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US20110045594 GENETIC REMODELING IN BIFIDOBACTERIUM  
A Bifidobacterium comprising a genome that is customized so as to lack an operable functional gene is disclosed. A method of making such cells is also disclosed. The method is used to make...
US20140141516 METHODS AND COMPOSITIONS FOR GENETICALLY ENGINEERING CLOSTRIDIA SPECIES  
The present invention relates to methods and compositions for engineering Clostridia species. In particular, embodiments of the present invention relate to the expression of recombinant resolvase...
US20120301964 METHODS AND COMPOSITIONS FOR GENETICALLY ENGINEERING CLOSTRIDIA SPECIES  
The present invention relates to methods and compositions for engineering Clostridia species. In particular, embodiments of the present invention relate to the expression of recombinant resolvase...
US20130143282 ENGINEERED MICROBES AND METHODS FOR MICROBIAL OIL PRODUCTION  
Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments,...
US20110003349 L-Threonine Overproducing Microorganism and Method for Preparing L-Threonine Using the Same  
The present invention relates to a mutant microorganism producing a high concentration of L-threonine in high yield, prepared using site-specific mutation, not random mutation, such as treatment...
US20110177495 CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS  
The present invention discloses generalizable methods of evolving nucleic acids and proteins utilizing continuous directed evolution. The invention discloses methods of passing a nucleic acid from...
US20130323803 METHODS AND COMPOSITIONS FOR THE PRODUCTION OF EXTREMOPHILE ENZYMES FROM GREEN MICROALGAE AND CYANOBACTERIA  
The present invention relates to compositions and methods for stable transformation of green microalgae and for production of transgenic green microalgae and/or cyanobacteria that produce...
US20120189662 Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti  
The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle...
US20120135033 MULTIPLE DELIVERY SYSTEM FOR HETEROLOGOUS ANTIGENS  
The invention is directed to an episomal recombinant nucleic acid encoding at least two heterologous antigens each fused to a PEST-endogenous polypeptide, vaccines comprising the same, methods of...
US20140154742 NOVEL EXPRESSION AND SECRETION VECTOR SYSTEMS FOR HETEROLOGOUS PROTEIN PRODUCTION IN ESCHERICHIA COLI  
The present invention relates to a recombinant DNA expression/secretion system in E. coli wherein the said system combines the potential of signal peptide-based translocation of recombinant...
US20140335623 METHODS AND COMPOSITIONS FOR GENERATING SPORULATION DEFICIENT BACTERIA  
The present invention relates to methods and compositions for engineering sporulating bacterial cells, particularly a cell of the class Clostridia. In particular, the present invention relates to...
US20140120623 Method for Enhancing Cell Growth of Microalgae  
Microalgae are potential energy resources for production of biofuels, such as biodiesel, ethanol, and butanol. A method for enhancing cell growth of microalgae enhances transgenic expression of a...
US20110229937 CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE  
Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine...
US20150250838 Oncolytic Measles Virus  
The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary...
US20110129487 PLASMIC PRODUCTION AND EXPRESSION OF RECOMBINANT PROTEINS IN CELLS GROWN WITHOUT ANTIBIOTICS  
The invention relates to a mutated cell such as a bacteria or yeast in which the thyA gene coding thymidylate synthase includes a nonsense codon, preferably the amber codon, said nonsense codon...
US20110059530 Novel Ecdysone Receptor-Based Inducible Gene Expression System  
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a...
US20120208281 METHOD FOR INCORPORATION OF RECOMBINANT DNA  
The invention provides methods of preparing bacteria of interest with a stably integrated nucleic acid sequence of interest.
US20140024086 OVER-EXPRESSION OF NADH-DEPENDENT OXIDOREDUCTASE (FUCO) FOR INCREASING FURFURAL OR 5-HYDROXYMETHYLFURFURAL TOLERANCE  
The subject invention pertains to the discovery that the NADH-dependent propanediol oxidoreductase (FucO) can reduce furfural. This allows for a new approach to improve furfural tolerance in...
