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US20090291439 |
PHOSPHATASES INVOLVED IN THE REGULATION OF CARDIOMYOCYTE DIFFERENTIATION
An object of the invention is to provide a dephosphorylation enzyme that regulates cardiomyocyte differentiation, dominant negative enzyme thereof, a gene encoding the enzyme protein and use...
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US20090280528 |
Method for Cloning and Expression of NruI Restriction Endonuclease
Recombinant DNA encoding NruI- and SboI-like restriction endonucleases and methylases and their amino acid sequences are provided as well as methods for expressing the enzymes in transformed host...
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US20090274795 |
Enzyme Granulate l Containing Phytase
The present invention relates to novel phytase-comprising enzyme granules, those particles of which have
A) a core which comprises at least one phytase and at least one solid carrier material...
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US20090274682 |
DEMETHYLATION AND INACTIVATION OF PROTEIN PHOSPHATASE 2A
Embodiments of the present invention relate to atomic coordinates for PME-1 alone or in complex with PP2A, as well as methods for using these atomic coordinates to prepare inhibitors of PME-1...
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US20090274681 |
NOVEL GENE ENCODING A DNA REPAIR ENZYME AND METHODS OF USE THEREOF
An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids,...
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US20090274680 |
Human Phospholipases
The invention provides human lipid metabolism enzymes (LME) and polynucleotides which identify and encode LME. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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US20090269785 |
CRYSTAL STRUCTURE OF MONOACYLGLYCEROL LIPASE (MGLL)
A number of soluble engineered forms of MGLL that are suitable for high-throughput screening and protein crystallization, as well as a crystallized form of monoacylglycerol lipase protein (MGLL)...
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US20090258406 |
Use of esterases for separating plastics
The invention relates to agents containing esterases, and to the use thereof for dressing fibres, in particular, artificial fibres, washing and cleaning agents comprising esterases and...
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US20090258380 |
Perhydrolase Epitopes
The present invention provides perhydrolase enzyme CD4+ T-cell epitopes, as well as variants that exhibit reduced immunogenic responses, as compared to the parental perhydrolase . The present...
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US20090249503 |
ENZYME CONJUGATES FOR USE AS DETOXIFYING AGENTS
Disclosed are detoxifying enzyme conjugates, including conjugates of variants of such detoxifying enzymes. The detoxifying enzymes are preferably chlolinesterases, and more preferably,...
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US20090247425 |
COMPOSITIONS AND METHODS FOR REUSING ARRAYS
The present disclosure relates generally to compositions and methods for the reuse of arrays, including microarrays. Specifically, the present disclosure discloses polynucleotide targets comprising...
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US20090246756 |
Thermostable polypeptide having polynucleotide kinase activity and/or phosphatase activity
Isolated polypeptides having 5′-kinase and/or 3′-phosphatase activity and temperature optimum of at least 60° C. are described. The invention also relates to isolated nucleic acids encoding...
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US20090246316 |
Esterase gene and use thereof
The present invention relates to a esterase gene and its uses, specifically, a brewery yeast producing alcoholic beverages with excellent aroma and flavor, alcoholic beverages produced using the...
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US20090246187 |
PROCESS FOR CONCENTRATION OF A POLYPEPTIDE
The present invention comprises a method of concentrating a composition comprising a polypeptide of interest and the use of such a concentrated composition for the treatment of diseases in mammals,...
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US20090233858 |
STRUCTURE OF A PROTEIN PHOSPHATASE 2A HOLOENZYME: INSIGHTS INTO TAU DEPHOSPHORYLATION
Embodiments of the present invention relate to crystals and atomic coordinates for PP2A, as well as methods for using these atomic coordinates to prepare modulators of PP2A and inhibitors prepared...
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US20090222937 |
MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM A XERODERMA PIGMENTOSUM GENE AND USES THEREOF
An I-CreI variant which has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG (SEQ ID NO: 229) core domain situated from positions 26 to 40 and 44 to 77 of...
