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US20130065789 |
COMPOSITIONS AND METHODS FOR CLASSIFYING LUNG CANCER AND PROGNOSING LUNG CANCER SURVIVAL
The application provides methods of prognosmg, diagnosing, screening and classifying lung cancer patients into poor survival groups or good survival groups. A number of altered genomic regions have...
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US20110224313 |
COMPOSITIONS AND METHODS FOR CLASSIFYING LUNG CANCER AND PROGNOSING LUNG CANCER SURVIVAL
The application provides methods of prognosing, diagnosing, screening and classifying lung cancer patients into poor survival groups or good survival groups. A number of altered genomic regions...
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US20110166028 |
METHODS FOR PREDICTING TREATMENT RESPONSE BASED ON THE EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS
The invention relates to the identification and use of gene expression profiles with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant...
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US20120122762 |
186 Human Secreted Proteins
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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US20110206704 |
Methods and compositions for modulating hepatocyte growth factor activator
The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns modulators of hepatocyte growth factor activator...
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US20120071339 |
BIOMARKERS
The invention relates to a method of diagnosing or monitoring multiple sclerosis.
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US20120165340 |
PTEN PHOSPHORYLATION-DRIVEN RESISTANCE TO CANCER TREATMENT AND ALTERED PATIENT PROGNOSIS
Indicators that can guide clinical decisions in cancer, particularly posttranslational modification of proteins which result in altered prognosis and differential sensitivity to targeted cancer...
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US20110097423 |
Gene Prognosis Predictor Signature for Colorectal Carcinoma
The present invention is drawn to methods of assessing colorectal cancer prognosis by examining the expression of particular genes disregulated in this disease state. Subjects exhibiting...
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US20110195854 |
DETECTING AND MONITORING INFLAMMATORY NEUROPATHY
The invention relates to detection and/or monitoring of inflammatory neuropathy using markers that specifically indicate the presence of inflammatory neuropathy, for example, allograft inflammatory...
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US20130072400 |
METHOD FOR THE DIAGNOSIS/PROGNOSIS OF COLORECTAL CANCER
The present invention relates to a method for obtaining useful data for the diagnosis, prognosis or monitoring of colorectal cancer (CRC) progression, to a method for the diagnosis of CRC, to a...
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US20120282631 |
METHOD FOR DIAGNOSIS NON-SMALL-CELL-LUNG-CARCINOMA (NSCLC) AND CLASSIFICATION OF ITS SUBTYPES WITH DIFFERENT COMBINATIONS OF 6 PROTEIN BIOMARKERS
A method of identifying and classifying non-small-cell lung carcinoma in a biological sample includes a first test wherein the expression level of at least one biomarker is measured in a sample,...
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US20060160135 |
SF-1 and LRH-1 modulator development
Structures of SF1 and LRH are described, along with methods for identifying or developing modulators of those receptors and uses for such modulators.
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US20110104695 |
METHODS OF PREDICTING THERAPEUTIC EFFICACY OF CANCER THERAPY
The present invention relates to novel methods and kits for predicting, prognosing, and/or monitoring therapeutic efficacy of cancer therapy on a subject having malignant tumor or cell...
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US20120045764 |
METHOD OF EXPANDING HUMAN HEPATOCYTES IN VIVO
Described herein is a method of expanding human hepatocytes in vivo using an immunodeficient mouse which is further deficient in fumarylacetoacetate hydrolase (Fah). The method comprises...
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US20130029351 |
A25 BACTERIOPHAGE LYSIN
The invention relates to the identification, sequencing, and isolation of an A25 bacteriophage lysin gene that expresses a protein involved in the lysis of bacterial cells during the phage life...
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US20110262447 |
HUMAN SYNTHETIC SINGLE-CHAIN ANTIBODIES DIRECTED AGAINST THE COMMON EPITOPE OF MUTANT P53 AND THEIR USES
Isolated polypeptides, isolated polynucleotides or expression vectors encoding same, viral display vehicles which can be specifically bind an exposed epitope shared by mutant, but not wild type,...
