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US20090258026 |
ANTI-NOTCH1 NRR ANTIBODIES AND METHODS USING SAME
The invention provides anti-Notch1 NRR antibodies, and compositions comprising and methods of using these antibodies.
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US20090229016 |
CAMBIUM/XYLEM-PREFERRED PROMOTERS AND USES THEREOF
The present invention related to nucleic acid molecules corresponding to regulatory portions of genes whose expression is predominant in cambium and/or xylem. The invention also relates to...
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US20090202559 |
Anti-Mesothelin Antibodies
This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce an immune effector activity...
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US20090053213 |
Anti-Gm-Csf Antibodies and Uses Therefor
The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an integral role in various disorders or...
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US20090010847 |
Connective Tissue Growth Factor-4
The present invention relates to a novel human protein called Connective Tissue Growth Factor-4, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells,...
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US20080305520 |
Mechanosensitive ion channels and methods of use
The present invention provides methods for identifying agents that decrease the activity of a mechanosenitive ion channels, preferably, a mechanosensitive Ca 2+ -permeable channel (MscCa) channel....
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US20080292632 |
Irta2 Antibodies and Methods of Use
Antibodies that specifically bind the extracellular domain of IRTA2 are disclosed herein. In one embodiment, these antibodies do not specifically bind IRTA1, IRTA3, IRTA4, or IRTA5. In one example,...
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US20080292628 |
Chimeric Protein
A fusion protein containing a first segment that is located at the amino terminus of the fusion protein and specifically binds to and neutralizes a first cytokine or growth factor; and a second...
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US20080280322 |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to glycosylation engineering to generate proteins with improved...
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US20080268499 |
WHITEFLY ECDYSONE RECEPTOR NUCLEIC ACIDS, POLYPEPTIDES, AND USES THEREOF
The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide,...
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US20080226586 |
Chemokine Beta-15
The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine β-15 protein. Chemokine β-15...
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US20080187540 |
Antibodies to OCIF-binding molecules
A novel protein which binds to Osteoclastogenesis Inhibitory Factor (OCIF-binding molecule; OBM), a process for preparing the same, DNA encoding said protein, a protein having an amino acid...
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US20080182236 |
Asthma Susceptibility Locus
The present invention describes a susceptibility locus which is functionally related to asthma. The locus maps within human chromosome 7p15-p14. The invention also describes a novel human gene,...
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US20080181906 |
Polyvalent Immunogen
The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for...
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US20080166755 |
Intracellular delivery of osteoinductive proteins and peptides
The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to...
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US20080138894 |
PURIFIED HEPATITIS C VIRUS ENVELOPE PROTEINS FOR DIAGNOSTIC AND THERAPEUTIC USE
The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that...
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US20080138796 |
NRIF3, a novel co-activator for nuclear hormone receptors
Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is...
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US20080124331 |
COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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US20080115237 |
NOVEL ECDYSONE RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a...
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US20080113931 |
RNAi MODULATION OF AHA AND THERAPEUTIC USES THEREOF
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an Aha gene (Aha1 gene), comprising an antisense strand having a nucleotide sequence which is...
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US20080113930 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK 9 gene (PCSK 9 gene), comprising an antisense strand having a nucleotide sequence...
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US20080113430 |
Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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US20080113429 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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US20080109923 |
EXPRESSION OF SPIDER SILK PROTEINS IN HIGHER PLANTS
The present invention relates to the fields of molecular biology and plant biology. Specifically, the invention is directed to the methods for expressing spider silk proteins in plants and the...
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US20080109919 |
ENHANCED ACCUMULATION OF CAROTENOIDS IN PLANTS
The present invention relates to polynucleotides and their use in methods of increasing the carotenoid content of seeds. In particular the invention provides a polynucleotide comprising: (a) a...
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US20080109917 |
CARD-DOMAIN CONTAINING POLYPEPTIDES, ENCODING NUCLEIC ACIDS, AND METHODS OF USE
The invention provides caspase recruitment domain (CARD)-containing polypeptides and functional fragments thereof, encoding nucleic acid molecules, and specific antibodies. Also provided are...
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US20080109914 |
DIFFERENTIAL LABELING OF CELLS
The invention relates to the generation of an animal model that exhibits neural cell-specific expression of a marker gene that correlates to remyelination or myelin repair. The compositions and...
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US20080108584 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF IKK-B GENE
The invention relates to a doable-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the IKK-B gene, comprising an antisense strand having a nucleotide sequence which is less that...
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US20080108552 |
HYD1 Peptides as Anti-Cancer Agents
The present invention concerns fragments and variants of the HYD1 peptide; polynucleotides encoding the peptides; host cells genetically modified with the polynucleotides; vectors comprising the...