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US20090221012 |
Method for Detecting Procoagulant Phospholipid
The present invention relates to a method for determining the amount of procoagulant phospholipid in a sample, said method comprising steps (i) to (iii) performed in the following order: (i)...
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US20090214510 |
Broad Spectrum Antiviral Compositions
The instant invention provides compositions and methods for the treatment of viral infections caused by enveloped viruses comprising phospholipase nucleic acid molecules or polypeptides, or fusion...
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US20090205083 |
Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
The present disclosure relates to engineered zinc finger proteins that target 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) genes in plants and methods of using such zinc finger proteins in...
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US20090197318 |
CRYSTALLIZATION OF ENZYME AND METHOD FOR PRODUCING SAME
The present invention provides a method of crystallizing of enzymes. The method is for rapidly crystallizing enzymes from impure mixtures. The method is simple and cheap, and it is compatible to...
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US20090191206 |
Human Semen Enhancer of Viral Infection Peptides (SEVI) and Their Use
Subject of the invention are peptides corresponding to a fragment of amino acids 240-290 of human prostatic acid phosphatase. The invention also relates to nucleic acids, antibodies, medicaments...
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US20090186011 |
Manufacture of Active Highly Phosphorylated Human Lysosomal Sulfatase Enzymes and Uses Thereof
This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase...
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US20090181431 |
Fusion Proteins Between Plant Cell-Wall Degrading Enzymes, and Their Uses
The invention relates to the use of fusion proteins between at least two plant cell-wall degrading enzymes, the enzymes being such that they do not contain a C-terminal...
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US20090169681 |
Solid Phytase Compositions
The present invention relates to solid enzyme, in particular phytase, compositions stabilized with a lactic acid source such as Corn Steep Liquor (CSL), and methods of producing the same. Preferred...
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US20090169649 |
TREATMENT OF NEURODEGENERATIVE DISEASES
The present invention relates to the use of selenate or a pharmaceutically acceptable salt thereof in methods and compositions for enhancing the activity of the protein phosphatase PP2A. Methods of...
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US20090161828 |
ISOLATED PHOSPHOLIPID-PROTEIN PARTICLES
Systems and methods are provided for producing a protein of interest that is typically not amenable to expression in soluble form in in vitro expression systems. In some aspects, the invention...
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US20090156457 |
METHODS AND MEANS FOR SCREENING FOR RHOMBOID ACTIVITY
This invention relates to methods of screening for rhomboid modulating compounds using a substrate polypeptide has a core domain comprising a rhomboid cleavable TMD sequence linked to an upstream...
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US20090155865 |
Esterases and their Use for Processes for Kinetic Resolution of Butinolesters
New enzymes having esterase activity and their use for processes for kinetic resolution of butinolesters.
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US20090155775 |
CLONED DNA POLYMERASES FROM THERMOTOGA AND MUTANTS THEREOF
The invention relates to a substantially pure thermostable DNA polymerase from Thermotoga (Tne and Tma) and mutants thereof. The Tne DNA polymerase has a molecular weight of about 100 kilodaltons...
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US20090151026 |
Polypeptides having feruloyl esterase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having feruloyl esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
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US20090124511 |
ANTIBODY COMPLEXES AND METHODS FOR IMMUNOLABELING
The present invention provides labeling reagents and methods for labeling primary antibodies and for detecting a target in a sample using an immuno-labeled complex that comprises a target-binding...
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US20090118141 |
METHODS OF OLIGOSACCHARIDE PROFILING FOR THE DETECTION OF OCULAR ROSACEA
The present invention provides methods for identifying oligosaccharides specific to an inflammatory or infectious disease, methods for diagnosing an inflammatory or infectious disease by detecting...
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US20090117628 |
Enzymatic processing in deep eutectic solvents
It has surprisingly been discovered that it is possible to use enzymes in deep eutectic solvents (DES). DES's are mixtures of a nitrogen salt or a metal salt and a strong hydrogen bond donor that...
