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US20110135620 |
PRODRUG ACTIVATION IN CANCER CELLS USING MOLECULAR SWITCHES
The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a...
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US20110189159 |
METHODS AND COMPOSITIONS FOR PROTEIN DELIVERY
The present invention provides methods and compositions for protein delivery. The invention features virus like particles, methods of making virus like particles and methods of using virus like...
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US20120010557 |
Drug Delivery System for Use in the Treatment of Vascular and Vessel-Related Pathologies
The present invention relates to a drug delivery system for use in the treatment of vascular and vessel-related pathologies, comprising a drug delivery platform that comprises at least one compound...
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US20110224143 |
NUCLEOBINDIN I VARIANT PROTEIN COMPOSITIONS AND METHODS OF USE
The invention relates to Nucleobindin-1 (NUCB1) protein variants that are capable of disaggregating amyloid fibrils as well as inhibiting the formation of fibrils in the presence of physiological...
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US20120070403 |
USE OF G-CSF FOR THE EXTENSION OF THE THERAPEUTIC TIME-WINDOW OF THROMBOLYTIC STROKE THERAPY
The present invention relates to the use of G-CSF and derivatives thereof for extending the therapeutic window of subsequent thrombolytic treatment of acute stroke, and thereby, allowing the...
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US20110300085 |
Home And Personal Care Compositions
The present invention relates to home and personal care compositions comprising a silicone oil-in-water emulsion stabilized by a protein or peptide and at least one home and/or personal care...
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US20110097715 |
METHOD FOR PURIFYING OR DETECTING A TARGET PROTEIN
A method for purifying or detecting a target protein present in a solution, includes, before carrying out the actual detection or purification step, a step of contacting the solution with an...
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US20120087905 |
TREATMENT OF DISEASES RELATED TO HYPERACTIVITY OF THE COMPLEMENT SYSTEM
Raising the level of Factor I above physiological levels can be used to treat diseases in which the underlying pathology is linked to overactivity of the C3b-feedback cycle and the generation and...
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US20100203582 |
Protein Expression System Involving Mutated Severe Respiratory Syndrome-Associated Coronavirus 3C-Like Protease
A mutated severe acute respiratory syndrome-associated coronavirus 3C-like protease and use thereof for cleaving a protein that includes a cleavage site recognizable by the mutated protease to...
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US20110008795 |
MARKER FOR DETECTION OF IL-17-PRODUCING HELPER T-CELL, AND METHOD FOR DETECTION OF IL-17-PRODUCING HELPER T-CELL
Disclosed is a polynucleotide marker or a protein marker for use in the specific detection of an IL-17-producing helper T-cell (a Th17 cell). Also disclosed is a method for detecting a Th17 cell,...
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US20110020315 |
TREATMENT OF INFLAMMATORY ILLNESSES WITH ACE2
The present invention relates to ACE2 for the therapeutic treatment or prevention of inflammation.
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US20100330649 |
EXPRESSION SYSTEMS FOR FUNCTIONAL MEMBRANE POLYPEPTIDES
Expression systems and methods for the expression of functional membrane polypeptides such as human cytochrome b5 are provided. The systems include recombinant expression vectors capable of...
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US20110086411 |
Method of Producing a Polypeptide or Virus of Interest in a Continuous Cell Culture
Described herein is a chemostat-like continuous cell culture system that combines certain advantages of perfusion open systems and chemostat open systems to improve the culturing of mammalian...
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US20110244549 |
HEPATITIS C VIRUS VARIANTS
The present invention relates to HCV variants, particularly variants that are resistant to a protease inhibitors such as VX-950. Also provided are methods and compositions related to the HCV...
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US20110059510 |
TRANSGENIC RABBITS PRODUCING HUMAN FACTOR VII
The invention relates to transgenic rabbits that produce human factor VII in their mammary glands. The milk of said transgenic rabbits can be used as a raw material for the production of...
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US20110281327 |
Compositions And Methods Comprising Variant Proteases
The present invention provides variant proteases, compositions comprising such variant proteases, and methods of cleaning comprising such variant proteases.
