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US20110212448 GAMMACARBOXYGLUTAMATE-RICH PROTEIN, METHODS AND ASSAYS FOR ITS DETECTION, PURIFICATION AND QUANTIFICATION AND USES THEREOF  
The presently disclosed subject matter refers to a gammacarboxyglutamate-rich protein that shows in vivo a high capacity to bind calcium through specific gamma carboxylated glutamic acid residues...
US20120141376 PROSTATE SPECIFIC TRANSCRIPTS AND THE USE THEREOF FOR PROSTATE CANCER THERAPEUTICS AND DIAGNOSTICS  
Genes that are up regulated in human prostate tumor tissues and the corresponding proteins are identified. These genes and the corresponding antigens are suitable targets for the treatment,...
US20140080141 CLEAR MARGIN DETERMINATION DURING CANCER SURGERY  
One or more aqueous, near infrared emitting, high yield, highly photoluminescent, stable quantum dots conjugated to one or more biomarkers specific moieties. The conjugated quantum dots have an...
US20130059744 METHOD FOR EARLY DETECTION OF CANCER  
The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present...
US20120070461 USE OF MYELOID CELL BIOMARKERS FOR THE DIAGNOSIS OF CANCER  
The present invention relates to the use of myeloid cell biomarkers for the differential diagnosis, prognosis, and monitoring of renal cell carcinoma (RCC) or colorectal cancer (CRC). The present...
US20140179807 MODULE-LEVEL ANALYSIS OF PERIPHERAL BLOOD LEUKOCYTE TRANSCRIPTIONAL PROFILES  
The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining individual gene expression levels from cells obtained from one or...
US20140073523 USE OF GLYCOLYTIC PATHWAYS FOR INHIBITING OR MEASURING ONCOGENIC SIGNALING  
Disclosed are methods in which glucose metabolism is correlated to oncogenesis through certain specific pathways; inhibition of certain enzymes is shown to interfere with oncogenic signaling, and...
US20130330719 EML4-ALK TRANSLOCATIONS IN LUNG CANCER  
The present disclosure relates to methods for the diagnosis and evaluation of neoplastic disorders, particularly non-small cell lung cancer. Assays are described in which patient test samples are...
US20140080138 Biomarkers for Head-and-Neck Cancers and Precancers  
The invention provides markers and methods for detecting head-and-neck precancers, (including OPLs), cancers and related disease conditions in a subject. The invention also provides localization...
US20140227698 USE OF FMN-BINDING FLUORESCENCE PROTEINS (FBFP) AS NEW TYPES OF SECRETION MARKERS  
To investigate protein-protein interactions, protein foldings and protein localization and also in the secretion of proteins, in vivo reporter proteins are used in biotechnology and in basic...
US20110287445 Mutant ROS Expression In Human Cancer  
The invention provides the identification of the presence of mutant ROS protein in human cancer. In some embodiments, the mutant ROS are FIG-ROS fusion proteins comprising part of the FIG protein...
US20100311045 CANCER  
The invention provides methods of diagnosis, prognosis and treatment of cancer related to the OBCAM and NTM genes. The methods are particularly suited to ovarian and colorectal cancers.
US20120040369 ON-BOARD CONTROL DETECTION  
Embodiments disclosed herein relate to a sensor comprising an on-board control system and a testing system. The on-board system can determine viability of the control system or the testing system....
US20140298498 INHIBITION OF ONCOGENIC KRAS-INDUCED GM-CSF PRODUCTION AND FUNCTION  
The present invention is directed to methods of inhibiting tumor growth in a subject. The present invention is further directed to methods of diagnosing cancer in a subject and identifying a...
US20110159017 TRYTOPHAN CATABOLISM IN CANCER TREATMENT AND DIAGNOSIS  
The unexpected expression of tryptophan 2,3-dioxygenase (TDO2) in cancer cells and tumors has been established. Methods for diagnosing cancer based on the expression of TDO2 are provided, as are...
US20140178339 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7 FOR TREATMENT OF CANCER  
Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an IGFBP7 agent...
US20120094925 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7 FOR TREATMENT OF CANCER  
Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an IGFBP7 agent...