US20130149785 METHODS FOR MAKING AND USING MOLECULAR SWITCHES INVOLVING CIRCULAR PERMUTATION  
The invention provides molecular switches which couple external signals to functionality, and combinatorial methods of making and using the same involving circular permutation of nucleic acid and...
US20140199767 USE  
The present invention relates to the use of one or more cas genes for modulating resistance in a cell against a target nucleic acid or a transcription product thereof.
US20130180012 SULFOTRANSFERASE OF A RED MICROALGA AND USES THEREOF  
An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel sulfotransferase is provided together with a composition which includes the isolated protein....
US20150072395 RECOMBINANT MICROORGANISMS AND METHODS OF USE THEREOF  
The present provides selection markers, methods, nucleic acids, and vectors of use in the preparation of recombinant Clostridium spp.
US20150175981 SELECTION IN FUNGI  
The present invention relates to methods for constructing a recombinant fungal host cell comprising one or more copies of a polynucleotide construct integrated in its genome, said method...
US20150011008 METHOD OF TRANSFERRING GENE INTO ALGAL CELL INVOLVING UTILIZING MULTIPLE SQUARE-WAVE PULSES IN THREE STEPS  
To provide a technology that solves the above-mentioned problems, and is directly applicable to eukaryotic algal cells with cell-wall, the technology enabling gene transfer and transformation to...
US20090162898 HIGH COPY NUMBER SELF-REPLICATING PLASMIDS IN PSEUDOMONAS  
Provided herein are improved copy number plasmids, particularly those plasmids capable of replication in a bacterial cell. The improved copy number plasmid contain a deletion, insertion, or...
US20100159523 Coryneform Bacteria Which Produce Chemical Compounds I  
The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the...
US20120156239 OPTIMIZED VACCINES TO PROVIDE PROTECTION AGAINST EBOLA AND OTHER VIRUSES  
The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively...
US20150093781 MICROORGANISM FOR EXPRESSING A HUMAN MEMBRANE PROTEIN  
The invention relates to an isolated, genetically modified, living non-mammal organism, having increased HMG-CoA-reductase activity compared to the wild type, and having reduced...
US20150157701 METHOD FOR ATTENUATING A BACTERIUM OF THE MYCOBACTERIUM TUBERCULOSIS COMPLEX FOR PRODUCING A TUBERCULOSIS VACCINE  
The present invention concerns the use of a strain of a mycobacterium of the Mycobacterium tuberculosis complex in which a mspA gene capable of expressing a porin A of Mycobacterium smegmatis has...
US20090035864 PLASMIDS FOR TRANSFORMING BACTERIA OF THE ACIDITHIOBACILLUS SPP. GENUS, AND TRANSFORMATION METHOD  
The present invention discloses functional plasmids in bacteria of the Acidithiobacillus genus, such as the Acidithiobacillus ferrooxidans, Acidithiobacillus thiooxidans and Acidithiobacillus...
US20110189233 Recombinant Varicella-Zoster Virus  
A recombinant varicella-zoster virus; a process for producing the same; a pharmacological composition containing recombinant varicella-zoster virus; a vector containing a genomic gene of...
US20140106458 Conjugative Plasmids and Methods of Use Thereof  
The present invention provides novel C. botulinum conjugatively transmissible plasmids and methods of use thereof. Specifically, described herein are novel, conjugatively transmissible clostridial...
US20110171734 CONJUGATIVE PLASMIDS AND METHODS OF USE THEREOF  
The present invention provides novel C. botulinum conjugatively transmissible plasmids and methods of use thereof. Specifically, described herein are novel, conjugatively transmissible clostridial...
US20050026293 Plasmids from an extremely thermophilic microorganism and derived expression vectors  
The present invention concerns the isolation of plasmids from extremely thermophilic anaerobic microorganisms and their use in genetic transformation of thermophilic and mesophilic microorganisms....
