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US20110165683 |
CHIMERIC GAMMARETROVIRUS
The invention is directed to a chimeric gammaretrovirus comprising an gammaretroviral virion which contains a lentiviral Vpx protein and methods of use thereof.
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US20100325746 |
Methods and sequences to suppress primate huntington gene expression in vivo
Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates including Macaca mulatta and Homo sapiens. These...
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US20120046340 |
Down Regulation of the Gene Expression by Means of Nucleic Acid-Loaded Virus-Like Particles
The present invention relates to compositions of virus-like particles for the introduction of RNA-interference (RNAi-) inducing molecules into eukaryotic cells and methods for the cell...
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US20110257080 |
Hepatitis B Virus Compositions and Methods of Use
A polypeptide comprising a preS1 region of hepatitis B virus (HBV), or a fragment thereof, and/or the preS2 region of HBV or a fragment thereof, and methods of use to inhibit virus infection are...
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US20120041050 |
ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
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US20120022144 |
Antisense Oligonucleotides for Inducing Exon Skipping and Methods of Use Thereof
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
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US20110262447 |
HUMAN SYNTHETIC SINGLE-CHAIN ANTIBODIES DIRECTED AGAINST THE COMMON EPITOPE OF MUTANT P53 AND THEIR USES
Isolated polypeptides, isolated polynucleotides or expression vectors encoding same, viral display vehicles which can be specifically bind an exposed epitope shared by mutant, but not wild type,...
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US20110275105 |
Methods of inducing pluripotency
Methods are provided for inducing non-pluripotent cells to become pluripotent. Methods also include identifying and isolating induced pluripotent (iPS) cells and uses thereof. Compositions and kits...
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US20110268705 |
HDAC4, HDAC5, HDAC6, HDAC7, AND HIF1 ALPHA MODULATION OF RETINAL CELL SURVIVAL
Methods for inhibiting retinal cell death by altering expression of one or more of HDAC4, HDAC5, HDAC6, HDAC7, and HIF1α in a retinal cell are provided.
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US20110052585 |
COMPOSITIONS AND METHODS FOR INHIBITING INTERLEUKIN PATHWAYS
Fusion proteins including an IL-17 receptor with a multimerization domain, or an IL-23 receptor and a multimerization domain, and recombinant viral vectors encoding such fusions, are described. The...
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US20110189730 |
VIRAL NUCLEOCAPSID PROTEIN AS A MULTIFUNCTIONAL TRANSLATION INITIATION FACTOR AND INCREASED PROTEIN AND POLYPEPTIDE PRODUCTION USING SAME
The present invention is directed to a system to significantly increase the expression of genes of interest, and in particular proteins and polypeptide products. Expression of hantavirus...
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US20070110716 |
Relationship of a specific metabolite to insulin resistance
Provided are methods and reagents for reducing ketone levels (for example, β-hydroxybutyrate) in skeletal muscle. Also provided are methods and reagents for treating insulin resistant states, such ...
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US20110182933 |
MODIFIED VACCINIA ANKARA VIRUS VARIANT
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus, wherein the MVA-BN virus, or a derivative thereof, induces at least substantially the same...
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US20100323383 |
Methods for in vitro differentiation of Th-17+cells
The present invention is directed to an in vitro method for promoting differentiation and proliferation of human T helper lymphocytes that express IL17 (Th-IL17+ cells). The instant method may be...
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US20110183908 |
YOPM AS DELIVERY VEHICLE FOR CARGO MOLECULES AND AS BIOLOGICAL THERAPEUTIC FOR IMMUNOMODULATION OF INFLAMMATORY REACTIONS
The present invention relates to the use of Yersinia outer protein M (YopM), a YopM fragment, or a YopM variant, which is capable of autopenetrating the cell membrane and of integrating into the...
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US20110165187 |
TUMOR CELLS FROM IMMUNE PRIVILEGED SITES AS BASE CELLS FOR CELL-BASED CANCER VACCINES
The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified...
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US20110243986 |
POLYNUCLEOTIDES ALLOWING THE EXPRESSION AND SECRETION OF RECOMBINANT PSEUDO-VIRUS CONTAINING FOREIGN EPITOPES, THEIR PRODUCTION, AND USE
This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic...
