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US20100323361 METHODS, SYSTEMS AND KITS FOR DETECTING PROTEIN-NUCLEIC ACID INTERACTIONS  
Methods, systems and kits for detecting protein-nucleic acid interactions, in particular, detecting the genomic location to near-base pair resolution at which a particular protein (e.g.,...
US20120028264 METHOD FOR USING GENE EXPRESSION TO DETERMINE PROGNOSIS OF PROSTATE CANCER  
Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis...
US20120135402 GENE SEQUENCE VARIANCES IN GENES RELATED TO FOLATE METABOLISM HAVING UTILITY IN DETERMINING THE TREATMENT OF DISEASE  
The present disclosure describes the use of genetic variance information for folate transport or metabolism genes or pyrimidine transport or metabolism genes in the selection of effective methods...
US20130210024 COMBINATION TREATMENT OF CANCER  
The present technology relates to a method of treating cancer by sensitizing human tumours to DNA damaging therapies through activating FBXO32 expression. Transactivation of FBXO32 through the...
US20120214677 LUCIFERASE BIOSENSOR  
A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided.
US20110287963 SYSTEM USEFUL FOR REPORTING PROTEIN-PROTEIN INTERACTIONS IN THE BACTERIAL PERIPLASM  
One aspect of the present invention relates to a reporter system for detection of protein-protein interactions in the periplasm of a prokaryotic host cell. The reporter system includes a first...
US20110250609 Methods For The Detection, Analysis And Isolation Of Nascent Proteins  
This invention relates to non-radioactive markers that facilitate the detection and analysis of nascent proteins translated within cellular or cell-free translation systems. Nascent proteins...
US20120171693 Methods for Generating Novel Stabilized Proteins  
The disclosure provides methods for identifying and producing stabilized chimeric proteins.
US20120040367 CONSTRUCT SYSTEM AND USES THEREFOR  
The present invention discloses construct systems and methods for comparing different iso-accepting codons according to their preference for translating RNA transcripts into proteins in cell or...
US20120171694 PREDICTIVE MARKERS AND BIOMARKER PANELS FOR OVARIAN CANCER  
Methods are provided for predicting the presence, subtype and stage of ovarian cancer, as well as for assessing the therapeutic efficacy of a cancer treatment and determining whether a subject...
US20110281750 Identifying High Risk Clinically Isolated Syndrome Patients  
Disclosed herein are methods and kits for identifying clinically isolated syndrome (CIS) patients at high risk of developing multiple sclerosis (MS).
US20110287957 METHODS AND KITS FOR DIAGNOSING COLORECTAL CANCER  
The invention pertains to a method for early detection and screening of colorectal cancer in human subjects based on RNA isolated from blood obtained from said subject. According to the invention,...
US20100323358 Use of KIR genes for predicting response to therapy  
The present invention relates to the use of at least one Killer cell immunoglobulin-like receptor gene for the identification of subjects likely to respond to tumour necrosis factor-based therapy....
US20110183858 GRADING OF BREAST CANCER  
Methods and compositions for the identification of breast cancer grade signatures are provided. The signature profiles are identified based upon multiple sampling of reference breast tissue samples...
US20110230372 GENE EXPRESSION CLASSIFIERS FOR RELAPSE FREE SURVIVAL AND MINIMAL RESIDUAL DISEASE IMPROVE RISK CLASSIFICATION AND OUTCOME PREDICTION IN PEDIATRIC B-PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA  
The present invention relates to the identification of genetic markers patients with leukemia, especially including acute lymphoblastic leukemia (ALL) at high risk for relapse, especially high risk...
US20120148559 COMPOSITIONS AND METHOD FOR DEIMMUNIZATION OF PROTEINS  
The invention provides deimmunized mutant proteins having reduced immunogenicity while exhibiting substantially the same or greater biological activity as the proteins of interst from which they...
