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US20090286321 |
METHODS FOR TARGETING MODIFIED RAAV VECTORS TO MAMMALIAN CELLS
Disclosed are improved VP2-modified recombinant adeno-associated viral (rAAV) vectors, expression systems, and rAAV virions that are fully virulent, yet lack functional VP2 protein expression. Also...
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US20090285861 |
Tumor cell-based cancer immunotherapeutic compositions and methods
The present invention is based, in part, on the discovery that immunotherapy using cell-based tumor cells genetically modified to express heat shock proteins is particularly effective in...
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US20090269850 |
Mutant Paramyxovirus and Method for Production Thereof
The present invention provides a modified paramyxovirus containing a reduced amount of receptor-binding protein compared with the wild type; a method of preparing a modified paramyxovirus,...
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US20090253208 |
Recombinant Viral Vector for Gene Transfer into Lymphoid Cells
A recombinant herpesvirus, a method for producing the recombinant herpesvirus, and a pharmaceutical composition comprising the recombinant herpesvirus, are provided with a method for producing a...
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US20090252763 |
BIOLOGICAL ADJUVANTS
A method of enhancing uptake of DNA by a host cell line comprises introducing the DNA into the host cell and contacting the host cell with non-infectious viral particles. The non-infectious...
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US20090241203 |
Transgenic animal models of disease
The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and...
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US20090235368 |
Transgenic animal models of disease
The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of...
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US20090233991 |
GENERATION OF BIOLOGICAL PACEMAKER ACTIVITY
Compositions and methods for enhancing hyperpolarization-activated cation inward current and disrupting inwardly rectifying potassium current of cells are described. The compositions and methods...
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US20090233990 |
GENERATION OF BIOLOGICAL PACEMAKER ACTIVITY
Compositions and methods for enhancing hyperpolarization-activated cation inward current and disrupting inwardly rectifying potassium current of cells are described. The compositions and methods...
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US20090227032 |
Nuclear reprogramming factor and induced pluripotent stem cells
The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present...
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US20090221077 |
Process for producing cytotoxic lymphocytes
The present invention provides a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one step selected from induction,...
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US20090215875 |
METHODS AND KITS FOR EXPANDING HEMATOPOIETIC STEM CELLS
A method of increasing the expansion and/or differentiation of a hematopoietic stem cell (HSC) comprising: (a) increasing the level and/or activity of a polypeptide encoded by at least one gene...
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US20090203141 |
Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant RNA agents
The present invention generally relates to a method for developing, generating and selecting tumor-free embryonic stem (ES)-like pluripotent cells using electroporation delivery of an inducible...
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US20090197304 |
Corynephage integrase-based site-specific insertion vector system
The present invention provides a system for site-specific directed gene insertion of desired genes or foreign DNA into cellular genomes. The system includes novel vectors for integrating DNA into...
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US20090191206 |
Human Semen Enhancer of Viral Infection Peptides (SEVI) and Their Use
Subject of the invention are peptides corresponding to a fragment of amino acids 240-290 of human prostatic acid phosphatase. The invention also relates to nucleic acids, antibodies, medicaments...
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US20090191169 |
Methods for gene transfer to mammals
To provide a transformed hair follicle and a method for transferring a gene to a mammal by means of the transformed hair follicle. The invention provides a method for producing a transformed hair...
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US20090181911 |
Role of gax in alzheimer neurovascular dysfunction
Neurovascular disorder critically contributes to the development and pathogenesis of Alzheimer's disease (AD). Transcriptional profiling of human brain endothelial cells (BEC) defines a subset of...
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US20090180989 |
Compositions and methods for delivering nucleotide sequences to vertebrates
The invention includes methods of producing viral particles which include introducing into avian cells a nucleotide sequence encoding a replication deficient retroviral vector and introducing into...
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US20090176200 |
Modified Human Hepatitis C Virus Genomic RNA That can be Autonomously Replicated
The present invention provides modified hepatitis C virus genomic RNA, comprising nucleotide sequences of genomic RNA portions of two or more types of hepatitis C viruses, which comprises a 5′...
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US20090170792 |
Peptide ligands
A peptide consisting of or comprising an amino acid sequence selected from a ) Px1X2X3 T [SEQ.ID.NO.:11]; b) PSX4S [SEQ.ID.NO.:2]; C) QX5X6X7Q [SEQ.ID.NO.:3]; d) SX8S [SEQ-ID.NO.:4], in which X1,...
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US20090162937 |
COMPOSITIONS AND METHODS COMPRISING THE USE OF CELL SURFACE DISPLAYED HOMING ENDONUCLEASES
According to particular exemplary aspects, DNA target site binding and cleavage properties of native, variant or modified homing endonucleases (HE) (e.g., LAGLIDAG (LHE), HNH, His-Cys Box, GIY-YIG,...
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US20090162936 |
Method For Transfer Of Gene Into Fat Cell Or Progenitor Fat Cell
A method for transferring a gene into a fat cell or progenitor fat cell comprising the step of infecting the fat cell or progenitor cell with a retrovirus vector having a foreign gene in the...
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US20090162320 |
GENE TRANSFER INTO AIRWAY EPITHELIAL STEM CELL BY USING LENTIVIRAL VECTOR PSEUDOTYPED WITH RNA VIRUS OR DNA VIRUS SPIKE PROTEIN
The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with F and HN, which are envelope...
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US20090155768 |
Reporter plasmid phage packaging system for detection of bacteria
The invention is related to a transducing particle that comprises a bacteriophage coat and a DNA core that comprises plasmid DNA comprising: a) a host-specific bacteriophage packaging site wherein...
