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US20120108464 |
TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system...
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US20130089526 |
Methods for Using Synthetic Triterpenoids in the Treatment of Bone or Cartilage Diseases or Conditions
The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
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US20110196343 |
Methods for Expansion and Analysis of Cultured Hematopoietic Stem Cells
Methods and kits for propagating hematopoietic stem cells are provided. The methods comprise culturing cells in medium comprising one or more angiopoietin-like proteins, under conditions sufficient...
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US20120003738 |
Method For Amplification And Functional Enhancment Of Blood Derived Progenitor Cells Using A Closed Culture System
The present invention provides a method for expanding and improving functional capacity of human adult-derived progenitor cells in vitro using a closed culture system. The present invention...
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US20080274092 |
Erythrocytes Containing Arginine Deiminase
Use of erythrocytes containing arginine deirainase for the preparation of a medicinal product for lowering the plasma concentration of arginine in vivo. Said use relates in particular to the...
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US20120148553 |
METHODS OF GENERATING NATURAL KILLER CELLS
Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of...
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US20110117061 |
Ex Vivo Expansion of Human Hematopoietic Stem Cells
Methods and kits for expanding the number of hematopoietic stem cells are provided. The methods comprise incubating cells in medium comprising isolated IGFBP-2 and an angiopoietin-like protein...
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US20100304483 |
T-CELL VACCINATION IN THE TREATMENT OF HIV INFECTION
A method for the preparation of a T cell vaccine for the treatment of immunodeficient HIV-infected patients is described herein, based on the enrichment of autologous CD4-reactive CD8 T cells. Also...
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US20120003254 |
Breast Cancer Vaccine
Compositions and methods for immunization against human breast cancer are disclosed. A breast cancer vaccine comprises an immunogenic polypeptide comprising human α-lactalbumin.
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US20110182937 |
Dendritic Cell Vaccines
Compositions and methods for the prophylaxis and treatment of human immunodeficiency virus (HIV) infections are disclosed herein. More specifically the present invention discloses describes an...
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US20130064859 |
COMBINATORIAL VITAMIN D AND PROBIOTIC THERAPY FOR INFLAMMATORY BOWEL DISEASE
A method of increasing the percentage of mouse and human Tregs is provided comprising providing B.fragilis or PSA and vitamin D or vitamin D metabolite to said mouse or human. Also, a method for...
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US20110212541 |
COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGEN PROTEINS
Pathogenic effector proteins include one or more virulence motifs of amino acid consensus sequence BXZ, where B=RK or H; X=any amino acid or is absent; Z=L, M, I, W, Y or F) which bind to target...
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US20100310532 |
GENE TARGETS IN ANTI-AGING THERAPY AND TISSUE REPAIR
Novel gene and protein targets are described for treatment of cardiac disorders, anti-aging therapies and tissue repair. Identified biomarkers are prognostic of long term survival of patients...
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US20070184030 |
Large scale storage of viable somatic stem and/or progenitor cells
A large scale storage system of viable somatic stem and/or progenitor cells for use in a method of treatment of a disease or a disorder of a patient is described. The storage system includes a...
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US20110268709 |
Generation of Histocompatible Tissues Using Nuclear Transplantation
Tissues produced by culture of cells produced by nuclear transfer on a matrix derived from nuclear transfer embryos or embryos and pluripotent cells provided by other methods are provided. These...
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US20120220032 |
OPTIMIZING CULTURE MEDIUM FOR CD34<+> HEMATOPOIETIC CELL EXPANSION
The present invention provides a method of determining the optimal composition of a serum-free, eukaryotic cell culture medium supplement, using 2-level factorial design and the steepest ascent...
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US20110065131 |
ASSAYS FOR MUTAGENESIS DETECTION
The disclosure provides methods, systems, and kits for assaying an agent for mutagenic properties. The methods systems and kits utilize a DEL selectable marker and a colorimetric detection systems....
