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US20110171654 Allelic ladder loci  
Disclosed are rare short tandem repeat (STR) alleles within the D10S1248 and D12S391 loci in humans. Provided are representative allelic ladders for each locus, methods and assays using these...
US20150140568 REFERENCE MARKERS FOR BIOLOGICAL SAMPLES  
DNA oligomers comprising sequences that are absent from the genome of one or more organisms of interest are used as reference markers (RMs). The RMs are added to biological samples to “tag” and...
US20120115154 REFERENCE MARKERS FOR BIOLOGICAL SAMPLES  
DNA oligomers comprising sequences that are absent from the genome of one or more organisms of interest are used as reference markers (RMs). The RMs are added to biological samples to “tag” and...
US20140274777 LIPID DROPLET PROTEIN MARKERS FOR ALGAL OIL ACCUMULATION  
The application relates to apparatuses, methods and kits for detecting and quantifying oil content in algal samples.
US20120315638 Moisture-Activated Self-Heating Analysis Device  
Provided are disposable, moisture-activated, self-heating cartridges useful for, e.g., isothermal nucleic acid amplification, incubation, and thermal actuation, and visual fluorescent detection of...
US20110104669 METHOD TO PREDICT IRIS COLOR  
The invention comprises a method to predict iris color of a human from a nucleic acid/protein sample comprising assaying for one or more polymorphisms in the region 5′ proximal of the OCA2 gene up...
US20140154696 PCR DIAGNOSTICS OF DERMATOPHYTES AND OTHER PATHOGENIC FUNGI  
Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic...
US20100311041 PCR DIAGNOSTICS OF DERMATOPHYTES AND OTHER PATHOGENIC FUNGI  
Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic...
US20140030715 METHOD OF USING BOTH MIR-196A AND MIR-196B AS BIOMARKERS FOR DETECTING ORAL CANCER  
A method of using miR-196a and miR-196b as biomarkers for oral cancer detection is provided with the steps of analyzing a sample from each of a plurality of human beings in terms of miR-196a and...
US20140206008 Salivary Protein Biomarkers for Human Oral Cancer  
The present invention relates to the identification of novel oral cancer and periodontal disease biomarkers. Further, the present invention provides novel methods of diagnosing and for providing a...
US20150110897 Sperm Protein as a Detection Biomarker of Early Stage Ovarian Cancer  
This disclosure provides a method for determining if a patient is likely to, or not likely to, experience ovarian cancer utilizing SP17 as a biomarker. It also provides methods and therapies to...
US20120231453 Brownian Microbarcodes for Bioassays  
An encoded microparticle carrying a spatial code is provided; and a set of encoded microparticles are provided with distinguishable spatial codes, wherein the codes comply with a pre-determined...
US20120028261 PROTEIN BIOMARKERS FOR SOFT TISSUE DISEASE DIAGNOSIS AND AS THERAPEUTIC TARGETS FOR ORAL CARE INTERVENTION  
Methods for identifying compounds useful for treating diseases or conditions of the oral cavity are described herein.
US20120204276 METHODS RELATED TO A MUTATION IN COMPLEMENT FACTOR H-RELATED PROTEIN 5 IN PATIENTS WITH GLOMERULONEPHRITIS  
The invention relates to methods of regulating complement. In particular, the inventors have identified a relationship between a particular gene, CFHR5, and irregularities in complement...
US20140056998 SYSTEM AND METHOD FOR DIAGNOSIS AND TREATMENT OF NEUROPSYCHIATRIC DISORDERS  
An assay for a GCH1 allele and associated genotype for the screening, prediction, diagnosis, prognosis, treatment and treatment response of psychiatric, neuropsychiatric, and neurological...
US20150250770 LKB1 AS PREDICTIVE MARKER OF EVEROLIMUS EFFICACY IN BREAST CANCER  
Method for identifying a breast cancer likely to respond to treatment with everolimus comprising the following steps: Measuring the level of expression of the LKB 1 gene in a breast tumour sample...
US20110123990 Methods To Predict Clinical Outcome Of Cancer  
The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More...
