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US20140273074 YEAST SCREENS FOR TREATMENT OF HUMAN DISEASE  
Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are...
US20120149055 PAPER STRIP FOR DETERMINING MINIMUM INHIBITORY CONCENTRATIONS OF ANTIBIOTICS  
The present invention concerns the sector of chemical, clinical, bacteriological and immunological analyses and more specifically it concerns the use of a strip of impregnated paper in order to...
US20120329086 CHEMO-SENSITIVITY ASSAYS USING TUMOR CELLS EXHIBITING PERSISTENT PHENOTYPIC CHARACTERISTICS  
The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring the progression of an individual patient malignancy. The assays, methods, tools and...
US20140248657 METHOD FOR PRODUCING INSOLUBLE AGGREGATE OF NEURODEGENERATIVE-DISEASE-RELATED PROTEIN  
The purpose of the present invention is to develop a method for producing a large amount of an insoluble aggregate that is equivalent to an insoluble aggregate formed in the brain of a patient. A...
US20110212101 MATERIALS AND METHODS FOR EXPLOITING SYNTHETIC LETHALITY IN MISMATCH REPAIR-DEFICIENT CANCERS  
Therapeutic approaches to the treatment of DNA mismatch repair (MMR) deficient cancers are disclosed based on the use of complimentary gene-function and drug screening synthetic lethality...
US20110165561 DIRECT AND CONTINUOUS ROOT ALONE OR ROOT/SHOOT PRODUCTION FROM TRANSGENIC EVENTS DERIVED FROM GREEN REGENERATIVE TISSUES AND ITS APPLICATIONS  
The present invention provides assays and methods for efficiently testing a polynucleotide of interest for a phenotype in a root. In some embodiments, the assays and methods include regenerating...
US20140099662 PHOTOTOXICITY TEST METHOD  
The present invention provides a phototoxicity test method using human retinal pigment epithelial cells, and so on.
US20150232910 BENEFICIAL EFFECTS OF BACTERIOPHAGE TREATMENTS  
The invention relates to use of one or more bacteriophages in vivo in a human or animal in order to induce sensitivity to chemical antibiotics in bacterial cells, where such susceptibility is...
US20120222139 Cancer Specific Mitotic Network  
Developed here is a mitotic network comprising a signature of up to 54 genes, and including also sub-sets of genes within the signature, which can identify members by requiring higher correlation...
US20100048422 Methods of Producing Modified Assembly Lines and Related Compositions  
The present invention provides a method producing a modified assembly line, such as those that produce non-ribosomal peptides and polyketides. The modified assembly lines of the invention can be...
US20120272347 CHITOSAN-ALGINATE SCAFFOLD CELL CULTURE SYSTEM AND RELATED METHODS  
Methods for culturing cancer cells in vitro using a three-dimensional scaffold, scaffolds that include the cultured cancer cells, and methods for using the cultured cancer cells and the scaffolds...
US20150174130 COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS  
Embodiments of the presently-disclosed subject matter include activators of HssRS that induce endogenous heme biosynthesis by perturbing central metabolism. These molecules are toxic to fermenting...
US20120142041 Methods And Kits For Measuring Toxicity And Oxidative Stress In Live Cells  
Compositions and methods for the measuring toxicity, antioxidant capacity, and oxidative stress are provided.
US20150072373 Measurement of Cell Growth and Drug Susceptibility by Resonant Mass Measurement  
System and Method for measuring the growth of a bacterial culture and its response to one or more antimicrobials using measurement of mass of individual microbes. Methods include periodic...
US20130071874 SYSTEM AND METHOD FOR ANTI-CANCER DRUG CANDIDATE EVALUATION  
The disclosure provides a method of evaluating the ability of an anti-cancer drug candidate to induce apoptosis in a known cancer cell line by placing a single-cell suspension of a known cancer...
US20110269176 METHODS FOR ASSAYING RESPONSES TO VACCINES  
The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an...
