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US20130274114 MULTIPOTENT STEM CELL-BASED CULTURE SYSTEMS AND MODELS  
This invention generally relates to multipotent stem cell-based research tools. More particularly, the present invention relates to culture systems and 3-dimensional tissue models that may be used...
US20130274124 ADHESION SIGNATURES  
The present invention provides arrays comprising polypeptides associated with extracellular matrix that can be used to isolate, differentiate, or culture certain cell types including stem cells,...
US20120301497 Plasmodium vivax Hybrid Circumsporozoite Protein and Vaccine  
Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any...
US20140120091 FUSION PROTEINS FOR THERAPY OF AUTOIMMUNE AND CARDIOVASCULAR DISEASE  
The present invention provides improved fusion proteins for therapy of autoimmune and cardiovascular disease.
US20120196321 SELECTABLE MARKERS AND RELATED METHODS  
The invention relates to newly identified selectable marker systems, cells for use in a selectable marker system, and methods for using the selectable marker systems.
US20110318730 MICROPATTERNED CO-CULTURE SYSTEMS AS INFECTIOUS DISEASE ANALYSIS PLATFORMS  
Cell cultures are provided that include a population of micropatterened hepatocytes and one or more non-parenchymal cell populations, where the hepatocytes are infected with a virus or parasite...
US20140322704 Hepatitis Virus Culture Systems Using Stem Cell-Derived Human Hepatocyte-Like Cells and Their Methods of Use  
The invention relates to the discovery that DHH derived from stem cells are permissive for infection by hepatitis viruses (HV), such as hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis...
US20140295548 BIOARTIFICIAL LIVER SYSTEM  
A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are...
US20120064537 USE OF PERFUSION DECELLULARIZED ORGANS FOR MATCHED RECELLULARIZATION  
The invention provides a method for preparing a perfusion based 3D cell culture system, a recellularized matrix culture system, and methods of using the culture system.
US20110117061 Ex Vivo Expansion of Human Hematopoietic Stem Cells  
Methods and kits for expanding the number of hematopoietic stem cells are provided. The methods comprise incubating cells in medium comprising isolated IGFBP-2 and an angiopoietin-like protein...
US20150073389 DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS  
Human hepatocyte cell cultures and their use in bioreactors and bioartificial liver (BAL) systems are provided. The cells have constitutive liver-specific metabolic activity resembling that of...
US20140315804 FUSION PROTEINS COMPRISING PDGF AND VEGF BINDING PORTIONS AND METHODS OF USING THEREOF  
The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions comprising the fusion proteins and viral...
US20140170123 Hepatocyte Based Insulin Gene Therapy For Diabetes  
A method and vectors for controlling blood glucose levels in a mammal are disclosed. In one embodiment, the method comprises the steps of: treating the hepatocyte cells of a patient with a first,...
US20110294194 EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 2B  
The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding...
US20150152392 HCV FULL-LENGTH INFECTIOUS CELL CULTURE SYSTEMS AND APPLICATIONS THEREOF  
The present invention relates to nucleic acid sequences that encode hepatitis C viruses (HCV) that are useful in the fundamental research of HCV as well as in the search of a vaccine against HCV....
US20120111795 DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS  
The present invention concerns human hepatocyte cell line cultures and their use in bioartificial liver (BAL) systems. These systems are used to treat subjects suffering from liver failure to...
US20150218240 p16 PROTEIN VARIANT AND USE THEREOF FOR PREVENTING OR TREATING CANCER  
A p16 protein variant; a polynucleotide encoding the p16 protein variant; a method for preparing the p16 protein variant; a pharmaceutical composition comprising the p16 protein variant; a method...
US20110117646 ANTISENSE MODULATION OF C-REACTIVE PROTEIN EXPRESSION  
Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense...
US20130164262 Recombinant Viruses and their Use for Treatment of Atherosclerosis and Othe Forms of Coronary Artery Disease and Method, Reagent, and Kit for Evaluating Susceptibiity to Same  
Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said...