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US20110262423 |
SUPPRESSION OF CANCER
The present invention relates to polypeptides for use in suppressing cancer and cancer disorders. The treatment employs use of a non-cytotoxic protease, which is targeted to the cancer cell, and,...
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US20110003363 |
Reduction of Dimer Content in Factor VII Polypeptide Compositions by Heat Treatment
The present application relates to a method of reducing the content of dimers in Factor VII polypeptide composition by heat treatment.
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US20100316624 |
TREATMENT OF FIBROSES AND LIVER DISORDERS
The present invention relates to ACE2 for the therapeutic treatment or prevention of a fibrosis or liver disorder.
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US20100317042 |
PROTEINS ACTIVATING PRO-PHENOLOXIDASE SYSTEM AND GENES ENCODING THE SAME
The present invention provides novel proteins activating pro-phenoloxidase (pro-PO) system of Tenebrio molitor, genes encoding the same, methods of detecting bacterial infection in a sample using...
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US20110177521 |
METHODS AND KITS FOR ISOLATING NUCLEIC ACID FROM AN ORGANISM
The invention generally relates to methods and kits for isolating nucleic acids from an organism. In certain embodiments, methods of the invention involve contacting a plurality of lytic enzymes to...
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US20110236367 |
RAT CATHESPIN DIPEPTIDYL PEPTIDASE I (DPPI): CRYSTAL STRUCTURE AND ITS USES
The present invention relates to structural studies of dipeptidyl peptidase I (DPPI) proteins, modified dipeptidyl peptidase I (DPPI) proteins and DPPI co-complexes. Included in the present...
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US20110045516 |
Kits Pertaining to Analyte Determination
This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling...
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US20100297727 |
Methods for Improving Protein Performance
The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides...
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US20090053193 |
Use of Factor VIIa for the Treatment of Burn Trauma
The invention relates to the use of Factor VIIa or a Factor VIIa equivalent for the manufacture of a medicament for treatment of burn trauma.
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US20110305688 |
NEW VIRULENCE FACTORS OF STREPTOCOCCUS PNEUMONIAE
The present invention provides proteins/genes, which are essential for survival, and consequently, for virulence of Streptococcus pneumoniae in vivo, and thus are ideal vaccine candidates for a...
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US20110152155 |
SUBTILASE VARIANTS
The present invention relates to novel subtilase variants exhibiting alterations relative to the parent subtilase in one or more properties including: Wash performance, thermal stability, storage...
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US20070010416 |
Protease with improved stability in detergents
The present invention relates to proteases having improved stability in detergent compositions. Further, the present invention relates to cleaning and detergent compositions comprising the...
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US20120034299 |
COMPOSITIONS FOR THE TREATMENT OF GLUTEN INTOLERANCE AND USES THEREOF
The present invention provides compositions for use in the prophylaxis or treatment of a condition arising from gluten intolerance, the compositions including at least partially purified caricain...
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US20110294191 |
INCREASED PRODUCTION OF ASPARTIC PROTEASES IN FILAMENTOUS FUNGAL CELLS
Described are compositions and methods relating to filamentous fungal cells genetically engineered to provide increased production of aspartic proteases, such as PEPAa, PEPAb, PEPAc, and PEPAd....
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US20110177580 |
Method of Controlling a Polypeptide Modification Reaction
The invention relates to a method of controlling a polypeptide modification reaction, in particular but not exclusively, a method of controlling the activation of human factor VII (FVII) to produce...
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US20110251094 |
BIOMARKERS FOR HYPERTENSIVE DISORDERS OF PREGNANCY
The application discloses new biomarkers for hypertensive disorders of pregnancy and particularly preeclampsia; methods for the diagnosis, prediction, prognosis and/or monitoring said disorders...
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US20110257386 |
ISOLATION OF NUCLEIC ACID
A method for isolating a nucleic acid comprises: binding the nucleic acid to a solid phase at a first pH in the presence of a binding buffer, washing the bound nucleic acid with a wash solution,...
