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US20120276145 EXTRACELLULAR MATRIX PROTEINS FROM HAEMOPHILUS INFLUENZAE BIOFILMS: TARGETS FOR THERAPEUTIC OR DIAGNOSTIC USE  
A method of identifying a biofilm that includes non-typeable Haemophilus influenza (NTHi) including a step of screening a sample for the presence of one or more biofilm-specific proteins that are...
US20110135620 PRODRUG ACTIVATION IN CANCER CELLS USING MOLECULAR SWITCHES  
The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a...
US20120009596 PROTEIN MARKERS FOR DETECTING LIVER CANCER AND METHOD FOR IDENTIFYING THE MARKERS THEREOF  
The present invention relates to the diagnosis of liver cancer. It discloses the use of protein ERBB3 and protein IGFBP2 in the diagnosis of liver cancer. It relates to a method for diagnosis of...
US20130053267 CELL FREE TRANSLATION SYSTEM FOR COMPOUND SCREENING AND RELATED USES  
The invention provides a cell-free system comprising not more than about 5% wheat germ extract for expressing proteins such as viral proteins and proteins required for viral capsid assembly, and...
US20110112037 CRYSTAL STRUCTURE  
The invention provides a method of predicting a three dimensional structural representation of a target protein of unknown structure, or part thereof, comprising: providing the coordinates of the...
US20150005182 PROTEIN BIOMARKERS OF RECURRENT BREAST CANCER  
This patent application discloses and describes proteins found to be differentially expressed between primary tumor breast cancer cells that did not give rise to recurrent breast cancer disease...
US20110136204 EXTRACT OF E. COLI CELLS HAVING MUTATION IN RIBOSOMAL PROTEIN S12, AND METHOD FOR PRODUCING PROTEIN IN CELL-FREE SYSTEM USING THE EXTRACT  
It is intended to provide an extract, kit and a process for synthesizing a protein in a cell-free system. The extract is characterized by being prepared from mutant Escherichia coli cells having a...
US20150203589 FUSION PROTEINS AND METHODS THEREOF  
The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.
US20130210004 EGFR-RELATED POLYPEPTIDES AND METHODS OF USE  
Described herein are truncated EGF receptor polypeptides, nucleic acids encoding them, and methods of using them to help select a method of treatment for an EGFR-related cancer, to predict...
US20150140603 METHOD FOR THE PRODUCTION OF A LYSATE USED FOR CELL-FREE PROTEIN BIOSYNTHESES  
The invention relates to a method for producing a lysate used for cell-fee protein biosynthesis, comprising the following steps: a) a genomic sequence in an organism, which codes for an essential...
US20130115655 METHOD FOR THE PRODUCTION OF A LYSATE USED FOR CELL-FREE PROTEIN BIOSYNTHESES  
The invention relates to a method for producing a lysate used for cell-fee protein biosynthesis, comprising the following steps: a) a genomic sequence in an organism, which codes for an essential...
US20110104782 CRYSTAL STRUCTURE OF AURORA-2 PROTEIN AND BINDING POCKETS THEREOF  
The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2....
US20130203088 METHODS AND MEANS FOR DIAGNOSING SPONDYLARTHRITIS USING AUTOANTIBODY MARKERS  
The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing...
US20110078821 HEAT RESISTANT PLANTS AND PLANT TISSUES AND METHODS AND MATERIALS FOR MAKING AND USING SAME  
The subject invention concerns materials and methods for providing plants or plant tissue with increased resistance to heat conditions and/or increased starch biosynthesis. Increased resistance of...
US20110117072 HYPERACTIVE VARIANTS OF THE TRANSPOSASE PROTEIN OF THE TRANSPOSON SYSTEM SLEEPING BEAUTY  
The present invention refers to hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB). The invention further refers to corresponding nucleic acids producing these...