US20150218243 P15 PROTEIN VARIANT AND USE THEREOF FOR PREVENTING OR TREATING CANCER  
A p15 protein variant; a polynucleotide encoding the p15 protein variant; a method for preparing the p15 protein variant; a pharmaceutical composition comprising the p15 protein variant; and a...
US20110212541 COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGEN PROTEINS  
Pathogenic effector proteins include one or more virulence motifs of amino acid consensus sequence BXZ, where B=RK or H; X=any amino acid or is absent; Z=L, M, I, W, Y or F) which bind to target...
US20130252282 OPTICAL CONTROL OF PROTEIN ACTIVITY AND LOCALIZATION BY FUSION TO PHOTOCHROMIC PROTEIN DOMAINS  
Engineered fusion proteins comprising photochromic protein domains are disclosed. In particular, the inventors have constructed fusion proteins containing photoswitchable photochromic fluorescent...
US20120087939 METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING SHIGA TOXIN-PRODUCING ESCHERICHIA COLI INFECTION  
Compositions and methods for stimulating an immune response against Shiga toxin-producing Escherichia coli (STEC) antigens are disclosed. The compositions include a multiple epitope fusion protein...
US20130267582 ADENO-ASSOCIATED VIRUS 2/8 - MICRO RNA-101 THERAPY FOR LIVER CANCER  
Adeno-associated virus 2/8-microRNA-101(AAV2/8-miR-101) therapy for liver cancer is provided. In particular, the invention provides a recombinant AAV 2/8 vector, comprising mutated capsid, for the...
US20130108588 MULTIPOTENT STEM CELL CULTURES  
The invention provides methods for propagation of multipotent stem cells from human skin fibroblast samples using an appropriate medium, such as an amniotic fluid medium (AFM), and subsequent...
US20140086939 COMPOSITIONS AND METHODS FOR DETECTING AND TREATING CANCER  
The invention provides methods for detecting the presence of cancer initiating cells in a tissue, methods for identifying test agent for reducing cancer, and methods for reducing cancer in a...
US20110306753 Method for Increasing Protein Expression in Cells  
The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryotic cells, by reducing the number of RNase L cleavage sites in the coding and/or...
US20120003741 HEPATITIS C VIRUS EXPRESSING REPORTER TAGGED NS5A PROTEIN  
The present inventors developed hepatitis C reporter viruses containing Core through NS2 of prototype isolates of all major HCV genotypes and the remaining genes of isolate JFH1, by insertion of...
US20130039894 Polypeptides and Use Thereof for Treatment of Traumatic or Degenerative Neuronal Injury  
The present invention relates to polypeptides transiently activating Ras homolog gene family member A (RhoA) GTPase, polynucleotides encoding said polypeptides and pharmaceutical compositions...
US20130157284 COLORIMETRIC AND FLUORESCENT PROTEINS  
The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths.
US20110294195 EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 7a  
Genotype 7a has been identified recently, thus not much is known about the biology of this new, major HCV genotype. The present inventors developed hepatitis C virus 7a/2a intergenotypic...
US20110117181 TREATING HEPATITIS C VIRUS INFECTION WITH OVER-EXPRESSION OF MICRORNA-196  
The present invention is directed to methods of treating cells infected with HCV and mammals suffering from HCV infection by transfecting the infected cells with miRNA-196 mimic. miRNA-196 mimic...
US20140363473 METHOD FOR PREPARING SPHEROIDS OF HUMAN PRIMARY HEPATOCYTES  
The present invention relates to a method for preparing spheroids of human primary hepatocytes. The method comprises culturing of isolated human primary hepatocytes on a polysaccharide scaffold...
US20130196430 PROTEIN PRODUCTION  
The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity...
