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US20100310586 IDIOTYPIC VACCINE  
The invention concerns the use of recombinant clonotypic immunoglobulins (Ig) as a vaccine in the treatment of HCV-related and non HCV-related lymphoproliferations, in particular the use of...
US20110117131 Production of OspA for Lyme Disease Control  
The present invention relates, generally, to the production of one or more OspA proteins in plant cells. Heterologous DNA comprising genes encoding one or more desired OspA protein(s) are...
US20130224798 Methods of Making Hemagglutinin Proteins  
Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring influenza viral hemagglutinin to form a...
US20130230884 Methods to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation  
The present invention provides reagents and methods for identifying translation enhancing elements, as well as isolated translation enhancing elements and their use in protein expression reagents...
US20110179503 PROTEIN PRODUCTION IN A HOST  
Recombinant DNA constructs that provide for expression of desired target proteins as protein bodies in various host cells, tissues, and organisms are disclosed. Such recombinant DNA constructs...
US20120284871 PROTEIN EXPRESSION SYSTEMS  
Disclosed herein are methods and materials, and particularly viral derived sequences, for boosting gene expression in plants and other eukaryotic cells. The methods and materials may be used for...
US20120005782 CHEMICALLY INDUCIBLE CUCUMBER MOSAIC VIRUS PROTEIN EXPRESSION SYSTEM  
The invention relates to a novel chemically inducible plant viral amplicon (CMViva) expression system that permits controllable, high level expression of foreign genes in plant hosts. This system...
US20110129872 METHOD FOR A PRODUCTION OF A RECOMBINANT PROTEIN USING YEAST CO-EXPRESSION SYSTEM  
The present invention relates to a method for mass production of a recombinant protein comprising the step of culturing a yeast transformed with: a recombinant gene construct comprising a yeast...
US20130028926 BIOSYNTHETIC SYSTEM THAT PRODUCES IMMUNOGENIC POLYSACCHARIDES IN PROKARYOTIC CELLS  
The invention is directed to bioconjugate vaccines comprising N-glycosylated proteins. Further, the present invention is directed to a recombinant prokaryotic biosynthetic system comprising...
US20110035841 Lipid Metabolism Proteins, Combinations of Lipid Metabolism Proteins and Uses Thereof  
Described herein are inventions in the field of genetic engineering of plants, including combinations of polynucleotides encoding LMPs to improve agronomic, horticultural, and quality traits. This...
US20140193854 Method for Mass-Producing Antifreeze Protein Derived from Polar Yeast  
The present invention relates to a method for mass-producing an antifreeze protein derived from a polar yeast, and more particularly, to a method for mass-producing an antifreeze protein derived...
US20130237475 SYNTHETIC GENE FOR EXPRESSING SM-14 IN PICHIA PASTORIS, METHODS FOR PRODUCING AND PURIFYING SM-14 AND THE USE THEREOF AS A VACCINE AND DIAGNOSTIC MEDIUM  
The present invention pertains to the field of production of recombinant proteins, using a synthetic gene for increased expression of the protein in Pichia pastoris. More specifically, the...
US20120315671 EXPRESSION MEDIA FOR PROTEINS IN YEAST SYSTEM  
The subject invention provides advantageous new media formulations, methods for their production, methods for cultivating cells using the media as well as compositions thereof and their use for...
US20150030584 TRANSPORT PROTEIN WHICH IS USED TO INTRODUCE CHEMICAL COMPOUNDS INTO NERVE CELLS  
The invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum. The protein binds specifically to nerve cells...
US20140065670 Expression System  
A perfect palindrome operator sequence-based protein expression system is provided. The expression system comprises a promoter; and a perfect palindrome operator sequence, wherein the promoter is...
US20100297694 NOVEL GENE FROM HANCENULA POLYMORPHA CAPABLE OF CONTROLLING UNFOLDED PROTEIN RESPONSE AND METHOD FOR INCREASING EFFECT OF SECRETION USING THE SAME  
The present invention relates to a novel H. polymorpha gene regulating Unfolded Protein Response (UPR) and a method for improving the efficiency of secretory expression of a recombinant protein...
