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US20100303789 Methods of Treating Chronic Neurogenic Inflammation Using Neurotrophin Retargeted Endopepidases  
The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating chronic neurogenic inflammation in a mammal using such TVEMPs and compositions.
US20100303788 Methods of Treating Chronic Neurogenic Inflammation Using Galanin Retargeted Endopepidases  
The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating chronic neurogenic inflammation in a mammal using such TVEMPs and compositions.
US20120094357 TAB MOLECULES  
The present invention relates to TAB molecules, ADEPT constructs directed against TAG-72, and their use in therapy.
US20130274129 TAL-EFFECTOR ASSEMBLY PLATFORM, CUSTOMIZED SERVICES, KITS AND ASSAYS  
The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional...
US20110081702 Method for the Production of Proteins  
The present invention relates to a process for the purification of a protease.
US20110085939 NODE POLYPEPTIDES FOR NANOSTRUCTURE ASSEMBLY  
Engineered proteins are used in the assembly of two-dimensional and three-dimensional nanostructure assemblies, based on systematic design and production of protein node structures that can be...
US20130224828 RNA-Directed Packaging of Enzymes Within Protein Particles  
Protein nanoparticles encapsulate cargo proteins within an enclosure containing a protected chemical milieu. Encapsulation within such protected chemical milieu enhances the employability and...
US20140274903 USE OF GALACTOSE OXIDASE FOR SELECTIVE CHEMICAL CONJUGATION OF PROTRACTOR MOLECULES TO PROTEINS OF THERAPEUTIC INTEREST  
This invention relates to novel compounds, methods for selective chemical conjugation of protractor molecules and the use thereof for diagnostic and/or therapeutic purposes.
US20110008348 SOLUBLE FRAGMENTS OF INFLUENZA VIRUS PB2 PROTEIN CAPABLE OF BINDING RNA-CAP  
A plastic container includes an upper portion having a mouth defining an opening into the container. A shoulder region extends from the upper portion. A sidewall portion extends between the...
US20120328534 ENZYMATIC PERACID GENERATION FOR USE IN ORAL CARE PRODUCTS  
Disclosed herein are compositions and methods to treat an oral cavity surface with a peracid-based benefit agent. The peracid benefit agent can be use for oral surface bleaching, whitening,...
US20140024056 SURROGATES OF POST-TRANSLATIONALLY MODIFIED PROTEINS AND USES THEREOF  
The present invention provides compounds that are surrogates of post-translationally modified proteins and uses thereof. Numerous diseases are associated with post-translationally modified...
US20140170702 METHOD FOR PRODUCING A RECOMBINANT PROTEIN OF INTEREST  
Disclosed is a method for producing a recombinant protein of interest, the method being characterised in by the following steps: (a) providing a fusion protein comprising an Npro autoprotease...
US20130071375 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION  
The present invention provides methods for treating sepsis comprising administering to an individual an effective amount of a chimeric protein.
US20140170701 METHOD FOR PRODUCING A RECOMBINANT PROTEIN OF INTEREST  
Disclosed is a method for producing a recombinant protein of interest which is characterised by the following steps: (a) providing a first part of an Npro autoprotease and providing a second part...
US20120121537 Methods and Compositions for Inhibiting Hepatitis C Virus Replication  
Compositions and methods for reducing hepatitis C virus (HCV) replication are provided. Also provided are compositions and methods of treating an HCV infection; methods of reducing the incidence...
US20120027742 METHODS FOR TREATING ADULT RESPIRATORY DISTRESS SYNDROME  
We have discovered that the activated phosphorylated form of focal adhesion kinase (hereafter “FAKp”) strengthens the microvascular endothelial cell (EC) junctions that form a barrier in pulmonary...
US20110207157 Labelling of Fusion Proteins With Synthetic Probes  
The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to...
US20140099294 Biotherapy for Pain  
The present invention is directed to analgesic Clostridial neurotoxin derivatives comprising polypeptides having a long-lasting SNARE protein-selective endopeptidase activity. These derivatives...
US20120142070 REHYDRATABLE MATRICES FOR DRY STORAGE OF TAQ POLYMERASE IN A MICROFLUIDIC DEVICE  
Formulations for dry storage of PCR reagents are described. These formulations find use in manufacture of self-contained microfluidic card devices for PCR clinical testing in which the reagents...
US20140127180 MUTANT CYTOCHROME P450 2B6 PROTEINS AND USES THEREOF  
The present invention to relates mutant human cytochrome P450 2B6 (CYP2B6) proteins, and fusion proteins comprising said mutant CYP2B6 proteins. In particular, fusion proteins comprising mutant...
US20110206736 Cancer Vaccines Against Mucosal Antigens and Methods of Making and Using the Same  
Nucleic acid molecules comprising a nucleotide sequence that encodes a chimeric protein are disclosed. The chimeric proteins comprise at least one epitope of a mucosally restricted antigen, at...
US20120077706 METHOD FOR ASSAYING PROTEIN-PROTEIN INTERACTION  
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the...
US20110142756 Method And Composition For The Treatment Of Cancer By The Enzymatic Conversion Of Soluble Radioactive Toxic Precipitates In The Cancer  
The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called...
US20100297219 Methods and Compositions for Modifying Apolipoprotein B mRNA Editing  
Products and methods for modifying apolipoprotein B mRNA editing in vivo, reducing serum LDL levels, and treating or preventing an atherogenic disease or disorder are disclosed. Such methods...
US20120177679 MATRIX METALLOPROTEINASE 11 VACCINE  
Compositions comprising matrix metalloproteinase 11 (MMP-11) or stromelysin-3 (ST-3) or the nucleic acid encoding the MMP-11 for use in vaccines for treating tumors and cancers, which overexpress...
