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US20090280569 |
Chloramphenicol Resistance Selection in Bacillus Licheniformis
The present invention relates to a modified Bacillus licheniformis host cell, wherein one or more naturally occurring chromosomal chloramphenicol acetyl transferase encoding gene(s), cat, has...
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US20090275031 |
Biomolecular nano device
Methods for measuring environmental parameters using chemical recording are provided. In some embodiments, the methods include generating a polymer comprising an ordered series of chemical units,...
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US20090274618 |
TADG-15: an extracellular serine protease overexpressed in carcinomas
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression...
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US20090271896 |
METHOD FOR AGROBACTERIUM-MEDIATED TRANSFORMATION OF PLANTS
The invention provides methods and compositions for enhancing the efficiency of Agrobacterium -mediated transformation of host cells such as plant cells. Plant expression constructs comprising a...
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US20090269852 |
Novel gene gms 01
The present invention relates to microorganisms genetically engineered to increase yield and/or efficiency of biomass production from a carbon source, such as e.g. glucose. Processes for generating...
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US20090269358 |
Proteins with Improved Solubility and Methods for Producing and Using Same
A method is provided for improving the solubility of proteins, for example, bacterial toxins. In one embodiment, solubility is improved by introducing point mutations that replace cysteine residues...
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US20090263846 |
Oxygen-resistant hydrogenases and methods for designing and making same
The invention provides oxygen-resistant iron-hydrogenases ([Fe]-hydrogenases) for use in the production of H 2 . Methods used in the design and engineering of the oxygen-resistant [Fe]-hydrogenases...
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US20090263418 |
MEANS AND METHODS FOR MANIPULATING SEQUENTIAL PHAGOLYSOMALCYTOSOLIC TRANSLOCATION OF MYCOBACTERIA, AND USES THEREOF
Mycobacteria such as M. tuberculosis and M. leprae are considered to be prototypical intracellular bacilli that have evolved strategies to enable growth in the intracellular phagosomes of the...
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US20090258366 |
pCryptoRNAi
A vector developed to transform fungi can be used to study the expression of a gene of interest. The vector can provide for the expression of signal proteins in fungi that can be observed and/or...
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US20090253189 |
Lactic Acid-Producing Yeast Cells Having Nonfunctional L- or D-Lactate:Ferricytochrome C Oxidoreductase Cells
Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of...
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US20090253173 |
FILAMENTOUS FUNGI WITH INACTIVATED PROTEASE GENES FOR ALTERED PROTEIN PRODUCTION
The invention relates to a filamentous fungal cell (e.g., Aspergillus sp.) comprising at least one inactivated protease gene chosen from apsB, a homolog of apsB, cpsA, a homolog cpsA, and...
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US20090253164 |
E. COLI FOR EFFICIENT PRODUCTION OF CARATENOIDS
An improved E. coli for carotenoid production comprising exogenous nucleic acids for expressing a carotenoid that the E. coli requires as necessary condition for the E. coli to reproduce....
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US20090252760 |
Construction of Recombinant Adenovirus With Genes That Codify for SAG1, SAG2 and SAG3
This invention refers to the construction of recombinant adenovirus with genes that codify for T. gondii SAG1, SAG2 and SAG3, through a homologue recombination technique between two vectors. A...
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US20090246876 |
HIGH EXPRESSION ZYMOMONAS PROMOTERS
Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids....
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US20090246846 |
ZYMOMONAS WITH IMPROVED XYLOSE UTILIZATION
Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The...
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US20090246836 |
Pgro expression units
The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for...
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US20090246826 |
Bi-Directional Selection Markers With Improved Activity
The present invention discloses a polypeptide selected from the group consisting of: a polypeptide having an amino acid sequence according to SEQ ID NO 3, a polypeptide having an amino acid...
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US20090246219 |
NOVEL SURFACE EXPOSED HAEMOPHILUS INFLUENZAE PROTEIN (PROTEIN E; pE)
The present invention relates to a surface exposed protein (protein E; pE), a virulence factor, which can be detected in Haemophilus influenzae , having an amino acid sequence as described in SEQ...
