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US20090311784 |
CYTOTOXIC RIBONUCLEASE VARIANTS
This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined...
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US20090293155 |
METHOD FOR PERFORMING HOMOLOGOUS RECOMBINATION IN PLANTS
The invention relates to modified restriction enzymes capable of being used for promoting homologous recombination in organisms, in particular plants, making it possible to either target gene...
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US20090286287 |
METHODS AND COMPOSITIONS FOR USE IN PREPARRING siRNAs
Methods and compositions for producing siRNAs, e.g., in the form of a d-siRNA composition, from dsRNAs are provided. In the subject methods, a dsRNA is contacted with a composition that includes an...
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US20090259035 |
Method for producing recombinant RNase A
The invention relates to a method for producing recombinant RNase A in E. coli . Said method is characterised in that it uses a DNA sequence, which codes for an RNase A of bovine origin and which...
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US20090202513 |
RIBONUCLEASE AND THIAZOLIDINEDIONE COMPOUNDS AND THEIR USE IN METHODS TO TREAT CANCER
The present invention relates to methods and kits for the treatment of cancer. A novel drug combination comprising a ribonuclease compound and a thiazolidinedione compound has been identified as...
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US20090197336 |
SUPPRESSION OF POLYMORPHIC ALLELES
Methods and agents for suppressing expression of a mutant allele of a gene having a polymorphism are provided. The methods of the invention provide suppression effectors such as antisense nucleic...
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US20090181007 |
CULTURE MEDIUM AND PHARMACEUTICAL COMPOSITION FOR REGENERATING CARTILAGE TISSUE, A METHOD, USES AND PRODUCTS RELATED THERETO
A composition for in vitro use as a culture medium or in vivo use as a pharmaceutical composition or a medical device, capable of accelerating the differentiation of stem cells into cells with a...
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US20090117622 |
MIXTURE OF REVERSIBLY INHIBITED ENZYMES
The invention relates to composition or a kit containing an enzyme that is reversibly inhibited by means of a chemical modification and an enzyme which is reversibly inhibited using non-covalent...
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US20090098101 |
COMPOSITIONS AND METHODS FOR RIBONUCLEASE-BASED THERAPEUTICS
The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the...
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US20080254018 |
IMMOBILIZED ANGIOGENIN MIXTURES AND USES THEREOF
Stabilized angiogenin compositions and methods of preparing a stabilized angiogenin compositions by covalent immobilization on a naturally occurring substrate, such as a polysaccharide substrate,...
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US20080227133 |
KpnI Restriction Endonucleases with Reduced Star Activity
Methods are provided for making restriction endonucleases with reduced star activity by one or more targeted mutations to a catalytic site within the restriction endonuclease. Examples of...
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US20080138795 |
Use of Intramolecularly, Covalently Cross-Linked Proteins As Binding Partners In Immunoassays
The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It...
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US20080138804 |
Buffer composition
The invention provides compositions for improving the accuracy of a sequencing-by-synthesis reaction by minimizing the incorporation of unlabeled dNTPs.
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US20080131952 |
Labeled nucleotides and nucleosides and methods for their use in DNA sequencing
Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide...
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US20080131419 |
Recombinant Human T2 Rnase and Uses Thereof
The cloning and heterologous expression of human T2 RNase6PL are disclosed. Further disclosed are methods for preventing, inhibiting and/or reversing cell motility, actin filament assembly or...
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US20080118968 |
Nucleic acid sequences from Cyanidium caldarium and uses thereof
Expressed Sequence Tags (ESTs) isolated from the unicellular red algae, Cyanidium caldarium , are disclosed. The invention encompasses nucleic acid molecules that encode Cyanidium caldarium ...
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US20080113359 |
DNAZYMES AND SENSORS INCORPORATING THE SAME
An arsenic ion active DNAzyme includes a nucleotide sequence, which has a base sequence selected from ATCTCCTCCTGTTC (SEQ ID NO: 62), ATCTGCTCCTGTTC (SEQ ID NO: 63), ATCTCCTCATGTTC (SEQ ID NO: 64),...
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US20080095755 |
Methods and compositions for the treatment of cancer
The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent...
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US20080090763 |
NOVEL GENE ENCODING A DNA REPAIR ENZYME AND METHODS OF USE THEREOF
An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids,...
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US20080064059 |
In Vivo Site-Specific Incorporation of N-Acetyl-Galactosamine Amino Acids in Eubacteria
Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a...
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US20080032377 |
Uracil-DNA nuclease: protein enzyme possessing nuclease activity specific for uracil containing nucleic acid, process for its preparation and methods of use
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US20080025964 |
Modified ribonucleases
The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the...
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US20080009036 |
Method for cloning and expression of Acc65I restriction endonuclease and Acc65I methylase in E. coli
An isolated DNA is provided which encodes a protein that is capable of binding to 5′GGTACC-3′, the isolated DNA being capable of hybridizing to SEQ ID NO:3 under stringent hybridization...
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