US20120171174 Methods of Inducing Tissue Regeneration  
Methods are provided for producing cells within a lineage (lineage restricted cells) from post-mitotic differentiated cells of the same lineage ex vivo and in vivo, and for treating a subject in...
US20120316211 Diagnostic Methods for Assessing Risk of Chagas Disease and Heart Failure  
Provided herein are methods of detecting evidence of Chagas disease in a biological sample, comprising the step of measuring the presence of at least one protein selected from the group consisting...
US20120245044 METHODS OF DETERMINING CHEMOTHERAPY RESPONSE IN CANCER  
This disclosure provides a biomarker profile, which is linked to cancer cell chemo-resistance. The disclosure further provides methods of diagnosis and theranosis, and screening of new therapeutic...
US20140206559 ASSAY FOR METASTATIC POTENTIAL OF TUMOR CELLS  
The present invention relates to methods, compositions and kits related to a novel in vitro assay for a high-capacity and high-throughput method for measuring the ability of cancer cells to...
US20100297680 METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE  
The present invention relates to diagnostic tests, methods and kits that are useful to assess a subject's risk of developing a pathologic condition related in part to the presence of HDL oxidation...
US20140037620 Methods of Treating Breast Cancer with Gemcitabine Therapy  
The application describes methods for predicting overall survival in subjects with breast cancer. The application also describes for screening subjects with breast cancer to determine if the...
US20140322721 MARKERS FOR PREECLAMPSIA  
This document provides methods and materials related to determining whether or not a pregnant mammal (e.g., a pregnant human) has preeclampsia. For example, methods and materials related to the...
US20140248632 Magnetically Induced Microspinning for Super-Detection and Super-Characterization of Biomarkers and Live Cells  
Identification, quantification and characterization of biological micro- and nano-systems is enabled by magnetically spinning these natural, non-magnetic systems with the aid of induced...
US20130251738 VACCINES  
There is provided a method of identifying a protective Leptospira vaccine composition, comprising determining that the composition contains a protective concentration of a Lipl32 epitope...
US20150087589 GENES AND PROTEINS ASSOCIATED WITH ANGIOGENESIS AND USES THEREOF  
Disclosed is a panel of biomarkers associated with angiogenesis, and the use of such biomarkers (genes, proteins, homologues and analogs thereof) to regulate angiogenesis. Methods for identifying...
US20140315863 TREATING BLADDER CANCER PATIENTS AND IDENTIFYING BLADDER CANCER PATIENTS RESPONSIVE TO TREATMENT  
This documents provided methods and materials involved in treating bladder cancer. This document also provides methods and materials involved in identifying bladder cancer patients likely or...
US20140162284 In Vitro Assay Method Using Immunological Technique  
The present invention relates to a novel method of in vitro assay of the molecules of the extracellular matrix synthesized by cells in culture and uses thereof in the form of a kit for in vitro...
US20110236915 ZAP-70 EXPRESSION AS A MARKER FOR CHRONIC LYMPHOCYTIC LEUKEMIA / SMALL LYMPHOCYTIC LYMPHOMA (CLL/SLL)  
It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is...
US20140302520 METABOLISM OF SOD1 IN CSF  
The disclosure relates to methods for the diagnosis and treatment of neurological and neurodegenerative diseases, disorders, and associated processes. Specifically, the disclosure relates to a...
US20140193814 ABCA1 DOWNREGULATION IN PROSTATE CANCER  
A method of providing a prognosis or diagnosis of prostate cancer in a subject is described. The method includes obtaining a urine or prostate sample from the subject; determining the level of...
US20130102486 PERP AS A PROGNOSTIC AND DIAGNOSTIC MARKER FOR DYSPLASIA AND CANCER  
Methods for prognosis and diagnosis of dysplasia and cancer are disclosed. In particular, the invention relates to the use of the biomarker PERP, a desmosome protein involved in cell adhesion and...
US20130281423 METHODS AND COMPOSITIONS FOR AMELIORATING PANCREATIC CANCER  
Embodiments of the present invention include methods and compositions for ameliorating cancer. Some embodiments include methods and compositions for ameliorating pancreatic cancer targeting the...