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US20060205080 |
Formulations for therapeutic viruses having enhanced storage stability
Therapeutic viral formulations having enhanced storage stability are described. The formulations comprise a viral vector in addition to one or more of an aqueous cosolvent, a reversible...
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US20110268701 |
STRESS-RESPONSIVE INDUCTION OF A THERAPEUTIC AGENT AND METHODS OF USE
This invention relates to compositions and methods for selective expression of a heterologous nucleic acid sequence in a targeted tissue, and more particularly to the glucose regulated protein 78...
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US20110184050 |
METHODS AND MEANS FOR TREATING DNA REPEAT INSTABILITY ASSOCIATED GENETIC DISORDERS
The current invention provides for methods and medicaments that apply an oligonucleotide comprising aninosine and/or an uracile and/or a nucleotide containing a base able to form a wobble base...
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US20110104734 |
NOVEL STRATEGY TO REDUCE LACTIC ACID PRODUCTION AND CONTROL PH IN ANIMAL CELL CULTURE
The present disclosure provides a method for culturing cells in exogenous lactic acid. Certain aspects of the present disclosure include the production of recombinant proteins, such as antibodies...
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US20050241009 |
Development of a murine model of HIV-1 infection on the basis of construction of EcoHIV, a chimeric, molecular clone of human immunodeficiency virus type 1 and ecotropic moloney murine leukemia virus competent to infect murine cells and mice
The present invention provides a chimeric HIV-1 construct, EcoHIV, capable of replication in a rodent cell. The invention also provides a convenient and safe rodent model of HIV-1 infection and...
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US20110104805 |
Pluripotent Stem Cells
The present invention provides methods to produce pluripotent stem cells from adult cells. In particular, the present invention provides methods to produce pluripotent stem cells from somatic cells...
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US20110250188 |
LCMV-GP-VSV-Pseudotyped Vectors and Tumor-Infiltrating Virus-Producing Cells for the Therapy of Tumors
The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus...
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US20070087330 |
Viral deconstruction through capsid assembly in vitro
A cell-free method for translation and assembly of viral capsid and capsid intermediates is disclosed for use in deconstructing an unknown virus and for screening for compounds that inhibit...
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US20110189234 |
ADENOVIRUS PARTICLES HAVING A CHIMERIC ADENOVIRUS SPIKE PROTEIN, USE THEREOF AND METHODS FOR PRODUCING SUCH PARTICLES
The present invention is concerned with means and methods for producing adenovirus particles comprising a chimeric adenovirus spike protein that essentially lacks a functional knob domain. One...
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US20120093772 |
VECTORS FOR DELIVERY OF LIGHT SENSITIVE PROTEINS AND METHODS OF USE
Provided herein are compositions and methods for gene and etiology-nonspecific and circuit-specific treatment of diseases, utilizing vectors for delivery of light-sensitive proteins to diseased and...
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US20100297084 |
METHOD FOR TRANSDUCING CELLS WITH PRIMARY CILIA
This invention provides methods for transducing a ciliated cell with a recombinant serotype 2 adeno-associated virus (AAV) vector. Additionally, the invention provides methods of treating diseases...
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US20120009268 |
Modified Virus Vectors and Methods of Making and Using the Same
The present invention provides AAV capsid proteins (VP1, VP2 and/or VP3) comprising a modification in the amino acid sequence in the three-fold axis loop 4 and virus capsids and virus vectors...
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US20050251873 |
Ace2 activation for treatment of heart, lung and kidney disease and hypertension
The invention relates to ACE2 activating compounds for prevention and treatment of cardiovascular disease, kidney disease, lung disease and hypertension. The invention also includes methods of...
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US20120082696 |
INTERGENIC REGIONS AS INSERTION SITES IN THE GENOME OF MODIFIED VACCINIA VIRUS ANKARA (MVA)
The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides...
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US20120064038 |
EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND METHODS OF USE IN ADENOVIRAL-ASSOCIATED VIRUS TYPE 6 (AAV6) TRANSDUCTION
Comparative gene analysis (CGA) was combined with pathway visualization software to identify a positive correlation between AAV6 transduction and epidermal growth factor receptor (EGFR) expression....
