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US20090304588 |
BIOLOGICALLY EXCITABLE CELLS
As an alternative strategy to electronic pacemaker devices, we explored the feasibility of converting normally-quiescent ventricular myocytes into pacemakers by somatic cell fusion. The idea is to...
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US20090307805 |
ALTERNATIVE NUCLEOTIDES FOR IMPROVED TARGETED NUCLEOTIDE EXCHANGE
A method and oligonucleotides for targeted nucleotide exchange of a duplex DNA sequence, wherein the donor oligonucleotide contains at least one modified nucleotide having a higher binding affinity...
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US20090305359 |
METHOD FOR PRODUCING CIRCULAR DUPLEX POLYNUCLEOTIDES FROM LINEAR DUPLEX POLYNUCLEOTIDES AND APPLICATIONS THEREOF
Methods are provided for making a circular duplex polynucleotide. Such methods can include providing a mixture of sequence specific linear duplex polynucleotides and denaturing and reannealing the...
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US20090305419 |
Compositions for linking DNA-binding domains and cleavage domains
Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases. Also described are methods of making and...
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US20090305418 |
CELL THERAPY METHOD FOR THE TREATMENT OF TUMORS
T cell responses are often diminished in humans with a compromised immune system. We have developed a method to isolate, stimulate and expand naïve cytotoxic T lymphocyte precursors (CTLp) to...
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US20090305991 |
33 Human Secreted Proteins
The present invention relates to 33 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host...
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US20090305420 |
SRSV DETECTION KIT
This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related virus constituting peptides selected from the following peptide groups (a) to (k), respectively: (a) a...
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US20090306131 |
CELL LINES WITH LATENT IMMUNODEFICIENCY VIRUS AND METHODS OF USE THEREOF
The present invention provides isolated cells that comprise, integrated into the genome of the cell, a transcription-competent immunodeficiency virus or a transcription-competent immunodeficiency...
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US20090304652 |
IDENTIFICATION AND SELECTION OF STEM CELLS BEING COMMITTED TO DIFFERENTIATE TO A SPECIFIC TYPE FOR OBTAINING A HOMOGENEOUS POPULATION OF STEM CELLS
The stem cell ( 1 ) includes a cellular DNA ( 2 ) comprising a plurality of sequences coding different genes and promoters allowing DNA-protein-interactions, at least one protein molecule ( 3 )...
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US20090305358 |
DNA Vector Production System
The invention discloses the production of double stranded DNA (dsDNA) vectors capable of delivering nucleic acids, including cDNA, antisense, ribozyme, and small interference RNA into cells. The...
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US20090304595 |
ANIMAL MODEL AND A METHOD FOR PRODUCING AN ANIMAL MODEL
The present invention discloses a non-human animal model for a hereditary autosomal dominant disease. The non-human animal model expresses at least one phenotype associated with the disease and is...
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US20090297506 |
Classification of cancer
The invention discloses a method for classification of cancer in an individual having contracted cancer. The method of classification involves the determination of microsatellite status and a...
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US20090297496 |
Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
The present invention comprises methods and compositions for the treatment or alleviation of NAFLD (non-alcoholic fatty liver disease) and those conditions associated with NAFLD, including fatty...
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US20090298105 |
RECONSTITUTED HISTONE METHYLTRANSFERASE COMPLEX AND METHODS OF IDENTIFYI NG MODULATORS THEREOF
The present invention provides a reconstituted complex including EED, EZH2 and SUZ12 wherein the reconstituted complex has histone methyltransferase (HMTase) activity for lysine 27 of histone H3...
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US20090300782 |
Targeted gene addition in stem cells
The present invention provides methods for adenoassociated virus-mediated site-specific integration of a transgene into a stem cell. Stem cells having a transgene integrated therein, and...
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US20090298921 |
METHODS AND COMPOSITIONS FOR USE IN HOMOLOGOUS RECOMBINATION
Methods for homologously recombining an exogenous nucleic acid into a target cell genome of a target cell are provided. In the subject methods, a targeting vector that includes a linearizing...
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US20090291502 |
GENE INJECTION APPARATUS AND GENE INJECTION METHOD
A gene injection apparatus for injecting a gene into a cell held on a substrate, includes a needle unit. The needle unit includes a fine needle to be inserted into the cell immersed in a culture...
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US20090291888 |
MODULATORS OF TNF RECEPTOR ASSOCIATED FACTOR (TRAF), THEIR PREPARATION AND USE
A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives...
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US20090291068 |
Modulation of bio-electrical rhythms via a novel engineering approach
The present invention relates to novel compositions and methods to induce, and/or modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of...
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US20090291104 |
NOVEL CONOTOXIN FRAMEWORK WITH A HELIX-LOOP-HELIX FOLD
A new family Here we report a new family of four-cystine/three-loop conotoxins (designated framework 14). Three peptides of this family (flf14a-c) were isolated from the venom of Conus floridanus...
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US20090286852 |
RNA containing modified nucleosides and methods of use thereof
This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing...
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US20090286319 |
MICROINJECTION METHOD AND DEVICE
An object of the present invention is to provide a method for introducing a physiologically active substance such as a gene into a cell, which introduces a physiologically active substance such as...
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US20090285861 |
Tumor cell-based cancer immunotherapeutic compositions and methods
The present invention is based, in part, on the discovery that immunotherapy using cell-based tumor cells genetically modified to express heat shock proteins is particularly effective in...
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US20090286320 |
SITE-SPECIFIC RECOMBINATION IN EUKARYOTES AND CONSTRUCTS USEFUL THEREFOR
Site-specific recombinases provide a means of efficiently manipulating chromosomal sequences in mammalian cells in culture and in mice. Embryonic stem cells containing recombinase nucleic acid...
