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US20150191714 FORMULATIONS OF RECOMBINANT HUMAN BILE SALT-STIMULATED LIPASE  
The present invention relates to improved formulations of recombinant human bile salt stimulated lipase (rhBSSL), including those suitable for forming a lyophilized formulation of rhBSSL,...
US20110151537 Synthetic Catalysts that Separate CO2 from the Atmosphere and Gas Mixtures  
The creation of a catalyst that can be used for a wide variety of applications including the steps of developing preliminary information regarding the catalyst, using the preliminary information...
US20140127777 METHOD FOR STABILIZATION OF PROTEINS USING NON-NATURAL AMINO ACIDS  
The present invention provides a method for producing modified stable polypeptides introducing at least one non-natural amino acid into the hydrophobic region of the polypeptide. The thermal and...
US20130014288 NOVEL REPORTER-TAGGED RECOMBINANT MEMBRANE PROTEINS WITH TRANSMEMBRANE LINKERS  
Recombinant protein constructs are described that comprises a membrane protein whose N- or C-terminus in the native state is recombinantly linked through a membrane-spanning linker polypeptide to...
US20140178895 RECOMBINANT PROTEIN BIOSENSORS AND A METHOD FOR DETECTING THE PRESENCE OF AN ANALYTE MOLECULE  
The present invention refers to a fusion protein biosensor, comprising a peptide or protein domain that binds an analyte of interest (A), an entity that can produce a detectable signal (B), and an...
US20140219983 SUPPRESSION OF CANCERS  
The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer...
US20110165137 SUPPRESSION OF CANCERS  
The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer...
US20110158973 SUPPRESSION OF CANCERS  
The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer...
US20110177052 Stabilized Proteases For Use In Skin Care  
Disclosed is an invention which relates to synthesizing immobilized and crosslinked proteases derived from plants for use as skin care agents. The resulting stabilized protease will minimally...
US20140038255 Methods and Compositions for Producing Alkenes of Various Chain Length  
The NonA alkene synthase in Synechococcus sp. displays selective synthesis of 1-nonadecene. Heterologous recombination of a domain, i.e. the acyl binding domain, with other acyl binding proteins,...
US20120064568 ENDOMANNOSIDASES IN THE MODIFICATION OF GLYCOPROTEINS IN EUKARYOTES  
The present invention generally relates to methods of modifying the glycosylation structures of recombinant proteins expressed in fungi or other lower eukaryotes, to more closely resemble the...
US20150104847 METHOD FOR STABILIZING CHOLESTEROL OXIDASE  
The present invention provides a method for stabilizing a cholesterol oxidase, a method for preserving a cholesterol oxidase, and a stabilized composition of cholesterol oxidase. A method for...
US20150218629 ENZYME CONSTRUCT  
The invention relates to methods using constructs comprising a helicase and an additional polynucleotide binding moiety. The helicase is attached to the polynucleotide binding moiety and the...
US20140302000 PHARMACEUTICAL COMPOSITIONS OF LIPASE-CONTAINING PRODUCTS, IN PARTICULAR OF PANCREATIN  
Orally administrable pharmaceutical compositions of lipase-containing products, particularly pancreatin and pancreatin-containing products, or of enzyme products which contain at least one lipase...
US20140072961 Method of Genome Surgery with Paired, Permeant Endonuclease Excision  
The use of P2E2 constructs in genome surgery includes a cell penetration component, a DNA binding component and a restriction endonuclease. The method for performing genome surgery includes: a)...
US20130145485 METHODS AND COMPOSITIONS FOR ALTERATION OF A CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) GENE  
Nucleases and methods of using these nucleases for alteration of a CFTR gene and generation of cells and animal models.
US20110033890 METHOD FOR THE SECRETORY PRODUCTION OF HETEROLOGOUS PROTEIN IN ESCHERICHIA COLI  
The present invention relates to a signal sequence peptide for the improvement of extracellular secretion efficiency of a heterologous protein in E. coli. More particularly, the present invention...
US20110200555 CONJUGATES OF HYDROXYALKYL STARCH AND A PROTEIN  
Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and...
US20110243849 HEME-BINDING PHOTOACTIVE POLYPEPTIDES AND METHODS OF USE THEREOF  
The present disclosure provides photoactive polypeptides. A subject photoactive polypeptide is useful in a variety of applications, which are also provided.
US20150211040 METHODS OF PRODUCTION OF PRODUCTS OF METABOLIC PATHWAYS  
A plurality of isolated polynucleotide sequences encoding enzymes of the astaxanthin pathway is disclosed. The polynucleotides include: (i) a polynucleotide which encodes Phytoene dehydrogenase...
US20110136182 SWOLLENIN COMPOSITIONS AND METHODS OF INCREASING THE EFFICIENCY OF A CELLULASE  
Described are compositions and methods relating to enhancing the efficiency of cellulases for sugar production from cellulosic biomass using the polypeptide swollenin.
US20140073029 TARGETED PERHYDROLASES  
Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a...
US20120321581 TARGETED PERHYDROLASES  
Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a...
US20100323421 METHOD FOR CHEMICALLY MODIFYING BIOPOLYMER AND POLYPEPTIDE  
It is an object of the present invention to provide a method for chemically modifying biopolymer and polypeptide with a hydrophobic compound or a compound which causes degradation or reaction...
