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US20130251738 VACCINES  
There is provided a method of identifying a protective Leptospira vaccine composition, comprising determining that the composition contains a protective concentration of a Lipl32 epitope...
US20150087589 GENES AND PROTEINS ASSOCIATED WITH ANGIOGENESIS AND USES THEREOF  
Disclosed is a panel of biomarkers associated with angiogenesis, and the use of such biomarkers (genes, proteins, homologues and analogs thereof) to regulate angiogenesis. Methods for identifying...
US20140315863 TREATING BLADDER CANCER PATIENTS AND IDENTIFYING BLADDER CANCER PATIENTS RESPONSIVE TO TREATMENT  
This documents provided methods and materials involved in treating bladder cancer. This document also provides methods and materials involved in identifying bladder cancer patients likely or...
US20140162284 In Vitro Assay Method Using Immunological Technique  
The present invention relates to a novel method of in vitro assay of the molecules of the extracellular matrix synthesized by cells in culture and uses thereof in the form of a kit for in vitro...
US20110236915 ZAP-70 EXPRESSION AS A MARKER FOR CHRONIC LYMPHOCYTIC LEUKEMIA / SMALL LYMPHOCYTIC LYMPHOMA (CLL/SLL)  
It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is...
US20140302520 METABOLISM OF SOD1 IN CSF  
The disclosure relates to methods for the diagnosis and treatment of neurological and neurodegenerative diseases, disorders, and associated processes. Specifically, the disclosure relates to a...
US20140193814 ABCA1 DOWNREGULATION IN PROSTATE CANCER  
A method of providing a prognosis or diagnosis of prostate cancer in a subject is described. The method includes obtaining a urine or prostate sample from the subject; determining the level of...
US20130102486 PERP AS A PROGNOSTIC AND DIAGNOSTIC MARKER FOR DYSPLASIA AND CANCER  
Methods for prognosis and diagnosis of dysplasia and cancer are disclosed. In particular, the invention relates to the use of the biomarker PERP, a desmosome protein involved in cell adhesion and...
US20130281423 METHODS AND COMPOSITIONS FOR AMELIORATING PANCREATIC CANCER  
Embodiments of the present invention include methods and compositions for ameliorating cancer. Some embodiments include methods and compositions for ameliorating pancreatic cancer targeting the...
US20100330587 Annexin Proteins and Autoantibodies As Serum Markers For Cancer  
The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin...
US20120028269 Methods For Detection Of Gastric Cancer  
The invention is directed to non-invasive methods of detecting gastric cancer in an individual in need thereof comprising determining an expression level of inter-alpha-trypsin inhibitor heavy...
US20110182881 SIGNATURE AND DETERMINANTS ASSOCIATED WITH METASTASIS AND METHODS OF USE THEREOF  
The present invention provides methods of detecting cancer using biomarkers.
US20130115612 METHOD FOR ANALYZING MUCIN 1 HAVING SIAALPHA2-8SIAALPHA2-3GALBETA GLYCANS  
The object of the present invention is to provide a clinical marker capable of distinguishing breast cancer from interstitial pneumonia; and a clinical marker for detecting malignancy or progress...
US20140056807 LARGE ONCOSOMES IN HUMAN TUMORS AND IN CIRCULATION IN PATIENTS WITH CANCER  
The invention provides methods for isolating large oncosomes and determining cancer metastasis based on the presence of large oncosomes in a subject in need thereof.
US20120115175 METHODS FOR DIAGNOSING ELEVATED RIGHT OR LEFT VENTRICULAR FILLING PRESSURE  
The present invention features a method of diagnosing elevated left or right ventricular filling pressure and cardiovascular dysfunction in a subject by detecting increased levels of sEng in a...
US20120171204 COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF IMMUNE DISORDERS  
The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast...
US20120129179 SCN5A SPLICING FACTORS AND SPLICE VARIANTS FOR USE IN DIAGNOSTIC AND PROGNOSTIC METHODS  
Provided herein are methods of identifying a subject at risk for arrhythmias, heart failure or sudden cardiac death. In exemplary aspects, the method comprises the step of determining a level of...