US20130011372 INACTIVATED MICROORGANISMS CONTAINING DOUBLE -STRAND RNA MOLECULES (DSRNA), THEIR USE AS PESTICIDES AND METHODS FOR THEIR PREPARATION  
The present invention relates to a new group of pesticides consisting of inactivated microorganisms containing double-strand RNA molecules (dsRNA), corresponding to receptor genes coupled with G...
US20130224865 ANTI-MICROBIAL BIOTHERAPEUTIC AGENTS: ALTERNATIVES TO CONVENTIONAL PHARMACEUTICAL ANTIBIOTICS  
Novel antimicrobial agents that can serve as replacements to conventional pharmaceutical antibiotics are disclosed. The antimicrobial agents comprise conjugatively transmissible plasmids that kill...
US20120238024 Anti-Microbial Biotherapeutic Agents: Alternatives to Conventional Pharmaceutical Antibiotics  
Novel antimicrobial agents that can serve as replacements to conventional pharmaceutical antibiotics are disclosed. The antimicrobial agents comprise conjugatively transmissible plasmids that kill...
US20130078694 PANTOTHENIC ACID BIOSYNTHESIS IN ZYMOMONAS  
Zymomonas is unable to synthesize pantothenic acid and requires this essential vitamin in growth medium. Zymomonas strains transformed with an operon for expression of 2-dehydropantoate reductase...
US20100105114 Methods and Compositions for Regulating Sporulation  
Methods and compositions are provided for producing fuel utilizing various strains of Clostridium phytofermentans with reduced sporulation activity. In some embodiments, the activity of a gene...
US20130280810 METHOD FOR THE SELECTION OF RECOMBINANT CLONES COMPRISING A SEQUENCE ENCODING AN ANTIDOTE PROTEIN TO TOXIC MOLECULE  
The present invention is related to a method for the selection of recombinant clones having integrated a gene of interest and a nucleotide sequence encoding a functional antidote protein to a...
US20100291140 ANTIBIOTIC RESISTANCE FREE LISTERIA STRAINS AND METHODS FOR CONSTRUCTING AND USING SAME  
The present invention provides Listeria strains that express a heterologous antigen and a metabolic enzyme, and methods of generating same.
US20130059334 PRODUCTION OF RECOMBINANT SELENOPROTEIN MUTANTS WITH ENHANCED CATALYTIC ACTIVITY  
The present invention generally relates to the production of industrially relevant quantities of selenoprotein enzymes in eukaryotic cell cultures. More specifically, the present invention...
US20100047384 METHODS OF PRODUCING TRANSFORMATION COMPETENT BACTERIA  
A method of producing transformation competent bacteria, comprising the steps of: (i) transforming a bacteria that is not naturally transformation competent with a plasmid, wherein said plasmid...
US20130045506 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
US20130045505 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
US20120276640 Polypeptides Having Cellobiohydrolase Activity And Polynucleotides Encoding Same  
The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
US20140363853 NUCLEOTIDE CLONING METHODS  
Methods of cloning insert sequences into cloning vectors with high efficiency and in the correct orientation are described. In one aspect, the invention features a method of producing a plasmid...
US20050191749 Novel plasmid vectors  
Phagemid vectors incorporating dimerization domains are provided which allow efficient production of biologically active polypeptides that may require dimerization for their biological activity.
US20150232578 HYBRID PROTEINS AND USES THEREOF  
There are disclosed hybrid proteins comprising at least one signal sequence; at least one DNA binding domain; and at least one cell penetrating peptide (CPP) domain. In embodiments the CPP domain...
US20100167405 PROCESSES FOR IMPROVED STRAIN ENGINEERING  
Improvements in strain engineering technology are needed to insure the economic feasibility of future engineered recombinant organisms for industrial biotechnology. Disclosed herein are rapid,...

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