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US20110009473 |
PTTG1 AS A BIOMARKER FOR CANCER TREATMENT
The present invention relates to the use of pituitary tumor transforming gene 1 (PTTG1) as a biomarker for diagnosing cancer as well as for determining cancer treatment responsiveness. In one... |
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US20100136562 |
Multivariate Analysis Involving Genetic Polymorphisms Related To Mediators Of Inflammatory Response For Prediction Of Outcome Of Critcally Ill Patients
A method of using genetic polymorphisms related to pro-inflammatory mediators to predict clinical outcome in critically ill patients admitted to an ICU is provided. |
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US20100136541 |
IDENTIFICATION AND VERIFICATION OF METHYLATION MARKER SEQUENCES
The present invention relates to methods for identifying among the genes that are down-regulated in cells or tissues having disease including cancer, the CpG sites within the CpG islands of said... |
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US20090253132 |
MUTATED ACVR1 FOR DIAGNOSIS AND TREATMENT OF FIBRODYPLASIA OSSIFICANS PROGRESSIVA (FOP)
This invention is directed to mutated Activin A type I receptor proteins (ACVR1) and isolated nucleic acids encoding same. The invention also relates to the use of mutated ACVR1 in the diagnosis... |
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US20080096195 |
Salmonella Selective Enrichment Medium Containing Tetrathionate and Magnesium Salt
The invention relates to a salmonella selective enrichment medium containing tetrathionate or a salt thereof and at least one type of magnesium salt and to a method for detecting salmonella in a... |
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US20100209920 |
Gene Expression Profiling in Biopsied Tumor Tissues
The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets... |
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US20110236897 |
NOVEL MARKERS FOR DIAGNOSING BRAIN DISEASE CAUSED BY BRAIN INJURY AND USE THEREOF
The present invention relates to novel markers for diagnosing brain disease caused by brain injury and the use thereof. More particularly, the present invention relates to novel diagnostic markers... |
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US20110045478 |
Genetic Fingerprinting And Identification Method
The present disclosure provides methods for molecular fingerprinting for the characterization and identification of organisms. More specifically, in one aspect the present invention provides a... |
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US20110034476 |
GENETIC POLYMORPHISMS AND INFERTILITY
Methods of screening for a cause of low sperm motility and/or for mitochondrial impairment in subjects are provided, comprising determining a genotype of the subject with respect to at least one... |
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US20060141472 |
Medical use of ras antagonists for the treatment of capillary malformation
The invention relates to the field of vascular anomalies and methods for diagnosing and treating them. The invention provides for the causative gene (RASA1) and mutations therein which are useful... |
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US20070003946 |
Use of biomarkers in screening for insulin resistance
The invention relates to methods and biomarkers useful in screening subjects for insulin resistance and for monitoring insulin resistance over time or after medical intervention. |
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US20060154265 |
LDLR genetic markers associated with age of onset of Alzheimer's Disease
Haplotypes in the LDLR gene associated: with age of onset of Alzheimer's Disease are disclosed. Compositions and methods for detecting and using these LDLR haplotypes in a variety of clinical... |
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US20050255495 |
SLC5A7 genetic markers associated with age of onset of Alzheimer's disease
Haplotypes in the SLC5A7 gene associated with age of onset of Alzheimer's Disease are disclosed. Compositions and methods for detecting and using these SLC5A7 haplotypes in a variety of clinical... |
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US20080160533 |
Assay for prediction of response to Met antagonists
A method for classifying cancer patients as likely to have lower response to MET receptor antagonist therapy comprises assessment of the presence or absence of a single nucleotide polymorphism in... |
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US20050214811 |
Processing and managing genetic information
Changes in association between a genetic variant and a disorder can be used as a prompt to automatically revise the diagnosis based on the patient's genetic information. For example, revisions in... |
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US20060019237 |
In vitro wound healing assay and device
Devices for creating model wounds in vitro are provided, along with kits and systems including the devices. Methods for making such devices and for modeling wounds are also provided. |
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US20110166206 |
UBIQUILIN REGULATION OF PRESENILIN ENDOPROTEOLYSIS, AND SUPPRESSION OF POLYGLUTAMINE-INDUCED TOXICITY IN CELLS