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US20050250093 |
Hepatitis c virus sub-genomic replicons
The present invention relates generally to the construction of sub-genomic HCV replicon systems that may provide the foundation for generating HCV replicons of all six major genotypes and subtypes...
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US20050130131 |
Method for isolation and replication of infectious human hepatitis-C virus
The present invention provides methods and compositions for replicating infectious Hepatitis C virus in vitro.
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US20050152878 |
Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases
A method of immunizing against plaque forming diseases using display technology is provided. The method utilizes novel agents, or pharmaceutical compositions for vaccination against plaque forming...
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US20110263027 |
Adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby
Adeno-associated virus 7 sequences, vectors containing same, and methods of use are provided.
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US20110117185 |
METHODS FOR TREATING OR PREVENTING HEART DAMAGE WITH INTEGRIN-LINKED KINASE (ILK) COMPOSITIONS
The present invention generally provides methods for administering a composition having an ILK-based protein or peptide having a sequence that is at least 90% homologous to wild-type human...
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US20110269235 |
METHODS FOR CULTURING MAMMALIAN TASTE CELLS
The invention provides methods of culturing mammalian taste cells, including taste receptor cells. Cells are maintained for a duration of up to three months and longer while maintaining molecular...
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US20070243608 |
Platelet bioreactor
Platelets are produced in a bioreactor in which hematopoietic stem cells (HSCs) are cultured to produce megakaryoctye progenitors, megakaryocytes, and platelets. The HSCs are stably genetically...
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US20050074887 |
Adenoviral VA1 Pol III promoter system for RNAi expression
An adenoviral VA1 Pol III expression system for RNAi expression is provided.
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US20110129928 |
Method of Manufacturing Induced Pluripotent Stem Cell Originated from Somatic Cell
Disclosed is a method for manufacturing stem cells including preparing Oct-4 gene, Sox2 gene, C-myc gene, and Klf-4 gene from mouse embryonic stem cells, and allowing each of the genes to be...
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US20080051328 |
Novel Muscle Growth Regulator
A muscle growth regulating factor includes polynucleotide and polypeptide sequences, promoter sequences, constructs comprising the sequences, and compositions for regulating muscle growth and...
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US20120028358 |
METHOD FOR INCREASING RETROVIRAL INFECTIVITY
The present invention is directed to methods for enhanced retroviral delivery of a nucleic acid to a target cell in vitro, ex vivo or in vivo, which involves increasing infectivity of a retrovirus...
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US20120003189 |
Materials and Methods to Enhance Hematopoietic Stem Cells Engraftment Procedures
This disclosure is directed to the methods of enhancing hematopoietic stem cells (HSPC) and progenitor cell (HSPC) engraftment procedure. Treatment in vivo of a HSPC donor with compounds that...
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US20110104120 |
Directed Evolution and In Vivo Panning of Virus Vectors
The present invention provides methods of achieving directed evolution of viruses by in vivo screening or “panning” to identify viruses comprising scrambled AAV capsids having characteristics of ...
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US20050214266 |
Combination of transplantation and oncolytic virus treatment
Oncolytic viruses can be used to purge cellular compositions to remove undesired neoplastic cells before the cellular compositions are used for transplantation. The present invention relates to the...
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US20080108140 |
CEACAM1 Mediated Protective Immunity
The presently described technology relates to the modulation of specific immune responses to create a protective immunity in the treatment of autoimmune diseases and diseases requiring the...
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US20100119538 |
CHIMERIC OSTEOGENIC FACTOR CONTAINING PROTEINS CAPABLE OF INCREASED NUCLEAR LOCALIZATION AND METHODS OF USE THEREOF
Compositions comprising osteogenic factors fused with membrane transduction domains of viral proteins are provided. Also provided are methods of expression and use of such compositions. Further,...
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US20110318389 |
HUMAN PANCREATIC BETA CELL LINES FOR DIAGNOSTIC OF DIABETES
The present invention relates to a method for preparing commercial scale quantities of human functional Betacells and to the establishment of cell lines. It also relates to a method of diagnosis...
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US20110287086 |
Regeneration of Pancreatic Islets and Reversal of Diabetes by Islet Transcription Factor Genes Delivered in Vivo
The present invention includes compositions and methods for regenerating glucose-responsive cells by ultrasound-targeted microbubble destruction in the pancreas, wherein the composition comprises a...
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