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US20090285852 |
Expression System Incorporating a Capsid Promotor Sequence as an Enhancer of a Cytomegalovirus Promotor
The invention provides a method for enhancing expression of a transgene in a host cell, which includes the steps of inserting a capsid promoter element (Pcap), or a sequence comprising the reverse...
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US20090280568 |
S100B mini-promoters
Isolated polynucleotides comprising an S100B promoter are provided, where an S100B regulatory element is operably joined to an S100B basal promoter utilizing a non-native spacing between the...
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US20090281167 |
COMPOSITIONS AND METHODS RELATED TO MIRNA MODULATION OF NEOVASCULARIZATION OR ANGIOGENESIS
The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases....
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US20090280123 |
Kinesin polypeptides, polynucleotides encoding same and compositions and methods of using same
An isolated polynucleotide comprising a nucleic acid sequence encoding a KIF18A polypeptide being expressed in mesenchymal stem cells is disclosed. Methods of detecting same are disclosed as well...
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US20090280096 |
PANCREATIC ENDOCRINE PROGENITOR CELLS DERIVED FROM PLURIPOTENT STEM CELLS
The invention provides pluripotent cells modified to overexpress Pdx1 and Ngn3. Pluripotent cells include embryonic stem cells and induced pluripotent stem cells. Methods of producing pancreatic...
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US20090274618 |
TADG-15: an extracellular serine protease overexpressed in carcinomas
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression...
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US20090275137 |
HIGH AFFINITY TCR PROTEINS AND METHODS
T cell receptors (TCRS) that have higher affinity for a ligand than wild type TCRs are provided. These high affinity TCRs are formed by mutagenizing a T cell receptor protein coding sequence to...
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US20090274671 |
VECTOR ENCODING HUMAN GLOBIN GENE AND USE THEREOF IN TREATMENT OF HEMOGLOBINOPATHIES
Recombinant lentiviral vectors having a region encoding a functional β-globin gene; and large portions of the β-globin locus control regions which include DNase I hypersensitive sites HS2, HS3...
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US20090275136 |
Nuclear Targeting Sequence
The present provides nuclear localization signaling (NLS) sequences derived from titin, comprised of amino acids 181-220: SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR and fragments thereof, such as...
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US20090275644 |
Novel adaptor protein that binds to mammalian toll-like receptor 3 and gene thereof
A novel adaptor protein and its gene are provided. The novel adaptor protein has a property of binding to mammalian Toll-like receptor 3, which controls type I interferon production that is...
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US20090274630 |
RED BLOOD CELL-DERIVED VESICLES AS A NANOPARTICLE DRUG DELIVERY SYSTEM
Red blood cell-derived vesicles (RDV) as a nanoparticle drug delivery system. The RDV are smaller than one micrometer, capable of encapsulating and delivering an exogenous substance into cells. The...
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US20090271896 |
METHOD FOR AGROBACTERIUM-MEDIATED TRANSFORMATION OF PLANTS
The invention provides methods and compositions for enhancing the efficiency of Agrobacterium -mediated transformation of host cells such as plant cells. Plant expression constructs comprising a...
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US20090270484 |
WWOX Vectors and Uses in Treatment of Cancer
The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer in a subject, by administering to the subject a polynucleotide encoding a...
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US20090269781 |
Single-Molecule-Format Probe And Utilization Thereof
A single-chain probe of the present invention for detecting a ligand, comprises: a ligand binding protein for binding the ligand; a recognition protein for recognizing that the ligand is bound by...
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US20090271335 |
Totipotent, Nearly Totipotent or Pluripotent Mammalian Cells Homozygous or Hemizygous for One or More Histocompatibility Antigent Genes
The present invention relates to totipotent, nearly totipotent and pluripotent stem cells that are hemizygous or homozygous for MHC antigens and methods of making and using them. These cells are...
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US20090266760 |
FUNCTIONAL NUCLEIC ACIDS FOR BIOLOGICAL SEQUESTRATION
The present invention generally relates to methods of improving the removal and/or treatment of substances in bulk volumes, particularly to methods of improving the removal and/or treatment of...
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US20090265796 |
Adeno-associated virus vectors
The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated...
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US20090263900 |
Linear donor constructs for targeted integration
Disclosed herein are linear donor molecules comprising homology arms of 50-750 base pairs (e.g., 50-100 base pairs) flanking one or more sequences of interest. The donor molecules and/or...
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US20090264511 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR VII GENE
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
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US20090265815 |
Sequence-determined DNA fragments and corresponding polypeptides encoded therapy
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
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US20090264312 |
METHOD FOR REMOVING DESIRED CHROMOSOME AND TAILOR-MADE MEDICAL TREATMENT UTILIZING THE SAME
It is intended to provide a regenerable cell in which a desired chromosome has been deleted, a method for producing the cell, and a gene cassette and a kit to be used for the method. More...
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US20090263395 |
GENES AND POLYPEPTIDES RELATING TO BREAST CANCERS
The present application provides novel human genes B1194, A2282V1, A2282V2, and A2282V3 whose expression is markedly elevated in breast cancer. These genes and polypeptides encoded thereby can be...
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US20090263864 |
Recombinant production of mixtures of antibodies
The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding...
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US20090263899 |
CELL MODIFICATION METHOD AND CELL MODIFICATION DEVICE
The present invention relates to a cell modification method for modifying human or mammal immune cells, especially effector cells outside the human or mammal body, wherein in a first step at least...
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US20090263901 |
STABLE NEURAL STEM CELL LINES
A systematic and efficient method for establishing stable neural stem cell lines and neuronal progenitor lines is described. The resulting cell lines provide robust, simple, and reproducible...
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US20090263365 |
Methods and compositions for transforming dendritic cells and activating cells
Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates...
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