US20150247134 TATk-CDKL5 FUSION PROTEINS, COMPOSITIONS, FORMULATIONS, AND USE THEREOF  
Disclosed herein are compositions and formulations containing a TATk-CDKL5 fusion protein. Also disclosed are methods of producing a TATk-CDKL5 fusion protein from vectors containing a TATk-CDKL5...
US20150159172 METHODS AND COMPOSITIONS FOR GENOME ENGINEERING  
Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease.
US20130084247 COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS  
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains...
US20120122179 MEANS FOR PURIFYING A PROTEIN OF BLOOD PLASMA AND METHODS FOR IMPLEMENTING SAME  
An affinity substrate for the selective binding of a protein of blood plasma includes a solid substrate material on which are immobilized deoxyribonucleic aptamers specifically binding with the...
US20110053244 NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS  
A novel protein delivery system to generate induced pluripotent stem (iPS) cells is described. The delivery system comprises a construct with a receptor binding domain that recognizes a receptor...
US20150087628 COMPOSITIONS AND METHODS FOR TREATING CANCER  
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
US20130236491 SPHERICAL NANO AND MICROPARTICLES DERIVED FROM PLANT VIRUSES FOR THE DISPLAY OF FOREIGN PROTEINS OR EPITOPES  
A novel type of particle platform for application in biotechnology is provided by the present invention. Said platforms comprise RNA-free particles generated by thermal denaturation and structural...
US20120202263 Bioactive Macromers and Hydrogels and Methods for Producing Same  
The invention concerns macromers, having a molecular weight of at least 2 kDa, comprising at least one unit of the formula P-(protein-P)n, wherein: P is selected from polyethylene glycol (PEG),...
US20150247133 METHODS AND TOOLS FOR IDENTIFICATION OF RSK/MSK KINASE INHIBITORS  
The present invention concerns 3D-crystals of complexes of ribosomal S6 kinase (RSK) and mitogen- and stress-activated protein kinase (MSK) proteins and their ligands, as well as methods for...
US20140322788 method for increasing protein thermal stability  
The invention provides a simple and effective method for increasing thermal stability of a wide range of proteins, comprising fusing a self-assembling amphipathic peptide to the C- or N-terminal...
US20140187444 METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION  
The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for identifying therapeutic compounds to treat glycosylation-associated disorders...
US20150024442 MODIFIED DIACYLGLYCEROL ACYLTRANSFERASE PROTEINS AND METHODS OF USE THEREOF  
Provided are fusion proteins of diacylglycerol acyltransferase (DGAT) polypeptides fused to at least one heterologous intracellular localization domain, such as a bacterial membrane-targeting...
US20120227120 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM  
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
US20110277046 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM  
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
US20100303757 Methods of Treating Chronic Neurogenic Inflammation Using Interleukin Retargeted Endopepidases  
The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating chronic neurogenic inflammation in a mammal using such TVEMPs and compositions.
US20140273142 NANOLIPOPROTEIN PARTICLES COMPRISING A NATURAL RUBBER BIOSYNTHETIC ENZYME COMPLEX AND RELATED PRODUCTS, METHODS AND SYSTEMS  
Provided herein are nanolipoprotein particles that comprise a biosynthetic enzyme more particularly an enzyme capable of catalyzing rubber or other rubbers polymerization, and related assemblies,...
US20130252282 OPTICAL CONTROL OF PROTEIN ACTIVITY AND LOCALIZATION BY FUSION TO PHOTOCHROMIC PROTEIN DOMAINS  
Engineered fusion proteins comprising photochromic protein domains are disclosed. In particular, the inventors have constructed fusion proteins containing photoswitchable photochromic fluorescent...
US20140051145 NUCLEIC ACID AND CORRESPONDING PROTEIN NAMED 158P1D7 USEFUL IN THE TREATMENT AND DETECTION OF BLADDER AND OTHER CANCERS  
The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and...
US20130143294 NUCLEIC ACID AND CORRESPONDING PROTEIN NAMED 158P1D7 USEFUL IN THE TREATMENT AND DETECTION OF BLADDER AND OTHER CANCERS  
The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and...
US20150125445 COMPOSITIONS AND METHODS FOR TREATING CANCER  
The present invention provides compositions for targeting SAS1B positive cancer cells using immunotoxin technology and discloses that kidney and pancreatic cancer cells are SAS1B positive, but not...
US20150203918 MUTATED ACVR1 FOR DIAGNOSIS AND TREATMENT OF FIBRODYPLASIA OSSIFICANS PROGRESSIVA (FOP)  
This invention is directed to mutated Activin A type I receptor proteins (ACVR1) and isolated nucleic acids encoding same. The invention also relates to the use of mutated ACVR1 in the diagnosis...
US20140134203 Respiratory Syncytial Virus (RSV) Sequences For Protein Expression and Vaccines  
The invention provides RSV fusion (F) protein ectodomain polypeptide sequences and nucleotide sequences encoding them, as well as cells containing the invention's polypeptide and nucleotide...
US20110236408 RESPIRATORY SYNCTIAL VIRUS (RSV) SEQUENCES FOR PROTEIN EXPRESSION AND VACCINES  
The invention provides RSV fusion (F) protein ectodomain polypeptide sequences and nucleotide sequences encoding them, as well as cells containing the invention's polypeptide and nucleotide...
US20130316962 Muteins of hNGAL and related proteins with affinity for a given target  
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related...
US20110262353 MUTEINS OF HNGAL AND RELATED PROTEINS WITH AFFINITY FOR A GIVEN TARGET  
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also relates...