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US20090238921 |
MUTANT STRAINS OF LACTIC ACID BACTERIA HAVING A NON-PHOSPHORYLABLE LACTOSE PERMEASE
The invention concerns lactic acid bacteria strains wherein the phosphorylable histidine of the IIA domain of lactose permease is replaced by a non-phosphorylable amino acid. Said strains have a...
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US20090226977 |
Mutant Strains of Pseudomonas Fluorescens And Variants Thereof, Methods For Their Production, And Uses Thereof In Alginate Production
It is described biologically pure bacterial cultures of mutant strains of Pseudomonas fluorescens , which produces large amounts of alginate. The alginate may contain a certain determined content...
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US20090221078 |
ZYMOMONAS WITH IMPROVED ETHANOL PRODUCTION IN MEDIUM CONTAINING CONCENTRATED SUGARS AND ACETATE
Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas further...
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US20090221031 |
NOVEL GROUP OF ESTERASES FOR THE PRODUCTION OF FINE AND SPECIALITY CHEMICALS
The present invention relates to a polynucleotide encoding an enzyme having carboxyl esterase [E.C. 3.1.1.1] activity, wherein the coding sequence is selected from the group consisting of (a) a...
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US20090220549 |
REAGENTS FOR RECOMBINOGENIC ENGINEERING AND USE THEREOF
The present invention features homologous recombination methods and systems. The methods and systems promote highly efficient homologous recombination in cells (e.g., in prokaryotic cells). The...
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US20090220517 |
METHOD FOR PRODUCING EPITOMERS AND THEIR USES ON CARRIER MICROORGANISMS
The present invention relates to a method for producing carrier microorganisms, in particular bacteria, which, through targeted genetic manipulation, carry epitopes or epitomers, respectively, on...
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US20090220459 |
NON-PATHOGENIC AND/OR ATTENUATED BACTERIA CAPABLE OF INDUCING APOPTOSIS IN MACROPHAGES, PROCESS OF MANUFACTURING AND USES THEREOF
The invention relates to an non-pathogenic and/or attenuated bacterium which is capable of inducing apoptosis in macrophages.
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US20090215179 |
Transgenically preventing establishment and spread of transgenic algae in natural ecosystems
Genetic mechanisms for mitigating the effects of introgression of a genetically engineered genetic trait of cultivated algae or cyanobacteria to its wild type or to an undesirable, interbreeding...
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US20090215138 |
MODIFIED YEAST CONSUMING L-ARABINOSE
The present invention relates to a method for producing a L-arabinose utilizing yeast strain for the production of ethanol, whereby a yeast strain is modified by introducing and expressing araA...
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US20090215135 |
Novel Gene STS 22
The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also...
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US20090215048 |
METHOD OF IN-SILICO IMPROVEMENT OF ORGANISMS USING THE FLUX SUM OF METABOLITES
The present invention relates to an in silico method for improving an organism on the basis of the flux sum (φ) of metabolites, and more particularly to a method for screening key metabolites that...
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US20090209038 |
Cell-Mediated Directed Evolution
The present invention relates to systems which harness the molecular biology of a living cell to direct evolution of biological entities of interest. According to the invention, a host cell is...
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US20090208461 |
RECOMBINANT BACTERIA WITH E.COLI HEMOLYSIN SECRETION SYSTEM AND INCREASED EXPRESSION AND/OR SECRETION OF HLYA, PROCESS OF MANUFACTURING AND USES THEREOF
The invention relates to a recombinant bacterium with E. coli hemolysin secretion system and increased expression and/or increased secretion of full length or partial HlyA.
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US20090203143 |
TRANS-SPLICING MEDIATED PHOTODYNAMIC THERAPY
An isolated nucleic acid fragment encoding a diverged delta-9 fatty acid desaturase is disclosed. Also the construction of a chimeric gene encoding all or a portion of the diverged delta-9 fatty...
