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US20110300533 |
Yeast Screens for Treatment of Human Disease
Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided...
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US20110045477 |
HUMAN SKIN EXPLANT CULTURE SYSTEM AND USE THEREFOR
The present invention features a human skin explant culture system and uses thereof.
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US20120009604 |
USE OF GRF1 PROTEIN FOR SCREENING MOLECULES
The invention concerns the use of whole or part of the GRF1 protein, or of cells expressing whole or part of the GRF1 protein, in methods for detecting compounds for preventing and/or treating...
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US20100297632 |
UPREGULATION OF RACK-1 IN MELANOMA AND ITS USE AS A MARKER
The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocyte cell of said mammal, and the deduction...
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US20110027817 |
TAU PROTEIN SCREENING ASSAY
This invention is directed to methods for determining if a test compound can ameliorate tau protein induced reduction of long term potentiation in a neural structure. The invention is also directed...
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US20110045475 |
UPREGULATION OF RACK-1 IN MELANOMA AND ITS USE AS A MARKER
The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocytic cell of said mammal, and the...
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US20110300206 |
VACCINES AGAINST CHLAMYDIAL INFECTION
The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the...
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US20110047633 |
Control of Exocrine Pancreatic Function Using Bone Morphogenetic Proteins
Methods are described for controlling exocrine pancreatic function, for reducing the level of amylase in the blood, and for treating pancreatitis in an individual comprising administering to the...
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US20110006221 |
METHOD FOR EVALUATING OIL-AND-FAT AMOUNT IN SEED AND METHOD FOR SCREENING FOR PLANT EXHIBITING VARIED LEVEL OF OIL-AND-FAT CONTENT
This invention is intended to evaluate the oil-and-fat amount in a seed and genetic changes thereof. A fusion protein of an oil body-specific protein, such as the oleosin-GFP fusion protein, and a...
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US20100298348 |
Method of Decreasing Ubiquitylated Protein Levels
The present invention provides a method of decreasing the level of ubiquitylated protein in a subject, the method comprising administering a heterocyclic compound disclosed herein or a...
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US20120108464 |
TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system...
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US20110105343 |
Systems Biology Approach Predicts Immunogenicity of Vaccines
A major challenge in vaccinology is to prospectively determine vaccine efficacy. Disclosed herein are methods and compositions for identifying early expression “signatures” that predicted imm...
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US20120009610 |
ENDOSTATIN AS A MARKER OF HEART FAILURE
Disclosed is a method for assessing heart failure in an individual including the steps of a) measuring in a sample obtained from the individual the concentration of the marker endostatin, of b)...
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US20120077778 |
Ladder-Frame Polyether Conjugates
Disclosed are compounds that are conjugates of ladder frame polyether compounds and biologically active compounds or research compounds, pharmaceutical formulations comprising the conjugates, and...
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US20110236921 |
CELL SYSTEM
The present invention relates to cellular systems for testing drug candidates and for evaluating the function of mitochondrial proteins. The invention is particularly useful for evaluating drug...
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US20100168006 |
IN-PLANT PRODUCTION OF DIMERIC AND/OR OLIGOMERIC (COMPRISING THREE OR MORE UNITS) FORMS OF HUMAN APO A-1 PROTEIN MUTEINS
The present invention encompasses a method for the production of Apolipoproteins in dimeric and/or oligomeric forms (comprising three or more units) of muteins of the human ApoA-1 protein in plant...
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US20110053198 |
UBIQUITIN PROTEASOME SYSTEM PROFILING AND THE USE THEREOF IN CLINICAL APPLICATIONS FOR PROLIFERATIVE HEMATOLOGICAL DISORDERS
Provided herein are methods for the diagnosis, prognosis, or management of proliferative hematological disorders and other diseases using profiles of the ubiquitin-proteasome system determined from...
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US20120003243 |
YEAST ECTOPICALLY EXPRESSING ABNORMALLY PROCESSED PROTEINS AND USES THEREFOR
Disclosed are yeast ectopically expressing abnormally processed proteins and methods of screening to identify compounds that modulate the function of such abnormally processed proteins in yeast....
