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US20100310586 |
IDIOTYPIC VACCINE
The invention concerns the use of recombinant clonotypic immunoglobulins (Ig) as a vaccine in the treatment of HCV-related and non HCV-related lymphoproliferations, in particular the use of...
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US20110117131 |
Production of OspA for Lyme Disease Control
The present invention relates, generally, to the production of one or more OspA proteins in plant cells. Heterologous DNA comprising genes encoding one or more desired OspA protein(s) are...
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US20110179503 |
PROTEIN PRODUCTION IN A HOST
Recombinant DNA constructs that provide for expression of desired target proteins as protein bodies in various host cells, tissues, and organisms are disclosed. Such recombinant DNA constructs...
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US20120005782 |
CHEMICALLY INDUCIBLE CUCUMBER MOSAIC VIRUS PROTEIN EXPRESSION SYSTEM
The invention relates to a novel chemically inducible plant viral amplicon (CMViva) expression system that permits controllable, high level expression of foreign genes in plant hosts. This system...
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US20110129872 |
METHOD FOR A PRODUCTION OF A RECOMBINANT PROTEIN USING YEAST CO-EXPRESSION SYSTEM
The present invention relates to a method for mass production of a recombinant protein comprising the step of culturing a yeast transformed with: a recombinant gene construct comprising a yeast...
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US20110035841 |
Lipid Metabolism Proteins, Combinations of Lipid Metabolism Proteins and Uses Thereof
Described herein are inventions in the field of genetic engineering of plants, including combinations of polynucleotides encoding LMPs to improve agronomic, horticultural, and quality traits. This...
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US20100297694 |
NOVEL GENE FROM HANCENULA POLYMORPHA CAPABLE OF CONTROLLING UNFOLDED PROTEIN RESPONSE AND METHOD FOR INCREASING EFFECT OF SECRETION USING THE SAME
The present invention relates to a novel H. polymorpha gene regulating Unfolded Protein Response (UPR) and a method for improving the efficiency of secretory expression of a recombinant protein...
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US20110288001 |
BIOLOGICALLY ACTIVE PROTEINS ACTIVATABLE BY PEPTIDASE
The present invention provides biologically active proteins that are activatable by peptidase exposure, such as dipeptidase exposure. The biologically active protein may be a recombinant version of...
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US20110306751 |
Independently Inducible System of Gene Expression
The present invention is directed to the improved methods for the temporal induction of proteins using the condensed single protein production (cSPP) system.
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US20110287481 |
HOST, TRANSFORMANT AND METHOD FOR PRODUCING THE TRANSFORMANT AND METHOD FOR PRODUCING O-GLYCOSYLATED HETEROLOGOUS PROTEIN
The object is to provide a transformant which can produce a heterologous protein having a structurally controlled O-linked sugar chain having an O-Man-Gal disaccharide structure, a method for...
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US20110053189 |
Type IV secretion system proteins in sero-detection of Anaplasma phagocytophium
Disclosed are two (2) proteins in the Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum (namely, virB 10 and virB11) useful in the ELISA detection of Anaplasma pathogen. The recombinant...
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US20100297108 |
METHOD OF PROVIDING PATIENT SPECIFIC IMMUNE RESPONSE IN AMYLOIDOSES AND PROTEIN AGGREGATION DISORDERS
A novel treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed...
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US20120028301 |
SOMATIC HYPERMUTATION SYSTEMS
The present application relates to somatic hypermutation (SHM) systems and synthetic genes. Synthetic genes can be designed using computer-based approaches to increase or decrease susceptibility of...
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US20120107856 |
New Fungal Production System
The present invention provides a new fungal production system comprising a fungal host strain of Chrysosporium lucknowense wherein the endogenous cellulase secretion is less than 20% of the...
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US20110189159 |
METHODS AND COMPOSITIONS FOR PROTEIN DELIVERY
The present invention provides methods and compositions for protein delivery. The invention features virus like particles, methods of making virus like particles and methods of using virus like...
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US20110008835 |
SYSTEM FOR THE HETEROLOGOUS EXPRESSION OF A VIRAL PROTEIN IN A CILIATE HOST CELL
The present invention relates to a system for the heterologous expression of a viral protein or a fragment thereof, said system comprising a) a ciliate host cell,b) at least one cDNA encoding for a...
