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US20110177957 Polymorphisms Associated With Age-Related Macular Degeneration And Methods For Evaluating Patient Risk  
The present invention provides for certain polynucleotide sequences that have been correlated to AMD. These polynucleotides are useful as diagnostics, and are preferably used to fabricate an...
US20150056629 Compositions, systems, and methods for detecting a DNA sequence  
Provided are compositions, systems, and methods that employ one or more fusion protein pairs, wherein each fusion protein within a fusion protein pair comprises a sequence-specific nucleic acid...
US20130089864 METHODS FOR CHARACTERIZING KIDNEY FUNCTION  
Embodiments of the invention relate generally to methods of characterizing kidney function. In particular, several embodiments quantify kidney-associated marker RNA isolated from vesicles...
US20140087390 METHOD AND SYSTEM FOR ANALYSIS OF PROTEIN AND OTHER MODIFICATIONS ON DNA AND RNA  
A protocol and system for determining sites at which proteins directly bind to DNA or RNA, modify other proteins including histones, or bind to other proteins as well as determining sites at which...
US20130089854 KIT FOR DOT IMMUNOGOLD DIRECTED FILTRATION ASSAY AND USE THEREOF  
A kit for dot immunogold directed filtration assay including a dot immunogold directed filtration card, a detection probe labeled by nano colloidal gold or latex beads, a negative standard, a...
US20150119333 METHODS OF INHIBITING ADVERSE CARDIAC EVENTS AND TREATING ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE USING GALECTIN-3 BINDING PROTEIN (GAL-3BP, BTBD17B, MAC-2 BINDING PROTEIN)  
The invention provides Galectin-3 binding protein (Gal-3BP, BTBD17B) polypeptide sequences and compositions that include Gal-3BP polypeptide sequences, and methods of using Gal-3BP polypeptide...
US20110177094 IVIG MODULATION OF CHEMOKINES FOR TREATMENT OF MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, AND PARKINSON'S DISEASE  
The present invention provides methods for providing a prognosis of treatment of diseases associated with inflammatory disease of the brain, including MS, e.g., relapsing-remitting multiple...
US20110081653 High Spatial Resolution Imaging of a Structure of Interest in a Specimen  
In high spatial resolution imaging, a structure in a specimen is marked with a substance which, in a first electronic state, is excited by light of one wavelength to emit fluorescent light, which...
US20100304379 SPORES FOR THE STABILIZATION AND ON-SITE APPLICATION OF BACTERIAL WHOLE-CELL BIOSENSING SYSTEMS  
The presently-disclosed subject matter is directed to biosensors comprising spore-forming bacterial cells and/or spores generated therefrom, a recognition unit within each spore-forming cell for...
US20140220587 METHODS FOR GENOME ASSEMBLY AND HAPLOTYPE PHASING  
The disclosure provides methods to assemble genomes of eukaryotic or prokaryotic organisms. The disclosure further provides methods for haplotype phasing and meta-genomics assemblies.
US20100311045 CANCER  
The invention provides methods of diagnosis, prognosis and treatment of cancer related to the OBCAM and NTM genes. The methods are particularly suited to ovarian and colorectal cancers.
US20120053112 METHODS AND COMPOSITIONS RELATED TO THE REGULATION OF GOBLET CELL DIFFERENTIATION, MUCUS PRODUCTION AND MUCUS SECRETION  
Disclosed are methods and compositions related to the regulation of goblet cell differentiation, mucus production and mucus secretion. In some embodiments, methods for the treatment of mucus...
US20150111217 MARKER QUANTITATION IN SINGLE CELLS IN TISSUE SECTIONS  
Improved assays incorporating single-cell based image analyses that enable quantitation of expression of individual cellular proteins and heterogeneity in terms of individual cellular protein...
US20140322719 Method For Detecting Nucleosome Adducts  
The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention...
US20110256121 METHODS AND KITS FOR DIAGNOSING OR MONITORING AUTOIMMUNE AND CHRONIC INFLAMMATORY DISEASES  
The present invention relates to compositions and methods for diagnosing, monitoring and/or treating disease (e.g., autoimmune or chronic inflammatory disease, heart disease and/or stroke). In...
