CELL PROGRESSION TO A MALIGNANT STATE  
Methods for screening compounds for their capability to inhibit CYP1B1-mediated proliferation and motility of and/or to reverse estrogen-induced reduction in apoptosis of premalignant or malignant...
US20110171221 COMPOSITIONS AND METHODS FOR THE TREATMENT OF A NEOPLASIA  
Compositions and methods for the diagnosis, treatment and prevention of cancer, including prostate cancer and renal cell carcinoma, as well as for treatment selection.
US20100297183 IMMUNOGENIC STREPTOCOCCUS PROTEINS  
The invention provides means and methods for identifying a Streptococcus protein which is capable of eliciting an immune response against at least two Streptococcus strains and/or serotypes. The...
US20110143336 MARKER FOR ESTIMATING THE DIAGNOSIS OF CERVICAL ADENOCARCINOMA OR FOR ESTIMATING THE PROGNOSIS OF CERVICAL CANCER  
To provide a novel biomarker for estimating the diagnosis of cervical adenocarcinoma or for estimating the prognosis of cervical cancer. An antibody against Villin 1 is employed as a biomarker.
US20130203068 DUAL-ACCEPTOR TIME-RESOLVED-FRET  
Methods for determining the presence or absence of a plurality of analytes in a sample with dual-acceptor time-resolved fluorescence resonance energy transfer are provided.
US20110098185 COMPOSITION AND METHOD FOR DETERMINING OF ESOPHAGEAL CANCER  
This invention relates to a composition, kit, or DNA chip for use in diagnosis of esophageal cancer, which comprises a plurality of polynucleotides selected from the group consisting of...
US20120130350 DETECTION AND TREATMENT OF AUTOIMMUNE DISORDERS  
Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients...
US20120244545 METHOD FOR SCREENING ACTIVE AGENTS THAT STIMULATE THE EXPRESSION OF CERT TO IMPROVE THE SKIN'S BARRIER FUNCTION  
A method for screening an active agent intended for preventing or combating the cutaneous signs resulting from a non-pathological impairment of barrier function, which includes the selection of...
US20100068729 METHOD AND KITS FOR THE DIAGNOSIS OF DIABETES  
Provided are methods for the detection and diagnosis of a predisposition for developing diabetes. The methods are based on the discovery that abnormal levels of the selected analyte in biological...
US20110009279 Methods of Diagnosing Non-Alcoholic Steatohepatitis (NASH)  
Non-invasive methods for detecting non-alcoholic fatty liver disease (NAFLD) and identifying the presence or absence of non-alcoholic steatohepatitis (NASH) in a subject utilize one or more...
US20140072556 PROTEINS AND NUCLEIC ACIDS USEFUL IN VACCINES TARGETING STAPHYLOCOCCUS AUREUS  
Disclosed are novel immunogenic proteins derived from Staphylococcus aureus, as well as methods for their use in conferring protective immunity against S. aureus infections. Also disclosed are...
US20110217702 METHODS FOR DIAGNOSIS OF AND PREDICTING TREATMENT EFFICACY OF HORMONE RECEPTOR EXPRESSING TUMORS, CANCERS AND NEOPLASIAS  
The invention relates to diagnosis, detection, screening, identifying and predicting methods. In various embodiments, methods of the invention include diagnosis, detection, or screening for a...
US20120046197 BIOMARKERS OF THERAPEUTIC RESPONSIVENESS  
The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment...
US20120129168 TUMOR MARKER AND USE THEREOF  
The present invention detects SNX5 in a sample from a subject. The SNX5 is used as a tumor marker specific to papillary thyroid carcinoma, whereby diagnosis of papillary thyroid carcinoma is...
US20120208188 DIAGNOSTIC AND TREATMENT FOR CHRONIC AND ACUTE PHASE MYELOID LEUKEMIA  
Disclosed are methods of predicting responsiveness of a cancer cell to a tyrosine kinase inhibitor, and methods of predicting the risk of progression of a cancer cell to a more aggressive form....
US20100310543 METHOD OF PREVENTING AND TREATING ACUTE BRAIN PATHOLOGIES  
Described are novel means in the treatment of cerebral neurological conditions such as ischemic insult of the brain. Furthermore, a kit for a non-radioactive protein serine/threonine phosphatase...
US20110281743 SYSTEMS AND METHODS FOR ISOLATING CELLS IN CELL COLONIES IN CULTURE  
Selecting and propagating a cell colony of interest from among a plurality of cell colonies carried on a common substrate in culture is carried out by: (a) selecting a cell colony of interest from...
US20130217014 METHODS OF USING CDK8 ANTAGONISTS  
Provided herein are CDK8 antagonists and methods of using the same.
US20100329982 PARTICLES WITH INDUCIBLE CHANGE OF SHAPE  
The invention relates to particles which exhibit a stimulable shape change and allow control of their uptake in active cells. The particles can be used as carrier systems for bioactive molecules or...
US20130177920 MODULAR COMPOSITING-MULTIPLE LOT SCREENING PROTOCOLS FOR DETECTION OF PATHOGENS, MICROBIAL CONTAMINANTS AND/OR CONSTITUENTS  
Particular aspects provide a method of sampling, testing and validating test lots (e.g., single-unit production lots), comprising: assembling a plurality of product portions from each of a...
US20120148495 METHODS FOR TREATING NICOTINIC ACETYLCHOLINE RECEPTOR ASSOCIATED DISEASES  
The present invention provides methods and compositions for treating subjects suffering from a disorder associated with a nicotinic acetylcholine receptor (nAChR), methods for treating a subject...
US20110117571 Transporter assay  
This invention concerns a non-radioactive homogenous proximity assay for cellular transport system. The assay format disclosed here takes advantageous of the fact that ABC transporters have two...
US20140038843 NOVEL TUMOR MARKER DETERMINATION  
A method of determining ovarian cancer disease in a subject, which comprises—measuring the PPIC expression of cells in a sample of peripheral blood of said subject, and—comparing to a reference val...
US20120094306 PREDICTIVE EVALUATION OF THE RESPONSE TO TAXANE-INCLUDING CHEMOTHERAPY  
The present invention relates to methods and kits for a predictive evaluation of the effectiveness of a taxane-including treatment of a tumour or of cancer cells.
US20110251097 DIAGNOSTIC KIT OF COLON CANCER USING COLON CANCER RELATED MARKER AND DIAGNOSTIC METHOD THEREOF  
The present invention relates to a composition for diagnosing colon cancer. The composition comprises at least one marker for measuring an mRNA or protein expression level of at least one gene...
US20110152122 Compositions and Methods for the Identification and Use of Epigenetic Markers Useful in the Study of Normal and Abnormal Mammalian Gametogenesis  
The invention includes compositions comprising a S. cerevisiae yeast library, and methods of identifying an epigenetic marker for the diagnosis of infertility or a disorder associated with...