US20120040848 MOLECULAR SIGNATURE OF LIVER TUMOR GRADE AND USE TO EVALUATE PROGNOSIS AND THERAPEUTIC REGIMEN  
The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a...
US20110183862 MOLECULAR SIGNATURE OF LIVER TUMOR GRADE AND USE TO EVALUATE PROGNOSIS AND THERAPEUTIC REGIMEN  
The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a...
US20100297639 QUANTITATIVE/SEMI-QUANTITATIVE MEASUREMENT OF EPOR ON CANCER CELLS  
The present invention provides for assays useful in predicting whether a cancer patient risks suffering erythropoietin-induced tumor progression if treated with erythropoietin. More specifically,...
US20110104693 QUANTITATIVE NUCLEASE PROTECTION SEQUENCING (qNPS)  
The present invention provides a new approach, quantitative Nuclease Protection Sequencing (qNPS™), for addressing several challenges that face sequencing and which provides improvements for r...
US20110091502 HUMAN PARVOVIRUS: HUMINK PARVOVIRUS  
Provided herein are sequences of the genomes and encoded proteins of a new human parvovirus, Humink parvovirus, and variants thereof. Also provided are methods of detecting the Humink parvovirus...
US20100310574 METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF STATIN-INDUCED MYOPATHY  
The invention provides compositions and kits containing an atrogin-1 inhibitor compound useful for the treatment of a statin-mediated myopathy. Kits for the diagnosis of a statin-mediated myopathy...
US20110150774 SCREENING FOR MODULATORS OF CES1 AND/OR CES3 FOR THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA  
An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea,...
US20120225425 Cathepsin E as a Marker of Colon Cancer  
Elevated levels of cathepsin E (catE) are demonstrated to be diagnostic of intestinal forms of cancer, such as colorectal cancer. Elevated levels of cathepsin E (catE, monomeric forms) are...
US20110044960 MEDICAMENT, DENTAL MATERIAL, AND METHOD OF SCREENING  
The present invention provides a novel and creative dental materials for treatment of pulpitis and/or enhancement of dentinogenesis. The dental materials of the present invention contain at least...
US20120122113 Signature Of Secreted Protein Isoforms Specific To Ovarian Cancer  
The present invention relates to the identification of secreted protein isoforms specific in ovarian cancer and methods for diagnosis or prognosis of ovarian cancer in a subject by detecting the...
US20140234287 SUMOYLATION OF SERCA2a AND CARDIOVASCULAR DISEASE  
Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a modulator of SERCA2a post-translation...
US20110262920 METHODS FOR PREDICTING SURVIVAL IN CANCER PATIENTS  
A method for survival prediction in cancer patients is provided. In one embodiment, the survival prediction is determined by the presence or absence of KRAS gene region deletion and/or loss of...
US20130305413 Pericarp tissue preferred regulatory region and method of using same  
A Zea mays regulatory region is shown, which provides improved seed preferred, and particularly pericarp preferred expression in plants. Methods of use are also shown in preferentially expressing a...
US20120121573 Treatment of Pulmonary Vascular Remodeling With Neprilysin  
The present invention relates to agonists of Neprilysin and their use in preventing and treating pulmonary vascular remodeling. Also described are diagnostic and screening applications stemming...
US20140249150 ACTIVATORS OF PYRUVATE KINASE M2 AND METHODS OF TREATING DISEASE  
The invention described herein features methods, compositions, and kits that utilize activators of pyruvate kinase M2 (PKM2) for the treatment or amelioration of disorders related to PKM2 function...
US20110212847 COMPOSITIONS AND METHODS RELATING TO MONITORING ALCOHOL CONSUMPTION AND ALCOHOL ABUSE  
Methods and compositions according to embodiments of the present invention are provided that specifically and sensitively detect alcohol consumption and whether alcohol consumption is moderate or...
