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US20110002904 SYNOVIAL VILLI FOR USE WITH TISSUE ENGINEERING  
Synovial villi derived explants and related surgical tools used to repair or prevent damage to injured or diseased tissue, including connective tissue. The tools including a harvesting tool for...
US20130274114 MULTIPOTENT STEM CELL-BASED CULTURE SYSTEMS AND MODELS  
This invention generally relates to multipotent stem cell-based research tools. More particularly, the present invention relates to culture systems and 3-dimensional tissue models that may be used...
US20130065310 USE OF ENDOGENOUS PROMOTERS TO EXPRESS HETEROLOGOUS PROTEINS  
The present invention provides methods for using endogenous transcriptional control systems to regulate the expression of heterologous protein(s). In particular, targeted genome editing is used to...
US20110045588 METHOD FOR CULTURING HUMAN PERIOSTEUM  
The present invention provides a method for forcingly culturing a piece of human periosteum tissue in a shorter culture period, the method including the steps of: (1) placing a periosteum piece...
US20130230884 Methods to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation  
The present invention provides reagents and methods for identifying translation enhancing elements, as well as isolated translation enhancing elements and their use in protein expression reagents...
US20140186947 Activation and Expansion of T-Cells Using an Engineered Multivalent Signaling Platform as a Research Tool  
Provided are a system and methods for selectively inducing expansion of a population of T cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research...
US20140273209 ARTIFICIAL IMMUNE SYSTEM: METHODS OF USE  
The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the...
US20140377861 Precise Control of Recombinant Protein Levels by Engineering Translation  
Compositions and methods are provided for user-specified fine-tuned protein expression levels, by controlling the initiation of protein translation; and a model for analysis of expression. This...
US20120184016 NOVEL PROTEIN AND GENE THAT CODES THEREFOR  
The present invention provides a novel protein having neuraminidase activity and/or β-galactoside-α2,6-sialyltransferase activity and a nucleic acid encoding the protein. The present invention...
US20130078222 Intervertebral Disc Nucleus Pulposus Stem Cell/Progenitor Cell, The Cultivation Method And Intended Use Thereof  
Provided are intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. An intervertebral disk nucleus pulposus cell is...
US20140341864 METHODS FOR PRODUCING RETINAL TISSUE AND RETINA-RELATED CELL  
The invention provides a method for producing a retinal tissue by (1) subjecting pluripotent stem cells to floating culture in a serum-free medium containing a substance inhibiting the Wnt signal...
US20120142097 FUSION PROTEINS OF HIV REGULATORY/ACCESSORY PROTEINS  
The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of...
US20120142096 FUSION PROTEINS OF HIV REGULATORY/ACCESSORY PROTEINS  
The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of...
US20120108464 TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN  
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system...
US20140335612 SUPPORTS AND METHODS FOR PROMOTING INTEGRATION OF CARTILAGE TISSUE EXPLANTS  
The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage...
US20130177980 SYNTHETIC MATRICES FOR SELF-RENEWAL AND EXPANSION OF STEM CELLS  
Provided herein is a synthetic polymer-based hydrogel for the self-renewal and expansion of human stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Also...
US20110217239 SYSTEM AND METHOD OF EVALUATING A PROTEIN OF INTEREST ON TUMOR GROWTH INHIBITION WHILE FOLLOWING THE TUMOR IN VIVO OR IN VITRO  
Disclosed herein are systems and methods for evaluating a protein of interest on growth inhibition of a tumor while following the tumor in vivo or in vitro through a co-expressed visible marker....
US20120301497 Plasmodium vivax Hybrid Circumsporozoite Protein and Vaccine  
Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any...
US20120114619 PROTEIN WITH PROMOTING EFFECTS FOR AXONAL GROWTH OF NEURONS OF CENTRAL NERVOUS SYSTEM  
This invention comprises a polypeptide, a recombinant vector, a recombinant organism as well as RNA- and DNA-sequences. Furthermore, the use of polypeptides and recombinant vectors is described....
US20120039908 Control of Protein Glycosylation and Compositions and Methods Relating Thereto  
The invention relates to novel methods for controlling the glycosylation of a protein and the protein produced thereby. An exemplary method of the invention comprises producing a protein...
US20120135520 UNSHRUNKEN TISSUE EQUIVALENT, SKIN EQUIVALENT COMPRISING SUCH AN UNSHRUNKEN TISSUE EQUIVALENT, AND METHODS FOR PRODUCING SUCH AN UNSHRUNKEN TISSUE EQUIVALENT AND SUCH A SKIN EQUIVALENT  
The invention relates to a method for producing an unshrunken tissue equivalent. Said method is comprising in that: a mixture is produced that contains at least one element of an extracellular...
US20120315699 STACKED, PATTERNED BIOMATERIALS AND/OR TISSUE ENGINEERING SCAFFOLDS  
Stacked, lamellar constructs comprised of, synthetic or natural, polymeric membrane structures which are brought together to form 3D scaffolds for biomaterial and guided tissue engineering...
US20120322147 DIRECT PROTEIN DELIVERY WITH ENGINEERED MICROVESICLES  
The present invention relates to direct protein delivery with engineered micro vesicles.
US20140356354 THERAPY FOR FILOVIRUS INFECTION  
The present invention addresses a need for improved treatments for filovirus infections.
US20140243523 HUMAN EPITHELIAL CELL LINE FOR 3-D MODELIZING OF CANCER AND TREATMENT THEREOF  
A cellular model is described that targets dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular...