US20130109049 Method of Establishing a Fungal Nail Infection  
The present invention provides a method of infecting a nail fragment with a fungus, to form an infected nail fragment comprising at least 1×102 fungal colony forming units (cfu) per cm2 of the...
US20130202717 MATERIALS AND METHODS FOR DIAGNOSING AND PREDICTING THE COURSE OF PROSTATE CANCER  
Expression of Forkhead-box protein A1 (FOXA1), a transcription factor important for the normal development of the prostate gland is thought to be controlled by steroid hormones and GATA-3....
US20110151455 Fish-ribosyn for antibiotic susceptibility testing  
The subject invention concerns materials and methods for evaluating the susceptibility of bacterial cells to an antibiotic or other antimicrobial compound or agent. In one embodiment, a sample...
US20130197106 METHODS OF IDENTIFYING A CANDIDATE COMPOUND  
The invention relates to methods identifying compounds for the treatment of cell proliferation-related disorders, e.g., proliferative disorders such as cancer.
US20120276577 Method for Determining the Susceptibility of a Cell Strain to Drugs  
The present invention relates to a method for determining the susceptibility of a cell strain to a compound intended for controlling the growth of said cell strain, comprising: growing the cell...
US20150044135 DUAL FUNCTION MARKERS FOR DIAGNOSTICS AND THERAPEUTICS FOR UPPER GASTROINTESTINAL TRACT PRECANCER  
The invention described herein relates to the detection, diagnosis, and treatment of intestinal metaplasias that develop to esophageal, gastric, and pancreatic adenocarcinoma. The stem cells and...
US20140249193 MODULATORS OF MITOCHONDRIAL PROTEIN IMPORT  
The present invention provides compounds that modulate protein translocation in mitochondria, compositions thereof, and methods of identifying, making and using these.
US20140287403 NANOSCALE MOTION DETECTOR  
Motion detector comprising a flexible support (1,5) adapted to hold at least one object (6-9), a sensor (4) for measuring the displacement of said support (1) and processing means for...
US20110150876 Prognosis and Treatment of Breast Cancer  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
US20120115128 SELECTIVE PROTEIN LABELING  
The present invention is related to methods of detecting protein-protein interactions in living cells, as well as detecting the formation and/or inhibition of protein-protein interactions in cells.
US20140294729 METHODS FOR IDENTIFICATION AND USE OF AGENTS TARGETING CANCER STEM CELLS  
The invention relates to methods for identifying compounds and compositions that target cancer stem cells. In some aspects, the invention relates to treatment methods that use compounds and...
US20130296230 METHOD FOR TREATING MALARIA, METHOD FOR KILLING MALARIA PARASITE, AND USE OF THE METHODS  
A method of the present invention for treating malaria includes the step of administering, to a human or an animal, a therapeutically effective amount of drug for suppressing calcium ion exit from...
US20120295804 Compositions and Methods for Diagnosis and Treatment of Breast Cancer  
The present invention is a population of breast cancer cells with preference for establishing dormancy in bone marrow. The breast cancer cells have characteristics of stem cells and express high...
US20120156226 Marker Differentially Expressed in Cancer Stem Cells and Methods of Using Same  
The present invention pertains to methods and agents that target nanog expression or activity for treating or preventing cancer. Alternative methods involve diagnosing cancer stage or type by...
US20140142180 METHODS OF TREATING TUMORS HAVING ELEVATED MCT1 EXPRESSION  
In some aspects, compositions and methods useful for classifying tumor cells, tumor cell lines, or tumors according to predicted sensitivity to 3-bromopyruvate (3-BrPA) are provided. In some...
US20140065062 Halogenated Di and Trisaccharides, Pharmaceutical Formulations, Diagnostic Kits and Methods of Treatment  
The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects,...
US20140296292 METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR  
Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments...
