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US20090304709 |
MODULATORS OF P-SELECTIN GLYCOPROTEIN LIGAND 1
Compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell...
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US20090297647 |
Assays, method and compositions that exploit a mycobacterial iron acquistion pathway in cells
Assays for the identification of antibacterial agents that inhibit mycobacterial growth by interfering with the iron acquisition pathway in host cells are disclosed. Also disclosed are methods of...
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US20090291064 |
Immortal unipotent porcine PICM-19H and PICM-19B stem cell lines
Two cell lines, PICM-19H and PICM-19B, were derived from the bipotent ARS-PICM-19 pig liver stem cell line and assessed for their potential application in artificial liver devices. The study...
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US20090275063 |
Distinguishing cells in a sample by inactivating extracellular enzyme before releasing intracellular enzyme
A method for detecting the absence or presence of cells of interest in a liquid sample, wherein: (a) the sample: (i) comprises an extracellular medium containing an enzyme with a measurable...
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US20090264398 |
METHOD FOR INDUCING TUMOR APOPTOSIS BY INCREASING NITRIC OXIDE LEVELS
The present invention refers to a method for inducing tumor apoptosis by influencing the ROS (reactive oxygen species) signaling pathway in tumor cells. Increasing the level of ROS leads to the...
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US20090258914 |
Inhibitor of Anti-Apoptotic Proteins
A compound having the structure A is described as well as the use of such compounds to inhibit at least one BCL-2 protein family member.
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US20090258384 |
Direct Antimicrobial Susceptibility Assay
An antimicrobial susceptibility assay, including the steps of: providing an assay dish; providing a growth medium in said dish; providing an antimicrobial agent sample; providing an interpretive...
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US20090253771 |
INHIBITION OF GLIOTOXIN
The present invention relates to the inhibition of the interaction between Gliotoxin (GT) and its intracellular target for the prevention and/or treatment of fungal infections. Further, novel...
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US20090239792 |
SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF
The present invention relates to a polymyxin derivative wherein the derivative has a total of three positive charges at physiological pH and wherein the terminal moiety (D) of the derivative...
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US20090238817 |
ANTI-CELL PROLIFERATIVE COMPOUNDS AND METHODS OF USE
The invention provides compounds such as proteins, peptides, peptidomimetics and small molecules, methods for treating cell proliferative disorders such as neoplasia, tumor, or cancer, and...
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US20090227554 |
STABLE LIQUID FORMULATIONS OF ANTI-INFECTIVE AGENTS AND ADJUSTED ANTI-INFECTIVE AGENT DOSING REGIMENS
Provided are methods of determining a resistance-adjusted dosage regimen of an anti-infective agent for treatment of an infection of a mammal by a resistant infective organism, wherein an effective...
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US20090227531 |
Transcription factors in neuronal dendrites-dendritic protein synthesis and cell death
The present invention relates to methods of altering the competence of a dendrite and/or the viability of a neuron. The present invention also provides methods of altering the ATP levels in a...
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US20090222933 |
Human Liver Cancer Cell Line
The present invention relates to a human hepatoma-derived cell line, LH86, liver cell cultures, non-human animal models, artificial livers, liver assist devices, screening assays, and other...
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US20090221017 |
ANTI-AMYLOID BETA ACTIVITY OF INTRAVENOUS IMMUNOGLOBULIN (IVIG) IN VITRO
The present invention relates to a cell-based in vitro screening assay for identifying and selecting therapeutic agents that inhibit amyloid r-induced cytotoxicity.
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US20090221568 |
Synthesis of Inhibitors of FtsZ
FtsZ, the bacterial analog of tubulin, is a promising new target for developing new antibiotics. It has been shown that polyphenols inhibit the GTPase activity of FtsZ, thereby inhibiting Z-ring...
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US20090215667 |
Utility of phylloplanins as antibiotics, selective fungicides and for enhancing microbial resistance in plants
The present invention relates to plant proteins produced by a plant's epidermal layer that contribute to the innate pest/disease resistance of the plant (“phylloplanins”), compositions...
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US20090202440 |
MODEL ANIMAL OF DENDRITIC CELL IMMUNORECEPTOR GENE KNOCKOUT DISEASE
It is intended to disclose the function of dendritic cell immunoreceptor (DCIR) and clarify its role in the onset of autoimmune arthritis. It is also intended to provide a method of screening a...