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US20110212464 |
PACAP AS A MARKER FOR CANCER
The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the proapoptotic caspase adaptor protein (=PACAP) as a universal marker of different types of...
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US20110257035 |
IDENTIFICATION OF SIGNATURE GENES ASSOCIATED WITH HEPATOCELLULAR CARCINOMA
The present invention relates to, for example, (1) a novel method for identification of clinically useful serum and/or tumor biomarkers and expression signatures that can be used for detection,...
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US20100304419 |
METHOD FOR DETERMINING THE PROGNOSIS OF GASTRIC CANCER
The 14-3-3β protein is used herein as a tumor marker for prognosis in gastric cancer. The method comprises steps of providing a biological sample, qualifying the 14-3-3β protein level in the s...
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US20110071123 |
Noninvasive Method for Measuring Histamine From Skin as an Objective Measurement of Itch
A method for measuring of histamine in an epidermis comprising applying an adhesive article to an epithelium of a mammal; allowing for adherence of epithelial cells to the adhesive article;...
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US20100311099 |
USE OF HE4 FOR ASSESSMENT OF BREAST CANCERS
The disclosure relates to use of the HE4 marker to assess breast cancer in a patient. The disclosure also relates to using HE4 and other tumors markers for diagnosis, grading and staging of breast...
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US20110313233 |
DOWN-REGULATION OF COLD SHOCK PROTEINS FOR CANCER TREATMENT
The present invention is in the field of treatment of diseased tissues, including cancerous tissues. In one embodiment, the present invention provides methods of identifying tissues that...
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US20110086796 |
METHODS FOR PREDICTING THE DEVELOPMENT AND RESOLUTION OF ACUTE RESPIRATORY DISTRESS SYNDROME
The subject invention features methods for predicting whether a subject at risk of developing Acute Respiratory Distress Syndrome (ARDS) will develop ARDS by determining the amount of elafin...
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US20120064565 |
System Setup For Biological Methane Potential Test
A system setup is disclosed for carrying out a biological methane potential test on a biosample and a system setup is disclosed for measuring biomethane gas in a biogas flow. In at least one...
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US20110070603 |
DISC FOR TESTING BLOOD, BLOOD TESTER HAVING THE SAME, AND CONTROL METHOD THEREOF
Disclosed are a blood tester for measurement of temperature of a sample placed in a blood-testing disc using a thermochromic pigment, and a control method thereof. The disclosed blood-testing disc,...
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US20110212483 |
Methods and Kits for the Diagnosis of RyR1-Related Diseases
The present invention encompasses methods for diagnosis of calcium channel related diseases (e.g., RyR1-related diseases) comprising contacting lymphocytes isolated from a subject with a calcium...
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US20110195446 |
METHOD AND KIT FOR SEMEN DIAGNOSIS THROUGH COLOR CHANGES IN METHYLENE BLUE AND SEMEN QUALITY EVALUATION USING SAME
The present invention relates to a method and a kit for diagnosis of semen quality (motility and concentration) through observation of color change visible with the naked eye in a solution...
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US20110311507 |
Methods for Diagnosing and Treating Autoimmune Disorders
Provided herein are, inter alia, methods of identifying patients who are at risk of developing an autoimmune disorder, and treating patients suffering from autoimmune disorders.
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US20110165130 |
Methods for Preparing Human Skin Substitutes from Human Pluripotent Stem Cells
The present invention relates to an ex vivo method for obtaining a population of human keratinocytes derived from human pluripotent stem cells comprising a step of co-culturing human pluripotent...
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US20110177092 |
INDIVIDUAL 5-FLUOROURACILE DOSE OPTIMIZATION IN FOLFIRI TREATMENT
The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5-FU dose administered by...
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US20110052581 |
USE OF PICOPLATIN AND CETUXIMAB TO TREAT COLORECTAL CANCER
The invention provides a method of treatment of metastatic colorectal cancer by administration of the anti-cancer platinum drug picoplatin in conjunction with cetuximab, 5-FU, and leucovorin in a...
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US20110236314 |
METHOD OF DETECTION AND DIAGNOSIS OF ORAL AND NASOPHARYNGEAL CANCERS
The present invention relates to cancer and in particular to oral and nasopharyngeal cancers. In particular, the present invention relates to a method of detection and diagnosis of oral squamous...