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US20110041215 |
Lipid Metabolism Protein And Uses Thereof I (BZIP Transcription Factor)
The present invention relates to a bZip transcription factor encoding polynucleotides and polypeptides. Further, the present invention relates to the use of the aforementioned nucleic acid...
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US20120094294 |
BMS1 PROTEIN EXPRESSION SYSTEM
Eukaryotic cells having upregulated BMS1 genes and a nucleotide sequence encoding a recombinant protein or fragment for the production of such proteins or fragments are provided. This is based on...
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US20110160081 |
FUNCTIONAL COMPLEMENTATION ASSAY FOR DEFINED GPCR OLIGOMERS
The present invention is directed to, inter alia, a biological reagent that includes a complex having a first GPCR and a second GPCR linked to a G-protein, the linkage between the second GPCR and...
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US20110021611 |
EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 5A
The present inventors developed 5a/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and all of or part of NS2 were replaced by the corresponding genes of the...
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US20110091935 |
PRODUCTION OF RECOMBINANT PROTEINS IN SYNTHETIC MEDIUM
The invention relates to a method for the production of recombinant proteins by eucaryotic cells in synthetic culture media, wherein said eucaryotic cells are transfected with a composition...
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US20110152171 |
HISTAMINE BINDING PROTEIN
The invention relates to histamine binding proteins. The invention also relates to the use of such histamine binding proteins in the treatment and prevention of diseases.
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US20110107466 |
VIRUS VECTOR AND USE THEREOF
It is intended to provide a polynucleotide comprising a viral base sequence, the viral base sequence containing: a first base sequence encoding a viral replication protein, and a second base...
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US20110105411 |
Disease-Associated Proteins
Disclosed are methods and compositions for early diagnosis, monitoring and treatment of an ocular disorder. In particular, the invention relates to a novel protein, that is differentially...
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US20110195431 |
HUMAN ORPHAN G PROTEIN-COUPLED RECEPTORS
The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.
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US20110129457 |
VARIANT HHIP1 PROTEIN AND METHODS AND USES THEREOF
The present invention is directed to derivatives of Hhip1 and methods of using the same for treatment and diagnosis of cancer in mammals.
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US20100323398 |
Baculoviruses With Enhanced Virion Production and a Method for the Production of Baculoviruses
The present invention provides a method for restoring budding capability to GP64null baculoviruses including gp64null AcMNPV by expressing therein a portion of the VSV G protein gene or a truncated...
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US20100313296 |
METHOD TO IMPROVE PLANT RESISTANCE TO INFECTIONS
The disclosed invention relates to expression systems that effect production of a protein in plants that confers resistance to trauma. The expression systems are used to modify plants to improve...
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US20120107873 |
Method of Producing a Sweet Protein
The present invention relates to a method of producing a recombinant sweet protein in a filamentous fungus. The invention also relates to isolated polynucleotides encoding the sweet protein and to...
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US20110033891 |
MUSSEL BIOADHESIVE
The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel Mytilus galloprovincialis foot protein type 5 (MGFP-5) and a recombinant protein that is a...
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US20110136170 |
METHOD AND KIT FOR PURIFICATION OF RECOMBINANT PROTEINS USING A SELF-CLEAVING PROTEIN INTEIN
The present invention provides a method for purifying a recombinant target protein by using an autolytic protein Intein, comprising: recombinantly expressing a fusion protein in a host cell,...
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US20100323905 |
Vhh for the Diagnosis, Prevention and Treatment of Diseases Associated with Protein Aggregates
The present invention provides heavy chain variable domain antibodies (VHH) for preventing and/or dissolving aggregates. VHH of the invention are preferably used in the treatment of human diseases...
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US20120071422 |
Therapeutic application of isolated naturally-occuring soluble truncated forms of IL-23 receptor
The present invention relates to an isolated naturally-occurring soluble truncated IL-23Rα protein, which is a translated protein resulting from a mRNA splice variant of IL-23Rα. The soluble I...
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US20100304436 |
Fucosylation-Deficient Cells
An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a...