US20120207708 BIOMARKERS FOR CANCER-RELATED FATIGUE AND USE THEREOF  
Described herein is the identification of genes that are significantly up- or down-regulated in patients suffering from cancer-related fatigue (CRF), providing a means for the diagnosis and...
US20150252415 ARID1B AND NEUROBLASTOMA  
Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common solid tumor in children. We performed whole-genome sequencing (6 cases), exome sequencing (16 cases),...
US20150086993 MICROFLUIDIC THREE-DIMENSIONAL OSTEOCYTE NETWORK RECONSTRUCTED WITH MICROBEADS AS SCAFFOLD  
A bed of microbeads is used as a foundation for reconstructing a three-dimensional osteocyte network by culturing osteocytes within the bed. The osteocytes are cultured such that they form a...
US20110150935 TARGETED TREATMENT FOR PATIENTS WITH ESTROGEN RECEPTOR NEGATIVE AND PROGESTERONE RECEPTOR NEGATIVE BREAST CANCERS  
Treatments for estrogen receptor and progesterone receptor negative breast cancer or estrogen receptor, progesterone receptor and c-erbB2 negative (triple negative) breast cancer are provided.
US20110143962 METHOD OF EVALUATING ORAL CANCER RISK IN HUMAN  
A method of providing a risk evaluation and diagnosis of human oral cancer, by examining at the presence in human saliva sample of a combination of particulate nucleic acids from bacteria, virus,...
US20140274773 SYSTEMS AND METHODS FOR EMPLOYING PODOCALYXIN AND TRA HUMAN STEM CELL MARKERS AS PROGNOSTIC MARKERS FOR AGGRESSIVE AND METASTATIC CANCER  
The invention relates to systems and methods to detect podocalyxin-expressing and TRA-expressing cancer stem cells or cancer cells with stem cell-like properties in a tissue cell sample obtained...
US20140237630 SCREENING METHOD  
The present invention provides a method of screening a mammal for the onset or predisposition to the onset of a neuropsychiatric disorder. More particularly, the present invention provides a...
US20140227705 SAFE SEQUENCING SYSTEM  
The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing...
US20120108464 TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN  
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system...
US20150057181 MICRORNA SIGNATURES INDICATIVE OF IMMUNOMODULATING THERAPY FOR MULTIPLE SCLEROSIS  
The present invention provides methods, systems, and kits for evaluating multiple sclerosis (MS) in a patient. Particularly, the invention provides convenient miRNA-based tests for evaluating a...
US20140017227 GENE SIGNATURES FOR USE WITH HEPATOCELLULAR CARCINOMA  
The present invention provides a method for predicting prognosis of hepatocellular carcinoma patients based on measurement of the relative level of expression of a combination of 15 immune genes...
US20110319472 METHODS OF PROGNOSTICATING AND TREATING EWING SARCOMA/PNET AND OTHER NEOPLASMS  
A method of distinguishing between Ewing sarcoma patients having a good prognosis relative to those having a poor prognosis by screening for specific genomic copy number alterations (CNA) isolated...
US20120129167 TRUNCATED CD20 PROTEIN, DELTACD20  
The present invention relates in particular to a protein from an alternative splicing of the gene encoding CD20, the nucleic acid sequences encoding the protein according to the invention, a...
US20140378334 METHOD FOR QUANTIFYING RENAL MARKERS BY ASSAYING URINE  
The invention pertains to a method of in vitro diagnosis of pathologies in a patient. According to the invention, the method comprises the following steps: a) obtaining a urine sample from said...
US20120040906 PROTEIN TARGETS IN DISEASE  
MicroRNAs have been shown to be critically involved in control of cell survival and cell death decisions. By identifying microRNAs implicated in Endoplasmic Reticulum stress-induced cardiomyocyte...
US20110306049 METHOD FOR DETECTING GYNECOLOGIC CANCER  
The object of the present invention is to provide a method for detecting gynecologic cancer and a kit for detecting the same. The object can be solved by a method for detecting gynecologic cancer...
US20120220487 Determination of 17q Gain in Neuroblastoma Patients by Analysis of Circulating DNA  
Methods for diagnosis of neuroblastoma comprising determining whether there is a gain of genetic material from chromosome arm segment 17q21-qter in the circulating DNA of a human subject.