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US20110020837 |
Method for isolating or identifying a target protein interacting with a lipid in a cell
The invention is in the field of molecular biology and cell biology. It provides tools and methods for studying the interaction of proteins and lipids in vivo as well as in vitro. The invention...
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US20110318730 |
MICROPATTERNED CO-CULTURE SYSTEMS AS INFECTIOUS DISEASE ANALYSIS PLATFORMS
Cell cultures are provided that include a population of micropatterened hepatocytes and one or more non-parenchymal cell populations, where the hepatocytes are infected with a virus or parasite and...
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US20110112155 |
METHODS FOR TREATING CANCER IN PATIENTS HAVING BREAST CANCER RESISTANCE PROTEIN OVEREXPRESSION
A method for treating cancer comprising identifying a mammal that overexpresses breast cancer resistance protein; and administering to said mammal a pharmaceutical composition comprising a...
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US20110028344 |
BIOMARKERS FOR ENDOMETRIAL DISEASE
This patent application discloses and describes a list of proteins that are found to be differentially expressed between normal endometrial epithelial cells and early stage cancerous endometrial...
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US20100322954 |
ENHANCED HIV-1 VACCINES AND METHODS FOR THEIR USE
The present invention provides peptides and proteins for use in second generation HIV vaccines and as diagnostic tools in the treatment and control of HIV infection. The antiviral protection shown...
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US20120107862 |
FACTORS
A method for determining a prognosis for benefit for a cancer patient receiving immunotherapy treatment involving (a) measuring a level of haematocrit and haemoglobin in a sample from the cancer...
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US20110165561 |
DIRECT AND CONTINUOUS ROOT ALONE OR ROOT/SHOOT PRODUCTION FROM TRANSGENIC EVENTS DERIVED FROM GREEN REGENERATIVE TISSUES AND ITS APPLICATIONS
The present invention provides assays and methods for efficiently testing a polynucleotide of interest for a phenotype in a root. In some embodiments, the assays and methods include regenerating...
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US20110263677 |
GOS2 MODULATORS IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA
An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea,...
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US20120115161 |
COMPOSITIONS AND METHODS FOR DEMONSTRATING SECRETORY IMMUNE SYSTEM REGULATION OF STEROID HORMONE RESPONSIVE CANCER CELL GROWTH
Serum-containing and serum-free immunoglobulin inhibitors of steroid hormone responsive cancer cell growth are disclosed, along with their methods of production. Also disclosed are defined cell...
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US20110126305 |
Mutant blue fluorescent protein and method of using the same for fluorescence resonance energy transfer and blue fluorescent fish
The present invention discloses a mutant blue fluorescent protein (BFP) exhibiting, at an aerobic or anaerobic system, larger fluorescent intensity than a BFPvv D7 of SEQ ID NO:2 derived from a...
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US20110257245 |
METHODS OF IDENTIFYING REGULATORS OF CELLULAR PROTEOSTASIS
Embodiments of the present invention provide methods for identifying and utilizing regulators of cellular proteostasis as new therapeutic targets against protein misfolding diseases.
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US20110195431 |
HUMAN ORPHAN G PROTEIN-COUPLED RECEPTORS
The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.
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US20120053449 |
MAGNETIC CONFIGURATION AND TIMING SCHEME FOR TRANSCRANIAL MAGNETIC STIMULATION
Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This...
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US20110177545 |
G-PROTEINS
Gαq-Gustducin chimeric G-proteins that functionally couple to G-protein coupled receptors. The chimeras can be expressed in heterologous cell systems and can be used as the basis of assays for ...
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US20120064537 |
USE OF PERFUSION DECELLULARIZED ORGANS FOR MATCHED RECELLULARIZATION
The invention provides a method for preparing a perfusion based 3D cell culture system, a recellularized matrix culture system, and methods of using the culture system.
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US20120129162 |
CELL CULTURE SYSTEM FOR DETERMINING THE SENSITIZING, ALLERGENIC AND/OR IRRITATING EFFECT OF A SUBSTANCE
The present invention refers to a cell culture system especially for investigating the sensitizing, allergenic and/or irritating effect of substances, comprising a first and a second compartment...
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