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US20140113373 THREE DIMENSIONAL SOY PROTEIN-CONTAINING SCAFFOLDS AND METHODS FOR THEIR USE AND PRODUCTION  
Porous soy protein-based scaffolds and methods for making the scaffolds using 3D printing techniques are provided. Also provided are tissue growth scaffolds comprising the porous soy protein-based...
US20130052712 SURFACE IMMOBILIZATION OF VARIOUS FUNCTIONAL BIOMOLECULES USING MUSSEL ADHESIVE PROTEIN  
The present invention relates to technology of immobilizing or coating various functional bioactive substances on various surfaces without physical chemical treatment using mussel adhesive...
US20150168378 RETINAL PIGMENT EPITHELIAL PRIMARY CELL CULTURE SYSTEM PRODUCING SUBCELLULAR DEPOSITS  
The present invention provides a retinal pigment epithelial (RPE) primary cell culture system on a material surface seeded at a high density that produces a layer of subcellular deposits, wherein...
US20130274124 ADHESION SIGNATURES  
The present invention provides arrays comprising polypeptides associated with extracellular matrix that can be used to isolate, differentiate, or culture certain cell types including stem cells,...
US20140335612 SUPPORTS AND METHODS FOR PROMOTING INTEGRATION OF CARTILAGE TISSUE EXPLANTS  
The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage...
US20140178343 SUPPORTS AND METHODS FOR PROMOTING INTEGRATION OF CARTILAGE TISSUE EXPLANTS  
The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage...
US20150257870 LAYERED SCAFFOLD SUITABLE FOR OSTEOCHONDRAL REPAIR  
The invention relates to a method for producing a multi-layer collagen scaffold. The method generally comprises the steps of: preparing a first suspension of collagen and freezing or lyophilising...
US20120135520 UNSHRUNKEN TISSUE EQUIVALENT, SKIN EQUIVALENT COMPRISING SUCH AN UNSHRUNKEN TISSUE EQUIVALENT, AND METHODS FOR PRODUCING SUCH AN UNSHRUNKEN TISSUE EQUIVALENT AND SUCH A SKIN EQUIVALENT  
The invention relates to a method for producing an unshrunken tissue equivalent. Said method is comprising in that: a mixture is produced that contains at least one element of an extracellular...
US20120315699 STACKED, PATTERNED BIOMATERIALS AND/OR TISSUE ENGINEERING SCAFFOLDS  
Stacked, lamellar constructs comprised of, synthetic or natural, polymeric membrane structures which are brought together to form 3D scaffolds for biomaterial and guided tissue engineering...
US20130243737 CALCIUM-CONTAINING STRUCTURES AND METHODS OF MAKING AND USING THE SAME  
The present invention generally relates to calcium-containing structures and methods of making and using the structures. In one aspect, hollow calcium containing microstructures are used in...
US20140099290 ENDOTHELIAL SCAFFOLDS  
Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells...
US20110027364 BIOACTIVE AND RESORBABLE SOYBEAN-BASED BIOMATERIALS  
A method of producing a soybean-based biomaterial which is suitable for use in a biomedical product, the method comprising: defatting soy flour; either prior to or at the same time as, performing...
US20110076316 SCALABLE MATRIX FOR THE IN VIVO CULTIVATION OF BONE AND CARTILAGE  
The present invention provides implantable receptacle devices (and methods) for use in bone and tissue regeneration which provide immediate structural stability and strength to a zone where tissue...
US20150166960 METHOD FOR PRODUCING FUNCTIONAL FUSION TISSUE  
The present invention relates to a universal method for producing functional tissue. The invention relates to the method for producing functional fusion tissue, the functional fusion tissue...
US20150152388 PREPARATION OF PARENTAL CELL BANK FROM FOETAL TISSUE  
The present invention relates to methods of in vitro preparation of a parental cell bank (PCB) from foetal tissue consisting of foetal epiphyseal tissue, foetal Achilles tendon tissue and foetal...
US20140162364 METHOD FOR PRODUCING A POROUS CALCIUM POLYPHOSPHATE STRUCTURE  
A method for producing a porous calcium polyphosphate structure, which comprises the steps of mixing monocalcium phosphate (MCP) with silicic acid, and sintering the mixture at a predefined...
