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US20120178124 STEROL SIDE CHAIN-CLEAVING ENZYME PROTEIN AND USE THEREOF  
It is an object of the present invention to obtain highly active P450scc enzyme protein which is an important enzyme protein that catalyzes the first step of the biosynthesis of industrially...
US20110217737 High Processivity Polymerases  
Chimeric proteins comprising a sequence nonspecific single-stranded nucleic-acid-binding domain joined to a catalytic nucleic-acid-modifying domain are provided. Methods comprising contacting a...
US20140275072 MORPHOLINYLBENZOTRIAZINES FOR USE IN CANCER THERAPY  
The invention relates to compounds of the formula (I) in which R1, L and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof,...
US20150240311 RECURRENT TRANSFORMING UBR5-ZNF423 FUSION GENE IN EBV-ASSOCIATED NASOPHARYNGEAL CARCINOMA  
The present invention provides a method for diagnosing nasopharyngeal cancer in a subject by detecting UBR5-ZNF423 fusion polypeptide or polynucleotide, which is in some cases due to a gene fusion...
US20140050713 CHIMERIC ANTIBACTERIAL POLYPEPTIDES  
Provided herein are antibacterial compositions and methods of making and using the compositions.
US20130143296 Delivery System for Cytotoxic Drugs by Bispecific Antibody Pretargeting  
The present invention relates to methods and compositions for pretargeting delivery of therapeutic agents. In preferred embodiments, the pretargeting method comprises: a) administering a...
US20130101577 Extended Soluble PH20 Polypeptides and uses thereof  
Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially...
US20120213767 Extended Soluble PH20 Polypeptides and uses thereof  
Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially...
US20150050713 Technology for the Preparation of Microparticles  
Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful...
US20140099696 Technology for the Preparation of Microparticles  
Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful...
US20140212896 METHODS AND COMPOSITIONS FOR SINGLE CHAIN VARIABLE REGION ENOX2 ANTIBODIES FOR CANCER DETECTION AND DIAGNOSIS  
All neoplastic cells express one or more members of a unique family of cell surface ubiquinone (NADH) oxidase proteins with protein disulfide-thiol interchange activity (ECTO-NOX proteins) that...
US20120052548 Modified Clostridial Toxins with Altered Targeting Capabilities For Clostridial Toxin Target Cells  
The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain;...
US20150225465 NEW MODULAR BASE-SPECIFIC NUCLEIC ACID BINDING DOMAINS FROM BURKHOLDERIA RHIZOXINICA PROTEINS  
The present invention concerns new modular base-per-base specific nucleic acid binding domains (MBBBD) derived from newly identified proteins from the bacterial endosymbiont Burkholderia...
US20140230083 MODULAR BASE-SPECIFIC NUCLEIC ACID BINDING DOMAINS FROM BURKHOLDERIA RHIZOXINICA PROTEINS  
The present invention concerns new modular base-per-base specific nucleic acid binding domains (MBBBD) derived from newly identified proteins from the bacterial endosymbiont Burkholderia...
US20130164815 PROCESS FOR THE PRODUCTION OF A REVERSIBLY INACTIVE ACIDIFIED PLASMIN COMPOSITION  
Disclosed is both a process for producing a reversibly inactive acidified plasmin by activating plasminogen and a process for producing a purified plasminogen. The produced plasmin is isolated and...
US20130023027 FUSION PROTEINS OF BACTERIAL LUCIFERASE AS MULTICOLOR LUMINESCENT SENSORS  
The present invention discloses systems and methods for altering the color of bacterial bioluminescence via a fusion protein complex by fusing Discosoma sp. fluorescent protein mOrange (mOrange)...
US20120156750 COMPOSITIONS AND METHODS FOR DEHYDRATED STORAGE OF ON-BOARD REAGENTS IN MICROFLUIDIC DEVICES  
Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are...
US20140377810 SSB-POLYMERASE FUSION PROTEINS  
Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in...
US20110300120 OLIGOSACCHARIDE-PROTEIN CONJUGATES  
Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further...
US20130295641 Production of Conjugates  
A method of reacting a first chemical entity and a second chemical entity to form a conjugate in which the first and second chemical entities are covalently bound with respect to each other,...
US20110182919 Immunoglobulin Chimeric Monomer-Dimer Hybrids  
The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion...
US20110142816 THERMOSTABILIZATION OF PROTEINS  
Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally...
US20140178300 THERANOSTIC IMAGING AGENTS AND METHODS OF USE  
The present invention provides targeted nanoplex molecules which carry multimodality imaging reporters together with target enzyme inhibitors such as siRNAs and target prodrug enzymes, that are...
US20130216513 Chimeric Clotting Factors  
Chimeric clotting factors which localize the therapeutic to sites of coagulation (e.g., by being targeted to platelets or being activatable at sites of coagulation), have reduced clearance rates,...
