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US20090304727 |
HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO THE LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN THE TREATMENT OF ALLERGIES
The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of...
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US20090297550 |
Chloroplast-derived human vaccine antigens against malaria
Disclosed is a method of making a malaria vaccine, the method comprising stably transforming a plant by inserting into its plastid genome a nucleic acid sequence encoding and operable to...
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US20090285821 |
Campylobacter Pilus Protein, Compositions and Methods
The present disclosure provides coding and amino acid sequences for a Campylobacter jejuni pilus protein (and from other species as well). This protein, when administered to a human or animal,...
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US20090288178 |
INSECT CELL LINE FOR PRODUCTION OF RECOMBINANT GLYCOPROTEINS WITH SULFATED COMPLEX N-GLYCANS
A transgenic insect cell line for production of recombinant glycoproteins possessing sulfated, complex N-glycans is provided.
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US20090280125 |
Prion epitopes and methods of use thereof
Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.
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US20090280168 |
CHLAMYDIA OMP ANTIGEN
The present invention provides purified and isolated polynucleotide molecules that encode Chlamydia polypeptides which can be used in methods to prevent, treat, and diagnose Chlamydia ...
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US20090246830 |
RECOMBINANT INFLUENZA VIRUSES FOR VACCINES AND GENE THERAPY
A method for producing influenza virus particles for preparation of a vaccine. The method comprises growing reassortant influenza viruses to produce virus particles and recovering the produced...
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US20090246228 |
Moraxella catarrhalis Proteins
Novel antigens of B. catarrhalis are provided, together with their use in vaccines as well as methods of diagnosing and/or detection.
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US20090239261 |
ASSEMBLY OF WILD-TYPE AND CHIMERIC INFLUENZA VIRUS-LIKE PARTICLES (VLPs)
Influenza virus-like particles (VLPs) comprising the structural proteins HA, NA, M1 and M2 are described. VLPs are also generated containing M1 alone, as are VLPs with M1 and any one or two of HA,...
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US20090238841 |
HIV VACCINE FORMULATIONS
Provided herein are HIV vaccines comprising HIV polypeptide-encoding DNA adsorbed to PLG and/or HIV proteins. Also provided are methods of using these vaccines to generate immune responses in a...
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US20090238822 |
Chimeric Hepatitis C Virus Antigens For Eliciting an Immune Response
Disclosed herein are chimeric antigens, comprising an hepatitis C virus (HCV) antigen and a Fc fragment of an immunoglobulin for eliciting an immune response against said antigen. The immune...
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US20090226485 |
Recombinant Porcine Adenovirus Vector
This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The...
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US20090220538 |
VACCINE FOR STAPHYLOCOCCAL INFECTIONS
The present invention describes method of preparation and use of polypeptide vaccine formulation for prevention and control of Staphylococci mediated infections in human, bovine and other mammals,...
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US20090214579 |
PROMOTER FOR INTRODUCING A GENE INTO A LYMPHOCYTE OR BLOOD CELL AND APPLICATION THEREOF
It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved...
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US20090215146 |
Method for Producing Virus-Type Particles Containing an Active Substance
The invention relates to a method for producing virus-type particles containing an active substance. Proteins, which comprise a first amino acid sequence which is derived from a first virus...
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US20090214570 |
METHODS AND COMPOSITIONS FOR IMMUNIZING AGAINST CHLAMYDIA INFECTION
The present invention relates, in part, to methods and compositions for immunizing against infection by Chlamydia trachomatis . The methods and compositions rely, in part, on administering an...
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US20090209003 |
MUTANT PCNA
The present invention is to construct a DNA replication reaction system which is excellent in versatility and is easily used. An amino acid sequence of a PCNA monomer which is one of factors...
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US20090208978 |
Panel Cell Used for Granulocyte Antibody Detection
A panel cell for detecting anti-HNA antibody is disclosed. The panel cell is obtained by introducing a DNA coding for an HNA antigen corresponding to the anti-HNA antibody into a cell so as to...
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US20090196884 |
Malaria Vaccines
The present invention relates to a synthetic antigenic sequence which represents a combination of epitope-containing sequences from the highly polymorphic block 2 repeat region of K1-type ...
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US20090197304 |
Corynephage integrase-based site-specific insertion vector system
The present invention provides a system for site-specific directed gene insertion of desired genes or foreign DNA into cellular genomes. The system includes novel vectors for integrating DNA into...
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US20090196883 |
Plasmodium vivax hybrid circumsporozoite protein and vaccine
Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any...
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US20090186337 |
N PROTEIN OF A VIRUS OF THE PARAMYXOVIRIDAE FAMILY-PROTEIN OF INTEREST FUSION PROTEINS
The invention relates to N protein-protein of interest fusion proteins, optionally in the form of soluble N protein-protein of interest/P protein complexes, the N and P proteins being proteins of a...
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US20090170162 |
NON-COILED PROTECTIVE REGIONS OF PNEUMOCOCCAL SURFACE PROTEINS PSPA AND PSPC
The embodiments described herein provide for immunogenic portions of Streptococcus pneumoniae surface protein A and surface protein C lacking alpha helical structure.
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US20090162391 |
VACCINE ANTIGENS FROM PISCIRICKETTSIA SALMONIS
The present invention discloses novel proteins, e.g., antigens, from Piscirickettsia salmonis . The present invention further discloses nucleic acids that encode these proteins. The present...
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US20090136532 |
Vaccine for Avian Influenza and Methods of Use
The subject invention pertains to influenza vaccines and particularly avian influenza vaccines (AIV). The invention includes methods for preparing transgenic plant cells to express know HA1...