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US20120315648 |
METHOD OF IDENTIFICATION OF CELLS THAT SHOW SENSITIVITY TO MODULATION OF SIGNALING MEDIATED BY A FIBROBLAST GROWTH FACTOR RECEPTOR OR A VARIANT THEREOF
The invention is based on the finding that cells that show (especially tyrosine) phosphorylation of FGF-R substrate 2 (FRS-2), in contrast to cells that lack such phosphorylation, allow a...
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US20120148599 |
METHODS AND COMPOSITIONS FOR NEURAL DISEASE IMMUNOTHERAPY
The invention provides antibodies to specific neural proteins and methods of using the same.
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US20110076692 |
Detection of Cardiac Markers on a Droplet Actuator
The present invention provides for the detection of cardiac markers on a droplet actuator. An aspect provides a method of assaying a cardiac marker in a biological sample from a subject, the method...
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US20100311078 |
IMMUNOREGULATION IN CANCER, CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES
The present invention primarily relates to a method for analyzing the amount of immunoregulatory integrin binding factors and/or patient endogenous antibodies which are directed against such...
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US20110305677 |
HUMAN EMBRYONIC STEM CELL CULTURES, AND COMPOSITIONS AND METHODS FOR GROWING SAME
Human pluripotential embryonic stem cell cultures are provided, as are human feeder cells useful for growing the human embryonic stem cells, conditioned medium obtained from cultures of the human...
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US20110076694 |
METHOD OF ASSESSING MAMMALIAN EMBRYO QUALITY
A method of assessing the health of each oocyte or embryo of a mammal from a plurality of oocytes/embryos of the mammal is provided. The method comprises the steps of: measuring gap junctional...
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US20120183544 |
DIAGNOSIS AND TREATMENT OF NEUROECTODERMAL TUMORS
The present invention provides fusion proteins for the detection and treatment of neuroectodermal tumors. Previous work demonstrated that chlorotoxin is specific for glial-derived or...
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US20120107831 |
METHOD FOR DETECTING AFFERENT LYMPH VESSEL INFLOW REGIONS AND METHOD FOR IDENTIFYING SPECIFIC CELLS
Regions where metastatic cancer cells can exist are detected with high accuracy in a sentinel lymph node. Quantum dots are injected into the vicinity of a cancer in a living body, thereby...
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US20110110926 |
COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PROSTATE CANCER AND FOR DETECTING ANDROGEN RECEPTOR VARIANTS
The invention features diagnostic and therapeutic methods and compositions featuring androgen receptor variant proteins and nucleic acid molecules whose expression is increased in androgen related...
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US20110054938 |
Devices and methods for detecting an analyte in salivary fluid
Methods and systems are described herein for detecting one or more analyte in salivary fluid. Systems include: a discrete oral component configured for complete enclosure in a human oral cavity; at...
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US20080118911 |
Test Device for the In-Vitro Diagnosis of Multi-Analyte Tests and Use Thereof
The present invention generally relates to the diagnosis of diseases and in particular novel methods and devices for an improved use of markers that are associated with diseases to be diagnosed....
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US20130089869 |
Methods For and Uses of Mechanical Stiffness Profiling of Cancer Cells
Methods of predicting the invasiveness or metastatic potential of cancer cells are provided herein. Methods of screening for cancer cells or diagnosing cancer in a subject are also provided....
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US20120295253 |
Dynamic Monitoring of Activation of Receptor Tyrosine Kinase (RTK) in Living Cells Using Real-Time Microelectronic Cell Sensing Technology
Methods for identifying a compound capable of interacting with a Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance, adding test cells...
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US20130029871 |
METHODS OF STRATIFYING ADOLESCENT IDIOPATHIC SCOLIOSIS, ISOLATED NUCLEIC ACID MOLECULES FOR USE IN SAME AND KITS USING SAME
A method of stratifying a subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting Paired-like homeodomain transcription factor...
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US20120171194 |
Method of Cell Differentiation and Uses Therefor in Screening, Diagnosis and Therapy
The present invention provides a method of producing non-haematopoietic cells, in particular cells having one or more properties of endothelial cells, from monocytes. A range of diagnostic and...
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US20110256152 |
Methods Of Treating And Preventing Glucose Toxicity
The present invention relates to a method for treating and/or preventing a disease associated with glucose toxicity in a subject which may comprise administering to the subject a compound that...
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US20120016340 |
COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF PROSTATE CANCER
Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides,...
