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US20120014924 Compositions and Methods for Improving the Functional Efficacy of Stem Cell-Derived Cardiomyocytes  
This invention provides an isolated stem cell modified to provide, enhance or contain the functional characteristics of the sarcoplasmic reticulum (SR) The isolated stem cells are modified by...
US20110245104 Method for screening the sensitizing properties of chemical compounds  
A method is provided for screening the sensitizing properties of chemical compounds. The method is based on keratinocytes or cells that share important hallmarks of these cells, but other...
US20130012429 ANTI-VIRAL THERAPY  
This invention relates to a method of treating viral infections, and compounds for use in the treatment of viral infections by modulating the BMP/SMAD signalling pathway. In particular, it relates...
US20110160160 METHODS FOR HEAT SHOCK PROTEIN DEPENDENT CANCER TREATMENT  
The present invention provides a method of treating an Hsp70 dependent cancer, including: providing at least one Hsp70 dependent cancer cell; contacting the at least one cell with a sub-effective...
US20130203624 Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions  
This invention provides methods of using phagocytic cells alone or in combination with non-phagocytic cells in the diagnosis, prognosis, or monitoring of prenatal or pregnancy-related diseases or...
US20140194366 OVARIAN CANCER STEM CELLS AND METHODS OF ISOLATION AND USES THEREOF  
The present invention generally relates to methods, assays, compositions and kits related to a subpopulation of ovarian cancer stem cells which are selected or enriched by chemotherapeutic agents...
US20140141980 Stratifying and annotating a clinical practice guideline  
Personalized medicine involves the use of a patient's molecular markers to guide treatment regimens for the patient. The scientific literature provides multiple examples of correlations between...
US20110002893 DIAGNOSIS AND TREATMENT OF CONGENITAL HEART DEFECTS USING NELL1  
The present invention provides diagnostic methods for detecting congenital heart defects, or increased risk thereof, based on the Nell1 gene, RNA and protein. The methods include obtaining a...
US20120171716 Measurement of Mitochondrial Membrane Potential to Assess Organ Dysfunction  
The present invention relates to the field of organ transplantation. More specifically, the present invention provides methods for predicting organ function after transplantation. In certain...
US20130316366 EXPRESSION OF SECRETED AND CELL-SURFACE POLYPEPTIDES  
Some embodiments herein provide compositions and methods for expressing secreted and cell-surface-bound polypeptides in a single cell. In some embodiments, secreted and cell-surface polypeptide...
US20120058507 Clonal Derivation and Cell Culture quality Control Screening Methods  
The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.
US20100330586 METHOD FOR IDENTIFYING COMPOUNDS FOR TREATMENT OF PAIN  
Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride...
US20120316240 METHOD OF DIAGNOSIS  
Disclosed herein are methods that generally to the fields of pharmaceutical chemistry, biochemistry, molecular biology and medicine. More particularly, aspects of the invention concern methods to...
US20110269173 Method for Producing Polarized Retinal Progenitor Cells from Pluripotent Stem Cells and their Differentiation into Retinal Pigment Epithelium Cells  
The present invention relates to a method and components for producing polarized retinal progenitor cells (RPC) from pluripotent stem cells in high yield and purity. The polarized retinal...
US20110190145 IN SITU ANALYSIS OF TISSUES  
The present invention provides for the simultaneous assessment of a plurality of tissue regions or microregions, the benefit being homogeneity of the sampling, both in terms of tissue content and...
US20120282647 ASSAY FOR QUANTIFYING CLOSTRIDIAL NEUROTOXIN  
Method of measuring an effect induced to a muscle tissue by a clostridial neurotoxin, comprising: (a) contacting a muscle tissue or a cell culture with a sample comprising the clostridial...
US20110059861 ANALYSIS OF CELL NETWORKS  
The present invention provides an approach for the determination of activation state of a plurality of discrete cell populations and/or the state of one or more cellular networks in an individual....
