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US20140199749 Compositions and Methods for cDNA Synthesis  
The present invention relates to methods and compositions for preparing cDNAs, and more particularly, compositions having trehalose for synthesizing a cDNA molecule or molecules from an mRNA...
US20140004142 PCSK9 VACCINE  
The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide containing a phosphorylation site (with or without phosphorylation of the site) linked to...
US20120263700 HUMAN CYSTATHIONINE BETA-SYNTHASE VARIANTS AND METHODS OF PRODUCTION THEREOF  
Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the...
US20120189606 Antimicrobial Agents  
The present invention relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of...
US20150190329 MINERAL-ENZYME COMPLEX FOR STRENGTHENING AND WHITENING TOOTH ENAMEL, ORAL HYGIENE COMPOSITION, AND TOOTHPASTE  
The invention relates to the field of cosmetology, namely to mineral-enzyme complexes for tooth enamel strengthening and whitening, and also to compositions for oral hygiene comprising said...
US20140044646 Labeled, Non-Peptidic, Multivalent Integrin Antagonist Compounds; Methods for Synthesis and Uses Thereof  
Disclosed are multivalent, integrin-receptor antagonists that are useful in a variety of therapeutic, prophylactic, and/or diagnostic imaging modalities. In illustrative embodiments, such...
US20130273021 NPP1 FUSION PROTEINS  
The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the...
US20150086998 VALUE-ASSIGNED SOLUTIONS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 HAVING A LONG SHELF-LIFE  
Value-assigned solutions having predetermined concentrations of recombinant Lp-PLA2 are described herein. In particular, described herein are solutions of rLp-PLA2 that are stable for an extended...
US20140079683 Multifunctional Cellulase And Hemicellulase  
A multifunctional polypeptide capable of hydrolyzing cellulosic materials, xylan, and mannan is disclosed. The polypeptide includes the catalytic core (cc) of Clostridium thermocellum Cthe_0797...
US20110136922 ACTIVATION INDUCED DEAMINASE (AID)  
The invention is directed to a cell comprising a nucleic acid encoding an Activation Induced Deaminase (AID) polypeptide, a fusion protein comprising an AID polypeptide, and methods of using a...
US20110236951 Biocomposite materials and methods for making the same  
A particle (and a composition that includes a plurality of the particles) that includes at least one polypeptide molecule and at least one polymer covalently bound to the polypeptide molecule so...
US20110104760 METHODS AND COMPOSITIONS FOR IMPROVING EFFICIENCY OF NUCLEIC ACIDS AMPLIFICATION REACTIONS  
The present invention provides methods and compositions for improving the efficiency of nucleic acid amplification reactions. The invention encompasses hybrid polymerases that show increased...
US20130288274 RECOMBINANT DEAMIDATED GLIADIN ANTIGEN  
The present invention provides a method for determining whether a subject is suffering from celiac disease by contacting a sample of bodily fluid from the subject, with an antigen formed from a...
US20140186957 ENGINEERED TAL EFFECTOR PROTEINS WITH ENHANCED DNA TARGETING CAPACITY  
The present invention provides compositions and methods for DNA targeting using TAL effectors and TAL effector based proteins, including but not limited to targeted gene regulation and targeted...
US20120195872 ANTIMICROBIAL AGENTS  
The present invention relates to antimicrobial agents against Gram-positive bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of...
US20130224801 TREATMENT OF CELLULOSIC MATERIAL AND ENZYMES USEFUL THEREIN  
The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from...
US20110104675 Methods and Compositions for Diagnosing Carcinomas  
The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble forms of mesothelin polypeptides, including mesothelin...
US20130338067 Fusion Polypeptides Comprising an Active Protein Linked to a Mucin-Domain Polypeptide  
The present invention provides fusion proteins comprising a mucin-domain polypeptide covalently linked to an active protein that has improved properties (e.g. pharmacokinetic and/or...