US20130095484 Systems And Methods For Predicting Response To Anti-Androgen Therapy For The Treatment Of Androgenetic Alopecia  
Methods, processes, systems, and apparatuses are disclosed for predicting anti-androgen therapy response in the treatment of androgenetic alopecia based on a fluorometric assay and proteomics.
US20140287944 MARKERS FOR FUNCTIONALLY MATURE BETA-CELLS AND METHODS OF USING THE SAME  
Markers for functionally mature β-cells and methods of using these markers are disclosed.
US20110098191 IN VITRO METHODS FOR DETECTING RENAL CANCER  
The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the individual...
US20140121128 METHOD FOR THE PROGNOSIS OF BREAST CANCER BASED ON THE EXPRESSION OF THE GENE PIN1 IN COMBINATION WITH MUTATIONS IN THE GENE TP53  
It is described the influence of the presence of mutations in the TP53 gene in association with high levels of the enzyme prolyl isomerase Pin1 and a molecular signature of 10 genes expression...
US20150037342 METHOD TO PREVENT CANCER METASTASIS AND INHIBIT INFLAMMATION BY INHIBITION OF P68 INTERACTION WITH CALMODULIN  
Compositions and methods for inhibiting cancer cell metastasis and inflammation are disclosed. The methods generally involve administering to a subject a composition containing an agent that...
US20120121608 USE OF SAM68 FOR MODULATING SIGNALING THROUGH THE TNF RECEPTOR  
Sam68 plays a role in TNF-dependent signaling, including NF-kB signaling and extrinsic activation of apoptosis. In some embodiments, inhibitors of Sam68 are administered to inhibit TNF-dependent...
US20110136133 METHOD FOR DIFFERENTIATING BETWEEN MULTIPLE SCLEROSIS SUBTYPES  
Disclosed herein is a method for differentiating between multiple sclerosis subtypes in a patient. The method comprises a) determining an amount of an IAP gene expression level in a blood sample...
US20120294929 METHOD OF DIAGNOSING AND TREATING CANCER USING B-CATENIN SPLICE VARIANTS  
The invention relates to method and compositions for treating and diagnosing cancer, in particular β-catenin related cancers. In general, the methods include administering RNAi constructs. The ...
US20130217021 METHOD FOR DETECTING AND EXAMINING TRAUMATIC BRAIN INJURY IN VITRO  
The present invention discloses a method for detecting and examining traumatic brain injury (TBI) in vitro. The method is according to the principle of expression of Etk/Bmx protein which is...
US20120301463 Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products  
The present disclosure relates to methods for the modulation of autophagy and the treatment of autophagy-related diseases, including cancer, neurodegenerative diseases and pancreatitis.
US20130035243 KLF6 ALTERNATIVE SPLICE FORMS AND A GERMLINE KLF6 DNA POLYMORPHISM ASSOCIATED WITH INCREASED CANCER RISK  
Disclosed are methods of identifying and diagnosing certain types of cancers and pre-stages thereof in a patient by identifying alternatively spliced isoforms of wild type KLF6 (KLF6wt), in...
US20090269350 Novel 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC1C, NARC 1A, NARC 25, 86604 and 32222 molecules and uses therefor  
The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 20A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3,...
US20130137096 Diagnosis of Hereditary Spastic Paraplegias (HSP) by Identification of a Mutation in the ZFVYE26 Gene or Protein  
The Invention relates to an ex vivo method of diagnosing or predicting a hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the ZFYVE26 gene or...
US20110117558 DIAGNOSIS OF HEREDITARY SPASTIC PARAPLEGIAS (HSP) BY IDENTIFICATION OF A MUTATION IN THE ZFYVE26 GENE OR PROTEIN  
The Invention relates to an ex vivo method of diagnosing or predicting a hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the ZFYVE26 gene or...
US20130157284 COLORIMETRIC AND FLUORESCENT PROTEINS  
The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths.