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US20090202985 |
METHOD AND APPARATUS FOR DETECTING AN ELECTRIC FIELD FLUCTUATION ASSOCIATED WITH THE PERMEABILIZATION OF A BACTERIAL CELL WALL
A sensor for detecting an electric field fluctuation associated with the permeabilization of a bacterial cell wall comprises a substrate, at least two electrodes integrated on the substrate, an...
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US20090202528 |
Surface-Located Streptococcus Pneumoniae Polypeptides
The present invention relates to cell-surface-located polypeptides of Streptococcus pneumoniae and their use in immunisation against Streptococcal infection, in diagnosis of Streptococcus and...
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US20090197809 |
ANTIFUNGAL METHODS
A system for reducing the incidence or severity of fungal infection of a plant, comprising a chemical fungicide component, which may be provided by foliar or root (soil or liquid nutrient)...
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US20090175974 |
NOVEL CADHERIN RECEPTOR PEPTIDE FOR POTENTIATING Bt BIOPESTICIDES
Disclosed is a novel cadherin peptide that enhances the toxicity of Cry proteins. A novel insecticide composition comprising an effective amount of cadherin peptide having SEQ. ID. NO:2 and an...
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US20090170150 |
Screening Assay for Ribosomal Antibiotics
The present invention is directed to a method for identifying ribosomal antimicrobial substances being selective for microbial but not for mitochondrial and/or cytosolic ribosomes. Specifically,...
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US20090163577 |
METHODS AND COMPOSITIONS FOR ANTAGONIZING ANTI-APOPTOTIC Bcl-2-FAMILY PROTEINS
The cytotoxic natural product gambogic acid (GA) competes for BH3 peptide binding sites on several anti-apoptotic members of the Bcl-2 family of proteins and neutralizes the ability of these...
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US20090142796 |
Detection of Inducible Resistance to Macrolide-Lincosamide-Streptogramin b
The embodiments of this invention provide a test panel and method for the detection of inducible resistance to macrolide-lincosamide-streptogramin b (iMLSb) in microorganisms in an automated...
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US20090136953 |
MOLECULAR DIAGNOSTIC METHOD FOR DETERMINING THE RESISTANCE OF A MICROORGANISM TO AN ANTIBIOTIC
A sample ( 103 ) containing a microorganism is divided into a first sample portion ( 107 ) and a second sample portion ( 113 ), a growth medium i( 109, 114 ) is added to both sample portions and an...
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US20090130064 |
DIFFERENTIATION OF STEM CELLS AND STABILIZATION OF PHENOTYPICAL PROPERTIES OF PRIMARY CELLS
Methods of inducing differentiation of stem cells and stem cells obtained are disclosed. A method for stabilizing the phenotype of isolated primary cells in vitro is disclosed. In both methods, a...
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US20090123432 |
Novel population of hepatocytes derived via definitive endoderm (DE-hep) from human blastocysts derived stem cells
The present invention relates to a novel hepatocyte-like cell progenitor and/or a novel hepatocyte-like cell derived via definitive endoderm from human blastocyst-derived stem (hBS) cells, to a...
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US20090104651 |
SCREENING PROCESS FOR ANTIBACTERIAL AGENTS
The present invention relates to a method of preparing a phenotypically antibiotic-resistant subpopulation of stationary phase bacteria by treating stationary phase bacteria with high doses of...
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US20090092553 |
MONOCARBOXYLATE TRANSPORTERS EXPRESSED IN CANCER CELLS
MCT1 and MCT4 are expressed at higher levels in many cancer cells than comparable normal cells of the same tissue. Disclosed herein are assays for determining whether a test material/molecule is a...
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US20090074712 |
Methods for Treatment and Prevention of Infection
Specific cytokines may be used as agents for the treatment and/or prevention of bacterial infection, by binding to components of the bacterial cell membrane and directly killing the bacteria. This...
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US20090068696 |
COMPOSITIONS AND MEANS FOR DIAGNOSING MICROBIAL INFECTIONS
The present invention pertains to the need for novel, reliable, fast and inexpensive approaches to diagnosing, including detecting and characterising microbial infections in humans and animals or...
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US20090054380 |
Methods for diagnosing and treating a mycobacterium avium subspecies paratuberculosis infection
The present invention relates to Mycobacterium avium subspecies paratuberculosis (MAP) as the etiological agent of IBD, including ulcerative colitis and Crohn's disease, as well as Multiple...
