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US20100003754 |
METHODS OF DIFFERENTIATING STEM CELLS
A method for at least partial differentiating stem cells and/or progenitor cells to at least one tissue type includes treating the stem cells and/or the progenitor cells with extracts which include...
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US20100005536 |
Promoter for Introducing a Gene into a Lymphocyte or Blood Cell and Application Thereof
It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved...
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US20100003721 |
HUMAN INTERFERON-BETA MUTEIN
The present invention relates to a human interferon-beta mutein. In particular, the present invention relates to the human interferon-beta mutein having one or two additional sugar chains compared...
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US20100003719 |
Trimerising Module
The present invention relates to the design of trimeric polypeptides using polypeptide structural elements derived from the tetranectin protein family, and their use in rational de novo design and...
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US20100003748 |
COMPOSITIONS, SYSTEMS, AND METHODS FOR STABILIZATION OF A CELL AND/OR MACROMOLECULE
The present disclosure relates to compositions, systems, and methods for stabilizing a cell (e.g. a whole cell), a biomolecule, and/or a macromolecule. A biomaterial stabilizing composition may...
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US20100004292 |
Iminooxazolidine Derivatives and Their Use
The present application relates to novel iminooxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for...
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US20100004323 |
PROMOTER CONSTRUCT
A polynucleotide comprising a β subunit cGMP-phosphodiesterase promoter operably linked to one or more enhancer elements.
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US20100003749 |
Enriched Pancreatic Stem Cell and Progenitor Cell, Populations, and Methods For Identifying, Isolating and Enriching For Such Populations
Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating, and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.
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US20100004134 |
Combinatorial libraries of conformationally constrained polypeptide sequences
The present invention concerns combinatorial libraries of conformationally constrained polypeptide sequences and their uses. In particular, the present invention concerns combinatorial libraries of...
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US20100004176 |
AXMI-115, AXMI-113, AXMI-005, AXMI-163 AND AXMI-184: INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE
Compositions and methods for conferring insecticidal activity to host cells are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding...
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US20100003265 |
Isolation, expansion and uses of tumor stem cells
Disclosed are methods for isolating cell populations enriched in tumor stem cells (cancer stem cells), and isolated cell populations substantially enriched in cancer stem cells that are tumorigenic...
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US20100003259 |
ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO B LYMPHOCYTE STIMULATOR PROTEIN
The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for...
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US20100003747 |
CULTURED XENOPUS LAEVIS CELL LINES EXPRESSING MUTANT ADENOMATOUS POLYPOSIS COLI GENE
Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these...
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US20100003232 |
INSULIN-DEGRADING ENZYME MUTANTS AND METHODS OF USE
Disclosed are mutant polypeptides of insulin degrading enzymes having at least 95% amino acid identity to SEQ ID NO: 1, having at least one mutation in a region corresponding to human IDE-N or...
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US20100003750 |
MAKING ENCODED GHOST CELLS FOR MULTIPLEXED DETECTION OF ANTI-RED CELL ALLOANTIBODIES
Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events...
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US20100003272 |
Method for Expanding Monocytes
The invention relates to an ex vivo method for expanding monocytes, macrophages or dendritic cells, which method comprises inhibiting the expression or the activity of MafB and c-Maf in monocytes,...
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US20100003756 |
Methods and compositions for generation of Bax-and Bak-deficient cell lines
Disclosed herein are methods and compositions for generation of Bak- and/or Bax-deficient cell lines using engineered nucleases.
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US20100005535 |
Compositions And Methods For Generating Transgenic Animals
The present invention provides methods of altering gene expression of embryos to provide compositions and methods for efficient generation of transgenic animals. In particular, the present...
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US20100003266 |
TARGETED IMMUNE CONJUGATES
Disclosed herein are materials and methods related to vaccines. Materials and methods for delivery of immunogens to the reticuloendothelial system via non-circulating lymphoid cells are provided.
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US20100004162 |
Lynx, a novel family of receptor ligands in the central nervous system, corresponding nucleic acids and proteins and uses thereof
The present invention provides a novel family of polypeptides which are ligand-gated channel receptor accessory molecules or ligands, denoted Lynx. This invention provides an isolated polypeptide...
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US20100004167 |
CSF3R POLYPEPTIDES AND USES THEREOF
The present invention relates to CSF3R polypeptide variants and their uses, particularly for therapeutic or prophylactic treatment in human subjects. The invention also relates to nucleic acids...
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US20100004168 |
Use of Crystallin For The Modulation of Angiogenesis
The present invention features therapeutic and prophylactic compositions and methods for modulating a blood vessel by altering angiogenesis, vasculogenesis, blood vessel stabilization, regression,...
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US20100003242 |
COMPOSITIONS AND METHODS FOR BINDING SPHINGOSINE-1-PHOSPHATE
The present invention relates to anti-S1P agents, for example, humanized monoclonal antibodies, and their uses for detection of S1P or for treatment of diseases and conditions associated with S1P.
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US20100003234 |
Cellulases, Nucleic Acids Encoding Them and Methods for Making and Using Them
This invention relates to molecular and cellular biology and biochemistry. In one aspect, the invention provides polypeptides having cellulase activity, e.g., endoglucanase, cellobiohydrolase,...