US20130260407 METHOD FOR THE PURIFICATION AND STABILISATION OF ENZYME GLUCONATE DEHYDROGENASE (GADH, EC 1.1.99.3), ENZYME GLUCONATE DEHYDROGENASE (GADH, EC 1.1.99.3), AND THE USE OF ENZYME GLUCONATE DEHYDROGENASE (GADH, EC 1.1.99.3)  
Process of purification and stabilization of the enzyme Gluconate Dehydrogenase (GADH, EC 1.1.99.3) either recombinant or not, from several microorganisms such as: Pseudomonas aeruginosa,...
US20130344051 Compostion of matter for treating or preventing various types of cancer and neoplastic diseases in a mammal  
A composition of matter can reduce size of cancerous tumors in mammals. The composition of matter comprises Bromelain infused with vitamin C creating a protein enzyme complex which can be...
US20120093795 COMPOUNDS TARGETING THE CATION-INDEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR  
The invention relates to conjugates of products of interest and of compounds targeting the cation-independent mannose 6-phosphate receptor with a high affinity. The invention also relates to their...
US20140219955 FUSION MOLECULES AND IL-15 VARIANTS  
The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making thesuch proteins. The instant invention...
US20110171191 SUPPRESSION OF NEUROENDOCRINE DISEASES  
The present invention relates to a method for suppressing neuroendocrine disease. The therapy employs use of a non-cytotoxic protease, which is targeted to a neuroendocrine tumour cell, preferably...
US20100255558 SUPRAMOLECULAR BIOCONJUGATES  
The invention relates to supramolecular bioconjugates and to methods for assembling and utilizing supramolecular bioconjugates. Supramolecular bioconjugates comprise a plurality of first nucleic...
US20140147380 GUANYLYLCYCLASE C LIGANDS  
Guanylin cyclase C compound of the inventions are disclosed. Conjugated compounds comprising guanylin cyclase C compound of the inventions conjugated to detectable or therapeutic moieties are...
US20120315676 ENDOGLUCANASES  
The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase.
US20140094385 SEQUENCE-SPECIFIC ENGINEERED RIBONUCLEASE H AND THE METHOD FOR DETERMINING THE SEQUENCE PREFERENCE OF DNA-RNA HYBRID BINDING PROTEINS  
The subject of the invention is the ribonuclease which cleaves RNA strand in DNA-RNA hybrids, wherein ribonuclease comprises fusion protein comprising catalytic domain of RNase HI (RNase HI) or...
US20110201001 METHODS AND MATERIALS FOR ASSESSING RNA EXPRESSION  
This document provides methods and materials for assessing RNA expression. For example, methods and materials for detecting the presence, absence, or amount of target nucleic acid (e.g., target...
US20120195908 COMBINATORIAL THERAPY  
The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal...
US20110165649 METHODS AND COMPOSITIONS TO IMPROVE THE HEALTH OF PLANTS, ANIMALS AND MICROBES BY MANIPULATING PROTEIN ENTRY INTO SYMBIONTS AND THEIR HOSTS  
Fusion constructs with i) a domain that is specific for binding, on the surface of a cell, a lipid that is characteristic of the cell, and ii) a domain or agent that possesses an activity of...
US20130157337 TEMPLATE-DIRECTED ASSEMBLY OF RECEPTOR SIGNALING COMPLEXES  
Transmembrane receptors in the signaling pathways of bacterial chemotaxis systems influence cell motility by forming noncovalent complexes with the cytoplasmic signaling proteins to regulate their...
US20120251573 Endopeptidase Treatment of Neuroendocrine Disorders  
The present specification discloses TEMs, compositions comprising such TEMs, compositions comprising such TEMs and Clostridial toxins, methods of treating a neuroendocrine disorder in an...
US20110086404 METHOD FOR MONITORING, DIAGNOSING, AND SCREENING CANCER THROUGH MEASURING THE CONCENTRATION OF DES-R PROTHROMBIN ACTIVATION PEPTIDE FRAGMENT F2 (DES-R F2) IN A SERUM  
The present invention relates to a method for diagnosis and screening of cancer by measuring the expression of des-R prothrombin activation peptide fragment F2 (des-R F2) in serum, more precisely,...