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US20110182950 |
COMBINATION OF BLOOD AND OF BIPHASIC CALCIUM PHOSPHATE CERAMIC PARTICLES
The invention relates to a biomaterial containing coagulated blood or coagulated bone marrow aspirate and biphasic calcium phosphate ceramic particles, to a production method thereof and to the use...
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US20110318318 |
ANTI-APOPTOTIC FUSION PROTEINS
The present invention relates to a fusion protein comprising a protein transduction domain capable of introducing the fusion protein into a mammalian cell and an anti-apoptotic protein comprising...
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US20120328587 |
Method for Activating Natural Killer Cells by Tumor Cell Preparation In Vitro
The present invention provides a method for activating a Natural Killer (NK) cell by contacting the NK cell in vitro with an activating tumour cell preparation (ATCP). The invention also provides...
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US20110104131 |
HEMATOPOIETIC STEM CELLS AND METHODS OF TREATMENT OF NEOVASCULAR EYE DISEASES THEREWITH
Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin− HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood v...
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US20110318264 |
METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER
The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of colorectal, in particular colonic, and gastric tumor tissues and colorectal,...
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US20100297090 |
HEMATOPOIETIC CELL CULTURE NUTRIENT SUPPLEMENT
The present invention provides a serum-free supplement which supports the growth of hematopoietic cells in culture. Also provided are a medium comprising a basal medium supplemented with the...
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US20120252060 |
Self-Renewing Single Human Hematopoietic Stem Cells, an Early Lymphoid Progenitor and Methods of Enriching the Same
This invention relates to human hematopoietic stem cells. Specifically the invention relations to the identification of single human hematopoietic stem cells capable of long-term multilineage...
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US20120315338 |
LARGE SCALE GENERATION OF FUNCTIONAL MEGAKARYOCYTES AND PLATELETS FROM HUMAN EMBRYONIC STEM CELLS UNDER STROMAL-FREE CONDITIONS
The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem cell derived hemangioblasts for...
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US20130028915 |
DENDRITIC CELL (DC)-VACCINE THERAPY FOR PANCREATIC CANCER
Compositions and methods for eliciting therapeutic immunity and improving clinical outcomes in patients with pancreatic cancer are disclosed herein. The present invention describes a dendritic cell...
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US20110093020 |
Poly-porous hollow screw for target delivery of growth factors and stem cells:the design and potential clinical application
Present invention depicts a poly-porous (micropore) hollow screws as diffusion chamber filled with core matrix for targeted delivery of growth factors and bone marrow stem cells. The screws...
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US20110300144 |
METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER
The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which...
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US20130058903 |
Stem-Cell Material and Method of Use
Provided herein are mesenchymal stem cells which have been modified by the introduction of polynucleotides encoding for a mammalian Cdk1 protein. These cells do not sense in culture and are...
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US20120329709 |
PRODUCTION OF GLYCOPROTEINS
The present invention provides methods and materials by which glycosylation of glycoproteins can be regulated. Methods include the monitoring and regulation of parameters such that a glycoprotein...
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US20120282694 |
Methods for the Isolation and Expansion of Cord Blood Derived T Regulatory Cells
The present invention encompasses methods, and kits for the isolation and expansion of T regulatory cells having the CD45RA+ phenotype, including such cells from human umbilical cord blood.
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US20120252117 |
OPTIMIZED MESSENGER RNA
The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The...
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US20120148530 |
Method for the treatment or prevention of virus infection using polybiguanide-based compounds
An inexpensive, easily available, and convenient method of treating or preventing a virus infection is provided. The present invention relates to a method for the treatment or prevention of virus...
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US20120070430 |
IDENTIFICATION OF TUMOR-ASSOCIATED MARKERS FOR DIAGNOSIS AND THERAPY
The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic...
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US20110052728 |
BOTANICAL EXTRACT FROM THE AQUEOUS STREAM OF THE PALM OIL MILLING PROCESS FOR THE PREVENTION AND INHIBITION OF OXIDATIVE STRESS AND HAEMOLYSIS IN HUMAN RED BLOOD CELLS
The invention provides a composition for the prevention and inhibition of oxidative stress and haemolysis in human red blood cell wherein said composition compounds obtained from the aqueous stream...