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US20090328243 |
Secreted proteins as markers for cell differentiation
Provided are means and methods for in vitro and in vivo detection of chemically induced effects on embryonic development and differentiation for the purpose of embryotoxicity/teratogenicity...
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US20090324555 |
Neural Stem Cells
Subject of the invention is a method for generating neural stem cells in vitro, wherein dental progenitor cells are isolated from soft tissue of tooth or wisdom tooth and cultivated until they form...
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US20090325877 |
Combination Product of Receptor Tyrosine Kinase Inhibitor and Fatty Acid Synthase Inhibitor for Treating Cancer
A pharmaceutical combination product is disclosed that comprises a receptor tyrosine kinase inhibitor and a fatty acid synthase inhibitor, and to the use thereof in the manufacture of a medicament...
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US20090324549 |
PROTEINS AND/OR PEPTIDES FOR THE PREVENTION AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES
Proteins and/or peptides originate from the gene which results from the retention of the intron 3 of the gene SMN identified in the gene bank with the access number AY876898 with use for the...
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US20090325198 |
Non-Denaturing Lysis Reagent For Use With Capture-In-Solution Immunoassay
The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting...
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US20090324553 |
Chimeric Viral Envelopes
The invention relates to chimeric polytropic viral envelope polypeptides and uses thereof, as well as to polynucleotides encoding said chimeric polypeptides and constructs comprising said...
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US20090325883 |
Peptides Which Interact with Anti-Apoptotic Members of the BCL-2 Protein Family, and Uses
The invention lies within the field of seeking out and identifying new peptides which interact with anti-apoptotic members of the Bcl-2 protein family, by means of the two-hybrid system. The...
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US20090324759 |
IMMUNE ENHANCEMENT BY SEED OIL AND/OR SEED FLOUR
A method of treating a subject requiring immune mediation includes administering to the subject an immunostimulatory composition which contains black raspberry seed oil. Administering this...
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US20090325286 |
METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
The invention provides compositions and methods for selectively reducing the expression of a gene product from a desired target gene, as well as treating diseases caused by expression of the gene....
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US20090325168 |
HOMO-DOUBLY LABELED COMPOSITIONS FOR THE DETECTION OF ENZYME ACTIVITY IN BIOLOGICAL SAMPLES
The present invention provides for novel reagents whose fluorescence changes upon cleavage or a change in conformation of a backbone. The reagents comprise a backbone (e.g. nucleic acid,...
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US20090324501 |
Vaccine Carrier
The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second...
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US20090324649 |
LEISHMANIA VACCINE USING SAND FLY SALIVARY IMMUNOGEN
The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against ...
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US20090325216 |
Process for the Preparation of Multicellular Spheroids
The invention pertains to a process for the preparation of multicellular spheroids from a suspension of single cells, wherein the cells are directly derived from a biological tissue and/or from...
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US20090328241 |
MITOCHONDRIAL-NUCLEAR EXCHANGED CELLS, TISSUES, ORGANS AND ANIMALS
Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a...
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US20090324566 |
T-Cell Receptor and Nucliec Acid Encoding the Receptor
A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion,...
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US20090324576 |
PHAGE DERIVED ANTIMICROBIAL ACTIVITIES
The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and...
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US20090326052 |
Promoters exhibiting endothelial cell specificity and methods of using same
An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further...
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US20090324618 |
NOVEL SIGNATURE SELF RENEWAL GENE EXPRESSION PROGRAMS
The present invention relates to compounds and methods which are useful in molecular investigations of target genes, as well as their encoded RNAs and protein, belonging to signature self renewal...
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US20090324651 |
Methods for Stimulating an Immune Response Using Bacterial Antigen Delivery System
The invention relates to the use of the type III secretion system of bacteria to stimulate immune responses against tumor antigen(s) for treating antigen-loss variant tumors. Methods are provided...
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US20090324630 |
FUSION MULTIVIRAL CHIMERIC ANTIGEN
Novel recombinant vectors encoding viral antigens within a single vector or construct are disclosed. The vectors may be used to initiate immunological responses to antigens and to combat...
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US20090324627 |
ISOLATED DNA DIRECTED 50kD REGULATORY SUBUNIT (POLD2) GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM CHOMOSOME 7 AND THEIR USES
The invention is directed to isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD...
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US20090324500 |
SCREEN FOR INFLAMMATORY RESPONSE MODULATORS
The present invention relates to transgenic aquatic vertebrate organisms and methods of their use in screening for, or identifying agents that are useful in modulating the inflammatory response and...
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US20090324626 |
ISOLATED SNARE YKT6 GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM CHOMOSOME 7 AND THEIR USES
The invention is directed to isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50kD...
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US20090325911 |
Use of Androgens for the Treatment of Parkinson's Disease
The invention generally provides therapeutic and prophylactic methods relating to the use of androgens for the treatment of Parkinson's disease or other neurodegenerative diseases. In addition, the...
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US20090325207 |
NOVEL PHOSPHODIESTERASE AND GENE THEREOF
The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected...
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US20090328242 |
Replication of Undifferentiated Cells in a Weightless Environment, Uses Thereof and a Facility for Such Replication and the Acceleration of the Evolution of Plants and Animals
The present invention provides manufacturing processes for biological replication of undifferentiated plant and animal cells and tissue in a weightless condition, including those systems used in...
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