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US20080108511 |
GENES AND GENE PRODUCTS DIFFERENTIALLY EXPRESSED DURING HEART FAILURE
Certain examples disclosed herein are directed to genes and gene products that are differentially expressed during heart failure. In particular, certain examples are directed to genes which are...
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US20080108126 |
PULLULANASE VARIANTS WITH INCREASED PRODUCTIVITY
The invention relates to novel variants of the enzymatic peptide pullulanase, the gene sequences encoding said novel peptides, expression vectors comprising those gene sequences as well as...
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US20080108108 |
NOVEL P. PASTORIS PASTORIS PROMOTERS, AND THE USE THEREOF TO DIRECT EXPRESSION OF PROTEINS IN YEAST, PREFERABLY USING A HAPLOID MATING STRATEGY
Novel promoters which are derived from P. pastoris pastoris which are inducible or repressible under specific growth conditions are provided. These promoters are useful for regulating the...
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US20080108105 |
Fungal Transcriptional Activators Useful in Methods for Producing a Polypeptide
The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which have transcriptional activity on a protease promoter, to PrtT proteins and to their use. The...
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US20080107693 |
Hybrid or chimeric polynucleotides, proteins, and compositions comprising hepatitis B virus sequences
H-2 class I negative, HLA-A2.1 transgenic HHD mice were used for a comparative evaluation of the immunogenicity of HLA-A2.1 restricted human tumor-associated CTL epitopes. A hierarchy was...
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US20080107667 |
PROMISCUOUS HER-2/NEU CD4 T CELL EPITOPES
The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to...
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US20080107656 |
IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF
The present invention relates generally to a method of eliciting or otherwise inducing an immune response to a Plasmodium microorganism and compositions for use therein. More particularly, the...
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US20080107643 |
MAMMALIAN CHEMOKINES; RECEPTORS; REAGENTS; USES
Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are...
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US20080104734 |
RECOMBINANT ANTIBODIES TO SCLEROTINIA ANTIGENS
The invention is directed to recombinant antibodies which bind to Sclerotinia sclerotiorum antigens and comprise a single chain variable fragment (scFv). The antigen may be selected from SSPG1d...
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US20080104728 |
POLYNUCLEOTIDES ENCODING PROTEINS INVOLVED IN PLANT METABOLISM
The invention provides isolated pyruvate dehydrogenase kinase nucleic acids and their encoded polypeptides. The present invention provides methods and compositions relating to altering pyruvate...
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US20080104726 |
FRUIT REGULATORY REGIONS
Regulatory regions suitable for directing expression of a heterologous polynucleotide in fruit tissues, e.g., flesh and peel tissues, of plants are described, as well as nucleic acid constructs...
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US20080103098 |
Recombinant Expression of Proteins in a Disulfide-Bridged, Two-Chain Form
Polypeptides or proteins are produced as a disulfide bridged dichain by recombinant expression in E. coli host cells and exert biologic activity as such a dichain. A C-terminal amino acid of the...
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US20080103090 |
Human Secreted Proteins
The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cancer and other hyperproliferative...
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US20080102523 |
Expression Vector for Animal Cell Comprising at Least One Copy of Mar Dna Sequences at the 3'Terminal of Transcription Termination Region of a Gene and Method for the Expression of Foreign Gene Using the Vector
Provided are an expression vector for an animal cell including a promoter, a cloning site or a polynucleotide encoding foreign product, and a transcription terminator, all of which are operably...
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US20080102492 |
Methods and compositions for the prevention and treatment of anemia
Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than...
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US20080102490 |
INTERFERON-LIKE PROTEIN ZCYTO21
The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level....
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US20080102489 |
DNA MOLECULES ENCODING LIGAND GATED ION CHANNELS FROM DERMACENTOR VARIABILIS
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present invention also...
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US20080102475 |
Alternatively spliced isoform of phosphodiesterase 4B (PDE4B)
The present invention features nucleic acids and polypeptides encoding novel splice variant isoform of phosphodiesterase 4B (PDE4B). The polynucleotide sequence of PDE4Bsv1 is provided by SEQ ID...
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US20080102463 |
GENE 4
A nucleotide acid sequence is provided encoding a protein having NAALAdase like activity. NALADase activity has been found to be decreased in schizophrenic brain tissue. Its encoded protein can be...
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US20080102115 |
Modified coagulation factor IX polypeptides and use thereof for treatment
Provided are modified factor IX (FIX) polypeptides and methods of generating modified FIX polypeptides. Also provided are pharmaceutical compositions, including compositions formulation for oral...
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US20080102084 |
Anti-cancer DNA Vaccine Employing Plasmids Encoding Mutant Oncoprotein Antigen and Calreticulin
Novel nucleic acid vectors comprising sequences encoding (a) calreticulin or a domain thereof, and (b) an antigen, such as human papillomavirus oncoproteins E7 or E6 in detoxified form, are...
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