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US20110045589 |
Methods Of Controlling Proliferation And Differentiation Of Stem And Progenitor Cells
A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions...
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US20110312543 |
Expression Vectors Based on Modified Ribosomal Protein Promoters and Uses Thereof in Post-Transcriptional Assessment
The present invention relates to expression vector comprising (a) a promoter region comprising a non-inducible constitutively active ribosomal protein gene promoter, (b) an operably linked reporter...
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US20130052728 |
COMPOSITIONS AND METHODS FOR MAKING AND USING BONE MARROW MESENCHYMAL STEM CELLS AND ERYTHROID PROGENITOR CELLS
The invention provides compositions for making erythroid progenitor cells that comprise in vitro-activated bone marrow mesenchymal stem cells and embryoid bodies (EBs) or pluripotent stem cells,...
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US20110306127 |
ENHANCING IRON UPTAKE IN PROTEIN-FREE MEDIA
Methods for enhancing iron uptake in cell culture are described. The methods include using a NTBI uptake activator and non-protein bound iron source. Suitable NTBI activators are delineated. Also...
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US20110318725 |
CELL CULTURE METHOD, CELL CULTURE DEVICE, METHOD FOR COUNTING SUBSJECT MATTERS TO BE COUNTED IN CONTAINER AND DEVICE FOR COUNTING
Cell aggregate formation control and cell aggregate disintegration control are carried out with respect to cells in a culture container to increase cell proliferation efficiency. The number of the...
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US20120122214 |
METHOD FOR PRODUCING CELL MEDICINE
It is an object of the present invention to provide a method for producing a cell medicine that is effective for diseases while causing a low risk to these diseases. The present invention provides...
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US20110070644 |
Monocyte-Derived Stem Cells (MDSC) and Methods of Use Thereof
Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals is provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical...
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US20130028875 |
Immune Effector Cells Pre-Infected with Oncolytic Virus
Compositions and methods are provided for the treatment of cancer. An immune effector cell population is pre-infected with an oncolytic virus. The combined therapeutic is safe and highly effective,...
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US20120258085 |
Expansion of NK Cells
A method of large scale expansion and simultaneous activation of NK cells and NK-like T cells in a closed cell culture system is presented, wherein the expanded cells exhibit increased cytotoxicity.
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US20110097795 |
Desiccated Biologics And Methods Of Preparing The Same
The present invention provides compositions comprising desiccated biologics comprising a cell, protein, virus, nucleic acid, carbohydrate, or lipid, or any combination thereof, along with at least...
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US20110014698 |
USE OF NANOPATTERNED SURFACES AND METHOD FOR ENRICHING OR ISOLATING CELLULAR SUBPOPULATIONS
The invention relates to the use of nanopatterned surfaces. It also relates to a method for enriching or isolating cellular subpopulations. To create a simple, versatile and specific method for...
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US20130045539 |
MEGANUCLEASE RECOMBINATION SYSTEM
The invention relates to a set of genetic constructs which comprises at least a first recombinogenic construct (i) with at least two portions homologous to the genomic regions preceding and...
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US20130137104 |
METHODS AND COMPOSITIONS FOR MODIFICATION OF THE HPRT LOCUS
Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals.
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US20130084636 |
SCAFFOLD FOR ARTICULAR CARTILAGE REGENERATION AND METHOD FOR MANUFACTURING SAME
Disclosed are scaffolds for regeneration of articular cartilage which are applicable to both the superficial zone and the middle zone of articular cartilage, and a method for manufacturing the...
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US20120114700 |
LAT ADAPTER MOLECULE FOR ENHANCED T-CELL SIGNALING AND METHOD OF USE
LAT (Linker for Activation of T-cells) is a protein involved in signaling through the T-cell receptor (TCR). The invention provides a LAT protein including mutations at ubiquitylation sites that...
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