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US20130274114 |
MULTIPOTENT STEM CELL-BASED CULTURE SYSTEMS AND MODELS
This invention generally relates to multipotent stem cell-based research tools. More particularly, the present invention relates to culture systems and 3-dimensional tissue models that may be used... |
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US20150118749 |
RETINAL PIGMENT EPITHELIAL CELLS DIFFERENTIATED FROM EMBRYONIC STEM CELLS WITH NICOTINAMIDE AND ACTIVIN A
The present invention concerns RPE cells obtainable by directed differentiation from stem cell, particularly, human stem cells. It has been specifically found that culturing stem cells in the... |
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US20130330302 |
RETINAL PIGMENT EPITHELIAL STEM CELLS
The present invention relates to a retinal pigment epithelial stem cell isolated from a posterior region of the retinal pigment epithelium of an adult mammal. The invention also relates to a... |
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US20140140965 |
LOW OXYGEN CULTURE CONDITIONS FOR MAINTAINING RETINAL PROGENITOR CELL MULTIPOTENCY
The present invention relates to methods for culturing human retinal progenitor cells under low oxygen conditions to allow the cells to retain the ability to differentiate into photoreceptors... |
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US20140186309 |
COMPOSITIONS AND METHODS FOR TREATING RETINAL DISEASES
Disclosed herein are compositions and methods for treating, ameliorating or preventing a retinal disease or condition; improving a photopic (day light) vision; for improving correcting visual... |
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US20150218240 |
p16 PROTEIN VARIANT AND USE THEREOF FOR PREVENTING OR TREATING CANCER
A p16 protein variant; a polynucleotide encoding the p16 protein variant; a method for preparing the p16 protein variant; a pharmaceutical composition comprising the p16 protein variant; a method... |
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US20130115299 |
METHOD FOR INHIBITING CANCER STEM CELL LIKE PROPERTIES AND CHEMORADIORESISTANT PROPERTIES OF CANCER OR TUMOR CELLS WITH MICRORNA145
The present invention provides a method for inhibiting cancer stem cell like properties and chemoradioresistant properties of cancer or tumor cells comprising delivering miR145 to the cancer or... |
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US20110244470 |
ISOLATED TRANSGENIC MAMMALIAN NEURAL CELL FOR DETECTION OF A SAMPLE CONTAINING A CHEMICAL SUBSTANCE DAMAGE TO NEUROLOGICAL SYSTEM OR SELECTION OF DRUGS FOR TREATING NEURODEGENERATIVE DISORDERS
The invention is to provide an isolated transgenic mammalian neural cell, which comprises at least one heterologous vector expressing AhR/ARNT. Also provided is methods the detection of a sample... |
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US20130164262 |
Recombinant Viruses and their Use for Treatment of Atherosclerosis and Othe Forms of Coronary Artery Disease and Method, Reagent, and Kit for Evaluating Susceptibiity to Same
Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said... |
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US20110212541 |
COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGEN PROTEINS
Pathogenic effector proteins include one or more virulence motifs of amino acid consensus sequence BXZ, where B=RK or H; X=any amino acid or is absent; Z=L, M, I, W, Y or F) which bind to target... |
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US20150037885 |
METHOD OF PRODUCING HUMAN RETINAL PIGMENTED EPITHELIAL CELLS
The production of human retinal pigment epithelial cells having a step of incubating human pluripotent stem cells with binder molecules binding to terminal N-acetyllactosamine (GalĪ²1-4Glc NAc)... |
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US20130108588 |
MULTIPOTENT STEM CELL CULTURES
The invention provides methods for propagation of multipotent stem cells from human skin fibroblast samples using an appropriate medium, such as an amniotic fluid medium (AFM), and subsequent... |
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US20140186391 |
VACCINE AGAINST RSV
Provided is a vaccine against respiratory syncytial virus (RSV), comprising a recombinant human adenovirus of serotype that comprises nucleic acid encoding a RSV F protein or immunologically... |
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US20110003003 |
MAGNETIC CELLS FOR LOCALIZING DELIVERY AND TISSUE REPAIR
Normal or genetically modified cell(s) having magnetic nanoparticle(s) bound (affixed) to their surfaces and methods of delivery to target tissues, e.g. for treatment of disease and or injury. |
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US20110014695 |
METHODS FOR OBTAINING ADULT HUMAN OLFACTORY PROGENITOR CELLS
An isolated human olfactory stem cell can be prepared by culturing human tissue from olfactory neuroepithelium to form neurospheres. |
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US20120149781 |
STEM CELL DIFFERENTIATION USING NOVEL LIGHT-RESPONSIVE HYDROGELS
This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem... |
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US20140134729 |