US20140170067 NEW LIGANDS FOR TARGETING OF S1P RECEPTORS FOR IN VIVO IMAGING AND TREATMENT OF DISEASES  
The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P...
US20110125136 INTRAVASCULAR DIAGNOSTIC AND THERAPEUTIC SAMPLING DEVICE  
A device and methods for continuous precision blood sampling from a patient with a micro impedance pump as the driver in a microfluidic system. Depending on the needs of medical technologies, the...
US20120011614 Dominant Gene Suppression Transgenes and Methods of Using Same  
Pairs of plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said...
US20110200982 GENETICALLY MODIFIED MICE AND ENGRAFTMENT  
A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described....
US20130331394 TREATING SCHIZOPHRENIA  
Methods of identifying new treatments for schizophrenia, and the use of the same.
US20120046233 MUTATIONS IN THE LNK GENE IN PATIENTS WITH MYELOPROLIFERATIVE NEOPLASMS AND OTHER HEMATOLYMPHOID MALIGNANCIES  
Aspects of the present invention include methods, compositions and kits for classifying a subject as having or being predisposed to a hematolymphoid neoplasm or malignancy if they harbor a...
US20140289877 METHOD FOR PRODUCING TISSUE AND ORGAN  
The present invention provides a means for reconstituting tissues and organs having mature functions. A method of preparing a tissue or an organ, comprising coculturing an organ cell with a...
US20130230462 METHOD FOR PREDICTING AND PREVENTING CARDIOVASCULAR DISEASE  
Disclosed are methods of identifying an individual having a predisposition to the development of a cardiovascular disease, and administering a suitable prophylactic agent to the identified...
US20150125490 COMPOSITIONS AND METHODS FOR LUNG REGENERATION  
Described herein are stein cells and related factors for treating degenerative and inflammatory disorders of lung tissue.
US20120282629 Enhancers of Protein Degradation  
The present invention relates to compounds suitable for modulating huntingtin protein processing and useful for treating or preventing huntingtin-related disorders. The invention provides...
US20110097710 Methods for detecting atrial fibrillation and related conditions  
Methods for detecting disorders associated with atrial fibrillation, and, thus, at risk for stroke and/or heart failure) in a subject based on a monitoring plasma levels of apelin are provided....
US20110301056 NECTIN-4 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS  
The present invention features methods for diagnosing cancer or assessing or determining the prognosis of a patient with lung cancer, by detecting the expression level of Nectin-4. The present...
US20120094325 Microfluidic Cell Motility Assay  
Certain isolated motile cells spontaneously migrate unidirectionally through a mechanically confined space, such as a microcapillary channel, in the absence of an external gradient (e.g., a...
US20120071335 Method for Identification, Selection and Analysis of Tumour Cells  
The present invention relates to a method for the diagnosis of tumoural conditions and/or of the corresponding state of advance, wherein a specimen of an organic fluid taken from the patient and...
US20110318312 Rejuvenation or preservation of germ cells  
Certain embodiments disclosed herein include, but are not limited to, at least one of compositions, methods, devices, systems, kits, or products regarding rejuvenation or preservation of germ...
US20150005243 NMR-BASED METABOLITE SCREENING PLATFORM  
Methods that enable one to specifically measure the metabolic product of a particular molecule in relatively few cells, e.g. primary cells, are described. The methods involve optionally preloading...
US20120039851 USE OF ANDROGENS FOR VASCULAR REGENERATION AND ENDOTHELIAL REPAIR  
The present invention relates to the field of therapy and prophylaxis of vascular tissue damage and/or complications and/or disease of vascular tissue by vascular regeneration and endothelium...
US20140314740 COMPOSITIONS AND METHODS FOR THE PREVENTION OR TREATMENT OF DIABETIC COMPLICATIONS  
The invention provides compositions and methods for the prevention, amelioration, and/or treatment of diabetes complications, including ocular diseases associated with increased glucose transport...