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US20110045531 |
METHOD FOR PRODUCING A RECOMBINANT PROTEIN ON A MANUFACTURING SCALE
A method for producing a protein of interest on a manufacturing scale is based on integration, by homologous recombination, of the DNA encoding the protein of interest into a bacterial cell genome...
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US20110091495 |
HCV E2 CONSTRUCT COMPOSITIONS AND METHODS
A construct comprising the ectodomain of the Hepatitis C Virus (HCV) E2 sequence and a mammalian expression system therefor is disclosed. The construct comprises a CMV promoter, prolactin signal...
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US20110046054 |
ANTI DIABETIC PROTEIN
The present invention relates to a novel hypoglycemic/anti-hyperglycemic protein named ADMc1 purified from the seeds of Momordica charantia for control of hyperglycemia. The process for the...
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US20110207801 |
Novel Genes, Compositions, and Methods for Modulating the Unfolded Protein Response
The present invention relates to methods and compositions for modulating the unfolded protein response. The method further relates to methods and compositions for the treatment and diagnosis of...
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US20110195512 |
NOVEL PROTEIN CAPABLE OF BINDING TO HYALURONIC ACID, AND METHOD FOR MEASUREMENT OF HYALURONIC ACID USING THE SAME
The present invention relates to a polynucleotide encoding a protein comprising an amino acid sequence shown in SEQ ID NO: 2, wherein the protein encoded by the polynucleotide has a hyaluronic acid...
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US20110053220 |
NOVEL PROTEIN CAPABLE OF BINDING TO HYALURONIC ACID, AND METHOD FOR MEASUREMENT OF HYALURONIC ACID USING THE SAME
The present invention relates to a polynucleotide encoding a protein comprising an amino acid sequence shown in SEQ ID NO: 2, wherein the protein encoded by the polynucleotide has a hyaluronic acid...
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US20110262953 |
Phosphate Limited Inducible Promoter and A Bacillus Expression System
An evolvable production strain of B. subtilis exhibiting continuous or high level expression during protein evolution is described. An evolved Bacillus subtilis pstS promoter facilitates screening...
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US20110008833 |
PROTEIN PRODUCTION IN PLANT CELLS AND ASSOCIATED METHODS AND COMPOSITIONS
The present invention relates to methods and compositions for the expression of protein. Embodiments of methods may comprise the cleavage and repair of a nucleotide sequence encoding a highly...
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US20100306880 |
NUCLEIC ACIDS FOR INDUCING EXPRESSION OF TRANSCRIPTS AND PROTEINS AND METHODS FOR MAKING AND USING THEM
The invention provides nucleic acids and polypeptides for enhanced expression of nucleic acids and proteins. In one aspect, the sequences serve as transcription and translation enhancers or...
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US20110003333 |
Method for Increasing Expression Yield of a Protein of Interest
The present invention relates to a method of producing a protein of interest comprising: (a) cultivating a mutant cell under conditions conducive for production of the protein wherein the mutant...
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US20120017336 |
TRANSGENIC ALOE PLANTS FOR PRODUCTION OF PROTEINS AND RELATED METHODS
The present inventions provide transgenic aloe plants and recombinant constructs for transforming aloe plants, aspects of which, may be applied to other monocots. The recombinant constructs may...
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US20120036589 |
VACCINE
The present invention is concerned with the development of a vaccine against Aeromonas hydrophila for use especially in fish. The invention provides an immunogenic S-layer protein of approximately...
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US20120022232 |
CELLS FOR INCREASED PROTEIN EXPRESSION COMPRISING ONE OR MORE RELEASE FACTORS AND METHODS OF USE
The invention provides recombinant cells or recombinant restrictive cells for overexpressing one or more proteins comprising one or more release factors. The invention also provides methods for...
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US20110294160 |
Cysteine Protease Autoprocessing of Fusion Proteins
Disclosed are fusion proteins, polynucleotides that encode the disclosed fusion proteins, and methods for expressing and autoprocessing of the disclosed fusion proteins to obtain a target protein....
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US20110081705 |
RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for...
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US20120054906 |
Method for Preparation and Purification of Recombinant Proteins
The present invention relates to a method for the production, isolation, and purification of a recombinant protein, more particularly, to a method for isolating and purifying a foreign protein...
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