Synthetic Surfaces for Culturing Stem Cell Derived Oligodendrocyte Progenitor Cells
Synthetic surfaces suitable for culturing stem cell derived oligodendrocyte progenitor cells contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many... |
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US20120060230 |
METHODS AND COMPOSITIONS FOR MODIFICATION OF A HLA LOCUS
Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator. |
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US20150087058 |
STEM CELL CULTURE MEDIUM AND METHOD FOR CULTURING STEM CELLS USING SAME
The present invention relates to a stem cell culture medium which can be substituted for a conventional stem cell culture medium containing the heterologous protein fetal bovine serum, and more... |
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US20110217774 |
Efficient and Universal Method for Neural Differentiation of Pluripotent Stem Cells
The present invention relates to a method for inducing neural differentiation of stem cells. In more detail, the present invention relates to a method for inducing neural differentiation of stem... |
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US20120252117 |
OPTIMIZED MESSENGER RNA
The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The... |
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US20130004985 |
METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS
Provided herein are methods and compositions useful in treating neurological disorders. |
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US20150126410 |
MEANS AND METHODS TO INCREASE ADENOVIRUS PRODUCTION
The invention relates in a first embodiment to a method for increasing the yield of replication-incompetent adenoviruses having at least a partial deletion in the E1-region, wherein said... |
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US20100324697 |
System and method for a piezoelectric scaffold for nerve growth and repair
Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric... |
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US20130004467 |
MYELINATION OF CONGENITALLY DYSMYELINATED FOREBRAINS USING OLIGODENDROCYTE PROGENITOR CELLS
One form of the present invention is directed to a method of remyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit... |
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US20110189135 |
HUMAN STEM CELL-DERIVED NEURAL PRECURSORS FOR TREATMENT OF AUTOIMMUNE DISEASES OF THE CENTRAL NERVOUS SYSTEM
The present invention concerns the use of a population of cells comprising: (a) neural precursor cells committed to an oligodendroglial fate; (b) uncommitted neural precursor cells (c)... |
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US20100330043 |
GPR125 AS A MARKER FOR STEM AND PROGENITOR CELLS AND METHODS USE THEREOF
The present invention relates to GPR1 25 as a marker of stem and progenitor cells, including multipotent adult spermatogonial-derived stem cells (MASCs), spermatogonial stem and progenitor cells,... |
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US20110052500 |
TAJ in Neuronal Function
The invention provides methods of treating diseases, disorders, injuries, or conditions involving modulating neurite outgrowth and/or survival, including CNS disorders, stroke, or spinal injury,... |
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US20140295547 |
METHOD TO CONSTRUCT IN-VITRO HUMAN BLOOD BRAIN BARRIER MODEL
A method to construct an in-vitro human blood brain barrier (BBB) model is disclosed, which comprises steps: attaching suspension liquids of human brain vascular pericytes (HBVPs) and human... |
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US20150093761 |
Differentiation and amplification method for inducing human neural
stem/progenitor cells to differentiate into oligodendrocyte progenitor cells and
application thereof
A Method for inducing human neural stem/progenitor cells to differentiate into oligodendrocyte progenitor cells and application thereof comprises following steps of: pre-treating neural stem cells... |
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US20120294949 |
METHODS OF PRODUCING STEM CELL CONDITIONED MEDIA TO TREAT MAMMALIAN INJURIES OR INSULTS
Methods of producing stem cell conditioned media to treat mammalian injuries or insults. In at least one embodiment of a method of producing a stem cell conditioned media of the present... |
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US20110217267 |
GENE THERAPY VECTORS AND CYTOSINE DEAMINASES
This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in... |
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US20130089926 |
METHOD FOR DIFFERENTIATING HUMAN NEURAL PROGENITOR CELLS INTO DOPAMINERGIC NEURONS, AND MEDIUM FOR DIFFERENTIATION THEREOF
The present invention provides a method for differentiating human neural progenitor cells into dopaminergic neurons, comprising the step of culturing human neural progenitor cells in a medium... |
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US20130267464 |
THERAPEUTIC USE OF A GROWTH FACTOR, METRNL
The present invention relates to the field of therapeutic use of proteins, genes and cells, in particular to the therapy based on the biological function of a secreted therapeutic protein, METRNL,... |