US20130295601 Systems and Methods for Testing Drugs and Drug Delivery Systems  
A system is provided that simulates the in vivo micro-environment of three-dimensional cellular structures or bodies, such as tumors. The system simulates the pressure gradients and fluid flows of...
US20140235453 GLOBAL TRANSCRIPTION MACHINERY ENGINEERING  
The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes.
US20120207817 SMALL INTERFERING RNAS AND METHODS FOR PREVENTION, INHIBITION AND/OR TREATMENT OF MALIGNANT PROGRESSION OF BREAST CANCER  
The invention found that overexpression and activation of α9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of...
US20120058507 Clonal Derivation and Cell Culture quality Control Screening Methods  
The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.
US20140295457 GENE CLUSTER FOR BIOSYNTHESIS OF GRISELIMYCIN AND METHYLGRISELIMYCIN  
The present invention refers to the gene cluster and genes comprised by the gene cluster which are involved in the biosynthesis of griselimycin and methylgriselimycin and to the use of the gene...
US20120100556 Functional Expression of Higher Plant Nitrate Transporters in Pichia Pastoris  
The present invention relates to a system for functional expression of higher plant nitrate transporter (Nrt) genes in Pichia pastoris, an in vivo nitrate uptake assay using these Pichia pastoris...
US20140348749 IDENTIFICATION AND TREATMENT OF TUMORS SENSITIVE TO GLUCOSE LIMITATION  
In some aspects, compositions and methods useful for classifying tumor cells, tumor cell lines, or tumors according to predicted sensitivity to glucose restriction are provided. In some aspects,...
US20150166952 CULTURED HEPATOCYTE AND METHOD FOR PREPARING THE SAME  
Cultured hepatocytes with hepatic-cord structure and the applications were disclosed. Also the disclosure performed the method for obtaining the cultured hepatocytes with hepatic-cord structure...
US20140194632 Method for Screening for Compounds Selectively Interacting with RAD9  
Natural and synthetic compounds of Formulae Ia-Ie having a lactone structure, in particular Securolide, have been determined to be effective anti-tumor compounds which target the hrad9 gene and/or...
US20150010940 METHOD FOR THE RAPID DETERMINATION OF SUSCEPTIBILITY OR RESISTANCE OF BACTERIA TO ANTIBIOTICS  
A method of rapidly evaluating the susceptibility of a strain of bacteria to a cell wall synthesis inhibiting antibiotic based on an assessment of cell enlargement in response to doses of the cell...
US20130065887 Treatment of Cancer with Dopamine Receptor Antagonists  
Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a...
US20110312019 Predicting Human Developmental Toxicity of Pharmaceuticals Using Human Stem-Like Cells and Metabolomics  
The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using...
US20130295198 METHODS OF SCREENING CHEMOTHERAPEUTIC AGENTS AND TREATING CANCER  
Methods for selecting chemotherapeutic agents for treating a cancer are provided that include the steps of providing a cancer cell sample having a population of bulk cancer cells and a population...
US20140315753 ENGINEERING A HETEROGENEOUS TISSUE FROM PLURIPOTENT STEM CELLS  
Aspects of the present disclosure are directed to methods and compositions for the production of heterogeneous tissue from human induced pluripotent stem (hiPS) cells.
US20140120573 ENGINEERING INDIVIDUALLY ADDRESSABLE CELLULAR SPHEROIDS USING AQUEOUS TWO-PHASE SYSTEMS  
Provided is multi-phase systems that may be used to prepare a three-dimension aggregate of cells referred to as a cellular spheroid. The multi-phase system includes a droplet of an aqueous polymer...
US20110008823 TOXICITY SCREENING METHODS  
The present invention provides methods of determining a level of toxicity of a given compound based on in vitro assays. The present invention provides particular methods of determining...
US20140154735 TUMOUR CELL AND TISSUE CULTURE  
The present invention relates to in vitro three-dimensional organotypic cell co-culture. Cultures of the invention comprise tumour cells three-dimensionally disposed within a matrix of matrix...