Match Document Document Title
US20110044975 TREATMENT OF PRION PROTEIN RELATED DISEASES  
According to the present invention, treatment of prion protein related diseases, and in particular cancer tumours, is effected by providing to a subject in need thereof a therapeutically effective...
US20100323905 Vhh for the Diagnosis, Prevention and Treatment of Diseases Associated with Protein Aggregates  
The present invention provides heavy chain variable domain antibodies (VHH) for preventing and/or dissolving aggregates. VHH of the invention are preferably used in the treatment of human diseases...
US20130164786 FUCOSYLATION-DEFICIENT CELLS  
An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a...
US20120315697 Cell Culture Media Containing Combinations of Proteins  
The present invention relates to cell culture media containing combinations of proteins, as well as methods of making the cell culture media, and methods of using the cell culture media to improve...
US20130309270 VACCINES COMPRISING BISPHOSPHONATE AND METHODS OF USE THEREOF  
The present invention demonstrates that bisphosphonates have an intrinsic adjuvant activity and directly stimulate B cell antibody secretion. Accordingly, the present invention provides vaccines...
US20150082471 METHOD FOR CULTURING AVIAN GONOCYTES  
A sustained culture of isolated avian gonocytes is provided, as well as a method of making and using the same. A chimeric avian containing an isolated gonocyte and a transgenic avian produced...
US20120301923 DIALYSIS FERMENTER-BIOREACTOR WITH DIALYSIS DEVICE  
The present disclosure provides systems and methods of using a semipermeable membrane in a dialysis fermenter as a separation layer between a cell-containing liquid culture medium and a...
US20110306753 Method for Increasing Protein Expression in Cells  
The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryotic cells, by reducing the number of RNase L cleavage sites in the coding and/or...
US20140356911 Method for Producing Protein  
The present invention relates to a recombinant host cell, wherein the cell is modified to increase the expression levels of Ero1 and XBP1 relative to the expression levels of Ero1 and XBP1 in an...
US20120094297 Method For Producing Protein  
The present invention relates to a recombinant host cell, wherein the cell is modified to increase the expression levels of Ero1 and XBP1 relative to the expression levels of Ero1 and XBP1 in an...
US20140163208 COLLECTION AND METHODS FOR ITS USE  
The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having...
US20120077713 Collection and Methods for its Use  
The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having...
US20110294145 REAGENTS AND METHODS FOR DETECTING A POLYMORPHIC PROTEIN  
The present invention provides antibodies that differentially react with allelic variants of a polymorphic protein, methods of identifying same, an antigen binding fragment comprised therein,...
US20120009579 MONOCYTE-DERIVED NUCLEIC ACIDS AND RELATED COMPOSITIONS AND METHODS  
Nucleic acids encoding various monocyte-derived proteins and related compositions, including purified proteins and specific antibodies are described. Methods of using such composition are also...
US20110104754 CELL CULTURE MEDIUM  
We describe a method of growing an animal cell in a culture medium, in which the culture medium comprises an elevated concentration of a thymidine family member, in which the growth or viability...
US20150140607 CHO EXPRESSION SYSTEM  
The present invention is within the field of industrial protein production. The inventors have designed and constructed a new expression system comprising an expression vector coding for a...
US20140030761 METHOD OF CLONING NUCLEIC ACID  
The present disclosure provides methods for producing expression constructs comprising linking a plurality of unlinked nucleic acids, including nucleic acid encoding a marker protein.
US20120252117 OPTIMIZED MESSENGER RNA  
The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The...
US20130130317 METHOD FOR PRODUCING SUBSTANCE  
The present invention provides a medium suitable for animal cell culture, a culture method using the same, and the like. The present invention relates to a method for culturing animal cells having...
US20150147343 METHOD OF PROVIDING DISEASE-SPECIFIC BINDING MOLECULES AND TARGETS  
Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which...
US20130266585 Method of Providing Disease-Specific Binding Molecules and Targets  
Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which...
US20140112910 MODIFIED GLYCOPROTEINS  
Sulfated glycoproteins, and methods of making and using such sulfated glycoproteins, are described.
US20140199319 METHODS FOR INCREASING THE EFFICIENCY OF HYBRIDOMA GENERATION  
Disclosed herein are methods for improving the efficiency of the production of hybridomas, e.g., through enrichment of IgG expressing B cells. Also disclosed are hybridoma compositions produced...
US20130236931 SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS AND OTHER PROTEINS  
An in vitro system for generating sequence, and thus structural, diversity in proteins is described. The system can be constructed using appropriately selected nucleic acid molecules that encode...
US20120272342 MOUSE ARTIFICIAL CHROMOSOME VECTOR  
Disclosed is a mouse artificial chromosome vector, comprising: a natural centromere derived from a mouse chromosome; a mouse-chromosome-derived long-arm fragment formed by deleting a long-arm...
