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US20090285892 |
METHODS AND SYSTEMS FOR EXPANDING AC133+ CELLS AND DIRECTING DIFFERENTIATION
The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in...
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US20090285815 |
IMMUNOCONJUGATES COMPRISING CD4 AND IMMUNOGLOBIN MOLECULES FOR THE TREATMENT OF HIV INFECTION
Nucleic acids encoding recombinant CD4-fusion proteins are disclosed herein that include a CD4 polypeptide ligated at its C-terminus with a portion of an immunoglobulin comprising a hinge region...
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US20090285751 |
CANCEROUS DISEASE MODIFYING ANTIBODIES
The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell...
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US20090280128 |
ANTI-ILT7 ANTIBODY
An antibody binding to IPC was obtained by using an animal cell in which a cell membrane protein associatable with ILT7 was co-expressed as an immunogen. The antibody of the invention has a high...
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US20090280097 |
PLURIPOTENT CELLS
Pluripotent cells that are immunopositive for both the neural progenitor marker nestin and a pluripotent cell marker are provided. The cells exhibit rapid doubling times and can be maintained in...
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US20090280096 |
PANCREATIC ENDOCRINE PROGENITOR CELLS DERIVED FROM PLURIPOTENT STEM CELLS
The invention provides pluripotent cells modified to overexpress Pdx1 and Ngn3. Pluripotent cells include embryonic stem cells and induced pluripotent stem cells. Methods of producing pancreatic...
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US20090275131 |
METHOD FOR PRODUCTION OF MAST CELLS FROM STEM CELLS
Provided are methods for generating mast cells from pluripotent stem cells in vitro. Methods are disclosed for the differentiation of pluripotent cells, such as iPS cells and/or human embryonic...
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US20090275130 |
BIOMIMETIC NUCLEIC ACIDS
The present invention is directed to nucleic acids with biomimetic properties and methods for producing said nucleic acids. In particular, this invention relates to nucleic acids exhibiting...
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US20090275129 |
TISSUE ENGINEERED BLOOD VESSELS
Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.
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US20090275128 |
MEDIUM AND CULTURE OF EMBRYONIC STEM CELLS
Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem...
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US20090275127 |
VIABLE CELLS FROM FROZEN UMBILICAL CORD TISSUE
Viable progenitor cells are extracted from frozen umbilical cord tissue. In embodiments, the umbilical cord tissue is a blood vessel bearing perivascular Wharton's jelly, and the extracted...
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US20090274671 |
VECTOR ENCODING HUMAN GLOBIN GENE AND USE THEREOF IN TREATMENT OF HEMOGLOBINOPATHIES
Recombinant lentiviral vectors having a region encoding a functional β-globin gene; and large portions of the β-globin locus control regions which include DNase I hypersensitive sites HS2, HS3...
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US20090274663 |
Materials and Methods Relating to Cell Based Therapies
The invention provides a novel multipotent cell population of adult origin that can be used to treat ageing and disease, particularly by transplantation to site of cellular damage.
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US20090269845 |
PLURIPOTENT CELLS
The present invention is directed to pluripotent cells that can be readily expanded in culture on tissue culture substrate that is not pre-treated with protein or an extracellular matrix, and do...
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US20090269830 |
Culture System and Method for Propagation of Human Blastocyst-Derived Stem Cells
The present invention relates to a culture system for and a method for propagation of human blastocyst-derived stem cells (hBS cells) upon enzymatic dissociation into a single cell suspension. The...
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US20090269389 |
ARPE-19 as a Platform Cell Line for Encapsulated Cell-Based Delivery
ARPE-19 cells were evaluated as a platform cell line for encapsulated and unencapsulated cell-based delivery technology. ARPE-19 cells were found to be hardy (the cell line is viable under...
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US20090269318 |
PROGENITOR CELLS FROM WHARTON'S JELLY OF HUMAN UMBILICAL CORD
Human progenitor cells are extracted from perivascular tissue of human umbilical cord. The progenitor cell population proliferates rapidly, and harbours osteogenic progenitor cells and MHC−/−...