Use of ubiquilin is described, including utilization for reducing fragmentation of presenilin 1 and 2 and to modulate γ-secretase components, Pen-2 and Nicastrin, as well as utilization for... |
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US20100299770 |
TARGETED CELL DEATH
The present invention provides compositions and methods for studying neuropathy. The compositions and methods provided herein are particularly useful for screening agents of therapeutic and/or... |
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US20050287574 |
Genetic diagnostic method for SCD risk stratification
A method of classifying individuals as to their risk of experiencing sudden cardiac death (SCD) utilizes single nucleotide polymorphisms (SNPs). A genotype profile, which includes one or more... |
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US20100303813 |
BIOMARKERS FOR PREDICTING ANTI-TNF RESPONSIVENESS OR NON-RESPONSIVENESS
The present disclosure provides biomarkers that are predictive a subject's responsiveness or non-responsiveness to an anti-TNF therapy. The biomarkers, compositions, and methods described herein... |
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US20090247454 |
Method for detecting a predisposition to develop gestational diabetes mellitus and treatment for this disease
Methods and kits for detecting a predisposition to develop gestational diabetes mellitus and pharmacological treatment for this disease. |
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US20110091866 |
DETECTION OF POLYOMAVIRUS
Methods and kits are provided for testing for the presence or absence of a polyomavirus, such as BKV, in a sample. The methods and kits are useful for quantifying BKV and differentiating BKV from JCV. |
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US20080182244 |
Pre-Implantation Genetic Diagnosis Test
A method for determining viable normal blastomeres for implantation entailing labeling the blastomere with an antibody to hyperglycoslyated hCG and determining the binding of chromosomal probes... |
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US20090227464 |
Prognosis determination in ewing sarcoma patients by means of genetic profiling
The present invention provides a method for assessing the prognosis of Ewing's Sarcoma patients comprising determining the expression pattern of a defined set of genes in tumor material obtained... |
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US20070077586 |
Maternal Chelation for Embryo, Fetal, and Infant Benefit
This invention teaches the use of chelating agents to diagnose and treat metal toxins in a patient. Chelation agents are given to the mother for the benefit of the baby. Metal toxins such as lead,... |
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US20090304736 |
NOVEL TUMOR ANTIGENS ELICIT ANTI-TUMOR HUMORAL IMMUNE REACTIONS IN A SUBSET OF PATIENTS WITH POLYCYTHEMIA VERA
The invention provides novel antigens, MPD5, PV13, and PV65, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame... |
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US20100077491 |
Modulators of RNF5 and Uses Thereof
Provided herein are compositions and methods relating to the involvement of RNF5 in muscle wasting. |
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US20080312519 |
Examination unit with an integrated mini-laboratory analysis unit
An examination unit, which can be used especially in the area of acute and intensive diagnostics in hospitals (e.g. in emergency rooms, intensive care units, operating theaters etc.) or in... |
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US20090093395 |
METHOD FOR DETERMINING PREDISPOSITION TO PULMONARY INFECTION
Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection... |
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US20110033843 |
METHOD FOR IN VITRO TESTING OF COMPOUNDS FOR ASSESSING THERAPEUTIC VALUE IN THE TREATMENT OF MULTIPLE SCLEROSIS AND OTHER DISEASES WHEREIN FOAMY CELLS ARE INVOLVED IN THE DISEASE ETIOLOGY
The invention provides a method for assessing or determining activity of a test Compound on modulation of gene product levels comprising culturing cells, contacting at least one of the cultured... |
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US20070087330 |
Viral deconstruction through capsid assembly in vitro
A cell-free method for translation and assembly of viral capsid and capsid intermediates is disclosed for use in deconstructing an unknown virus and for screening for compounds that inhibit... |
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US20100284915 |
GENES ASSOCIATED WITH CHEMOTHERAPY RESPONSE AND USES THEREOF
The invention provides molecular markers that are associated with responsiveness of a cancer patient to a chemotherapy treatment, and methods and computer systems for determining such... |
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US20100021913 |
Stimulus-Elicited Genomic Profile Markers of Alzheimer's Disease
The present invention relates to a method for diagnosing Alzheimer's Disease (AD) using PKC-elicited gene expression profiles PKC-activation elicits different genomic profiles in AD cells, as... |
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US20100323349 |