US20110288001 BIOLOGICALLY ACTIVE PROTEINS ACTIVATABLE BY PEPTIDASE  
The present invention provides biologically active proteins that are activatable by peptidase exposure, such as dipeptidase exposure. The biologically active protein may be a recombinant version...
US20110306751 Independently Inducible System of Gene Expression  
The present invention is directed to the improved methods for the temporal induction of proteins using the condensed single protein production (cSPP) system.
US20140272964 Blue Fluorescent Protein and Methods of Use Thereof  
This invention provides methods of making and using a fluorescent probe from the Sandercyanin protein as set forth in SEQ ID NO: 1 or SEQ ID NO: 2. In one embodiment, the invention provides a...
US20130345400 IDENTIFICATION OF A HUMAN GYROVIRUS AND APPLICATIONS  
The present invention relates to HGyV, a human gyrovirus related to the chicken anemia virus (CAV). The present invention also relates to a new proteins encoded by HGyV, which proteins display...
US20140256796 IN VITRO AND IN VIVO DELIVERY OF GENES AND PROTEINS USING THE BACTERIOPHAGE T4 DNA PACKAGING MACHINE  
Described is T4 DNA packaging machine comprising: one or more DNA molecules packaged in a head of the T4 DNA packaging machine, one or more Hoc-fused proteins displayed on the head of the T4 DNA...
US20130115242 Modified Viral Strains and Method for Improving the Production of Vaccine Seeds of Influenza Virus  
Modified influenza A/PR/8/34 virus and reassortant influenza A/PR/8/34 virus including a modified PB1 gene and methods for improving the production of HA (hemagglutinin) and NA (neuraminidase)...
US20120225453 SYSTEMS AND METHODS FOR THE SECRETION OF RECOMBINANT PROTEINS IN GRAM NEGATIVE BACTERIA  
Disclosed herein are systems and methods for producing recombinant proteins utilizing mutant E. coli strains containing expression vectors carrying nucleic acids encoding the proteins, and...
US20110287481 HOST, TRANSFORMANT AND METHOD FOR PRODUCING THE TRANSFORMANT AND METHOD FOR PRODUCING O-GLYCOSYLATED HETEROLOGOUS PROTEIN  
The object is to provide a transformant which can produce a heterologous protein having a structurally controlled O-linked sugar chain having an O-Man-Gal disaccharide structure, a method for...
US20110053189 Type IV secretion system proteins in sero-detection of Anaplasma phagocytophium  
Disclosed are two (2) proteins in the Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum (namely, virB 10 and virB11) useful in the ELISA detection of Anaplasma pathogen. The...
US20100297108 METHOD OF PROVIDING PATIENT SPECIFIC IMMUNE RESPONSE IN AMYLOIDOSES AND PROTEIN AGGREGATION DISORDERS  
A novel treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed...
US20120028301 SOMATIC HYPERMUTATION SYSTEMS  
The present application relates to somatic hypermutation (SHM) systems and synthetic genes. Synthetic genes can be designed using computer-based approaches to increase or decrease susceptibility...
US20120107856 New Fungal Production System  
The present invention provides a new fungal production system comprising a fungal host strain of Chrysosporium lucknowense wherein the endogenous cellulase secretion is less than 20% of the...
US20110189159 METHODS AND COMPOSITIONS FOR PROTEIN DELIVERY  
The present invention provides methods and compositions for protein delivery. The invention features virus like particles, methods of making virus like particles and methods of using virus like...
US20110008835 SYSTEM FOR THE HETEROLOGOUS EXPRESSION OF A VIRAL PROTEIN IN A CILIATE HOST CELL  
The present invention relates to a system for the heterologous expression of a viral protein or a fragment thereof, said system comprising a) a ciliate host cell,b) at least one cDNA encoding for...
US20130039938 HIGHLY EFFICIENT INFLUENZA MATRIX (M1) PROTEINS  
This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using...
US20140120091 FUSION PROTEINS FOR THERAPY OF AUTOIMMUNE AND CARDIOVASCULAR DISEASE  
The present invention provides improved fusion proteins for therapy of autoimmune and cardiovascular disease.
