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US20120029074 CONTROLLING TRANSGENE EXPRESSION ACROSS THE SKIN  
The invention relates to the use of a skin permeating compound such as phloretin for controlling transgene expression under control of the Pseudomonas putida DOT-T1E-derived bacterial repressor...
US20130065310 USE OF ENDOGENOUS PROMOTERS TO EXPRESS HETEROLOGOUS PROTEINS  
The present invention provides methods for using endogenous transcriptional control systems to regulate the expression of heterologous protein(s). In particular, targeted genome editing is used to...
US20130217123 METHOD FOR DENTAL PULP CRYOPRESERVATION  
The present invention relates to a method for cryopreserving the pulp of a non-exfoliated deciduous tooth, comprising a step of making with a laser a hole into the tooth removed from its...
US20110212162 LYMPHATIC ZIP CODES IN TUMORS AND PRE-MALIGNANT LESIONS  
Disclosed herein are compositions and methods for and involving selectively targeting tumor lymphatics.
US20120204276 METHODS RELATED TO A MUTATION IN COMPLEMENT FACTOR H-RELATED PROTEIN 5 IN PATIENTS WITH GLOMERULONEPHRITIS  
The invention relates to methods of regulating complement. In particular, the inventors have identified a relationship between a particular gene, CFHR5, and irregularities in complement...
US20130005590 SYNTHETIC BIOLOGY TOOLS  
Methods for design of genetic circuits are provided.
US20120064049 USE OF STEM CELLS FROM HAIR ROOT SHEATHS AND KERATINOCYTE PRECURSOR CELLS FOR THE REGENERATION OF AGED SKIN  
The present invention relates to the use of stem cells from hair root sheaths and/or keratinocyte precursor cells for the regeneration of aged but otherwise healthy and non-injured skin for the...
US20130230884 Methods to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation  
The present invention provides reagents and methods for identifying translation enhancing elements, as well as isolated translation enhancing elements and their use in protein expression reagents...
US20110020433 COMPOSITIONS FOR DELIVERY OF CARGO SUCH AS DRUGS PROTEINS AND/OR GENETIC MATERIALS  
Compositions and methods for delivery of cargo molecules to a patient or subject in need thereof include a proteoliposome carrier vehicle that incorporates an RLIP76 protein and contains the cargo...
US20110179503 PROTEIN PRODUCTION IN A HOST  
Recombinant DNA constructs that provide for expression of desired target proteins as protein bodies in various host cells, tissues, and organisms are disclosed. Such recombinant DNA constructs...
US20120284871 PROTEIN EXPRESSION SYSTEMS  
Disclosed herein are methods and materials, and particularly viral derived sequences, for boosting gene expression in plants and other eukaryotic cells. The methods and materials may be used for...
US20130071429 BUNYAVIRUS VACCINE  
The present invention provides attenuated viruses for use as vaccines and for the treatment and/or prevention of viral diseases and/or infections.
US20150079123 LIVE, ATTENUATED RUBELLA VECTOR TO EXPRESS VACCINE ANTIGENS  
Disclosed herein are isolated rubella viral vector constructs that include a rubella non-structural protein open reading frame (ORF) without an in-frame deletion, a rubella structural protein ORF,...
US20110256620 NUCLEIC ACID ENCODING A SELF-ASSEMBLING SPLIT-FLUORESCENT PROTEIN SYSTEM  
The invention provides a protein labeling and detection system based on self-complementing fragments of fluorescent and chromophoric proteins. The system of the invention is exemplified with...
US20110142812 SUPPRESSIVE MACROPHAGES, C-REACTIVE PROTEIN AND THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS AND IMMUNE THROMBOCYTOPENIC PURPURA  
The present invention relates to the use of suppressive macrophage or dendritic cells (activated with C-reactive protein or CRP-related compounds), for the treatment of various disease states and...