US20140335565 METHOD FOR PRODUCTION OF POLYPEPTIDE  
The present invention provides a method capable of producing a natural or recombinant protein in high yield. The present invention relates to a method of producing a polypeptide, comprising...
US20120066780 HUMANIZED NSG MOUSE, METHOD OF PRODUCING THE SAME AND USE THEREOF  
A mouse model in which human fetal thymus and human fetal bone fragments are transplanted into NSG mice, a method of producing the same, and a use thereof.
US20120178126 METHODS AND MATERIALS FOR INCREASING EXPRESSION OF RECOMBINANT POLYPEPTIDES  
The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of...
US20140072579 METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES  
The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like...
US20120156704 IN VITRO METHOD FOR DETECTING GP91PHOX AS A MARKER OF OXIDATIVE STRESS  
The invention relates to an in vitro method for detecting the activation of NADPH oxidase by measuring gp91phox protein levels in biological fluids, as a marker of oxidative stress. The method is...
US20110256554 METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY HCG ASSAY  
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
US20140273095 Serum-Free Cell Culture Medium  
The specification describes an improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Ornithine, or a combination of ornithine and putrescine...
US20110206702 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR  
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
US20140295495 Methods of Preventing and Removing Trisulfide Bonds  
The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide...
US20110301331 Stabilized polypeptide compositions  
The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules.
US20140314779 CELL CULTURE COMPOSITIONS WITH ANTIOXIDANTS AND METHODS FOR POLYPEPTIDE PRODUCTION  
Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells. Compositions comprising polypeptides,...
US20130189737 DIPEPTIDES TO ENHANCE YIELD AND VIABILITY FROM CELL CULTURES  
The present invention relates to the culture of animal cells in serum-free culture medium. The present invention provides particular dipeptides that can improve recombinant protein production and...
US20110059056 Method for the Generation of Genetically Modified Vertebrate Precursor Lymphocytes and Use Thereof for the Production of Heterologous Binding Proteins  
The present invention generally relates to the fields of genetic engineering and antibody production. In particular, it relates to the generation of genetically modified vertebrate precursor...
US20140154726 Perfusion Culturing Methods and Uses Thereof  
Provided herein are improved methods of culturing a mammalian cell in a conical container, and methods that utilize these culturing methods.
US20110313139 METHOD FOR POLYCLONAL IMMUNOGLOBULIN G PRODUCTION BY HUMAN B CELLS  
This application relates to an in vitro method of producing a polyclonal IgG preparation. The method comprises (i) placing a polyclonal B-cell population enriched in IgG-secreting B cells in a...
US20140170746 METHOD FOR PREPARING INDUCED PLURIPOTENT STEM CELLS USING MICROVESICLES DERIVED FROM EMBRYONIC STEM CELLS  
Provided is a method of dedifferentiating somatic cells using embryonic stem cell-derived microvesicles. Particularly, a method of preparing induced pluripotent stem cells by treating a...
US20150252385 Methods for Producing Recombinant Proteins  
The present disclosure relates to a host cell transfected with a NHEJ protein or a functional fragment thereof or a polynucleotide encoding the same, wherein said polynucleotide sequence is under...
US20140221619 Methods and Compositions for Increasing Protein Production  
The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell. ABC50 expression or activity is increased which increases...
US20140227291 AMYLOID-BETA BINDING PROTEINS  
The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Aβ(20-42) globulomer or any Aβ form that comprises the globulomer epitope....
US20110230642 METHOD FOR INCREASING RECLONING EFFICIENCY  
The present invention relates to the field of cell culture technology and relates to methods of replicating/cloning cells, preferably cell lines which are important for the production of...
US20140178984 METHOD FOR CULTURING MAMMALIAN CELLS TO IMPROVE RECOMBINANT PROTEIN PRODUCTION  
The present invention relates to methods for mammalian cell culture. The methods make use of independent tyrosine and cystine feed streams.
US20150010532 Clostridium Histolyticum Enzymes and Methods for the Use Thereof  
The invention relates to recombinant nucleic acid and polypeptides encoding collagenase I and collagenase II, methods for the preparation thereof and methods for the use thereof. The invention...
US20140349394 TARGETED INTEGRATION INTO THE PPP1R12C LOCUS  
Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest.
US20130209445 Optimized Fc Variants  
The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized...
US20110151472 NOVEL MEANS FOR THE DIAGNOSIS AND THERAPY OF CTCL  
The invention relates to a novel molecule, termed SC5 by the inventors, to a novel allelic form of p140, and to the biological applications of SC5 and p140 molecules, notably in the diagnosis and...