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US20090269317 |
IRREVERSIBLE ELECTROPORATION TO CREATE TISSUE SCAFFOLDS
The present invention provides engineered tissue scaffolds, engineered tissues, and methods of using them. The scaffolds and tissues are derived from natural tissues and are created using...
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US20090269314 |
HUMAN CARDIOVASCULAR PROGENITOR CELLS
The present invention provides populations of human cardiovascular progenitor cells, methods of making such cells, and methods of using the cells for production of populations of cardiovascular...
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US20090269310 |
METHOD FOR OBTAINING HUMAN SMOOTH MUSCULAR CELLS AND USES THEREOF
The invention concerns a method for obtaining in vitro a population of cells comprising essentially human smooth muscular cells expressing calponin and SM-MHC from a sample of human muscular biopsy...
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US20090269309 |
Retinoic acid stimulates differentiation of pancreatic progenitor cells into insulin producing cells
The invention relates to a method of forming pancreatic hormone-producing endocrine cells in vitro, wherein pancreatic stem cells are treated with one or more retinoids and/or retinoic acid in...
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US20090264309 |
Methods for Screening for Compounds that Modulate Insulin Promoter Activity
Compositions and methods are provided for screening for compounds that modulate insulin promoter activity. Vectors that express green fluorescent protein under the control of the human insulin...
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US20090263899 |
CELL MODIFICATION METHOD AND CELL MODIFICATION DEVICE
The present invention relates to a cell modification method for modifying human or mammal immune cells, especially effector cells outside the human or mammal body, wherein in a first step at least...
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US20090263896 |
METHODS FOR PURIFYING ENDODERM AND PANCREATIC ENDODERM CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
The present disclosure relates to compositions and methods comprising cell surface markers for hES-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells,...
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US20090263895 |
Cell line for producing a non-retroviral vector
Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial...
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US20090263878 |
Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof
The present disclosure describes mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. The ELSCs of the present disclosure are capable...
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US20090263403 |
MAMMALIAN CELL MEMBRANE PROTEINS; RELATED REAGENTS
The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells,...
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US20090263361 |
HUMAN TROPHOBLAST STEM CELLS AND USE THEREOF
Existence of human trophoblast stem (hTS) cells has been suspected but unproved. The isolation of hTS cells is reported in the early stage of chorionic villi by expressions of FGF4, FGFR-2, Oct4,...
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US20090263359 |
Particulate Delivery Vehicles for Embryoid Bodies
The present invention provides a vehicle for delivering various chemicals, compositions and proteins to stem cells and embryoid bodies. The vehicle may be biocompatible and biodegradable polymer...
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US20090258421 |
EMBRYONIC STEM CELLS AND NEURAL PROGENITOR CELLS DERIVED THEREFROM
The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production...
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US20090258337 |
Thawed organ or tissue or thawed cell group to be donated, transplanted, added, or administered to living body, production process thereof, supercooled solution therefor, and production apparatus of the organ or tissue
The present invention aims to freeze and store organs or tissues taken from human bodies or animals and after thawing, use the resulting organs or tissues, or cells taken and extracted therefrom...
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US20090258023 |
TGF-BETA SUPERFAMILY BINDING PROTEINS AND MODULATION OF BONE FORMATION AND LOSS
The present invention relates to novel polynucleotides and polypeptides that are expressed in osteoblasts, interact with members of the TGF-β superfamily, and inhibit mineralization. The invention...
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US20090257987 |
Method of generating dopamine-secreting cells
Methods of generating cells which secrete dopamine are disclosed. One method comprises incubating mesenchymal stem cells in a culture medium comprising brain derived neurotrophic factor (BDNF),...
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US20090253202 |
DEFINITIVE ENDODERM
Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive...
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US20090252736 |
Mammalian Genes; Related Reagents
Nucleic acids encoding a new family of small cysteine rich soluble proteins, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of...
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US20090252715 |
IMMORTALIZATION OF MAMMALIAN CELLS
Genomic instability in T antigen expressing cells can be overcome by modifying the gene expressing T antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the...