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US20090042814 |
Treatment and Diagnosis of Obligate Intracellular Pathogens
This invention relates to the detection of pathogens, in particular persistent forms of obligate intracellular or membrane associated microorganisms such as Chlamydia, Mycoplasma and Ureaplasma ...
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US20090042240 |
RAPID DETECTION OF ANTIMICROBIAL DRUG RESIDUES
The present invention relates to a novel method for the rapid detection of the presence or absence of antimicrobial drug residues belonging to the class of the quinolones in liquid samples such as...
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US20090023170 |
Methods And Kits For The Detection of Biotoxic and Antibiotic Residues
The invention provides a kit for the detection of antibiotic residues comprising inducible bacterial spores which produce an induced enzyme after germination and induction; a germinant that...
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US20090017489 |
Methods For Modulating The Development Of Dopamine Neuron By The Dopamine D2 Receptor And Compositions Thereof
The present invention relates to a composition for modulating the activation of Nurr1, the composition comprising an agonist or an antagonist of a dopamine D2 receptor, methods for modulating the...
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US20090011457 |
Method and device for testing the bactericidal effect of substances
The method for checking the degree of microbial loading of laundry after a wash cycle is characterized in that a defined amount of living microorganisms are washed together with the laundry, in...
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US20080318267 |
Methods and Compositions for Ultra-High Throughput Screening of Natural Products
The present invention provides cells having more than two drug resistance genes and at least two different resistance genes that have been recombined into the chromosome of a cell. It also teaches...
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US20080293093 |
Determining presence of antibiotic in a fluid
A test system for the determination of the presence of an antibiotic in a fluid using Bromthymol Blue as an indicator.
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US20080287345 |
Polymyxin derivatives and uses thereof
The present invention relates to a polymyxin derivative wherein R1, R2 and R3 are optional and R1, R2, R3, R5, R8 and R9 are cationic or neutral amino acid residues selected so that the total...
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US20080261263 |
In Vitro Evaluation of Micro-Organisms and Their Antimicrobial Agent Susceptibilities
A method of identifying a micro-organism and determining the susceptibility of the micro-organism to an antimicrobial agent by inserting a sample of the micro-organism in a primary culture...
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US20080254442 |
Crystal structures of human peptide deformylase
The present invention provides the three-dimensional structure of human mitochondrial Homo sapiens peptide deformylase (HsPDF) protein, and HsPDF complexed to a binding compound, such as a PDF...
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US20080254501 |
CHEMICAL PROBE COMPOUNDS THAT BECOME FLUORESCENT UPON REDUCTION, AND METHODS FOR THEIR USE
Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction,...
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US20080220465 |
Antibiotic Sensitivity Testing Method
The method includes several steps including obtaining a bacterial sample; identifying the type of bacteria in the bacterial sample; selecting a set of antibiotics based on the identity of the...
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US20080221120 |
Modulation of Aquaporin in Modulation of Angiogenesis and Cell Migration
The invention provides compositions, pharmaceutical preparations, and methods for modulating angiogenesis and/or cell migration in a subject having a cellular proliferative disease (e.g., cancer),...
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US20080213820 |
Method for Determining the Selectivity of a Pre-Synaptic Neuromuscular Blocking Substance
The invention relates to a method for determining the quantity of pre-synaptic neuromuscular blocking substance (notably botulinum toxin) contained in a sample. In one aspects, the method comprises...
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US20080207522 |
Antimicrobial Peptides
A novel class of peptides having antimicrobial activity is provided. Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. Pharmaceutical...
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US20080200374 |
MUTATIONAL DERIVATIVES OF MICROCIN J25
Analogs of bacteriocidal peptide microcin J25 (MccJ25) are provided that have an amino acid sequence that differs from that of MccJ25 by having at least one amino acid substitution; and that...
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US20080193966 |
Multiple-Valent Opsonophagocytic Assay Selection Panel Arrays And Uses Therefor
This application discloses a multivalent opsonophagocytosis assay that does not rely on counting of bacterial colonies to determine bacteria viability following opsonophagocytosis. Instead, the...
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US20080182289 |
High-Throughput Screen For Identifying Selective Persistent Sodium Channels Channel Blockers
A method for identifying a selective persistent Na + channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na + current to a greater degree than a transient Na...
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