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US20090117113 |
Immunogenic And Therapeutic Compositions For Streptococcus Pyogenes
Group A streptococcal (GAS) antigens useful for providing immunity against pyogenes infection.
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US20090087883 |
Novel expression vector with enhanced gene expression capacity and method for using the same
The present invention provides a novel expression vector which comprises a gene of interest, a nuclear anchoring element, and at least one inverted repeat element, preferably two inverted repeat...
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US20090087448 |
Stable Immunoprophylactic and Therapeutic Compositions Derived From Transgenic Plant Cells and Methods for Production
The present invention generally relates to the field of immunology and provides immunoprotective compositions and methods for preparing such compositions from transgenic plant cells. The present...
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US20090068229 |
MODIFIED SURFACE ANTIGEN
Novel proteins that constitute modified forms of a Neisseria meningitidis surface antigen and encoding nucleic acids are provided. The modified surface proteins are characterized by having...
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US20090068705 |
Use of Copper Glutamate in Cell Culture for Production of Polypeptides
An improved system for large scale production of polypeptides in cell culture is provided. In accordance with the present invention, cells expressing a polypeptide of interest are grown in media...
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US20090060949 |
Flu vaccines and methods of use thereof
This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for...
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US20090060932 |
Groups Of Borrelia Burgdorferi And Borrelia Afzelii That Cause Lyme Disease In Humans
The present invention is drawn to an immunogenic composition comprising OspC polypeptides from Lyme Disease causing Borrelia. In one embodiment, the immunogenic composition of the present...
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US20090060935 |
AMEBIASIS VACCINE
An isolated protein fragment containing an epitope which is specific for E. histolytica and is commonly shared by all polymorphic strains of E. histolytica is provided, and which exhibits...
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US20090060865 |
MAMMALIAN RECEPTOR PROTEINS; RELATED REAGENTS AND METHODS
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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US20090047302 |
Chimaeric Human Papillomavirus 16 L1 Virus Like Particles and a Method for Preparing the Particles
A method for producing a chimaeric human papillomavirus (HPV) L1 polypeptide containing a heterologous peptide, and in particular, a HPV L2 peptide comprising the steps of introducing a DNA...
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US20090042212 |
DETECTION OF PRIMARY INFECTIONS WITH PATHOGENS
The present invention relates to fusion proteins: suitable as test antigens in the detection of infections with pathogens, particularly of primary infections with pathogens. Further, the invention...
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US20090035328 |
fHbp- AND LPXL1-BASED VESICLE VACCINES FOR BROAD SPECTRUM PROTECTION AGAINST DISEASES CAUSED BY NEISSERIA MENINGITIDIS
The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, using vesicle vaccines made from Neisseria ...
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US20090028893 |
Methods for producing fusion polypeptides or enhancing expression of fusion polypeptides
The present invention relates to the cloning and expression of foreign protein or polypeptides in bacteria, such as Escherichia coli . In particular, this invention relates to expression tools...
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US20090022762 |
Polyvalent influenza virus-like particle (VLP) compositions
Polyvalent influenza virus-like particles (VLPs) comprising influenza antigenic polypeptides are described. Also described are compositions comprising these polyvalent VLPs as well as methods of...
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US20090022753 |
Surface proteins of streptococcus pyogenes
β-hemolytic streptococci polynucleotides, polypeptides, particularly Streptococcus pyogenes polypeptides and polynucleotides, and antibodies of these polypeptides are described. The...
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US20090017495 |
ESCHERICHIA COLI-DERIVED VACCINE AND THERAPY AGAINST BOTULISM
A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an...
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US20090010951 |
Epitope/Peptide Recognized By Hla-A2402-Restricted Ep/Cam-Specific Ctl And Use Of The Same
A peptide consisting essentially of the amino acid sequence represented by SEQ ID NO:1; a peptide consisting essentially of the amino acid sequence represented by SEQ ID NO:2; or a mutant peptide...
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US20080318274 |
Methods and Compositions for Combinatorial-Based Production of Multivalent Recombinant Antigens
The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of...
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US20080317779 |
Hiv Tat-Cd4 Hybrid Molecules and Methods of Use Thereof
Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of...
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US20080311094 |
Isolated Liver Stem Cells
Isolated liver progenitor stem cells and cell populations of isolated liver progenitor stem cells are disclosed. The progenitor stem cells originate from adult liver, especially human adult liver....
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US20080311158 |
Hepatitis C Virus Replication System
A cell including: (a) a hepatitis C virus genome, and/or nucleic acid encoding a hepatitis C virus genome; and (b) nucleic acid encoding one or both of hepatitis C virus proteins E 1 and E 2 . The...
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US20080299127 |
PROTECTIVE STAPHYLOCOCCUS AUREUS VACCINE BASED ON CELL WALL-ASSOCIATED PROTEINS
The present invention relates to a pharmaceutical composition or a medicament, notably a protective Staphylococcus aureus vaccine, comprising at least one cell wall-associated Staphylococcus...
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US20080299544 |
Hcv Multiple Epitope Fusion Antigens With Modified Proteolytic Cleavage Sites And Uses Thereof
Modified HCV multiple epitope fusion antigens (MEFAs) are described. The proteins include modified sequences such that proteolytic cleavage of the MEFAs by HCV NS3 protease is inhibited. HCV...
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US20080292662 |
Vaccine Comprising Recombinant Clpp Protein of Streptococcus Pneumoniae
This invention is about vaccine comprising recombinant CLPP protein of Streptococcus pneumoniae . In this study, it was demonstrated that the CLPP was translocated into the cell wall after heat...
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US20080279877 |
HPV antigens, vaccine compositions, and related methods
The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by human papilloma...
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