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US20120276145 EXTRACELLULAR MATRIX PROTEINS FROM HAEMOPHILUS INFLUENZAE BIOFILMS: TARGETS FOR THERAPEUTIC OR DIAGNOSTIC USE  
A method of identifying a biofilm that includes non-typeable Haemophilus influenza (NTHi) including a step of screening a sample for the presence of one or more biofilm-specific proteins that are...
US20130184173 BIOMARKERS FOR MULTIPLE SCLEROSIS  
Biomarkers that can be used for the diagnosis and prognosis of multiple sclerosis in pediatric patients presenting with clinically isolated syndrome or acquired demyelination syndrome are described.
US20120077209 PROTEIN BIOMARKERS AND THERAPEUTIC TARGETS FOR AUTOIMMUNE AND ALLOIMMUNE DISEAES  
A method for characterizing the risk a subject will develop an autoimmune and/or alloimmune disease following tissue transplant includes obtaining a biological sample from the subject, wherein the...
US20150140589 AUTOMATED PROTEIN DIGESTION, RECOVERY, AND ANALYSIS  
The present disclosure provides an automated system and method for protein digestion, recovery, and analysis. The present disclosure also provides a buffer solution for use therein.
US20140112955 BIOMARKERS OF IMMUNOTHERAPY EFFICACY  
The invention relates to proteins for use as a marker for the efficacy of sublingual immunotherapy. In particular, the proteins may be used to predict the responsiveness of a patient to...
US20130172186 PROTEINS RELATED TO THE SUPPRESSION OF PHYTOPHTHORA INFECTIONS IN MEMBERS OF THE SOLANACEAE FAMILY  
The present disclosure provides a method of suppressing oomycete infection, such as a Phytophthora infection, or triggering programmed cell death in Solanaceae plants comprising administering at...
US20110053197 UBIQUITIN PROTEASOME SYSTEM PROFILING AND THE USE THEREOF IN CLINICAL APPLICATIONS FOR CANCER DIAGNOSIS  
Provided herein are methods for the diagnosis, prognosis, or management of neoplastic diseases, i.e. cancer, and other diseases using profiles of the ubiquitin-proteasome system determined from...
US20120040389 METHOD FOR DEMONSTRATION OF A MOLECULAR EVENT IN A CELL BY MEANS OF FLUORESCENT MARKER PROTEINS  
The invention relates to a method for demonstration of the occurrence of a molecular event, particularly in a cell, characterised by the detection of the ‘solubilisation’ of a fixed protein marker...
US20120171144 METHODS OF TREATING, REDUCING AND INHIBITING THE APPEARANCE OF AGEING IN THE SKIN  
Methods of treating, reducing and inhibiting the appearance of ageing in the skin are provided. Also provided are uses and methods of maintaining a youthful appearance, reducing an appearance of...
US20110086796 METHODS FOR PREDICTING THE DEVELOPMENT AND RESOLUTION OF ACUTE RESPIRATORY DISTRESS SYNDROME  
The subject invention features methods for predicting whether a subject at risk of developing Acute Respiratory Distress Syndrome (ARDS) will develop ARDS by determining the amount of elafin...
US20130338243 METHOD OF PREDICTING ACUTE APPENDICITIS  
Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers:...
US20120107856 New Fungal Production System  
The present invention provides a new fungal production system comprising a fungal host strain of Chrysosporium lucknowense wherein the endogenous cellulase secretion is less than 20% of the...
US20110244500 Gel electrophoresis method useful for resolution and characterization of nerve tissue ultra high molecular weight protein aggregates  
The instant disclosure describes an electrophoretic procedure capable of resolving and isolating ultra high molecular weight (MW) protein aggregates from nerve tissue. The procedure is based on...
US20120171693 Methods for Generating Novel Stabilized Proteins  
The disclosure provides methods for identifying and producing stabilized chimeric proteins.
US20150005182 PROTEIN BIOMARKERS OF RECURRENT BREAST CANCER  
This patent application discloses and describes proteins found to be differentially expressed between primary tumor breast cancer cells that did not give rise to recurrent breast cancer disease...