US20130123346 SYNTHETIC CONSTRUCTS FOR POLYNUCLEOTIDE & PROTEIN EXPRESSION  
The present invention features, inter alia, nucleic acid constructs that include nucleotide sequences for regulating the expression of a sequence of interest. The sequences in the construct are...
US20130078222 Intervertebral Disc Nucleus Pulposus Stem Cell/Progenitor Cell, The Cultivation Method And Intended Use Thereof  
Provided are intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. An intervertebral disk nucleus pulposus cell is...
US20120142097 FUSION PROTEINS OF HIV REGULATORY/ACCESSORY PROTEINS  
The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of...
US20120142096 FUSION PROTEINS OF HIV REGULATORY/ACCESSORY PROTEINS  
The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of...
US20140162340 SYNTHETIC HEPATITIS C GENOME AND METHODS OF MAKING AND USE  
Synthetic representative HCV subtypes, including a 1a and 1b genome, dubbed Bole1a and Bole1b, are provided using an inventive method of Bayesian phylogenetic tree analysis, ancestral sequence...
US20110035841 Lipid Metabolism Proteins, Combinations of Lipid Metabolism Proteins and Uses Thereof  
Described herein are inventions in the field of genetic engineering of plants, including combinations of polynucleotides encoding LMPs to improve agronomic, horticultural, and quality traits. This...
US20130254909 SYNTHETIC REGULATION OF GENE EXPRESSION  
Synthetic regulation of gene expression is provided. In some embodiments, synthetic regulatory constructs are provided. In some embodiments, a synthetic regulatory construct expresses a...
US20120108464 TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN  
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system...
US20130239853 HOT SPRING BACTERIAL STRAIN BKH1 AND PROTEIN ISOLATED THEREFROM, CONCRETE COMPOSITIONS, AND USES THEREOF  
Disclosed is a Thermoanaerobacter sp. bacterial strain (BKHI) isolated from a hot spring, a purified protein (bioremediase) isolated from bacterial strain BKH1, as well as concrete compositions...
US20140255361 ESTROGEN-RECEPTOR BASED LIGAND SYSTEM FOR REGULATING PROTEIN STABILITY  
Disclosed herein are systems, methods and compositions for rapidly and reversibly destabilizing a target protein in vitro or in vivo, in the presence or absence of a cell-permeable, synthetic...
US20110135620 PRODRUG ACTIVATION IN CANCER CELLS USING MOLECULAR SWITCHES  
The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a...
US20120183509 MICROGLIAL PRECURSOR CELLS FOR THE TREATMENT OF MALIGNANT NEOPLASMS OF THE CENTRAL NERVOUS SYSTEM  
Microglial precursor cells for use in the treatment of malignant neoplasms of the central nervous system. A method of treating malignant neoplasms of the central nervous system comprising...
US20150132285 Proteinase-engineered Cancer Vaccine Induces Immune Responses to Prevent Cancer and to Systemically Kill Cancer Cells  
The present invention provides a method of making a proteinase-engineered cancer vaccine for treating a cancer patient, especially for cancer patient at advanced/metastatic stage. The cancer...
US20110196343 Methods for Expansion and Analysis of Cultured Hematopoietic Stem Cells  
Methods and kits for propagating hematopoietic stem cells are provided. The methods comprise culturing cells in medium comprising one or more angiopoietin-like proteins, under conditions...
US20140237685 SPL16 compositions and methods to increase agronomic performance of plants  
Methods and compositions that affect grain shape, width, and yield in rice are disclosed. Methods of transgenic modulation and marker-assisted breeding methods improve grain length to width ratio...
US20120141552 ULTRASOUND TECHNOLOGY TO CONTROL THE SPATIAL ORGANIZATION OF CELLS AND PROTEINS IN ENGINEERED TISSUES  
The present invention is directed to methods of inducing spatial organization of cells an in vitro culture system using ultrasound technology. The invention is further directed to methods of...
US20130345400 IDENTIFICATION OF A HUMAN GYROVIRUS AND APPLICATIONS  
The present invention relates to HGyV, a human gyrovirus related to the chicken anemia virus (CAV). The present invention also relates to a new proteins encoded by HGyV, which proteins display...