US20150017098 CARRIER THAT TARGETS FUCOSYLATED MOLECULE-PRODUCING CELLS  
The present invention relates to a carrier that is targeted at fucosylated molecule-producing cells, which comprises an effective amount of fucose for targeting said cells, to a composition...
US20130224212 METHODS AND PRODUCTS RELATING TO GSK3SS REGULATION  
The invention relates to methods and compositions for regulation of GSK3β activity. The invention provides phosphorylated GSK3β polypeptides and antibodies that recognize such polypeptides. The...
US20120252092 CLOSTRIDIUM HISTOLYTICUM RECOMBINANT COLLAGENASES AND METHOD FOR THE MANUFACTURE THEREOF  
The present invention relates to the production of recombinant collagenases, and in particular describes a method for the production of recombinant Clostridium histolyticum collagenases CoI...
US20150093788 METHODS AND REAGENTS FOR MOLECULAR CLONING  
The present invention provides compositions, methods, and kits for covalently linking nucleic acid molecules. The methods include a strand invasion step, and the compositions and kits are useful...
US20130323797 METHODS AND REAGENTS FOR MOLECULAR CLONING  
The present invention provides compositions, methods, and kits for covalently linking nucleic acid molecules. The methods include a strand invasion step, and the compositions and kits are useful...
US20120189601 ASSISTED ENZYME REPLACEMENT THERAPY  
Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various...
US20110201024 COMPOSITIONS COMPRISING A DEHALOGENASE SUBSTRATE AND A FLUORESCENT LABEL AND METHODS OF USE  
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase...
US20130004996 METHODS AND COMPOSITIONS FOR SYNTHESIS OF NUCLEIC ACID MOLECULES USING MULTIPLERECOGNITION SITES  
The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition...
US20080145910 STABILIZED COMPOSITIONS OF THERMOSTABLE DNA POLYMERASE AND ANIONIC OR ZWITTERIONIC DETERGENT  
The present invention provides compositions, methods, and kits for protecting thermostable DNA polymerase during amplification reactions conducted at a temperature ranging from about 40° C. to...
US20150050715 Stably Tethered Structures of Defined Compositions with Multiple Functions or Binding Specificities  
The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments...
US20110143417 Stably Tethered Structures of Defined Compositions with Multiple Functions or Binding Specificities  
The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments...
US20120142062 ENGINEERED CLEAVAGE HALF-DOMAINS  
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and...
US20110201055 Engineered cleavage half-domains  
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and...
US20120021437 TETRANOR-PGDM/PGJM SPECIFIC IMMUNOGENS, ANTIBODIES, TRACERS, ASSAY KITS AND METHODS FOR MAKING SAME  
Tetranor-PGDM/tetranor-PGJM-specific antibodies, immunogens used to generate them, the processes of their manufacture, and their uses in assay kits for detecting and quantifying tetranor-PGDM and...
US20140193890 THERMOSTABLE ENZYMES AND METHODS OF MAKING AND USING THE SAME  
Provided herein are compositions and methods for enhancing enzyme activity, half-life and/or thermostability. Also provided herein are compositions and methods including the enhanced enzymes. Also...
US20120329748 ACTIVATION AND ACTIVATORS OF SIRT5  
The invention provides a method of increasing a deacetylase activity of SIRT5 by contacting SIRT5 with an agent that binds SIRT5 and reduces the Km of SIRT5 for a substrate, thereby increasing the...
US20110229451 TEMPERATURE SENSITIVE MUTANTS OF MATRIX METALLOPROTEASES AND USES THEREOF  
Provided are modified matrix metalloprotease (MMP) enzymes that exhibit temperature-dependent activity and uses thereof. The MMPs can be used, for example, to treat ECM-mediated diseases or...