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US20140193341 |
HUMAN INDUCED NEURONAL CELLS
A method for reprogramming a fibroblast into a human induced neuronal cell (hIN) is described. The method comprises expressing heterologous reprogramming factors Bm2, Myt11, Zic1, Olig2, Asc11 or... |
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US20140065669 |
NEUROBLASTOMA HOST CELL LINE FOR STABLY EXPRESSING HUMAN EXOGENOUS PROTEIN AND METHOD
A neuroblastoma host cell line for stably expressing human exogenous protein is provided. The cell line is generated by independently integrating control plasmid and switch plasmid into genome of... |
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US20120129260 |
METHOD FOR PRODUCING PLURIPOTENT STEM CELLS
Methods are provided for producing a human embryo capable of developing to the blastocyst stage. The method includes transferring a human somatic cell genome into a mature human oocyte by nuclear... |
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US20150017139 |
Methods of Generating Neural Stem Cells
The present disclosure provides methods of generating neural stem cells from differentiated somatic cells. The present disclosure also provides induced neural stem cells generated using a subject... |
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US20120269778 |
METHODS OF GENERATING NEURAL STEM CELLS
The present disclosure provides methods of generating neural stem cells from differentiated somatic cells. The present disclosure also provides induced neural stem cells generated using a subject... |
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US20150159133 |
METHOD OF IN VITRO DIFFERENTIATION OF MOTOR NEURON PROGENITORS (MNPS) FROM HUMAN INDUCED PLURIPOTENT STEM CELLS AND CRYOPRESERVATION OF MNPS
Methods are disclosed for the initiation and differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) into motor neuron progenitor cells (MNPs). Methods are... |
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US20100323385 |
NITROGEN INDEPENDENCE IDENTIFIES A HIGHLY MALIGNANT POPULATION OF TUMOR STEM CELLS
The present invention is directed to a method for isolating and establishing Growth Factor-Independent (GF-I) Tumor Stem Cells (TSCs) from tumor biopsies or tumor cell lines consisting in... |
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US20120308530 |
Materials Composition and Methods to Control Neural Progenitor and Stem Cell Attachment, Proliferation and Guide Cell Differentiation
This invention disclosure provides culture surface compositions and methods that control the NPCs and NSCs, and/or MSCs to either largely maintain their phenotypes, or differentiate on these... |
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US20130224162 |
HUMAN NEURAL STEM CELLS EXPRESSING HUMAN CHOLINE ACETYLTRANSFERASE, AND USE THEREOF
The present invention relates to human neural stem cells (NSCs) transfected with a vector comprising a polynucleotide encoding human choline acetyltransferase (ChAT) and thereby stably expressing... |
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US20120094381 |
METHODS OF NEURAL CONVERSION OF HUMAN EMBRYONIC STEM CELLS
The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human... |
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US20150031129 |
METHOD FOR PROLIFERATING STEM CELLS BY ACTIVATING C-MET/HGF SIGNALING AND NOTCH SIGNALING
The present invention relates to stem cells in which a gene that activates signaling is introduced and to a method for proliferating the stem cells. More specifically, the invention relates to a... |
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US20120295348 |
METHOD FOR PROLIFERATING STEM CELLS BY ACTIVATING C-MET/HGF SIGNALING AND NOTCH SIGNALING
The present invention relates to stem cells in which a gene that activates signaling is introduced and to a method for proliferating the stem cells. More specifically, the invention relates to a... |
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US20150175965 |
NOVEL METHODS TO REGENERATE HUMAN LIMBAL STEM CELLS
The invention disclosed herein provides systems and methods designed to facilitate human limbal stem/progenitor cell culture including a novel 3-dimensional (3D) sandwich method/system in which... |
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US20060233764 |
Skin regeneration system
A cell culture medium and system are provided which eliminate or at least reduce the requirement for exogenous components such as serum and feeder cells. The cell culture medium comprises an IGF... |
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US20150118198 |
BONE MARROW-DERIVED MESENCHYMAL STEM CELLS AS A SOURCE OF NEURAL PROGENITORS
Methods are provided for treating and/or reducing the severity of multiple sclerosis in a human, by administering autologous mesenchymal stem cell-derived neural precursors. Also described is an... |
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US20120190108 |
NEURONAL PROGENITOR CELLS AND METHODS OF DERIVATION AND PURIFICATION OF NEURONAL PROGENITOR CELLS FROM EMBRYONIC STEM CELLS
The invention provides neuronal progenitor cells, populations and cultures of cells, cell compositions and methods of producing neuronal progenitor cells. Neuronal progenitor cells can be prepared... |