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US20090155301 |
Pseudoinfectious flavivirus and uses thereof
The present invention discloses a replication-deficient pseudoinfective virus belonging to the Flaviviridae family that lack the capsid gene, where the replication-deficient pseudoinfective virus...
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US20090148949 |
rAAV Expression Systems and Methods of Use
Disclosed are improved VP2-modified recombinant adeno-associated viral (rAAV) vectors, expression systems, and rAAV virions that are fully virulent, yet lack functional VP2 protein expression. Also...
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US20090148425 |
THERAPEUTIC METHOD FOR BLOOD COAGULATION DISORDER
The present invention provides agents for treating blood coagulation abnormalities, which contain as an active ingredient a lentiviral vector carrying a blood coagulation factor gene operably...
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US20090123438 |
Multivalent Vaccines Comprising Recombinant Viral Vectors
The invention relates to vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding for at least two antigens from one or...
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US20090117658 |
Macrophage transfection method
Described are a method and a composition for transfecting monocytes, as well as use of the same for therapeutic purposes. The composition is composed of a nucleic acid component, a lysosome evading...
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US20090117084 |
BACTERIOPHAGE AND PROPHAGE PROTEINS IN CANCER GENE THERAPY
The present invention relates to the use of a polypeptide having a proliferation inhibitory activity or a cell death inducing activity on animal cells. The invention provides further means and...
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US20090104155 |
TREATMENT OF CONNECTIVE TISSUE DISORDERS
The present invention relates to methods of delivering nucleic acids to connective tissue cells and to methods of treating connective tissue disorders; in particular, the invention provides methods...
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US20090081251 |
Production of Viral Vaccines in Suspension on Avian Embryonic Derived Stem Cell Lines
The present invention relates to the development and manufacturing of viral vaccines, particularly the industrial production of viral vectors and vaccines, and more particularly the use of avian...
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US20090068157 |
Derivation of unlimited quantities of neutrophils on monocyte/dendritic cells
A method to generate unlimited numbers of macrophage/dendritic cells or neutrophils from mice, using conditional Hox oncoproteins is disclosed. The invention further includes the establishment of a...
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US20090055941 |
Novel Neural Cell Specific Promoter And Baculovirus And Method For Gene Delivery
There is provided a novel hybrid promoter region that utilizes a neural specific promoter and an enhancer element, in one embodiment from a viral promoter, located upstream or downstream of the...
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US20090054248 |
CONNEXIN 40 TISSUE SPECIFIC GENE MUTATIONS
A method of detecting cardiac arrhythmia in a patient is described. This method involves determining whether there is a mutation in the nucleotide sequence, the amino acid sequence, or both, of...
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US20090042299 |
Vectors and methods for tissue specific synthesis of proteins in eggs of transgenic hens
Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to...
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US20090041740 |
CANCER TREATMENT BY METABOLIC MODULATIONS
The invention provides compositions and methods for inhibiting the growth or proliferation of hyperproliferative cells or inducing regression of hyperproliferative cells. More specifically, the...
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US20090041725 |
Replication-Deficient RNA Viruses as Vaccines
The present invention relates to a genome-replication-deficient and transcription-competent negative-strand RNA virus, which can be used for the expression of transgenes and in particular for the...
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US20090017543 |
Viral Vectors
The present invention relates to an integration defective retroviral vector particle for gene therapy comprising a viral genome, wherein said vector particle is capable of infecting a mammalian...
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US20080318208 |
Dengue Reporter Virus and Methods of Making and Using the Same
The present invention relates to the production and uses of Dengue virus replicons and Dengue reporter virus particles. The present invention relates to methods of identifying inhibitors of Dengue...
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US20080299660 |
Methods For Transfecting Natural Killer Cells
Methods for stably transfecting mammalian natural killer cells comprising: transfecting a packaging cell line with a retroviral expression vector; culturing the transfected packaging cell line in a...
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US20080293143 |
Generation of human embryonc stem-like cells using intronic RNA
This invention generally relates to a method for developing, generating and selecting human embryonic stem (hES)-like pluripotent cells using transgenic expression of intronic microRNA-like RNA...
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US20080286779 |
Host Cells Containing Multiple Integrating Vectors
The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating...
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US20080286247 |
METHOD FOR SELECTIVELY TRANSDUCING PATHOLOGIC MAMMALIAN CELLS USING A TUMOR SUPPRESSOR GENE
A method for transducing a pathologic hyperproliferative mammalian cell is provided by this invention. This method requires contacting the cell with a suitable retroviral vector containing a...
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US20080280363 |
Pseudotyped Baculovirus and its Use
A viral G protein-pseudotyped baculovirus, in which the G protein is truncated and comprises the ectodomain, transmembrane domain and cytoplasmic tail domain. Such a baculovirus can be used for...
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US20080267992 |
Sars Virus Vaccine with Adenovirus Carrier and Preparation Method Thereof, and Use of Sars Virus S Gene for Preparation of Vaccine
The present invention relates to the field of biological engineering technology, specifically, to a SARS virus vaccine with adenovirus carrier, preparation method thereof and use of SARS virus S...
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US20080261882 |
Methods for Inhibiting Heregulin and Treating Cancer
The present invention discloses a method using human soluble ErbB3, for example p85-sErbB3, as a negative regulator of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention...
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US20080260775 |
New Live Virus Vaccines
The present invention provides novel self-replicating and self-propagating chimeric viral vectors and chimeric virus particles comprising a modified genome of a carrier RNA virus packaged within...
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US20080255064 |
Methods for modulating cholecystokinin expression
The invention provides a method for upregulating cholecystokinin (CCK) expression in mammalian pancreatic islets by administrating a CCK upregulating agent. The increased CCK expression activates...
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US20080233650 |
Method for propagating adenoviral vectors encoding inhibitory gene products
The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a...
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