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US20110135620 PRODRUG ACTIVATION IN CANCER CELLS USING MOLECULAR SWITCHES  
The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a...
US20130323751 Urine Biomarkers For Prediction Of Recovery After Acute Kidney Injury: Proteomics  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, renal...
US20130183737 NOVEL BIOMARKERS OF LIVER CANCER  
The invention is based on the surprising finding that proteins regulated by excessive EGFR signalling in the liver may be used as biomarkers in the diagnosis, prognosis and/or monitoring of...
US20110110918 ROLE OF (DE)ACETYLATION IN COUNTERACTING PROTEIN AGGREGATION  
The invention provides a method for influencing an activity of a heat shock protein which is a member of the Hsp40/DnaJ family, the method comprising acetylating or deacetylating said heat shock...
US20120148559 COMPOSITIONS AND METHOD FOR DEIMMUNIZATION OF PROTEINS  
The invention provides deimmunized mutant proteins having reduced immunogenicity while exhibiting substantially the same or greater biological activity as the proteins of interst from which they...
US20140186924 METHODS FOR TRANSFORMING TARWI AND FOR PRODUCING MOLECULAR FARMING PRODUCTS IN TRANSGENIC TARWI SEED  
The present disclosure describes reproducible methods for the Agrobacterium-mediated production of stable, genetically transformed, fertile tarwi plants (Lupinus mutabilis Sweet) having...
US20110300109 COMPOSITIONS AND METHODS FOR TREATING CANCER  
The present invention is based, in part, on our discovery of compositions and methods that can be used to systemically deplete arginine and thereby treat arginine-dependent cancers. Our studies...
US20150240226 NUCLEIC ACIDS AND PROTEINS AND METHODS FOR MAKING AND USING THEM  
The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides...
US20120266329 Nucleic Acids and Proteins and Methods for Making and Using Them  
The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides...
US20110265197 Signatures and PCDeterminants Associated with Prostate Cancer and Methods of Use Thereof  
The present invention provides methods of detecting cancer using biomarkers.
US20130210037 METHODS OF DIAGNOSING AND TREATING AUTISM  
The present invention provides diagnostic methods for determining the risk of developing an autism spectrum disorder (ASD) in a fetus or child by detecting in a biological sample from the mother...
US20100323424 Targeted modification of chromatin structure  
Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for...
US20110217267 GENE THERAPY VECTORS AND CYTOSINE DEAMINASES  
This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in...
US20120172340 Compositions and Methods for Selectively Activating Human Sirtuins  
Methods for identifying selective activators of SIRT5 and/or SIRT1 and methods for using these selective activators in the modulation of SIRT5 and/or SIRT1 are provided.
US20150225728 CELL MODIFICATION METHOD USING ESSENTIAL GENES AS MARKERS AND OPTIONALLY RECYCLING THESE  
The invention relates to a method for modification of a host cell at a target locus, which method comprises: providing a host cell comprising, at a first locus, at least two site-specific...
US20130244237 Methods and Compositions for Discrimination Between Cytosine and Modifications Thereof and for Methylome Analysis  
Compositions and methods are provided for discrimination between cytosine and modifications thereof using cytidine deaminases and/or oxygenases. Variants of wild type cytidine deaminases are...
US20140148502 MODIFIED POLYNUCLEOTIDES FOR TREATING PROTEIN DEFICIENCY  
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
US20150125928 NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM  
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
US20130316409 Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them  
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
US20120009637 Nitrilases, Nucleic Acids Encoding Them and Methods For Making and Using Them  
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
US20110251094 BIOMARKERS FOR HYPERTENSIVE DISORDERS OF PREGNANCY  
The application discloses new biomarkers for hypertensive disorders of pregnancy and particularly preeclampsia; methods for the diagnosis, prediction, prognosis and/or monitoring said disorders...
US20120177628 ARGINASE FORMULATIONS AND METHODS  
Methods and composition for generation of arginase variants with high serum persistence are provided. For example, in certain aspects methods for purifying pegylated arginase are described....
US20090117628 Enzymatic processing in deep eutectic solvents  
It has surprisingly been discovered that it is possible to use enzymes in deep eutectic solvents (DES). DES's are mixtures of a nitrogen salt or a metal salt and a strong hydrogen bond donor that...
US20150044675 MODIFIED GENE OF HUMAN ACTIVATION-INDUCED CYTIDINE DEAMINASE (AID), A METHOD OF MODIFICATION OF HUMAN AID GENE, A COMPOSITION SHOWING AID ACTIVITY, A METHOD OF PREPARATION OF SUCH COMPOSITION IN A BACTERIAL SYSTEM AND USE OF THE COMPOSITION IN THE ANALYSES OF DNA/RNA AMINATION/DEAMINATION AND/OR METHYLATION/DEMETHYLATION  
The subject of the invention is a modified gene of human activation-induced cytidine deaminase (AID), a method of modification of human AID gene, a composition showing AID activity, and a method...
US20130195884 NOVEL MODULATORS OF TRAIL SIGNALLING  
The present invention relates to an agent for use as a modulator of apoptosis-factor-associated cell death, apoptosis, cell survival, migration and/or proliferation, a method of diagnosing or...
US20130177949 NITRILASES  
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
US20150037312 Binding Proteins To The Constant Region Of Immunoglobulin G  
The present invention provides polypeptides that bind to immunoglobulin G and methods for their use.