US20130344600 COMPOSITIONS COMPRISING NANOSTRUCTURES FOR CELL, TISSUE AND ARTIFICIAL ORGAN GROWTH, AND METHODS FOR MAKING AND USING SAME  
The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and/or cell growth, e.g., for bone, kidney or...
US20120264190 Decellularized and Delipidized Extracellular Matrix and Methods of Use  
Compositions comprising decellularized and delipidized extracellular matrix derived from adipose or loose connective tissue, and therapeutic uses thereof. Methods for treating, repairing or...
US20120272347 CHITOSAN-ALGINATE SCAFFOLD CELL CULTURE SYSTEM AND RELATED METHODS  
Methods for culturing cancer cells in vitro using a three-dimensional scaffold, scaffolds that include the cultured cancer cells, and methods for using the cultured cancer cells and the scaffolds...
US20130236879 THREE-DIMENSIONAL, PREVASCULARIZED, ENGINEERED TISSUE CONSTRUCTS, METHODS OF MAKING AND METHODS OF USING THE TISSUE CONSTRUCTS  
Embodiments of the present disclosure provide for three-dimensional (3D), prevascularized, engineered tissue constructs, 3D prevascularized engineered tissue models of cancer, and bioreactors and...
US20130078666 SCAFFOLD-BASED ORGANOTYPIC CULTURE FOR THE LONG-TERM CULTIVATION OF HUMAN EPIDERMAL STEM CELLS  
The present invention relates to organotypic cultures of epidermal cells and the use thereof for the screening of pharmaceutical and cosmetic agents. Specifically, means for the improvement of the...
US20140206028 Stable Electrically Active Neurons from Adult Tissue  
Disclosed are compositions and methods of making stable electrically active adult neurons from adult neural tissue. The disclosed compositions can be used with microelectrode arrays in vitro to...
US20120171258 Modular Assembly of Tissue Engineered Constructs  
Scaleable, vascularised tissue constructs that are composed of a multiplicity of cell containing, discrete and separable modules, methods of fabricating same and uses thereof. The tissue construct...
US20100316690 Modular assembly of tissue engineered constructs  
Scaleable, vascularised tissue constructs that are composed of a multiplicity of cell containing, discrete and separable modules, methods of fabricating same and uses thereof. The tissue construct...
US20130156744 METHODS OF RECELLULARIZING A TISSUE OR ORGAN FOR IMPROVED TRANSPLANTABILITY  
Described herein are methods of recellularizing an organ or tissue matrix.
US20140220555 IN VITRO MICROPHYSIOLOGICAL SYSTEM FOR HIGH THROUGHPUT 3D TISSUE ORGANIZATION AND BIOLOGICAL FUNCTION  
Techniques for generating microtissues, including a micro-fabricated platform including at least one micro-well including a plurality of micro-cantilevers coupled thereto and surrounded by a...
US20110064809 SCAFFOLDS  
The invention relates to methods of preparing tissue implants for use in the augmentation, repair and regeneration of tissues.
US20120077272 CELLULAR SCAFFOLD  
A cellular scaffold that is suitable for tissue regeneration, cell culture and in vitro assays. The invention relates to a layered cell scaffold that is seeded with mesenchymal and ectodermal...
US20140004549 Method for Enzymatic Treatment of Tissue Products  
Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a...
US20120039961 IMPLANT AND THERAPEUTIC COMPOSITION FOR TREATING DAMAGE AND/OR DISEASES RELATING TO THE HUMAN ANIMAL MUSCULOSKELETAL SYSTEM  
An implant includes a support material, cartilage cells and/or precursor cells thereof, and a cartilage-specific collagen type. A method for preparing the implant, to a therapeutic composition,...
US20120259415 STRUCTURALLY MODIFIED ACELLULAR TISSUE ENGINEERING SCAFFOLDS AND METHODS OF PRODUCTION  
Methods are provided for producing a bioscaffold from natural tissues by oxidizing a decellularized tissue to produce a bioscaffold having pores therein. The pore size and porosity is increased to...