US20150252408 METHODS AND KITS USEFUL IN THE DIFFERENTIATION OF BURKHOLDERIA SPECIES  
The invention pertains to sequences, methods, and kits useful in the identification of and differentiation between Burkholderia pseudomallei and Burkholderia mallei. The methods generally involve...
US20110177504 METHODS FOR DETECTING INFLAMMATORY BOWEL DISEASE  
The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes...
US20120322674 DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER  
This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer...
US20110123986 METHODS FOR THE DIAGNOSIS OF METABOLIC DISORDERS USING EPIMETABOLIC SHIFTERS, MULTIDIMENSIONAL INTRACELLULAR MOLECULES, OR ENVIRONMENTAL INFLUENCERS  
Methods and formulations for diagnosing metabolic disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described.
US20140255948 SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS  
The present invention relates a simple method for evaluating free eukaryotic cell nuclei for biomarkers of DNA damage and/or transcription factor activation, activity, or expression levels and/or...
US20110275086 NEGATIVE CORRELATION BETWEEN IRP-2 AND TRANSFERRIN RECEPTOR EXPRESSION AS A DIAGNOSTIC OF ALZHEIMER'S DISEASE  
A method of diagnosing Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) is disclosed which was identified by the fact that an increased level of iron regulating protein-2 (IRP-2) was...
US20130337445 METHOD FOR THE CLINICAL DEVELOPMENT AND MEDICAL APPLICATION OF MULTIPLEX ASSAYS DERIVED FROM PATTERNS OF INDIVIDUAL BIOMARKERS OF OXIDATIVE OR NITROSATIVE STRESS  
A method and apparatus for the discovery, development and clinical application of multiplex synthetic assays based on patterns of free radicals, indicators of oxidative or nitrosative stress, or...
US20150099269 Hybridization- Independent Labeling Of Repetitive DNA Sequence In Human Chromsomes  
The present invention discloses a transcription activator-like effector-based strategy, termed “TALEColor”, for labeling specific repetitive DNA sequences in human chromosomes. TALEs were custom...
US20140206014 METHOD FOR DETECTING NUCLEOSOMES CONTAINING HISTONE VARIANTS  
The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such...
US20120237473 Compositions And Methods For Cell Based Retinal Therapies  
The invention relates to pharmaceutical compositions comprising trophic factors, methods to decrease the degeneration of a retina, methods of treating ocular degenerative diseases and methods to...
US20120115132 IDENTIFICATION OF CENTROMERE SEQUENCES USING CENTROMERE ASSOCIATED PROTEINS AND USES THEREOF  
The present invention is directed to methods of centromere discovery using centromere-associated proteins in a variety of experimental formats. The methods of the invention can be used on any...
US20120192315 RESISTANCE GENES AND PROTEINS ACTIVE AGAINST FUSARIUM ROOT ROTS, CYST NEMATODES AND SOYBEAN SUDDEN DEATH SYNDROME AND METHODS EMPLOYING SAME  
Fusarium root rot, cyst nematode and soybean sudden death syndrome resistance genes; Fusarium root rot, cyst nematode and soybean sudden death syndrome resistance proteins; Fusarium root rot, cyst...
US20130089563 METHOD OF DIAGNOSING AND TREATING CANCER  
A method of diagnosing and treating a glioma or a breast cancer is disclosed. The method of diagnosing comprises analyzing an amount or activity of heterogeneous nuclear ribonucleoprotein A2/B1...
US20150253323 METHODS AND KITS FOR HIGH THROUGHPUT SCREENING FOR COMPOUNDS TARGETING DNA-BINDING AND RNA-BINDING PROTEINS  
The present invention provides methods of screening compounds that inhibit or enable or activate or enhance the sequence-specific or nonspecific binding of a polynucleotide binding protein to a...
US20120009589 SUB-DIFFRACTION IMAGE RESOLUTION AND OTHER IMAGING TECHNIQUES  
The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from...
US20150037809 METHOD TO OVERCOME DNA CHEMICAL MODIFICATIONS SENSITIVITY OF ENGINEERED TALE DNA BINDING DOMAINS  
The present invention relates to polypeptides and more particularly to Transcription Activator-Like Effector derived proteins that allow to efficiently target and/or process nucleic acids....
US20100304394 Screening methods involving the detection of short-lived proteins  
A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter...