US20120034239 PROTEINS WITH IMPROVED SOLUBILITY AND METHODS FOR PRODUCING AND USING SAME  
A method is provided for improving the solubility of proteins, for example, bacterial toxins. In one embodiment, solubility is improved by introducing point mutations that replace cysteine...
US20120003715 Process for Producing Recombinant Lyosomal Using Insect Larvae  
A method for expressing and industrial scale production of recombinant lysosomal enzymes utilizing insect larva including the steps of infecting an insect larva population of the species...
US20150133531 METHOD FOR EXPRESSION OF HETEROLOGOUS PROTEINS USING A RECOMBINANT NEGATIVE-STRAND RNA VIRUS VECTOR  
The present invention provides a method of expressing at least one heterologous nucleic acid sequence in a cell, the method comprising introducing at least one heterologous nucleic acid sequence...
US20110113498 SIRT1 POLYMORPHIC VARIANTS AND METHODS OF USE THEREOF  
Provided herein are Sirt1 polymorphic variants having a substitution at amino acid residue 107 or nucleotide 373. In certain embodiments, the Sirt1 polypeptide variants have a L107P substitution...
US20120142063 NITRILASE BIOCATALYSTS  
The present disclosure relates to polypeptides having nitrilase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
US20110086407 Bacillus licheniformis chromosome  
The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus...
US20130059931 ACTIVATION INDUCED DEAMINASE (AID)  
The invention is directed to a cell comprising a nucleic acid encoding an Activation Induced Deaminase (AID) polypeptide, a fusion protein comprising an AID polypeptide, and methods of using a...
US20110052758 HEAT-STABLE ASPARAGINASE FOR REDUCING ACRYLAMIDE IN FOOD STUFFS OR STIMULANTS  
The invention relates to the use of an amidohydrolase for preparing foodstuffs or stimulants.
US20130316406 THERMOPHILIC AND THERMOACIDOPHILIC BIOPOLYMER-DEGRADING GENES AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND RELATED ORGANISMS, METHODS  
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially...
US20090170145 MODIFIED CREATININE AMIDE HYDROLASE HAVING IMPROVED AFFINITY FOR SUBSTRATE, AND REAGENT COMPOSITION FOR DETERMINATION OF CREATININE  
[Problems] To overcome disadvantages of a known creatinine amide hydrolase, and provide a creatinine amide hydrolase having improved affinity for creatinine or having a decreased Km value for...
US20100111925 Compositions of Engineered Human Arginases and Methods for Treating Cancer  
Compositions and methods for the treatment of cancer are described, and, more preferably, to the treatment of cancers that do not express, or are otherwise deficient in, argininosuccinate...
US20110033873 PROTEINIC MARKER FOR EARLY DIAGNOSIS OF LIVER CANCER  
The present invention relates to proteomic markers for early detection of hepatocellular carcinoma, compositions for detecting changes of these proteomic markers, kits for detection of...
US20090269831 Modified cytosine deaminases  
The document provides modified cytosine deaminases with increased solubility and high levels of DNA cytosine deaminase activity.
US20110129490 MODULATION OF PRODUCTION OF RETROVIRUSES BY APOBEC4  
The invention relates to APOBEC4 proteins and N- or C-terminally modified APOBEC4 proteins for the modulation of the release of retroviruses or viral particles thereof from cells and various uses...
US20110138491 Compositions and Method for Epigenetic Modification of Nucleic Acid Sequences in Vivo  
Demethylation of a methylated DNA sequence in a eukaryotic cell is described, utilising a molecule that includes at least a first domain that exhibits a cytidine deaminase activity and at least a...
US20150166980 FUSIONS OF CAS9 DOMAINS AND NUCLEIC ACID-EDITING DOMAINS  
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the...
US20110172107 ASSAY FOR IDENTIFYING AGENTS THAT MODULATE EPIGENETIC SILENCING, AND AGENTS IDENTIFIED THEREBY  
A high throughput RNAi-based assay for identify factors involved in maintaining epigenetic silencing is disclosed. The assay measures reactivation of a silent reporter gene in cells, resulting...
US20140363417 Human Arginase and Pegylated Human Arginase and the UseThereof  
The present invention provides a site-directed mutated arginase and the preparation method thereof, and the use of said site-directed mutated arginase in preparing a medicament for treating an...
US20130085187 DEACETYLATION HYDROLASE OF HYALURONIC ACID, HYALURONIC ACID DEACETYLATED BY SAME AND DERIVATIVE THEREOF  
The present disclosure relates to a deacetylation hydrolase of a hyaluronic acid a hyaluronic acid deacetylated by same and a derivative thereof. The deacetylated hyaluronic acid and the...
US20110087012 NUCLEIC ACID MOLECULES CODING FOR A PROTEIN WITH DEACETYLASE ACTIVITY, SAID PROTEIN, AND METHOD FOR THE PRODUCTION OF CHITOSAN  
The invention relates to nucleic acid molecules selected from the group comprising: a) nucleic acid molecules that code for a form of the polypeptide with the derived amino acid sequence according...
US20100273659 Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them  
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
US20100216214 Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them  
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
US20130052179 ARGININE DEIMINASE MUTANT AND PREPARATION AND APPLICATION THEREOF  
The present invention relates to an arginine deiminase mutant with partial lysine-deficient and preparation and application thereof. The arginine deiminase mutant of the present invention has...

Matches 1 - 50 out of 98 1 2 >