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US20110097737 |
Methods and Compositions for Targeting Proteins of Interest to the Host Cell Envelope
Methods and compositions are provided for producing membrane proteins or toxic proteins from recombinant DNA introduced into a prokaryotic host cell by targeting the expressed proteins to the...
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US20070259366 |
DIRECT PRINTING OF PATTERNED HYDROPHOBIC WELLS
The present invention comprises a diagnostic platform. The platform has a substrate having plurality of hydrophobic wells formed thereon. The hydrophobic wells are directly printed onto the...
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US20100297603 |
ANALYTE-RELEASING BEADS AND USE THEREOF IN QUANTITATIVE ELISPOT OR FLUORISPOT ASSAY
The present invention relates to a method of quantifying analyte secreted by a cell or released from a drug delivery vehicle, typically by ELISpot or fluorispot assay. Quantification is possible...
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US20120171695 |
SPONTANEOUSLY CONTRACTING FISH CELL AGGREGATES, USE THEREOF AND METHOD FOR THE PRODUCTION THEREOF
The invention relates to an in vitro method for producing spontaneously contracting fish cell aggregates, to the fish cell aggregates obtained thereby, and to the use thereof, in particular for...
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US20130064799 |
METHODS FOR PROMOTING CELL REPROGRAMMING
The present invention is based on the seminal discovery that several kinases play important roles in barrier pathways in somatic cell reprogramming. The present invention provides that modulating...
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US20120190573 |
BIOMARKER OF LUNG CANCER
The present invention provides methods of providing a prognosis for a lung cancer in a subject and methods of predicting the risk of metastasis of a lung cancer in a subject. The present invention...
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US20110256539 |
Methods for Detecting Tumor Origin Based on MUC1, MUC2, and CK-17 Expression Levels
Methods and compositions for detecting tumor origin are disclosed. In certain embodiments, the origin is determined by detecting expression levels of pan-epithelial membrane mucin (MUC1),...
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US20110150882 |
COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF OVARIAN CANCER
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic...
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US20070207993 |
Molybdenum carbonyl complexes for treating rheumatoid arthritis and other inflammatory diseases
The present invention relates to molybdenum carbonyl complexes useful for inhibiting tumor necrosis factor (TNF) production and for treating inflammatory diseases.
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US20130059301 |
ASXL1 AS A NEW DIAGNOSTIC MARKER OF MYELOID NEOPLASMS
A method for diagnosing a myeloid cancer in a subject, includes the step of analyzing a biological sample from the subject by determining the presence or the absence of a mutation in the ASXL1...
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US20120202217 |
AUTOANTIBODY ENHANCED IMMUNOASSAYS AND KITS
The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies...
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US20110136103 |
AUTOANTIBODY ENHANCED IMMUNOASSAYS AND KITS
The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies...
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US20120041048 |
COMPOSITIONS AND METHODS RELATING TO miR-31
MicroRNA-31 (miR-31), targets of miR-31, the role of miR-31 in inhibiting tumor metastasis, and the role of miR-31 target genes in promoting tumor metastasis are disclosed.
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US20120282597 |
BIOMARKER AND METHOD FOR EVALUATING RISK OF PROLIFERATION, INVASION, OR METASTASIS OF CANCER
The present invention relates to a biomarker associated with a cancer and a method using the biomarker to evaluate a risk of proliferation, invasion, or metastasis of a cancer. The method of the...
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US20130123360 |
METHODS AND USES RELATING TO THE IDENTIFICATION OF COMPOUND ASSOCIATED WITH BACTERIAL INFECTION
The present invention relates to a method of identifying a compound useful for the treating, reducing or preventing pathogenic infection caused by a microorganism and to the use of the PqsD protein...
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US20130064832 |
NOTCH INHIBITION IN THE TREATMENT AND PREVENTION OF A METABOLIC DISEASE OR DISORDER AND CARDIOVASCULAR COMPLICATIONS THEREOF
The present invention is directed to methods of treating or preventing a metabolic disease or disorder and cardiovascular complications and other complications thereof by administering agents that...
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US20120114670 |
METHODS AND COMPOSITIONS RELATED TO SYNERGISTIC RESPONSES TO ONCOGENIC MUTATIONS
Disclosed are compositions and methods related to new targets for cancer treatment.
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