US20110072539 Compositions and Methods for Modulating Pigment Production in Plants  
This invention relates to polynucleotides encoding novel transcription factors and to the encoded transcription factors, that are capable of regulating anthocyanin production in plants. The...
US20110189669 METHODS OF AIDING IN THE DIAGNOSIS OF PROSTATE CANCER  
The current invention provides a method for aiding in the assessment of prostate cancer (including metastatic prostate cancer) and/or benign prostate hyperplasia in a patient, wherein the method...
US20110097715 METHOD FOR PURIFYING OR DETECTING A TARGET PROTEIN  
A method for purifying or detecting a target protein present in a solution, includes, before carrying out the actual detection or purification step, a step of contacting the solution with an...
US20100322949 METHODS FOR DIAGNOSING AND TREATING ASTROCYTOMAS  
The invention relates to the identification of astrocytoma markers, astrocytoma stem cells and markers of such stem cells, and diagnostic, prognostic and therapeutic methods based on an...
US20100330575 MOLECULAR DIAGNOSTICS REAGENTS AND METHODS  
The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all...
US20110183337 Method and Kit for Use in the Differentiation of IBD and IBS and Further Distinction Between Disease Types of IBD  
A quantification of the expression levels of a number of specific genes and their corresponding proteins can be utilized in accurately determining, using samples from faeces or blood, whether the...
US20100129797 USE OF GENETIC MODIFICATIONS IN HUMAN GENE CHK1 WHICH CODES FOR CHECKPOINT KINASE 1  
The invention relates to an in vitro method for predicting disease risks, progression of diseases, drug risks, success of treatment and for finding drug targets by looking for one or more genetic...
US20110067147 Development of Very Early Flowering and Normal Fruiting Plum With Fertile Seeds  
To produce early flowering genotypes, plum (Prunus domestica) was transformed with the poplar (Populus trichocarpa) Flowering Locus T1 (PtFT1) gene. Ectopic expression of 35S::PtFT1 Induced early...
US20110059449 METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING TRANSPLANT REJECTION  
Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the...
US20120171688 Gene Expression Markers for Colorectal Cancer Prognosis  
A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression...
US20110251086 NEUROBLASTOMA PROGNOSTIC MULTIGENE EXPRESSION SIGNATURE  
The current invention relates to new tools and methods enabling neuroblastoma patient stratification into prognostic favorable or unfavorable groups. The invention is based on the re-analysis of...
US20050164208 Storage of genetic information  
Methods for the long-term storage of hereditary information such as DNA are described herein. In some instances, lyophilized DNA and sugar is introduced into a hermetically sealed vial. Kits for...
US20120077203 REPORTER GENE CONSTRUCT, ASSAY KIT AND DETECTION METHOD  
According to one embodiment, there is provided a reporter gene construct. The reporter gene construct comprises a transcriptional regulatory sequence and a reporter gene that is functionally bound...
US20120213761 USE OF GSTP1  
The invention discloses the use of glutathione S-transferase P1 (GSTP1) for the prevention or treatment of cardiomyopathies or ischemic heart diseases and for the diagnosis thereof.
US20120225433 Gene Expression Markers for Breast Cancer Prognosis  
The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
US20110003704 USE OF MICROVESICLES IN DIAGNOSIS AND PROGNOSIS OF MEDICAL DISEASES AND CONDITIONS  
The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker...
US20110281270 EFFICIENT DETECTION OF DOUBLE MUTANTS OF THE CEBPA GENE IN ACUTE MYELOID LEUKEMIA  
The invention is in the field of molecular diagnostics for cancer, in particular, for acute myeloid leukemia (AML). The invention provides methods for diagnosing AML patients with a favorable...
US20120020954 METHODS OF PREDICTING CLINICAL COURSE AND TREATING MULTIPLE SCLEROSIS  
Provided are methods and kits for classifying a subject as being more likely to have benign multiple sclerosis (BMS) or as being more likely to have typical relapsing remitting multiple sclerosis...