US20150126402 Method for Quantifying Proteins and Isoforms Thereof  
A method for quantifying metallothionein protein isomers is described herein. Such metallothionein isomer protein quantification is useful for detecting and monitoring disease. As illustrated...
US20130137595 BIOMARKERS FOR LYMPHOMA  
A biomarker, method, test kit, and diagnostic system for detecting the presence of lymphoma in a person are disclosed. The lymphoma may be Hodgkin's lymphoma or non-Hodgkin's lymphoma. The person...
US20140234347 METHODS OF USING BIOMARKERS FOR PREDICTING THE OUTCOME OF AN IMMUNOTHERAPY AGAINST CANCER  
The present invention relates to methods for predicting the effect of an immunotherapy against cancer in a patient based on new biomarkers. The present invention furthermore relates to a prognosis...
US20140030735 BIOMARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE  
The methods described herein are based on the discovery that the plasma level of a panel of specific proteins differs between two subject populations: 1) subjects at risk for chronic obstructive...
US20110269162 UBIQUITIN PROTEASOME SYSTEM PROFILING FOR DIAGNOSIS OF CHRONIC LIVER DISEASE  
Provided herein are methods for the diagnosis, staging, prognosis, or management of liver disease, e.g. chronic liver disease, and other diseases using profiles of the ubiquitin-proteasome system...
US20150005183 PROTEIN BIOMARKERS OF LATE STAGE BREAST CANCER  
This patent application discloses and describes proteins found to be differentially expressed between primary tumor breast cancer cells histologicaly defined as early stage (stage 0) breast cancer...
US20150104809 DETECTION AND TREATMENT OF CANCER  
The present invention relates to a method for diagnosing, evaluating the prognosis of a cancer patient and evaluating the aggressiveness of a cancer. The methods comprise detecting the...
US20150031065 COMPOSITIONS, METHODS AND KITS FOR DIAGNOSIS OF LUNG CANCER  
The present invention provides methods for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a...
US20140106369 BIOMARKERS FOR AGGRESSIVE PROSTATE CANCER  
The present invention relates to the field of biomarkers and, more specifically, to biomarkers useful in diagnosing aggressive prostate cancer. In specific embodiments, a method for diagnosing...
US20140030751 Devices and Methods for the Fast Photochemical Oxidation of Proteins  
Embodiments of the present disclosure provide for devices and methods that can be used in a process for the fast photochemical oxidation of proteins, and the like.
US20110152341 CLEAVAGE OF B-AMYLOID PRECURSOR PROTEIN  
Methods and means for the identification of meprin-α and meprin-β as novel β-secretases and antagonists thereof for use in the treatment of amyloidosis.
US20120115173 BIOMARKERS FOR MOTOR NEURON DISEASE  
The invention provides methods of determining a diagnosis or prognosis of motor neuron disease in a mammal comprising determining the expression level of one or more proteins or polypeptides of...
US20130230877 Compositions, Methods and Kits for Diagnosis of Lung Cancer  
Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung...
US20130217057 Compositions, Methods and Kits for Diagnosis of Lung Cancer  
Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung...
US20110251073 Compositions And Methods Comprising Variant Microbial Proteases  
The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more...
US20110207627 EX VIVO THERAPEUTICS SCREENING OF LIVING BONE MARROW CELLS FOR MULTIPLE MYELOMA  
Methods of selecting a treatment for a patient with multiple myeloma are provided. Prior to commencing a treatment regime, bone marrow aspirates are isolated from a patient and incubated with one...
US20110236917 Diagnosis of Alzheimer's Disease  
Embodiments of an assay for the screening, diagnosis, and differentiation of Alzheimer's disease uses selected sets of serum protein biomarkers. The assay is used to distinguish Alzheimer's...
US20110070601 CLASSIFICATION OF INDIVIDUALS SUFFERING FROM CARDIOVASCULAR DISEASES ACCORDING TO SURVIVAL PROGNOSES AS FOUND BY MEASURING THE LEVELS OF BIOMARKER YKL-40  
The present invention relates to the method of measuring the YKL-40 level and using this measurement as a prognosis for survival of an individual suffering from heart disease caused by...