US20140283208 Novel Insecticidal Proteins and Methods of Use  
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic...
US20140227741 Biological Systems for Production of Highest Quality Proteins  
Vaccines and therapeutic proteins, including polyclonal and monoclonal antibodies, must be maximally pure and stable in their most active native form. This is a requirement for their maximal...
US20110041215 Lipid Metabolism Protein And Uses Thereof I (BZIP Transcription Factor)  
The present invention relates to a bZip transcription factor encoding polynucleotides and polypeptides. Further, the present invention relates to the use of the aforementioned nucleic acid...
US20120094294 BMS1 PROTEIN EXPRESSION SYSTEM  
Eukaryotic cells having upregulated BMS1 genes and a nucleotide sequence encoding a recombinant protein or fragment for the production of such proteins or fragments are provided. This is based on...
US20140187741 MEANS AND METHODS FOR MEDIATING PROTEIN INTERFERENCE  
The present invention belongs to the field of functional proteomics and more particularly to the field of protein aggregation. The invention discloses a method for interfering with the function of...
US20110160081 FUNCTIONAL COMPLEMENTATION ASSAY FOR DEFINED GPCR OLIGOMERS  
The present invention is directed to, inter alia, a biological reagent that includes a complex having a first GPCR and a second GPCR linked to a G-protein, the linkage between the second GPCR and...
US20140335127 SYSTEM AND METHOD FOR THE PRODUCTION OF RECOMBINANT GLYCOSYLATED PROTEINS IN A PROKARYOTIC HOST  
A system and a method for the production of recombinant N-glycosylated target proteins. The system comprises a prokaryotic organism (e.g. Escherichia coli) into which is introduced a genetic...
US20140315248 PROTEIN PRODUCTION METHOD USING TRANSFORMED PLANT CELLS  
An object of this invention is to produce a protein by efficiently culturing plant cells while escaping mRNA translational repression in cultured plant cells under stress caused by lack of...
US20110021611 EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 5A  
The present inventors developed 5a/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and all of or part of NS2 were replaced by the corresponding genes of the...
US20110091935 PRODUCTION OF RECOMBINANT PROTEINS IN SYNTHETIC MEDIUM  
The invention relates to a method for the production of recombinant proteins by eucaryotic cells in synthetic culture media, wherein said eucaryotic cells are transfected with a composition...
US20110152171 HISTAMINE BINDING PROTEIN  
The invention relates to histamine binding proteins. The invention also relates to the use of such histamine binding proteins in the treatment and prevention of diseases.
US20130084604 Method for improved protein production in filamentous fungi  
The present invention relates to a method for genetically modifying a filamentous fungus host for improved protein production. The method comprises that a filamentous fungus host is genetically...
US20130078674 Method for protein production in filamentous fungi  
The present invention relates to a method for genetically modifying a filamentous fungus host for improved protein production. The method comprises that a filamentous fungus host is genetically...
US20140134673 MEANS AND METHODS FOR PRODUCING AUTHENTIC HUMAN BASIC FIBROBLAST GROWTH FACTOR  
The present invention is concerned with an engineered biological system for production of authentic human basic fibroblast growth factor (hbFGF). The system makes use of a bacterial host and has a...
US20110107466 VIRUS VECTOR AND USE THEREOF  
It is intended to provide a polynucleotide comprising a viral base sequence, the viral base sequence containing: a first base sequence encoding a viral replication protein, and a second base...
US20130231464 METHODS OF USE OF SOLUBLE CD24 FOR THERAPY OF RHEUMATOID ARTHRITIS  
Provided herein is a method of treating rheumatoid arthritis using a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a...
US20130102544 Disease-Associated Proteins  
Disclosed are methods and compositions for early diagnosis, monitoring and treatment of an ocular disorder. In particular, the invention relates to a novel protein, that is differentially...
US20110105411 Disease-Associated Proteins  
Disclosed are methods and compositions for early diagnosis, monitoring and treatment of an ocular disorder. In particular, the invention relates to a novel protein, that is differentially...