US20110124046 Extracellular Secretion of Recombinant Proteins  
Nucleic acids encoding secretion signals, expression vectors containing the nucleic acids, and host cells containing the expression vectors are disclosed. Also disclosed are polypeptides that...
US20110171634 METHODS AND DEVICES FOR SINGLE-MOLECULE WHOLE GENOME ANALYSIS  
Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These...
US20150071899 CAS9-FOKI FUSION PROTEINS AND USES THEREOF  
Some aspects of this disclosure provide compositions, methods, and kits for improving the specificity of RNA-programmable endonucleases, such as Cas9. Also provided are variants of Cas9, e.g.,...
US20140212403 CHEMICALLY MODIFIED CYSTATHIONINE BETA-SYNTHASE ENZYME FOR TREATMENT OF HOMOCYSTINURIA  
The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related...
US20100284913 Methods and compositions for studying, imaging, and treating pain  
Saxitoxin analogue compounds, compositions, pharmaceutical compositions, methods of synthesis of saxitoxin analogues, methods of imaging, methods of treatment, including methods of treating pain,...
US20130011890 WHOLE CELL BIOCATALYST  
The present invention relates to a method for producing a product of a reaction catalysed by a nitrilase, which method comprises the steps (i) providing a microorganism comprising said nitrilase...
US20140242608 COMPOSITION FOR DIAGNOSIS OF LUNG CANCER AND DIAGNOSIS KIT FOR LUNG CANCER  
The present invention provides serum paraoxonase 1 protein as a biomarker useful for early diagnosis of lung cancer.
US20150050215 PROTEIN-BASED THERAPY AND DIAGNOSIS OF TAU-MEDIATED PATHOLOGY IN ALZHEIMER'S DISEASE  
The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute...
US20120164130 Modified Factor IX Polypeptides and Uses Thereof  
The invention relates to modified Factor IX polypeptides such as Factor IX polypeptides with one or more amino acid substitutions. The invention also relates to methods of making modified Factor...
US20140227291 AMYLOID-BETA BINDING PROTEINS  
The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Aβ(20-42) globulomer or any Aβ form that comprises the globulomer epitope....
US20130295004 IL-1 BINDING PROTEINS  
The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β...
US20120275996 IL-1 Binding Proteins  
The present invention describes IL-1α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1α. Binding proteins of the invention have high affinity for IL-1α...
US20110165063 IL-1 BINDING PROTEINS  
The present invention describes IL-1α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1α. Binding proteins of the invention have high affinity for IL-1α...
US20110142761 IL-1 BINDING PROTEINS  
The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β...
US20120207737 MEDICAL UTILITY OF GLYCAN-BINDING PROTEINS AND GLYCANS  
The present invention relates to the use of glycan-binding polypeptides and glycans as a medicament, in particular for treating and/or preventing helminthic infections or an immune disease....
US20110136158 PROTEIN ELECTRON MEDIATOR  
The problem to be resolved is to provide an electron mediator and a fusion body with high affinity with an enzyme, a measuring method using extracellular secretion type cytochrome and an enzyme,...
US20110045513 PROTEIN ELECTRON MEDIATOR  
The problem to be resolved is to provide an electron mediator and a fusion body with high affinity with an enzyme, a measuring method using extracellular secretion type cytochrome and an enzyme,...
US20120058120 Targets for Growth Factor Signalling and Methods of Therapy  
Methods of screening or designing therapeutic agents effective for the treatment of a transglutaminase-associated disease, disorder and/or condition are provided which include determining whether...
US20140170129 PREPARATION OF STABILIZED CATALASE ENZYMES WITH A SURFACTANT  
There is provided a method of producing a stabilized microcrystalline cellulose powder containing catalase enzyme. In the method, cellulose is thoroughly mixed with phosphate borate and catalase,...
US20130028843 KALLIKREIN 7 MODULATORS  
The present invention relates to the crystal structure of the serine protease kallikrein 7 and to the use of this crystal structure in drug discovery. The present invention also relates to...
US20130084569 NANOMOTORS AND MOTION-BASED DETECTION OF BIOMOLECULAR INTERACTIONS  
Techniques and systems are disclosed for detecting biomolecular interactions based on the motion of nanomotors. In one aspect, a method of detecting biomolecular interactions based on a motion of...
US20120014964 ALPHA SYNUCLEIN TOXICITY  
Present inventions demonstrates that alpha synuclein toxicity such as α-synuclein mediated cell death, alpha synuclein induced reactive oxygen species (ROS) in a cell requires the proapoptotic...
US20130247232 COLON AND PANCREAS CANCER PEPTIDOMIMETICS  
The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages....
US20110314564 ENZYMES AND METHODS FOR HYDROLYSING PHENYLUREAS, CARBAMATES AND ORGANOPHOSPHATES  
The present invention relates to enzymes which are able to hydrolyse phenylureas, carbamates, and/or organophosphates, as well as polynucleotides encoding these enzymes. The present invention also...
US20130071431 Method for Preserving Polypeptides Using A Sugar and Polyethyleneimine  
The invention relates to the preservation of an active agent, such as a polypeptide, by contacting the active agent with a preservation mixture including a sugar and polyethyleneimine.
US20110212127 Method for Preserving Polypeptides Using a Sugar and Polyethyleneimine  
The invention relates to the preservation of an active agent, such as a polypeptide, by contacting the active agent with a preservation mixture including a sugar and polyethyleneimine.