US20130029400 GENETIC ELEMENTS, PROTEINS, AND ASSOCIATED METHODS INCLUDING APPLICATION OF ADDIITNAL GENETIC INFORMATION TO GRAM (+) THERMOACIDOPHILES  
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering...
US20110275135 Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles  
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering...
US20100331268 Nitrated Lipids and Methods of Making and Using Thereof  
Described herein are nitrated lipids and methods of making and using the nitrated lipids.
US20130267030 EFFICIENT METHOD FOR ESTABLISHING INDUCED PLURIPOTENT STEM CELLS  
The invention provides a method of improving the efficiency of establishment of induced pluripotent stem cells by increasing, in a nuclear reprogramming step of somatic cell, the level of...
US20100136654 METHOD FOR TRANSCRIPTION-DEGRADATION DUAL REGULATION FOR PROTEIN BY ANTIBIOTIC  
The present invention provides an expression vector, containing expressibly (a) a polynucleotide encoding a fusion protein of a mutant of a repressor protein, which binds to an antibiotic, and a...
US20150250863 Method for Eliciting an Immune Response to Human Telomerase Reverse Transcriptase  
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
US20140193869 CELL-FREE SYSTEM FOR CONVERTING METHANE INTO FUEL AND CHEMICAL COMPOUNDS  
The present disclosure relates, in some aspects, to cell-free methods and systems for large-scale conversion of methane to isobutanol, comprising combining, in a bioreactor at elevated pressure,...
US20150218636 Mutations In Calmodulin Genes  
The present invention relates to an isolated polynucleotide encoding at least a part of calmodulin and an isolated polypeptide comprising at least a part of a calmodulin protein, wherein the...
US20130133111 COMPOSITIONS AND METHODS OF USE OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE  
Methods and compositions for modulating plant response, development and yield under varying environmental conditions are provided. Methods employing MAPKKK are provided. The MAPKKK sequences are...
US20110159568 Crystallographic Structure of Mnk-1 and Mnk-2 Proteins  
The present invention relates to crystalline Mnk-1 and Mnk-2 kinases and, in particular, to the crystal structure of Mnk-1 and Mnk-2 kinase domain.
US20130095551 METHOD FOR CHANGING CONFORMATION OF GLOBULAR PROTEINS  
A method for changing conformation of globular proteins is provided. The method controls the concentration of the globular proteins and the adsorption time of the globular proteins from the...
US20110165596 Use of Carbamoyl Phosphate Synthetase 1 (Cps) as a Humoral Biomarker For the Diagnosis of Tumour Diseases and Chronic Inflammatory Intestinal Diseases  
The invention relates to the use of carbamoyl synthetase 1 (CPS 1) as a humoral biomarker in in vitro methods for early diagnosis and detection, progress prognosis, the evaluation of the severity,...
US20130004966 STRUCTURE OF CYTOKININS AND CYTOKININ RECEPTORS, AND MODULATION OF CYTOKININ SIGNALING  
Provided herein are seven high resolution crystal structures showing the cytokinin receptor AHK4 complexed with various naturally occurring and synthetic ligands. Further provided are strategies...
US20110085939 NODE POLYPEPTIDES FOR NANOSTRUCTURE ASSEMBLY  
Engineered proteins are used in the assembly of two-dimensional and three-dimensional nanostructure assemblies, based on systematic design and production of protein node structures that can be...
US20120083423 Biomarkers, Methods and Kits for the Diagnosis of Rheumatoid Arthritis  
The present invention relates to peptides biomarkers that are specifically recognized by autoantibodies present in the sera of patients with Rheumatoid Arthritis (RA). More specifically, the...
US20110008348 SOLUBLE FRAGMENTS OF INFLUENZA VIRUS PB2 PROTEIN CAPABLE OF BINDING RNA-CAP  
A plastic container includes an upper portion having a mouth defining an opening into the container. A shoulder region extends from the upper portion. A sidewall portion extends between the...