US20120202209 CELL IMAGING METHOD FOR VIEWING MICRORNA BIOGENESIS IN THE CELLS  
The present invention relates to a method for viewing the biogenesis of at least one microRNA, preferably a microRNA group, in a living cell, characterised in that said method includes the...
US20110104126 Human Hepatic Stem Cell, Method for Preparation of the Same, Method for Induction of Differentiation of the Same, and Method for Utilization of the Same  
The present invention provides a human hepatic stem cell which is sorted based on the presence or absence of the expression of at least one marker selected from the group consisting of CD318,...
US20120004254 G PROTEIN-COUPLED RECEPTOR ANTAGONIST AND ITS USE FOR PREVENTING AND TREATING ALZHEIMER'S DISEASE  
The invention discloses methods for screening a reagent for treating or preventing Alzheimer's disease or related neurological pathology. A method according to the invention includes the steps of:...
US20110262959 METHOD FOR EVALUATION OF DIFFERENTIATION ABILITY OF STEM CELL  
The present invention provides a method of evaluating the possibility of a stem cell being able to differentiate into a cell that constitutes a desired tissue in a living organism, comprising the...
US20130179997 TRANSGENIC ANIMAL EXPRESSING ALZHEIMER'S TAU PROTEIN  
The present invention provides transgenic non-human animals and non-human mammalian somatic and germ cells harbouring a human DNA sequence encoding Alzheimer's Disease (AD) derived tau protein,...
US20110256555 USE OF CXCR4 PROTEIN EXPRESSION ON THE SURFACE OF STEM CELLS AS A MARKER FOR TUMOR TROPIC POTENTIAL  
The present invention relates to tumor tropic stem cells, and particularly to neural stem cells, and their use as delivery vehicles for therapeutic gene products to neoplastic foci. The stem cells...
US20110016583 DROUGHT TOLERANT PLANTS AND RELATED CONSTRUCTS AND METHODS INVOLVING GENES ENCODING PROTEIN TYROSINE PHOSPHATASES  
Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA...
US20150258151 GUT BARRIER DYSFUNCTION TREATMENT AND PREVENTION  
Methods are disclosed for treating and preventing gut barrier dysfunction or an illness associated with gut barrier dysfunction in a subject comprising administering to the subject bacterium that...
US20130236924 COMPLIANT MULTI-WELL PLATE  
Multi-well plate (1) comprising a plurality of wells (4), a frame (5) for holding the plurality of wells (4) in a defined arrangement, a support element (50) for contacting a surface when the...
US20110078819 Method and Appartus for Extraction of Plant Embryos  
The invention relates to rapid and efficient methods and apparatuses for displacing target plant materials from seeds. In one embodiment, the invention relates to methods and apparatuses for...
US20110171132 Methods, Compounds, and Compositions for Treatment and Prophylaxis in the Respiratory Tract  
The present invention provides a method of reducing the quanitity of mucus in the respiratory tract of a subject with elevated levels of mucus in said respiratory tract. The method includes...
US20110151497 METABOLOMIC PROFILING OF PROSTATE CANCER  
The present invention relates to cancer markers. In particular, the present invention provides metabolites and panels of metabolites that are differentially present in cancer (e.g., prostate or...
US20110154540 RECOMBINANT VECTORS CARRYING ZEARALENONE-INDUCIBLE PROMOTER AND METHODS FOR PRODUCING PROTEINS AND DETECTING ZEARALENONE USING THEM  
The present invention relates to a zearalenone-inducible promoter originated from Gibberella zeae, recombinant vectors comprising the promoters, methods of producing proteins and detecting plants...
US20150166952 CULTURED HEPATOCYTE AND METHOD FOR PREPARING THE SAME  
Cultured hepatocytes with hepatic-cord structure and the applications were disclosed. Also the disclosure performed the method for obtaining the cultured hepatocytes with hepatic-cord structure...
US20140248651 NUTRIENT MEDIUM  
The invention relates to a nutrient medium, containing 10 to 20 parts by weight of yeast extract, 15 to 30 parts by weight of peptone, 35 to 75 parts by weight of monosaccharides and...