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US20100322915 |
Protease Variants for Pharmaceutical Use
The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved...
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US20100310546 |
ACE2 Polypeptide
The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for...
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US20090117628 |
Enzymatic processing in deep eutectic solvents
It has surprisingly been discovered that it is possible to use enzymes in deep eutectic solvents (DES). DES's are mixtures of a nitrogen salt or a metal salt and a strong hydrogen bond donor that...
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US20110020870 |
METHODS FOR PRODUCING MODIFIED GLYCOPROTEINS
Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been...
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US20100086971 |
GROWTH MEDIUM FOR CLOSTRIDIUM HISTOLYTICUM
The present invention provides improved media for the cultivation of Clostridium histolyticum and culture supernatants for the biotechnological production of collagenase enzymes. The nutrient media...
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US20100129844 |
AMINOACYLASE 1 ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER
A method for the in vitro diagnosis of colorectal cancer by determining the presence of Aminoacylase 1 tumor marker in a biological sample taken from a patient suspected of having colorectal...
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US20100233782 |
ISOLATED PHOSPHOLIPID-PROTEIN PARTICLES
Systems and methods are provided for producing a protein of interest that is typically not amenable to expression in soluble form in in vitro expression systems. In some aspects, the invention...
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US20090098105 |
Treatment of neurodegenerative diseases by the use of scd4 inhibitors
The present invention relates to the use of SCD4 interacting molecules, especially SCD4 inhibitors, for the preparation of a medicament for the treatment of neurodegenerative diseases, particularly...
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US20110262424 |
RECOMBINANTLY PRODUCED HUMAN FACTOR VIII AND IX
A recombinant human factor VIII or IX protein having a human glycosylation pattern but the protein is devoid of N-glycolylneuraminic acid and/or the carbohydrate group GalĪ±-3Gal.
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US20110195482 |
SERINE PROTEASE ISOLATED FROM THE VENOM OF BOMBUS IGNITUS AS FIBRINOGENOLYTIC AND FIBRINOLYTIC ENZYMES
Disclosed is serine protease isolated from Bombus ignitus, a bumble bee, capable of activating prothrombins and degrading fibrinogens and fibrins. Since the serine protease of the present invention...
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US20110300201 |
DELIVERY SYSTEM FOR CO-FORMULATED ENZYME AND SUBSTRATE
The invention provides methods, compositions, systems, and kits that include an enzyme/substrate co-delivery system. The liquid delivery system includes at least one enzyme encapsulated in a...
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US20110027256 |
FUSION PROTEINS
A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion...
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US20120045813 |
GENE ENCODING A PROTEIN HAVING AN ABILITY TO ENHANCE A SELENATE REDUCTION ACTIVITY
According to the present invention, a protein having an ability to enhance a selenate reduction activity, a gene encoding it, and a method for selenate reduction using them are provided
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US20110027859 |
METHOD FOR PRODUCING AMINOPEPTIDASE
Disclosed is an efficient method for production of aminopeptidase. The method comprises either transforming host bacteria with an aminopeptidase gene and with a neutral protease gene, or...
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US20110098207 |
Cellulase-Free Enzyme Compositions and Host Cells for Producing the Same
The present invention provides recombinant bacterial cells for producing a detergent-additive protein. In some embodiments, the cells are of the genus Bacillus. In additional embodiments, the cells...
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US20110023137 |
FUSION PROTEIN COMPRISING A CASPASE DOMAIN AND A NUCLEAR HORMONE RECEPTOR BINDING DOMAIN AND METHODS AND USES THEREOF
The present invention relates to a fusion protein comprising a Caspase domain or a functionally active variant thereof and a ligand binding domain of a nuclear hormone receptor, a nucleic acid...
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US20100075396 |
Botulinum Neurotoxin Serotype B Activatable Botulinum Neurotoxin Serotype Bs
The specification discloses modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located within the di-chain loop region; polynucleotide molecules encoding such...
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