US20110131678 COMPOSITIONS AND METHODS FOR DIFFERENTIAL REGULATION OF FATTY ACID UNSATURATION IN MEMBRANE LIPIDS AND SEED OIL  
Aspects of the invention provide methods for differential regulation of fatty acid unsaturation in seed oil and membrane lipids of plants based on modulation of a previously unknown biosynthetic...
US20120027742 METHODS FOR TREATING ADULT RESPIRATORY DISTRESS SYNDROME  
We have discovered that the activated phosphorylated form of focal adhesion kinase (hereafter “FAKp”) strengthens the microvascular endothelial cell (EC) junctions that form a barrier in pulmonary...
US20110059434 P13k pathway mutations in cancer  
Given the important role of protein kinases in pathways affecting cellular growth and invasion, we have analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. Mutations...
US20130274135 COMPOSITIONS OF TOEHOLD PRIMER DUPLEXES AND METHODS OF USE  
Provided herein are primers and primer systems having improved specificity and kinetics over existing primers, and methods of use thereof.
US20140178941 METHODS FOR NUCLEIC ACID MANIPULATION  
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing...
US20130137145 METHODS FOR NUCLEIC ACID MANIPULATION  
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing...
US20130224223 Compositions and Methods for Treating Neurological Disorders  
Methods and compositions for modulating GABA release in a subject are provided. A preferred embodiment provides a composition containing an effective amount of an ErbB4 ligand to enhance or...
US20110311586 Materials and methods for respiratory disease control in canines  
The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and...
US20120178647 ENGINEERING OF ZINC FINGER ARRAYS BY CONTEXT-DEPENDENT ASSEMBLY  
A method of designing a multi-zinc-finger polypeptide predicted to bind to a sequence of interest that has at least three subsites includes the steps of: a) providing a nucleotide sequence of...
US20130330778 METHOD OF ADAPTOR-DIMER SUBTRACTION USING A CRISPR CAS6 PROTEIN  
A method of processing a target RNA is provided. In certain embodiments, this method comprises: contacting the products of an RNA ligase-mediated ligation reaction with an CAS6 protein, wherein:...
US20130203622 TRANSCRIPTOMIC BIOMARKER OF MYOCARDITIS  
Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.
US20130025002 PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME  
Nucleic acids and encoded phosphofructokinases (PFKs) are provided. A method for enhancing yield-related traits in plants by modulating expression of nucleic acids encoding PFKs is provided....
US20110287445 Mutant ROS Expression In Human Cancer  
The invention provides the identification of the presence of mutant ROS protein in human cancer. In some embodiments, the mutant ROS are FIG-ROS fusion proteins comprising part of the FIG protein...
US20140017764 METHOD FOR ENGINEERING PROTEASES AND PROTEIN KINASES  
Provided are methods for protein engineering, such as engineering proteases or kinases. The methods may utilize yeast display and/or ER sequestration of proteins or substrates. In some aspects,...
US20130084300 DIAGNOSIS AND PREVENTION OF CANCER CELL INVASION  
The present invention relates to diagnostic and therapeutic methods in the field of malignant disorders. More particularly, the invention provides methods of determining the invasivity of...
US20150072380 COMPOSITIONS AND METHODS FOR IMPROVED PROTEIN PRODUCTION  
The present invention relates to the identification of novel nucleic acid sequences, designated herein as 7p, 8k, 7E, 9G, 8Q and 203, in a host cell which effect protein production. The present...
US20150147780 METHOD FOR HARVESTING ORGANIC COMPOUNDS FROM GENETICALLY MODIFIED ORGANISMS  
Disclosed herein are embodiments for a novel method of producing an organic compound, including harvesting at least one organic compound from an organism or cell line genetically engineered with a...
US20150224457 SYSTEM AND METHODS FOR MAKING AND PROCESSING EMULSIONS  
An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a...
US20120258516 System and Methods for Making and Processing Emulsions  
An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a...