US20140335612 SUPPORTS AND METHODS FOR PROMOTING INTEGRATION OF CARTILAGE TISSUE EXPLANTS  
The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage...
US20140256798 TALEN-BASED GENE CORRECTION  
The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat...
US20120164725 DEEPWELL PLATE SYSTEM WITH LID  
The present invention relates to a deepwell plate system, comprising a deepwell plate and a lid system which can be detachably fitted to the deepwell plate by snap- or clamp-fastening means so as...
US20110152352 SMAD PROTEINS CONTROL DROSHA-MEDIATED MIRNA MATURATION  
The invention, in some aspects, relates to compositions and methods useful for modulating expression of miRNAs that are regulated by the TGF-β/BMP signaling pathway. In some aspects, the invention...
US20110217239 SYSTEM AND METHOD OF EVALUATING A PROTEIN OF INTEREST ON TUMOR GROWTH INHIBITION WHILE FOLLOWING THE TUMOR IN VIVO OR IN VITRO  
Disclosed herein are systems and methods for evaluating a protein of interest on growth inhibition of a tumor while following the tumor in vivo or in vitro through a co-expressed visible marker....
US20110207213 Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof  
The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic...
US20140273156 LUCIFERASE BIOSENSOR  
A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided.
US20150210751 Method and Composition for Crystallizing G Protein-Coupled Receptors  
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion...
US20110009603 Method and composition for crystallizing G protein-coupled receptors  
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion...
US20110027267 Fusion Proteins of Mannose Binding Lectins for Treatment of Disease  
Fusion proteins having sequences that target specific moieties such as carbohydrates, lipids, and/or proteins that are associated with certain cell types and/or pathogens; and a sequence that...
US20120301497 Plasmodium vivax Hybrid Circumsporozoite Protein and Vaccine  
Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any...
US20110189218 Plasmodium vivax hybrid circumsporozoite protein and vaccine  
Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any...
US20120114619 PROTEIN WITH PROMOTING EFFECTS FOR AXONAL GROWTH OF NEURONS OF CENTRAL NERVOUS SYSTEM  
This invention comprises a polypeptide, a recombinant vector, a recombinant organism as well as RNA- and DNA-sequences. Furthermore, the use of polypeptides and recombinant vectors is described....
US20100297108 METHOD OF PROVIDING PATIENT SPECIFIC IMMUNE RESPONSE IN AMYLOIDOSES AND PROTEIN AGGREGATION DISORDERS  
A novel treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed...
US20120117673 GENETIC ENCRYPTION  
The present invention relates to a method to engineer either the genome of a genetically modified organism, other bioengineered reagent, or in vitro translation system for protein synthesis from...
US20140335608 CELL CULTURE KIT, AND METHOD OF USING CELL CULTURE KIT  
A cell culture kit for cultivating cells in a closed system that comprises at least one or more of each of: a culture container for cultivating cells; a culture medium storage container for...
US20110189232 RECOMBINANT HUMAN PARAINFLUENZA TYPE 1 VIRUSES (HPIV1s) CONTAINING MUTATIONS IN OR DELETION OF THE C PROTEIN ARE ATTENUATED IN AFRICAN GREEN MONKEYS AND IN CILIATED HUMAN AIRWAY EPITHELIAL CELLS AND ARE POTENTIAL VACCINE CANDIDATES FOR HPIV1  
Two recently characterized live attenuated HPIV1 vaccine candidates, rHPIV1-CR84G/Δ170HNT553ALY942A and rHPIV1-CR84G/Δ170HN-T553ALΔ1710-11, which contain temperature sensitive (ts) attenuating...
US20100330038 METHODS FOR EXPRESSING PROTEINS IN AXONS  
The invention relates to expressing proteins in the axons of mammalian polypeptide in neuronal axons, viruses that can be used deliver nucleic acids of the invention into neuronal axons, as well...