US20130035253 METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT  
The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a...
US20150119270 METHODS FOR DETECTING ALLOSTERIC MODULATORS OF PROTEIN  
The present invention discloses, inter alia, methods for labeling a target protein with an SHG-active probe for detection by second harmonic or sum-frequency generation in order to identify agents...
US20120214684 COMPOSITIONS AND METHODS FOR DETECTING AND TREATING PROSTATE CARCINOMA  
Compositions and methods for the diagnosis, treatment and prevention of prostate cancer, as well as for treatment selection.
US20130288248 CANCER STEM CELL MASS AND PROCESS FOR PRODUCTION THEREOF  
The purpose of the present invention is to provide: a cancer stem cell mass from which cells incapable of forming cancer are substantially removed and which has a characteristic property of...
US20140100127 LIVER CANCER DIAGNOSIS MARKER AND USE THEREOF  
A marker for the detection of liver cancer and application of the marker thereof. The application includes use of cytochrome p450 family 17 subfamily A polypeptide 1 (CYP17A1 protein) in the...
US20140179620 GENE EXPRESSION MARKERS FOR INFLAMMATORY BOWEL DISEASE  
The present invention relates to methods of gene expression profiling for inflammatory bowel disease pathogenesis, in which the differential expression in a test sample from a mammalian subject of...
US20120149017 DIAGNOSTIC MARKERS OF HUMAN FEMALE INFERTILITY  
The subject invention pertains to methods and reagents for the diagnosis of female infertility, prognostic indicators for female infertility, compounds for the treatment of female infertility,...
US20110262934 METHOD FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE USING PHOTOTRANSISTOR  
Disclosed is a method for the early diagnosis of Alzheimer's disease. In the method, cells in which a biomarker characteristic of Alzheimer's disease, preferably beta-amyloid, is labeled with...
US20140249042 DETECTION OF BIOAGENTS USING A SHEAR HORIZONTAL SURFACE ACOUSTIC WAVE BIOSENSOR  
Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge...
US20110091865 MEASURING MULTIPLE ANALYTES OVER A BROAD RANGE OF CONCENTRATIONS USING OPTICAL DIFFRACTION  
The invention relates to method, devices, and kits for measuring multiple analytes in a sample having a broad range of concentrations using optical diffraction. Devices, methods, and kits useful...
US20130122517 METHOD OF PERFORMING AN ASSAY  
The present invention relates to a method and kit for performing assays like immunoassays. The assays are performed by using two different types of magnetic beads.
US20130004942 METHODS OF TESTING FOR INTRACELLULAR PATHOGENS  
A first intracellular pathogen in a biological sample that may contain more than one intracellular pathogen is studied by a method comprising the steps of (i) contacting the sample with a...
US20120021925 DIAGNOSTIC ASSAYS FOR PROSTATE CANCER USING PSP94 AND PSA BIOMARKERS  
The application refers to a method for diagnosing prostate cancer through the measurement of the combination of PSP94 (β-microseminoprotein) and F/T PSA biomarkers, the method using urine samples ...
US20120122124 NEW BACTERIOPHAGE ADHESION PROTEINS  
The present invention relates to bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, lacking the ability of binding to a bacteriophage and of hydrolysing...
US20110118135 Mutations in Contaction Associated Protein 2 (CNTNAP2) are Associated with Increased Risk for Ideopathic Autism  
The present invention provides compositions and methods for the examination of cells, tissues, and fluids, collectively known as body samples, to identify human subjects at-risk of developing...
US20120178097 METHODS AND DESIGN OF MEMBRANE FILTERS  
The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods...
US20140243433 MARKER GENES FOR PROSTATE CANCER CLASSIFICATION  
The present invention relates to a method for classifying a prostate cancer in a subject, the method comprising the steps of a) determining a gene expression level or gene expression pattern of the...
US20140147857 METHODS FOR DIAGNOSIS PROGNOSIS AND METHODS OF TREATMENT  
The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a...