US20130337464 ARSENIC ASSAY USING ELISA  
The invention relates to a process involving analyzing the presence of arsenic in a sample, comprising the following steps: (a) contacting a sample suspected of containing arsenic on a solid...
US20150111761 SUPER-ENHANCERS AND METHODS OF USE THEREOF  
The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are...
US20140296218 SUPER-ENHANCERS AND METHODS OF USE THEREOF  
The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are...
US20140349304 ASSAY METHODS USING NICKING ENDONUCLEASES  
Assay methods and apparatus for the analysis of biopolymers are disclosed. The assays employ nicking endonucleases to enable the generation of flaps on target biomolecules which are detected in...
US20060029948 Sealing cover and dye compatibility selection  
A method of testing compatibility of a detection probe comprising an oligonucleotide and a fluorophore to a composition of a sealing cover, can comprise (a) depositing a quantity of the...
US20110311970 COMPOSITIONS AND METHODS FOR INTRACELLULAR ANALYTE ANALYSIS  
Compositions and methods for multiplex immunodetection of analytes in single cells or cell populations are described. The invention utilizes analytical nanotags (ANTs) each specific for a...
US20110136103 AUTOANTIBODY ENHANCED IMMUNOASSAYS AND KITS  
The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies...
US20110281744 METHOD OF IDENTIFYING COMPOUNDS THAT MODULATE REGULATION OF IRON RESPONSE ELEMENTS  
The invention features methods for identifying compounds that inhibit binding between iron response elements (IREs) and iron response proteins (IRPs). These compounds are potentially useful for...
US20150152495 COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE SEQUENCING  
Methods and compositions for characterizing a target polynucleotide, including, characterizing the sequence of the target polynucleotide, using the fractional translocation steps of the target...
US20130109018 Methods and Compositions for Detection and Enrichment of Target Small RNAs  
Methods and compositions are provided for detecting small target RNAs where the target RNA may be single-stranded or double-stranded and may be contained in a mixture of RNAs of different types...
US20130089855 METHOD OF CHARACTERIZING VASCULAR DISEASES  
Embodiments of the invention relate generally to methods of diagnosing diseases and measuring homeostatic states. In particular, the methods described here are used to characterize RNA from...
US20130109737 MEDIATOR AND COHESIN CONNECT GENE EXPRESSION AND CHROMATIN ARCHITECTURE  
In some aspects, the present invention provides compositions and methods relating at least in part to modulation of the Cohesin-Mediator interaction. The invention provides compositions and...
US20140162280 METHODS AND SYSTEM FOR THE AUTOMATED DETERMINATION OF IMMUNOFLUORESCENT FOCI USING A CELL-BASED IMMUNOFLUORESCENCE ASSAY USING SYNTHETIC CALIBRATION PARTICLES  
The invention relates to a method for automated determination of immunofluorescent foci by means of an immunofluorescence assay using synthetic calibration particles, in addition to a system and...
US20110196042 COMPOSITIONS AND METHODS FOR INFLUENCING SATIETY, LIPID METABOLISM, AND FAT UTILIZATION  
The invention provides (1) genes differentially expressed in animals administered fatty acid amides that affect one or more of food intake, satiety, lipid metabolism, and fat utilization and (2)...
US20110306508 Method of Mycotoxin Detection  
The presence of mycotoxins in agricultural products necessitates large scale testing of a wide range of sample material to ensure the safety of food and feed. The mycotoxin ochratoxin A represents...
US20130203052 FREE CIRCULATING DNA BIO-MARKERS AND THEIR APPLICATIONS  
This invention relates generally to methods for detecting cell damage as a consequence of pathophysiological or traumatic insults such as in a nuclear accident, bioterror attack, tumorigenesis,...
US20130252245 METHOD FOR DETECTING THE PRESENCE OF A GYNAECOLOGICAL GROWTH  
The invention relates to a method for detecting the presence of a gynaecological growth, in particular for the diagnosis of endometriosis. The invention also relates to a method of identifying a...
US20140206013 SPLIT PEROXIDASES AND METHODS OF USE  
An imaging method utilizing a split peroxidase is described herein. Imaging methods involve contacting a cell with a split peroxidase and a substrate thereof to allow conversion of a substrate...

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