US20130164839 METHOD FOR CULTURING CELLS IN A SYSTEM COMPRISING LAMININ-5  
The present invention is directed to providing a method for culturing cells in a system containing laminin-5. The method of the present invention is characterized by a culture system containing a...
US20140099290 ENDOTHELIAL SCAFFOLDS  
Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells...
US20140120091 FUSION PROTEINS FOR THERAPY OF AUTOIMMUNE AND CARDIOVASCULAR DISEASE  
The present invention provides improved fusion proteins for therapy of autoimmune and cardiovascular disease.
US20120196321 SELECTABLE MARKERS AND RELATED METHODS  
The invention relates to newly identified selectable marker systems, cells for use in a selectable marker system, and methods for using the selectable marker systems.
US20130323220 TAL-Tet1 Fusion Proteins and Methods of Use Thereof  
Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines...
US20110165130 Methods for Preparing Human Skin Substitutes from Human Pluripotent Stem Cells  
The present invention relates to an ex vivo method for obtaining a population of human keratinocytes derived from human pluripotent stem cells comprising a step of co-culturing human pluripotent...
US20130344597 CELL CULTURE METHOD AND AUTOMATIC CULTURE SYSTEM USING THE METHOD  
A culturing method according to the present invention including a step of injecting cells extracted from a human body and a culture medium into a culture container, (2) a step of culturing cells...
US20100317102 Cell Culture Method and Automatic Culture System Using the Method  
A culturing method according to the present invention including a step of injecting cells extracted from a human body and a culture medium into a culture container, (2) a step of culturing cells...
US20130209499 VACCINES FOR USE IN THE PROPHYLAXIS AND TREATMENT OF INFLUENZA VIRUS DISEASE  
Provided herein are polypeptides comprising portions of the influenza virus hemagglutinin, compositions comprising such polypeptides that can be used as immunogens in vaccines and methods of their...
US20110318730 MICROPATTERNED CO-CULTURE SYSTEMS AS INFECTIOUS DISEASE ANALYSIS PLATFORMS  
Cell cultures are provided that include a population of micropatterened hepatocytes and one or more non-parenchymal cell populations, where the hepatocytes are infected with a virus or parasite...
US20130280801 FLOWABLE TISSUE MATRICES  
Disclosed herein are flowable tissue matrix compositions comprising small pieces of partially or completely decellularized tissue suspended in a gelatinized tissue or gelatin gel comprising...
US20140212968 SYNTHETIC MATRICES FOR LONG TERM EXPANSION OF PLURIPOTENT HUMAN EMBRYONIC STEM CELLS  
Provided herein is a synthetic polymer-based hydrogel for the self-renewal and expansion of human stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Also...
US20110070204 MEDIUM FOR HANDLING AND STORING BIOLOGICAL TISSUES OF THE MUSCULOSKELETAL SYSTEM OUTSIDE AN ORGANISM  
The present disclosure relates to a medium for handling, including storing, cultivating, coating, impregnating and/or preserving musculoskeletal tissues such as bone, cartilage, tendon, muscle,...
US20110020810 TRPC6 INVOLVED IN GLOMERULONEPHRITIS  
Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology and up to 20% of patients on dialysis have this diagnosis. A large family with hereditary FSGS carries a...
US20140170122 ADULT STEM CELLS DERIVED FROM HUMAN SKIN DERMIS  
Provided in the present invention are adult stem cells derived from human skin dermis, and a method for isolating same. Further provided in the present invention are osteoblastic cells and...
US20110110899 Combined Chemical and Genetic Approaches for Generation of Induced Pluripotent Stem Cells  
The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
US20120251504 PLURIPOTENT STEM CELLS OBTAINED FROM DENTAL PULP  
The present invention relates to pluripotent stem cells obtained from the dental pulp of patients of different ages, the invention furthermore comprises cultures of said cells, means for obtaining...
US20130115234 Ectodomains of Influenza Matrix 2 Protein, Expression System, and Uses Thereof  
The present invention provides a polynucleotide, polypeptide, recombinant modified vaccinia virus Ankara (rMVA) and related vaccine compositions and methods useful in the prevention and treatment...
US20120148553 METHODS OF GENERATING NATURAL KILLER CELLS  
Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of...
US20130236959 FGF-2 HAVING ENHANCED STABILITY  
Thermostable FGF-2 proteins having enhanced ability to support human pluripotent stem cell cultures are provided. Also provided are methods and compositions utilizing thermostable FGF-2 proteins.
US20120100116 NEURON GENERATION, REGENERATION AND PROTECTION  
The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth...
US20110201110 EFFICIENT METHOD FOR ESTABLISHING INDUCED PLURIPOTENT STEM CELLS  
The present invention provides a method of producing induced pluripotent stem (iPS) cells, comprising bringing a nuclear reprogramming substance into contact with dental pulp stem cells. By using...
US20120064537 USE OF PERFUSION DECELLULARIZED ORGANS FOR MATCHED RECELLULARIZATION  
The invention provides a method for preparing a perfusion based 3D cell culture system, a recellularized matrix culture system, and methods of using the culture system.
US20150044772 CRISPR/CAS SYSTEM-BASED NOVEL FUSION PROTEIN AND ITS APPLICATIONS IN GENOME EDITING  
An inactive CRISPR/Cas system-based fusion protein and its applications in gene editing are disclosed. More particularly, chimeric fusion proteins including an inCas fused to a DNA modifying...
US20120237519 PESTVIRUS SPECIES  
The application relates to a pestivirus, designated PMC virus, that is associated with porcine myocarditis syndrome, and the gene and protein sequences derived therefrom. The application further...