US20100330587 Annexin Proteins and Autoantibodies As Serum Markers For Cancer  
The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin...
US20120028269 Methods For Detection Of Gastric Cancer  
The invention is directed to non-invasive methods of detecting gastric cancer in an individual in need thereof comprising determining an expression level of inter-alpha-trypsin inhibitor heavy...
US20110182881 SIGNATURE AND DETERMINANTS ASSOCIATED WITH METASTASIS AND METHODS OF USE THEREOF  
The present invention provides methods of detecting cancer using biomarkers.
US20130115612 METHOD FOR ANALYZING MUCIN 1 HAVING SIAALPHA2-8SIAALPHA2-3GALBETA GLYCANS  
The object of the present invention is to provide a clinical marker capable of distinguishing breast cancer from interstitial pneumonia; and a clinical marker for detecting malignancy or progress...
US20140056807 LARGE ONCOSOMES IN HUMAN TUMORS AND IN CIRCULATION IN PATIENTS WITH CANCER  
The invention provides methods for isolating large oncosomes and determining cancer metastasis based on the presence of large oncosomes in a subject in need thereof.
US20120115175 METHODS FOR DIAGNOSING ELEVATED RIGHT OR LEFT VENTRICULAR FILLING PRESSURE  
The present invention features a method of diagnosing elevated left or right ventricular filling pressure and cardiovascular dysfunction in a subject by detecting increased levels of sEng in a...
US20120171204 COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF IMMUNE DISORDERS  
The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast...
US20120129179 SCN5A SPLICING FACTORS AND SPLICE VARIANTS FOR USE IN DIAGNOSTIC AND PROGNOSTIC METHODS  
Provided herein are methods of identifying a subject at risk for arrhythmias, heart failure or sudden cardiac death. In exemplary aspects, the method comprises the step of determining a level of...
US20130095484 Systems And Methods For Predicting Response To Anti-Androgen Therapy For The Treatment Of Androgenetic Alopecia  
Methods, processes, systems, and apparatuses are disclosed for predicting anti-androgen therapy response in the treatment of androgenetic alopecia based on a fluorometric assay and proteomics.
US20140287944 MARKERS FOR FUNCTIONALLY MATURE BETA-CELLS AND METHODS OF USING THE SAME  
Markers for functionally mature β-cells and methods of using these markers are disclosed.
US20110098191 IN VITRO METHODS FOR DETECTING RENAL CANCER  
The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the...
US20140121128 METHOD FOR THE PROGNOSIS OF BREAST CANCER BASED ON THE EXPRESSION OF THE GENE PIN1 IN COMBINATION WITH MUTATIONS IN THE GENE TP53  
It is described the influence of the presence of mutations in the TP53 gene in association with high levels of the enzyme prolyl isomerase Pin1 and a molecular signature of 10 genes expression...
US20150037342 METHOD TO PREVENT CANCER METASTASIS AND INHIBIT INFLAMMATION BY INHIBITION OF P68 INTERACTION WITH CALMODULIN  
Compositions and methods for inhibiting cancer cell metastasis and inflammation are disclosed. The methods generally involve administering to a subject a composition containing an agent that...
US20120121608 USE OF SAM68 FOR MODULATING SIGNALING THROUGH THE TNF RECEPTOR  
Sam68 plays a role in TNF-dependent signaling, including NF-kB signaling and extrinsic activation of apoptosis. In some embodiments, inhibitors of Sam68 are administered to inhibit TNF-dependent...
US20110136133 METHOD FOR DIFFERENTIATING BETWEEN MULTIPLE SCLEROSIS SUBTYPES  
Disclosed herein is a method for differentiating between multiple sclerosis subtypes in a patient. The method comprises a) determining an amount of an IAP gene expression level in a blood sample...
US20120294929 METHOD OF DIAGNOSING AND TREATING CANCER USING B-CATENIN SPLICE VARIANTS  
The invention relates to method and compositions for treating and diagnosing cancer, in particular β-catenin related cancers. In general, the methods include administering RNAi constructs. The...