US20130172186 PROTEINS RELATED TO THE SUPPRESSION OF PHYTOPHTHORA INFECTIONS IN MEMBERS OF THE SOLANACEAE FAMILY  
The present disclosure provides a method of suppressing oomycete infection, such as a Phytophthora infection, or triggering programmed cell death in Solanaceae plants comprising administering at...
US20130281502 POST-TREATMENT BREAST CANCER PROGNOSIS  
The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to extended treatment and cancer-free survival in a patient. In particular, the...
US20120184454 GENE SIGNATURE IS ASSOCIATED WITH EARLY STAGE RECTAL CANCER RECURRENCE  
Applicants have identified a 36-gene signature that is associated with recurrence of stage I and II rectal cancers not treated with chemotherapy or radiation. This signature can be used to...
US20120245235 CLASSIFICATION OF CANCERS  
A system for classifying a patient's cancer as belonging to one or more Cancer Modules of 1 of 15 different cancer types is provided. The Cancer Modules are useful to identify patient populations...
US20130158023 IDENTIFICATION OF GENE EXPRESSION AS A PREDICTIVE BIOMARKER FOR LKB1 STATUS  
Provided herein are methods for predicting the LKB1 status of a patient or a biological sample, comprising the measurement of particular gene expression levels relative to a set of reference...
US20150133326 BIOMARKERS FOR RECOVERED HEART FUNCTION  
Disclosed herein is a method for determining recovered heart function in a subject based in the biomarker ceruloplasmin in patient samples. Also disclosed are computer systems, kits and software.
US20130065786 METHOD FOR BREAST CANCER RECURRENCE PREDICTION UNDER ENDOCRINE TREATMENT  
The present invention relates to methods, kits and systems for the prognosis of the disease outcome of breast cancer, said method comprising: (a) determining in a tumor sample from said patient...
US20120021935 SIGNATURE FOR THE DIAGNOSIS OF CANCER AGGRESSIVENESS AND GENETIC INSTABILITY  
The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of said patient, comprising: a) measuring in vitro...
US20140141420 METHOD FOR SUCCESSFUL RETRIEVAL OF SPERM  
Measurement of expression levels of heat shock factor Y chromosome (HSFY) in testicular tissue samples or semen can be used to identify whether testicular sperm extraction can be used for patients...
US20140038186 ALZHEIMER'S DISEASE-SPECIFIC ALTERATIONS OF PROTEIN KINASE C EPSILON (PKC-EPSILON) PROTEIN LEVELS  
The present invention relates to methods of diagnosing Alzheimer's Disease in a human patient by detecting alterations in the ratio of PKC epsilon protein levels in a human patient compared with...
US20140143897 EPHA4 IS A DISEASE MODIFIER IN MOTOR NEURON DISEASE  
The present application relates to the field of motor neuron diseases, most particularly to amyotrophic lateral sclerosis and spinomuscular atrophy. Provided herein are strategies to improve...
US20130089864 METHODS FOR CHARACTERIZING KIDNEY FUNCTION  
Embodiments of the invention relate generally to methods of characterizing kidney function. In particular, several embodiments quantify kidney-associated marker RNA isolated from vesicles...
US20150258170 Diagnosis and Treatment of SMA and SMN Deficiency  
The present invention provides for methods for diagnosing and treating a motor neuron disease. More specifically, the present invention offers new methods for diagnosing and treating SMA or SMN...
US20120064087 METHODS TO DIAGNOSE A REQUIRED REGULATION OF TROPHOBLAST INVASION  
Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-β3, receptors of cytokines of the TGfβ family, or...
US20140024811 CANCER DETECTION  
Provided are methods of detecting cancer or pre-cancerous conditions in patients comprising assaying a patient sample for an elevated level of target molecules representative of expression of...
US20140274780 METHODS OF IMPROVING SURVIVAL IN CANCER  
Methods of improving cancer therapy outcomes are provided. Diagnostics useful for evaluating patients based on microRNA signatures of cancer tissue are provided.