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US20090117580 |
Structure of prl-1 protein crystal and the method of crystallization thereof
The present invention relates to a crystal structure of PRL-1 (Phospatase of Regenerating Liver) protein and a method of crystallization thereof. It has been found that the PRL-1 protein has a...
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US20090099079 |
Novel Fungal Enzymes
This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such...
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US20090094709 |
Use of protein phosphatase 2Ce (PP2Ce) having dephosphorylating action on AMPK
A drug includes, RNA interference with protein phosphatase 2Cε (PP2Cε) as an active ingredient. According to the present invention, the activation and deactivation of AMPK can be regulated.
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US20090078384 |
Esterases from rumen
The invention provides polypeptides coding for new esterases from rumen. The invention also relates to functional fragments or functional derivatives thereof as well as to nucleic acids encoding...
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US20090074728 |
Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential cells. The present invention also...
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US20090068644 |
METHOD FOR PRODUCING HIGHLY SENSITIVE ENDONUCLEASES, NOVEL PREPARATIONS OF ENDONUCLEASES AND USES THEREOF
The present invention pertains to methods for producing recombinant endonucleases having a high sensitivity, as well as to endonucleases preparations obtained by said methods, and uses thereof,...
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US20090068165 |
Uniformly Conjugated Serine Hydrolases
An organophosphate scavenger is provided, with extended residence time in the mammalian circulation, which can be used in preventive and therapeutic treatment of organophosphate poisoning. The...
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US20090041741 |
MODIFIED ENZYME AND TREATMENT METHOD
There is disclosed an isolated, modified recombinant β-glucuronidase wherein the modification is having its carbohydrate moeties chemically modified so as to reduce its activity with respect to...
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US20090029376 |
High Fidelity Restriction Endonucleases
Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins....
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US20090025107 |
Polypeptides Having Organophosphorus Hydrolase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having organophosphorus hydrolase (OPH) activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic...
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US20090017010 |
NOVEL ARTEMIS/DNA-DEPENDENT PROTEIN KINASE COMPLEX AND METHODS OF USE THEREOF
In the present invention, it is disclosed that Artemis forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PK cs ) in vitro and in vivo in the absence of DNA. The purified Artemis...
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US20080299622 |
Starch Hydrolysis Using Phytase with an Alpha Amylase
The present invention relates to a method for liquefying starch comprising contacting a slurry of a starch substrate with an enzyme composition comprising a phytase and an alpha amylase. The...
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US20080286847 |
ALTERNATE MORPHEEINS OF ALLOSTERIC PROTEINS AS A TARGET FOR THE DEVELOPMENT OF BIOACTIVE MOLECULES
A composition having an agent adapted to affect a multimeric protein by binding to a binding site of the multimeric protein and thereby affecting an equilibrium of units, wherein the multimeric...
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US20080275006 |
Process for the Preparation and Isolation of Phosphatides
Process for the preparation of phosphatidylserine of formula
wherein R 1 and R 2 independently represent a saturated, mono-unsaturated or polyunsaturated acyl C 10 -C 30 , X═OH or OM where...
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US20080268507 |
Recombinant Dna Nicking Endonuclease and Uses Thereof
Recombinant nicking endonucleases and associated methylases have been obtained and sequenced and their specificity has been defined. A mutant form of the nicking endonuclease has been cloned where...
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US20080263688 |
Hafnia Phytase
The present invention relates to isolated polypeptides having phytase activity and isolated polynucleotides encoding the polypeptides. The polypeptides are related to a phytase derived from Hafnia...
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US20080261208 |
2'-Nitrobenzyl-Modified Ribonucleotides
This disclosure provides novel reversibly terminated ribonucleotides which can be used as a reagent for DNA sequencing reactions. Methods of sequencing nucleic acids using the disclosed nucleotides...
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