Matches 1 - 32 out of 32


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US20120070403 USE OF G-CSF FOR THE EXTENSION OF THE THERAPEUTIC TIME-WINDOW OF THROMBOLYTIC STROKE THERAPY  
The present invention relates to the use of G-CSF and derivatives thereof for extending the therapeutic window of subsequent thrombolytic treatment of acute stroke, and thereby, allowing the...
US20120231505 Gene Expression Technique  
The present invention provides a method for producing a desired protein (such as a desired heterologous protein) comprising: (a) providing a host cell comprising a first recombinant gene encoding...
US20140356344 MIRAC PROTEINS  
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly...
US20120164127 MIRAC PROTEINS  
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly...
US20120231503 Gene Expression Technique  
The present disclosure relates to a method for producing heterologous protein including: (c) providing a host cell comprising a 2 μm-family plasmid, the plasmid comprising a gene encoding a...
US20140199287 NON-NEUROTOXIC PLASMINOGEN ACTIVATING FACTORS FOR TREATING OF STROKE  
The invention concerns the use and the production of non-neurotoxic plasminogen activating factors, derived, for example, from the common vampire Desmodus rotundus (DSPA), for therapeutic...
US20130039902 NON-NEUROTOXIC PLASMINOGEN ACTIVATING FACTORS FOR TREATING OF STROKE  
The invention concerns the use and the production of non-neurotoxic plasminogen activating factors, derived, for example, from the common vampire Desmodus rotundus (DSPA), for therapeutic...
US20120270254 METHOD FOR ANALYZING SECRETOME, BIOMARKER FOR LUNG CANCER METASTASIS, AND SIRNA COMPOUND FOR INHIBITING LUNG CANCER METASTASIS  
A method for analyzing secretome, a biomarker for lung cancer metastasis, and a siRNA compound for inhibiting lung cancer metastasis are disclosed. The method for analyzing secretome of the...
US20110091936 PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA  
The present invention relates generally to glutamine-free cell culture media supplemented with arginine. The invention further concerns the production of recombinant proteins, such as antibodies,...
US20120003695 METABOLIC ENGINEERING OF A GALACTOSE ASSIMILATION PATHWAY IN THE GLYCOENGINEERED YEAST PICHIA PASTORIS  
Lower eukaryotic cells such as Pichia pastoris that normally cannot use galactose as a carbon source but which have been genetically engineered according to the methods herein to use galactose as...
US20110020870 METHODS FOR PRODUCING MODIFIED GLYCOPROTEINS  
Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been...
US20150079633 PRODUCTION OF MODIFIED GLYCOPROTEINS HAVING MULTIPLE ANTENNARY STRUCTURES  
The present invention relates to lower eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar and...
US20050069453 Methods for sterilizing preparations of urokinase  
Methods are disclosed for sterilizing preparations of urokinase to reduce the level therein of one or more active biological contaminants or pathogens, such as viruses, bacteria (including inter-...
US20110053214 PRODUCTION OF GALACTOSYLATED GLYCOPROTEINS IN LOWER EUKARYOTES  
The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal β-galactose residue and essentially lacking fucose and...
US20130324593 Novel Hybrid Promoter and Recombinant Vector Comprising the Same  
The present invention relates to a hybrid promoter, in which a whole or a part of a CMV enhancer, a whole or a part of a β-actin promoter, a whole or a part of a CMV promoter, and a whole or a...
US20090123452 Protease screening methods and proteases identified thereby  
Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a...
US20120232007 METHOD FOR PRODUCING PROTEINS IN PICHIA PASTORIS THAT LACK DETECTABLE CROSS BINDING ACTIVITY TO ANTIBODIES AGAINST HOST CELL ANTIGENS  
Methods for producing proteins and glycoproteins in Pichia pastoris that lack detectable cross binding activity to antibodies made against host cell antigens are described. In particular, methods...
US20060148697 Methods for treating and preventing brain cancers  
Methods are provided for treating brain cancer, preventing or slowing proliferation of cells of prostate origin, preventing brain cancer in a patient at risk of contracting brain cancer,...
US20110070607 GLYCOPROTEIN SYNTHESIS AND REMODELING BY ENZYMATIC TRANSGLYCOSYLATION  
A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and...
US20050260219 Carboxypeptidases B from anopheles gambiae. compositions comprising them, vaccine applications and use as therapeutical targets  
The present invention provides two carboxypeptidase B enzymes from Anopheles gambiae and homologs thereof. The present invention also provides compositions and vaccines containing the...
US20080286803 Method for the Functional Determination of Mannan-Binding-Lectin Associated Serine Proteases (Masps) and Complexes Thereof  
This invention relates to the field of determining, assaying or quantifying activity of components of the complement system. More particularly, the invention relates to methods for detecting the...
US20070009506 Methods for production of recombinant urokinase  
Highly efficient methods of producing properly folded recombinant urokinase are provided. Denatured recombinant pro-urokinase is refolded by first solubilizing the protein with a chaotroph at high...
US20130034547 RELIABLE STABILIZATION OF N-LINKED POLYPEPTIDE NATIVE STATES WITH ENHANCED AROMATIC SEQUONS LOCATED IN POLYPEPTIDE TIGHT TURNS  
A chimeric therapeutic polypeptide of a pre-existing therapeutic polypeptide is disclosed, as are a method of enhancing folded stabilization and a pharmaceutical composition of the glycosylated...
US20100184641 Novel Plasma Protein Affinity Tags  
Method for increasing half-life of therapeutic agents in plasma and novel polypeptide derivatives.
US20100254943 AMINO ACID SUBSTITUTED MOLECULES  
The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids....
US20150252346 METHOD FOR ISOLATING UROKINASE ENZYME FROM AMNIOTIC FLUID  
A method for isolating urokinase enzyme from amniotic fluid. The method includes the steps of: contacting the amniotic fluid containing the urokinase enzyme and contaminates with a library of...
US20050244819 Assay system for screening protease inhibitors  
Compositions and methods for identifying agents that inhibit protease activity are provided. In particular, polynucleotides, recombinant expression vectors, and host cells are provided that may be...
US20100055762 Method for Preparation of Hepatocyte Using Es Cell  
This invention relates to an agent for promoting differentiation of an ES cell, preferably an agent for promoting differentiation of an ES cell into a hepatocyte or a prophylactic agent for...
US20050277132 Nematode GS-like sequences  
Disclosed is a nucleic acid molecule from nematodes encoding for glutamine synthetase (GS) polypeptides. The GS-like polypeptide sequence is also provided, as are vectors, host cells, and...
US20090098049 Targeting transducible molecules to specific cell types  
The disclosure provides fusion polypeptides and constructs useful in targeting molecules including diagnostics and therapeutics to a cell type of interest. The fusion constructs include a protein...
US20100015123 NOVEL THROMBOLYTIC MOLECULES AND A PROCESS THEREFOR  
New thrombolytic protein molecules such as recombinant staphylokinase or streptokinase, urokinase, tissue plasminogen activator and the like, and suitable variants thereof, for targeting to brain...
US20080020416 Enzyme and Preparation Method  
A method for preparing a soluble protein comprising urokinase-type plasminogen activator (uPA) or an active fragment thereof, or a variant of either of these which has uPA activity, which method...

Matches 1 - 32 out of 32