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US20090252711 |
Stem Cells And Methods Of Making And Using Stem Cells
The invention provides a method of making a pluripotent stem cell from a cell that is not pluripotent, such as from a differentiated stem cell or a lineage-restricted stem cell. The methods...
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US20090246181 |
THERAPEUTIC COMPOSITION FOR ATOPIC DERMATITIS
A novel type of therapeutic agent, human mesenchymal stem cells, and a composition containing the same for the treatment of atopic dermatitis is disclosed. A method for the treatment of atopic...
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US20090239298 |
Methods of generating embryoid bodies using three dimensional scaffolds
A method of generating embryoid bodies is provided. The method comprising culturing undifferentiated embryonic stem cells on a three dimensional scaffold under conditions suitable for formation of...
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US20090238853 |
Hybrid Biomedical Device Fabricated From Biomaterials and Coated With a Natural Extra Cellular Matrix (ECM) Coating
The present invention relates to a hybrid biomedical device formed from a prefabricated biomedical device and coated with an extracellular matrix coating which is produced by directly culturing...
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US20090238800 |
ISOLATION AND THERAPEUTIC APPLICATION OF ADULT RETINAL STEM CELLS COLLECTED FROM EXTRA-RETINAL TISSUES
The present invention is directed to an adult retinal cell line isolated from extra-retinal ocular tissue, and methods of isolating adult retinal cells from extra-retinal ocular tissue. The present...
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US20090238799 |
Conditionally-Immortalised Pancreatic Cells
Conditionally immortalized pancreatic cells are produced which remain immortal in the presence of 4-hydroxytamoxifen (4-OHT) but express normal pancreatic cell markers when 4-OHT is not present....
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US20090233379 |
Taste Receptors Of The T1R Family From Domestic Dog
The present invention relates to the discovery of several genes of the domestic dog ( Canine familiaris ) associated with taste perception. The invention provides, inter alia, the nucleotide...
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US20090233334 |
CELL CULTIVATION AND PRODUCTION OF RECOMBINANT PROTEINS BY MEANS OF AN ORBITAL SHAKE BIOREACTOR SYSTEM WITH DISPOSABLE BAGS AT THE 1,500 LITER SCALE
The present invention provides a novel method for culturing cells as well as a novel method for producing a recombinant protein by culturing cells at large scale (up to 1,500 L nominal volume and...
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US20090232813 |
Four-Jointed Box (FJX1) In Cancer Diagnosis and Treatment
The present invention relates to a new tumor suppressor, designated FJX1. Also described are diagnostic, prognostic and therapeutic uses of the FJX1 protein and the FJX1 gene, alone or in...
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US20090232779 |
OLIGODENDROCYTES DERIVED FROM HUMAN EMBRYONIC STEM CELLS FOR REMYELINATION AND TREATMENT OF SPINAL CORD INJURY
This invention provides populations of neural cells bearing markers of glial cells, such as oligodendrocytes and their precursors. The populations are generated by differentiating pluripotent stem...
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US20090232772 |
HUMAN CORNEAL ENDOTHELIAL CELL-DERIVED PRECURSOR CELLS, CELLULAR AGGREGATES, METHODS FOR MANUFACTURING THE SAME, AND METHODS FOR TRANSPLANTING PRECURSOR CELLS AND CELLULAR AGGREGATES
Providing is cellular aggregates derived from corneal endothelial cells that, when transplanted, readily adhere to the parenchyma of cornea and function in a manner equivalent to corneal...
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US20090232771 |
Method of controlling cell functions
The present invention provides methods of screening genes associated with cell regeneration, growth and differentiation and regulators for cell regeneration, growth or differentiation; regulators...
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US20090227032 |
Nuclear reprogramming factor and induced pluripotent stem cells
The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present...
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US20090227025 |
Ex vivo human lung/immune system model using tissue engineering for studying microbial pathogens with lung tropism
A method for studying scaffold-based tissue engineering approaches in combination with the use of progenitor or stem cells to generate new lung tissue in an in vitro system. The engineered tissue...
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