US20140315308 GLUCOMANNAN SCAFFOLDING FOR THREE-DIMENSIONAL TISSUE CULTURE AND ENGINEERING  
The present invention provides a neutralized glucomannan scaffold capable of promoting cell growth and suitable for three-dimensional tissue culture and engineering. The present invention also...
US20130302426 Modalities for the treatment of degenerative diseases of the retina  
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment...
US20140227782 THERMOSENSITIVE, BIOACTIVE BIOPOLYMER AND ASSOCIATED METHOD OF CELL HARVESTING  
The present invention relates to a biopolymer and a cell-harvesting scaffold comprising same, as well as the associated cell-harvesting method that allows said harvesting to be performed in a...
US20110287071 METHODS OF GENERATING TISSUE USING DEVITALIZED, ACELLULAR SCAFFOLD MATRICES DERIVED FROM MICRO-ORGANS  
A composition of matter is provided comprising a devitalized, acellular tissue-derived scaffold seeded with differentiated cells, particularly pancreatic islet cells, wherein the cells can...
US20120183944 DECELLULARIZATION AND RECELLULARIZATION OF ORGANS AND TISSUES  
The invention provides for methods and materials to decellularize an organ or portion thereof and to recellularize such a decellularized organ or portion thereof to thereby generate an organ or...
US20120028234 TISSUE AND ORGAN GRAFT BIOREACTOR AND METHOD OF OPERATION  
A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts,...
US20120244617 MESH ENCLOSED TISSUE CONSTRUCTS  
Described is a scaffold that is strong enough to resist forces that exist inside a body, while possessing biocompatible surfaces. The scaffold is formed of a layer of mesh (e.g., Stainless Steel...
US20110262487 De Novo Anembryonic Trophoblast Vesicles and Methods of Making and Using Them  
De novo, anembryonic trophoblast vesicles and methods of making and using them are provided.
US20130344114 COMPOSITION FOR REPAIRING CARTILAGE TISSUE AND METHOD FOR MAKING THE SAME  
A composition for repairing cartilage tissues includes a scaffold and a plurality of endothelial progenitor cells. The endothelial progenitor cells adhere on the scaffold. A method of making the...
US20130164269 CELL CULTURE SYSTEM FOR BIOREACTOR SCALE-UP OF CELLS  
The present invention relates to growing stem cells, for e.g., MSCs, in large-scale under GMP-compliance, using media and reagents that satisfy GMP requirements, while maintaining stemness, for...
US20140243979 System and Method for Forming Bone, Ligament, and Bone-Ligament Constructs  
A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in...
US20150050735 WELL PLATES  
Well plates for use in various laboratory experiments may include a plurality of wells each having an interior wall that includes a ledge positioned at a fixed depth within the well.
US20140074253 SCAFFOLDS COMPRISING NANOELECTRONIC COMPONENTS FOR CELLS, TISSUES, AND OTHER APPLICATIONS  
The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires...
US20110268709 Generation of Histocompatible Tissues Using Nuclear Transplantation  
Tissues produced by culture of cells produced by nuclear transfer on a matrix derived from nuclear transfer embryos or embryos and pluripotent cells provided by other methods are provided. These...
US20110223209 Oxygen delivering scaffold for tissue engineering  
The invention relates to compositions, implantable devices and methods related to tissue engineering. Provided is a composition comprising (i) at least one biocompatible polymer suitable for use...
US20120301507 METHOD OF TISSUE REPAIR  
The present invention relates to methods of repairing tissue. More specifically, the present invention relates to methods of using cells and an implantable support for the repair of tissue...
US20150050736 Hybrid Tissue Scaffold For Tissue Engineering  
A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary...
US20110189285 HYDROGEL CAPABLE OF CONTAINING AND CONVEYING CELLS  
An interpenetrating biodegradable polymeric matrix hydrogel and the use thereof to support, encapsulate, convey and release several types of cells under conditions which allow the cells to be kept...
US20110281358 System For Seeding Cells Onto Three Dimensional Scaffolds  
Systems are provided for convenient and sterile isolation, collection, and seeding of cells onto a scaffold or tissue graft. The systems may be closed. Methods for use of the disclosed systems for...