US20120264208 MATERIALS AND METHODS FOR ENHANCED IRON UPTAKE IN CELL CULTURE  
A serum-free, synthetic tissue culture media is described which is completely defined chemically. The media do not require any supplementation with serum to support growth of cells. The media and...
US20120028353 HEPATIC STELLATE CELL PRECURSORS AND METHODS OF ISOLATING SAME  
The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class...
US20130224246 MODIFIED HEPATITIS C VIRUS PROTEINS  
A composition comprising a hepatitis C virus (HCV) Envelope 2 (E2) polypeptide including a receptor binding variant, wherein the polypeptide is modified to comprise: (i) a cysteine mutated or...
US20110104126 Human Hepatic Stem Cell, Method for Preparation of the Same, Method for Induction of Differentiation of the Same, and Method for Utilization of the Same  
The present invention provides a human hepatic stem cell which is sorted based on the presence or absence of the expression of at least one marker selected from the group consisting of CD318,...
US20120282271 METHODS AND COMPOSITIONS FOR MODULATING HEPSIN ACTIVATION OF MACROPHAGE-STIMULATING PROTEIN  
The invention provides methods and compositions for modulating hepsin activity and the MSP/Ron pathway, in particular by regulating pro-MSP activation by hepsin.
US20150166952 CULTURED HEPATOCYTE AND METHOD FOR PREPARING THE SAME  
Cultured hepatocytes with hepatic-cord structure and the applications were disclosed. Also the disclosure performed the method for obtaining the cultured hepatocytes with hepatic-cord structure...
US20100311124 Methods and compositions for inactivating glutamine synthetase gene expression  
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage...
US20130115592 MODIFIED HUMAN HEPATITIS C VIRUS GENOMIC RNA THAT CAN BE AUTONOMOUSLY REPLICATED  
The present invention provides modified hepatitis C virus genomic RNA, comprising nucleotide sequences of genomic RNA portions of two or more types of hepatitis C viruses, which comprises a 5′...
US20130337459 A METHOD OF ENHANCING MIR-185 EXPRESSION TO REDUCE LOW DENSITY LIPOPROTEIN/CHOLESTEROL ACCUMULATION IN A CELL  
The present invention provides a method of quantifying miR-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of...
US20110217725 CELL CULTURE KIT, SCREENING METHOD, AND METHOD OF MANUFACTURING CELL CULTURE KIT  
To provide a cell culture kit including cultured living cells of various donors, and a manufacturing method thereof. The cell culture kit includes a culture plate and living cells cultured...
US20130071365 INDUCED HEPATOCYTES  
An object of the present invention is to produce hepatic cells from non-hepatic cells that can be obtained less invasively and at low cost. The gene of HNF3α, HNF3β, or HNF3γ and the gene of HNF4α...
US20130052716 JFH-1 BASED HCV CELL CULTURE SYSTEMS FOR NS5A OF GENOTYPES 1-7  
The present inventors developed hepatitis C virus recombinants expressing NS5A from genotype 1a, 1b, 2a, 3a, 4a, 5a, 6a or 7a in the context of a genotype 2a backbone. Additional recombinants...
US20120329709 PRODUCTION OF GLYCOPROTEINS  
The present invention provides methods and materials by which glycosylation of glycoproteins can be regulated. Methods include the monitoring and regulation of parameters such that a glycoprotein...
US20120237999 HERPES SIMPLEX VIRUSES AND METHODS OF VIRAL REPLICATION  
A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.
US20130111612 PRIMATE MODEL FROM THE FAMILY CERCOPITHECIDAE INFECTED BY A HBV STRAIN OF HUMAN GENOTYPE  
The invention relates to a non-human primate animal model for HBV infection, said animal model being of the Cercopithecidae family.
US20150203540 Cytoplasmic Tail Modifications to Boost Surface Expression and Immunogenicity of Envelope Glycoproteins  
The invention provides compositions and methods for enhanced expression of a viral envelope protein. The invention provides a composition comprising a cytoplasmic tail modification to enhance...

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