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US20090203095 |
NOVEL ENGINEERED MICROORGANISM PRODUCING HOMO-SUCCINIC ACID AND METHOD FOR PREPARING SUCCINIC ACID USING THE SAME
The present invention relates to a mutant microorganism, which is selected from the group consisting of genus Mannheimia , genus Actinobacillus and genus Anaerobiospirillum , producing...
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US20090203093 |
Protein Targeting To Lipid Bodies
The present invention relates to a method of targeting a protein of interest to an intracellular hydrophobic inclusion body of a bacterial cell by means of a fusion protein comprising a hydrophobic...
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US20090202489 |
ADENOVIRUSES MUTATED IN THE VA GENES FOR CANCER TREATMENT
This invention refers to the use of an adenovirus for cancer treatment, being this adenovirus defective in its virus-associated (VA) RNAs. Said adenovirus has a mutation in the VAI or VAII gene...
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US20090197339 |
In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
The invention provides orthogonal translation systems for the production of polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris . Methods for producing...
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US20090197338 |
Method of Increasing the Function of an AAV Vector
A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided....
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US20090197304 |
Corynephage integrase-based site-specific insertion vector system
The present invention provides a system for site-specific directed gene insertion of desired genes or foreign DNA into cellular genomes. The system includes novel vectors for integrating DNA into...
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US20090193544 |
GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE PROMOTER AND HETEROLOGOUS GENE EXPRESSION
The invention relates to discovery of an isolated glyceraldehyde-3-phosphate dehydrogenase promoter in Pleurotus and a construct comprising the promoter of the invention operably linked to a...
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US20090191610 |
Microorganisms With Increased Efficiency for Methionine Synthesis
The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis,...
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US20090186415 |
METHOD FOR PRODUCTION OF CYTOCHROME P450 WITH N-TERMINAL TRUNCATED P450 REDUCTASE
The present invention provides a P450 reductase lacking N-terminal amino acids, as well as a nucleic acid encoding the P450 reductase. When co-expressed with a cytochrome P450, the P450 reductase...
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US20090186354 |
METHODS AND TOOLS FOR THE SCREENING OF FACTORS AFFECTING PROTEIN MISFOLDING
The present invention relates in general to the fields of chemical, pharmaceutical and genetic screening and to diseases associated with protein misfolding. In particular, it discloses engineered...
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US20090181056 |
Toxoplasma gondii mutant with enhanced homologous recombination and uses thereof
The present invention relates to a mutant Toxoplasma gondii which exhibits enhanced homologous recombination. The mutant of the present invention is a knockout in the KU80-dependent nonhomologous...
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US20090176659 |
TRANSCRIPTIONAL ENGINEERING OF LACTOBACILLUS
The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes and methods for evaluating phenotypic diversity.
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US20090176219 |
DNA BINDING SITE OF A TRANSCRIPTIONAL ACTIVATOR USEFUL IN GENE EXPRESSION
We have discovered DNA binding sites which are specifically recognized by PrtT, a transcriptional activator for protease genes. The DNA binding site can be defined structurally by a consensus...
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US20090175913 |
AMMENDOLA/SALMONELLA ENTERICA STRAINS OF REDUCED PATHOGENICITY, METHOD FOR THEIR PREPARATION AND USES THEREOF
The invention concerns novel Salmonella enterica attenuated strains, characterized in that they are inactivated at the level of the znuABC operon through mutation in at least one of the znuA,...
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US20090175907 |
Multi Plasmid System For The Production Of Influenza Virus
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid...
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US20090170807 |
Methods and means for producing hyaluronan
The present invention relates to fungal cells and fungi which synthesize hyaluronan and to methods for preparing such fungi, and also to methods for preparing hyaluronan with the aid of these...
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US20090170170 |
P2-10 expression units
The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for...
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US20090170154 |
Mutant bacterium belonging to the genus bacillus
The present invention provides a mutant Bacillus bacterium capable of enhancing productivity of proteins or polypeptides, a recombinant microorganism produced by introducing genes encoding...
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