US20150252351 Methods and Compositions for Amplification of Nucleic Acids  
The present invention provides methods, compositions, and kits for storing and enhancing the activity of polymerases and particularly thermostable polymerases. The methods comprise mixing a...
US20150159198 METHODS AND COMPOSITIONS FOR AMPLIFICATION OF NUCLEIC ACIDS  
The present invention provides methods, compositions, and kits for storing and enhancing the activity of polymerases and particularly thermostable polymerases. The methods comprise mixing a...
US20110305723 Molecular Antigen Array  
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
US20140377243 CELL-PENETRATING FUSION PROTEIN FOR REGENERATING OR PROLIFERATING STEM CELL  
The present invention relates to a cell permeable fusion protein for strengthening regenerative potential of stem cells, and more particularly to a cell permeable fusion protein for strengthening...
US20120276608 Multivalent Immunoglobulin-Based Bioactive Assemblies  
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred...
US20110151536 THROMBIN ACTIVATOR COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME  
Disclosed are compositions for activating thrombin precursors to thrombin. The compositions provided include polypeptide compositions wherein the pre-pro-sequence comprises a thrombin cleavage...
US20120269731 POLYPEPTIDES THAT HOME TO ATHEROSCLEROTIC PLAQUE  
Described herein are homing polypeptides that home to atherosclerotic plaque(s) in mammals and nucleic acids that encode such polypeptides. Also described are methods for detecting and treating...
US20110300600 METHODS AND COMPOSITIONS FOR DELIVERING POLYNUCLEOTIDES  
Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein...
US20110195452 SET OF SEQUENCES FOR TARGETING EXPRESSION AND CONTROL OF THE POST-TRANSLATIONAL MODIFICATION OF A RECOMBINANT POLYPEPTIDE  
The present invention provides new tools useful for controlling the post-translational modifications of recombinant polypeptides. These tools are particular signal peptides allowing the targeting...
US20120225064 Sphingosine 1-Phosphate Antagonism  
Materials and Method for treating cancer and screening for anti-neoplastic agents are provided. These materials and methods can include sphingosine 1-phosphate antagonists that bind to...
US20130217090 CRYSTAL STRUCTURE OF GLUTAMINYL CYCLASE  
Novel crystal structures of human and murine glutaminyl cyclase (QC, EC 2.3.2.5), methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of...
US20110020341 NOVEL MULTIDRUG RESISTANCE-ASSOCIATED POLYPEPTIDE  
Compositions and methods are disclosed for improving the effectiveness of a chemotherapeutic regimen to eradicate multidrug-resistant transformed cells from the body of a mammal, preferably from...
US20120134978 Cross-Linking of Superoxide Dismutase Monomers  
A stabilized superoxide dismutase (SOD1) analogue, wherein the side chains of two amino acids on two different SOD1 monomers are connected is provided. A method of producing a stabilized...
US20120076728 HUMAN PROTEIN SCAFFOLD WITH CONTROLLED SERUM PHARMACOKINETICS  
This invention provides constructs comprising a protein scaffold, wherein the scaffold comprises Domain III, Domain IIIa, or Domain IIIb of human serum albumin or a polypeptide having substantial...
US20110207155 Method for the preparation of immunoconjugates and use thereof  
The present invention concerns a method for the preparation of molecular conjugates comprising immunoglobulins and biomarkers occurring in neoplastic diseases characterized by high levels of...
US20140227269 THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS  
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
US20140178379 Therapeutic Nuclease Compositions and Methods  
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
US20130184334 THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS  
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
US20130183308 THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS  
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
US20130089546 THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS  
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
US20120225066 THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS  
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
US20140335163 TARGETED IDURONATE-2-SULFATASE COMPOUNDS  
The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, where compound is a fusion protein including iduronate-2-sulfatase and...
US20120270812 COMPOSITIONS, METHODS, AND KITS FOR DETERMINING AN ALKYL TRANSFERASE  
The present invention relates to novel compounds as well as to compositions, methods, and kits comprising the compounds for determining an alkyltransferase (ATase), in particular an...
US20140186877 COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF 1-ALKENES IN ENGINEERED MICROORGANISMS  
Various 1-alkenes, including 1-nonadecene and 1-octadecene, are synthesized by the engineered microorganisms and methods of the invention. In certain embodiments, the microorganisms comprise a...
US20140162956 POLYPEPTIDES  
The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other...
US20130243690 ALPHA 1-3 N-GALACTOSYLSTRANSFERASE WITH ALTERED DONOR SPECIFICITIES, COMPOSITIONS AND METHODS OF USE  
The invention generally features compositions and methods based on the structure-based design of alpha 1-3 N-Acetylgalactosaminyltransferase (alpha 3 GalNAc-T) enzymes from alpha...