Identification of the Gene and Mutation Responsible for Progressive Rod-Cone Degeneration in Dog and a Method for Testing Same
Tools and methods are provided for determining whether or not a dog is genetically normal, is a carrier of, or is affected with or predisposed to progressive rod-cone degeneration. The method is... |
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US20100304988 |
DIAGNOSTIC OF IMMUNE GRAFT TOLERANCE
The present invention concerns a method for the in vitro diagnosis of a graft tolerant phenotype, comprising: determining from a grafted subject biological sample an expression profile comprising,... |
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US20060258607 |
Ghrelin binding nucleic acids
The present invention is related to a nucleic acid, preferably binding to ghrelin, whereby the nucleic acid comprises a first stretch Box A, and a second stretch Box B, whereby the first stretch... |
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US20080113345 |
Predicting Response And Outcome Of Metastatic Breast Cancer Anti-Estrogen Therapy
Gene signatures, specific marker genes, and diagnostic assays for predicting progression free survival and objective response to anti-estrogen, e. g., tamoxifen therapy for recurring breast cancer... |
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US20100151480 |
EXOSOME-ASSOCIATED MICRORNA AS A DIAGNOSTIC MARKER
The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more RNAs present in cancer-derived... |
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US20100144838 |
Methods for Identifying Modulators of Pyrimidine Tract Binding Protein
Provided herein are methods and materials for identifying compounds that modulate polypyrimidine tract binding protein (PTB), a protein that functions as a negative regulator of pre-mRNA splicing... |
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US20090042208 |
Assays for erectile and bladder dysfunction and vascular health
Assays are provided for erectile and bladder dysfunction and vascular health (e.g., cardiovascular disease, hypertension), where the assays detect the expression of one or more of the human Vcsa1... |
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US20070218482 |
DIAGNOSTIC ASSAY FOR LUNG TRANSPLANT
Methods and compositions for determining the suitability of a lung for transplantation are described. |
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US20100317532 |
INHIBITION-BASED HIGH-THROUGHPUT SCREEN STRATEGY FOR CELL CLONES
A method for screening cells with high level expression of a target protein is disclosed. The method includes introducing into a plurality of host cells a DNA construct that encodes both a target... |
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US20110091524 |
BIOMARKERS FOR SENSITIVITY TO ANTI-IGF1R THERAPY
The present invention provides, for example, methods for conveniently determining if a cancerous condition in a subject will be responsive to an IGF1R inhibitor. The invention includes patient... |
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US20090055939 |
Probe for detection and quantification of nitric oxide, and method for detecting and quantifying nitric oxide using the same
Probe 1 for detection and quantification of nitric oxide, which, comprises two subunits 21 and 22 of soluble guanylate cyclase 2 and cGMP-visualization probes 3 respectively connected with each... |
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US20090305259 |
Early Diagnosis of Congenital Abnormalities in the Offspring of Diabetic Mothers
The present invention relates to the identification of a series of biomarkers, the detection of which is prognostic for women at risk of becoming hyperglycemic during pregnancy and/or fetuses at... |
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US20090214555 |
Proteoglycan Splice Variants as Therapeutics and Diagnostics for Amyloid Diseases
The identification of novel Syndecan-2 splice variants and their use in the diagnosis and therapeutic intervention of Alzheimer's disease and other amyloid diseases. In addition the use of new... |
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US20110229905 |
COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CANCER AND NEURODEGENERATIVE DISEASES RLATED TO BECLIN-1
The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing... |
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US20110060605 |
METHODS FOR PREDICTING RESPONSIVENESS OF A DISEASE OR DISORDER TO A RECEPTOR TYROSINE KINASE INHIBITOR BY ANALYSIS OF MUTATIONS IN PIK3CA
The present disclosure relates generally to methods and materials for determining the responsiveness of a subject with a disease or disorder to an inhibitor of a receptor tyrosine kinase... |
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US20060127917 |
Comprehensive virus disinfecting strategy and methods for making a preventive anti-virus medical product
The present invention provides a comprehensive virus disinfecting strategy with more than two biologically active anti-virus components work synergistically to form a multi-hurdle defending line... |
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US20070248981 |
Predicting mortality and detecting severe disease
Measurement of circulating ST2 and/or IL-33 concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, and... |