US20120283114 NEW DIAGNOSTIC TOOLS FOR ALZHEIMER DISEASE  
The present invention relates to development, validation and application of new sets of biomarkers for diagnosis of Alzheimer's disease (AD) and related disorders including early diagnosis of MCI...
US20110287958 Method for Using Gene Expression to Determine Colorectal Tumor Stage  
The invention relates to methods of determining a colorectal tumor stage in a patient by gene expression analysis. The method comprises assaying the level of at least one RNA transcript, or its...
US20140135271 Lamin A, An Activator of Longevity/Anti-Aging SIRT1 Protein  
In one embodiment, the present invention provides methods of modulating the deacetylase activity of SIRT1 in one or more cell by modifying the binding affinity of lamin A to SIRT1 via one or more...
US20110201021 USE OF THE IRAP PROTEIN FOR IMPLEMENTING METHODS OF DIAGNOSIS AND OF PROGNOSIS  
The use of the IRAP protein for implementing methods of diagnosis and of prognosis.
US20140044673 Classifying Skin Lesions Using Mass Spectrometry Proteomic Approach  
The present invention provides for a mass spectrometry proteomic approach to distinguishing Spitz nevi from Spitzoid malignant melanoma. Histology directed mass spectral profiling allows for...
US20130230865 Methods for Monitoring Methotrexate Therapy  
The present invention provides methods for assessing efficacy of a methotrexate (MTX) dosing regimen in a patient.
US20130177544 BIOMARKERS ASSOCIATED WITH PRE-DIABETES, DIABETES AND DIABETES RELATED CONDITIONS  
Biomarkers for pre-Diabetes, Diabetes and/or a Diabetes related conditions, and methods of their use, including the biomarkers in Tables 1 and 2 such as peroxiredoxin-2, complement C1q...
US20110245150 TARGETS FOR TREATMENT OF CHLAMYDIAL INFECTIONS  
The present invention relates to a screening method for identification of a compound suitable for the prevention, treatment or/and diagnosis of an infection with Chlamydiaceae.
US20140162289 IDENTIFYING MOLECULES MODULATING PROTEIN-PROTEIN INTERACTIONS USING PROTEASE ACTIVATED REPORTERS  
Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter.
US20100311096 IDENTIFYING MOLECULES MODULATING PROTEIN-PROTEIN INTERACTIONS USING PROTEASE ACTIVATED REPORTERS  
Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter.
US20140249049 USE OF CD5 ANTIGEN-LIKE AS A BIOMARKER FOR DIABETIC NEPHROPATHY  
Biomarkers for pre-Diabetes, Diabetes and/or a Diabetes related conditions, and methods of their use, including the biomarkers in Tables 1 and 2 such as peroxiredoxin-2, complement C1q...
US20140004549 Method for Enzymatic Treatment of Tissue Products  
Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a...
US20110294138 METHODS FOR SIMULTANEOUSLY MEASURING THE IN VIVO METABOLISM OF TWO OR MORE ISOFORMS OF A BIOMOLECULE  
The present invention encompasses methods for the simultaneous measurement of the in vivo metabolism of two or more isoforms of a biomolecule. The biomolecule is typically produced in the central...
US20140309247 Systems And Methods For Detecting Scalp Follicular Inflammation In Humans  
Methods, processes, systems, and apparatuses are disclosed for detecting biomarkers associated with the inflammation response in the pilosebaceous unit of the human scalp using plucked human hair...
US20130295590 FOXA1 AS A MARKER FOR INVASIVE BLADDER CANCER  
The present invention provides for a proteomic approach to predicting, diagnosing and staging invasive bladder cancer, and for predicting patient survival and therapeutic efficacy. More...
US20110045518 YKL-40 AS A GENERAL MARKER FOR NON-SPECIFIC DISEASE  
The present invention relates to methods of diagnosing the presence of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above a reference level indicates the...
US20140199718 METHODS FOR MEASURING THE METABOLISM OF NEURALLY DERIVED BIOMOLECULES IN VIVO  
The present invention relates to methods of diagnosing, monitoring, and assessing treatment effects for neurological and neurodegenerative diseases and disorders, such as Alzheimer's Disease,...